BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s disease.The disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patie...BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s disease.The disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is unclear.AIM To explore the near-infrared brain function characteristics of MCI with sleep disorders.METHODS A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were selected.All subjects underwent the functional near-infrared spec-troscopy test.Collect baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task period.The relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<0.05.CONCLUSION Patients with MCI and sleep disorders have lower near-infrared brain function than normal people,which is related to sleep quality.Clinically,a comprehensive assessment of the near-infrared brain function of patients should be carried out to guide targeted treatment and improve curative effect.展开更多
Recent studies have revealed that patients with septic shock and acute skin failure(ASF)exhibit significantly higher levels of inflammatory cytokines,lactate,and C-reactive protein,along with elevated skin mottling sc...Recent studies have revealed that patients with septic shock and acute skin failure(ASF)exhibit significantly higher levels of inflammatory cytokines,lactate,and C-reactive protein,along with elevated skin mottling score;modified early warning score(MEWS);and anxiety,depression,and Pittsburgh sleep quality index scores compared to those without ASF.Notably,these indicators are significantly correlated.Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9,indicating severe disease progression.Therefore,it is ess-ential to not only manage septic shock but also mitigate anxiety,depression,sleep disorders,and disturbances of consciousness.This article explores the impact of severe anxiety,depression,and sleep disorders on the prognosis of septic shock and discusses intervention strategies.展开更多
BACKGROUND Doctoral students often encounter mental health challenges,including stress,anxiety,depression,and sleep disorders.It is important to explore effective intervention methods to enhance their overall physical...BACKGROUND Doctoral students often encounter mental health challenges,including stress,anxiety,depression,and sleep disorders.It is important to explore effective intervention methods to enhance their overall physical and mental well-being.It is anticipated that targeted exercise will lead to a significant reduction in stress,anxiety,and depression levels as well as an improvement in sleep quality.AIM To assess the feasibility and potential benefits of both intervention models in enhancing the sleep quality of doctoral students while alleviating stress,anxiety,and depression.METHODS A retrospective analysis of health data from 64 doctoral students across three universities in Shenyang during the 2024-2025 academic year was conducted.The participants were divided into a targeted exercise group and a Tai Chi group.The study employed the Epworth Sleepiness Scale,Insomnia Severity Index,Pittsburgh Sleep Quality Index,Perceived Stress Scale-10,Generalized Anxiety Disorder Scale-7,and Patient Health Questionnaire-9 to evaluate the impact of the two interventions on reducing stress,anxiety,depression,and sleep disorders.RESULTS The primary results of the study indicated that targeted exercise interventions are significantly effective in alleviating symptoms of anxiety,stress,and depression,as well as in improving sleep quality.Compared to Tai Chi interventions,this approach demonstrates greater durability of effects.Although the efficacy of targeted interventions may gradually diminish over time,the overall research findings suggest that targeted exercise remains a more effective therapeutic approach than Tai Chi interventions.CONCLUSION The impact of targeted exercise on stress,anxiety,depression,and sleep disorders was greater than that of Tai Chi,confirming the potential benefits for psychological health intervention for doctoral students.展开更多
As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,ci...As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,cirrhosis)and aflatoxin exposure.However,with evolving lifestyles and environmental changes,sleep disorders have become increasingly prevalent.Emerging evidence suggest that sleep disorders may contribute to hepatocarcinogenesis through multiple mechanisms,including immunity environment disorder,oxidative stress,metabolic dysregulation,disruption of gut microbiota,and circadian rhythm disruption,thereby influencing disease progression and patient prognosis.This review summarizes epidemiological evidence on the relationship between sleep disorders and HCC incidence,explores the underlying mechanisms through which sleep disorders contribute to HCC,and discusses clinical challenges and potential intervention strategies.Our objective is to provide novel insights into HCC prevention and therapeutic approaches.展开更多
Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor sympto...Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.展开更多
Recent years have seen a burgeoning interest in elucidating the intricate relationship between vestibular dysfunction and sleep disorders,owing to their substantial impact on daily functioning and overall health.Despi...Recent years have seen a burgeoning interest in elucidating the intricate relationship between vestibular dysfunction and sleep disorders,owing to their substantial impact on daily functioning and overall health.Despite significant advancements,the precise mechanisms underpinning this interplay remain elusive.This review aims to synthesize the current literature on the association between vestibular dysfunction and sleep disorders,focusing on potential causal mechanisms and therapeutic implications.We systematically examine various sleep disorders,including insomnia,circadian rhythm disorders,and sleep apnea,in association with specific vestibular dysfunctions,such as Meniere’s disease(MD),vestibular migraine(VM),benign paroxysmal positional vertigo(BPPV),vestibular neuritis(VN),and persistent postural perceptual dizziness(PPPD).By exploring these complex interactions,our goal is to provide a comprehensive understanding that contributes to the ongoing discourse in this field.We seek to encourage further investigations into innovative diagnostic and therapeutic strategies,ultimately aiming to improve the clinical management and enhance the quality of life for patients affected by both vestibular dysfunction and sleep disorders.展开更多
OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathw...OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathway. METHODS:Forty Sprague-Dawley rats were randomly divided into four groups, and administered distilled water, XYAS and its two different disassembly prescriptions by gavage respectively. Four types of drug-containing serums corresponding to the four groups were then prepared. Tumor necrosis factor(TNF)-α stimulated Ha Ca T was used to establish a psoriasis cell model, and the serums and the retinoid related orphan receptor alpha(RORα) inverse agonist were used respectively to intervene in the model. Enzyme-linked immunosorbent assay was used to detect the levels of interleukin(IL)-6 and melatonin in each group;flow cytometry was used to detect the levels of reactive oxygen species(ROS), mitochondrial membrane potential, and apoptosis;Western blot was used to evaluate the levels of superoxide dismutase 2(SOD2), cytochrome-c(Cyt-c), inhibitor of kappa-B alpha(IκBα), p65 and phosphorylated p65. RESULTS:XYAS and its disassembly prescriptions inhibited the secretion of inflammatory factors such as IL-6, reduced the ROS content and Cyt-c expression, increased the mitochondrial membrane potential and SOD2 content, promoted the apoptosis in Ha Ca T cells and inhibited the activation of the NF-κB pathway. XYAS was also found increase the melatonin content. The above effects are beneficial in the treatment of psoriasis combined with sleep disorders. Meanwhile, XYAS no longer had a significant ameliorative effect after applying the RORα inverse agonist, suggesting that the therapeutic effect of XYAS is related to RORα. CONCLUSIONS:The results of this study confirm that XYAS can be utilized for the treatment of psoriasis combined with sleep disorders via inhibiting the NF-κB pathway, anti-inflammatory, antioxidant and proapoptotic, which is in part related to the regulatory role of melatonin and its receptor RORα.展开更多
Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that d...Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that discrepancies can occur between subjective data regarding sleep disturbances and the impact of insomnia and objective assays, and surrogate markers of sleep and sleep disturbances. Both objective and subjective measures should be incorporated into clinic studies. It seems likely that sleep quality is represented by a combination of more than one subjective sleep parameter. Objective and subjective assessments of sleep quality may relate to different parameters. Future studies incorporated both subjective and objective measures could help to address the sleep disorders.展开更多
BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult....BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult.Identifying the factors associated with spinal infection and early intervention can reduce the occurrence of the disease.At present,the research mainly focuses on the accurate diagnosis and treatment of spinal infection,and there are few studies on the prevention of spinal infection.The concept of"preventive treatment of diseases"in traditional Chinese medicine may help identify the causes and reduce the occurrence of NOSI.AIM To determine the association of age,bowel movements,and sleep patterns with NOSI.METHODS Data of 69 NOSI patients and 84 healthy controls in a tertiary hospital from January 2019 to June 2024 were collected.Patients with NOSI had imaging evidence(magnetic resonance imaging)of spinal infections(including infections caused by tuberculosis,brucopathy,and other pathogens)and had no history of spinal surgery in the last 1 year were included in the analysis.Patients with spinalinfection due to spinal surgery are excluded in the study.Data including age,sex,place of residence,sleeping status,and bowel movements were collected.SPSS22.0 was used for correlation analysis of all data.RESULTS The mean age of the NOSI group and the control group was 63.55±14.635 years and 59.18±17.111 years,respectively,without statistical difference(P=0.096).There was also no statistically significant difference in gender between the two groups.In the NOSI group,45(65.22%)were over 60 years old,and 44(63.77%)were rural residents.Compared with the control group,the NOSI group had more patients with sleep disorder and defecation disorder,accounting for 69.57%and 68.12%,respectively,with significant statistical difference(both P<0.001).Regression analysis showed that defecation and sleep disorders were closely related to NOSI(both P<0.001).CONCLUSION Most patients with NOSI are older and have sleep disorders and abnormal defecation.展开更多
Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s disease.Sleep disorders further impair cognitiv...Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s disease.Sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-βand tau in patients with Alzheimer’s disease.At present,sleep disorders are considered as a risk factor for,and may be a predictor of,Alzheimer’s disease development.Given that sleep disorders are encountered in other types of dementia and psychiatric conditions,sleep-related biomarkers to predict Alzheimer’s disease need to have high specificity and sensitivity.Here,we summarize the major Alzheimer’s disease-specific sleep changes,including abnormal non-rapid eye movement sleep,sleep fragmentation,and sleep-disordered breathing,and describe their ability to predict the onset of Alzheimer’s disease at its earliest stages.Understanding the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer’s disease.This paper therefore explores some potential mechanisms that may contribute to sleep disorders,including dysregulation of the orexinergic,glutamatergic,andγ-aminobutyric acid systems and the circadian rhythm,together with amyloid-βaccumulation.This review could provide a theoretical basis for the development of drugs to treat Alzheimer’s disease based on sleep disorders in future work.展开更多
Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morb...Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morbidity and mortality burden. The complex and dynamic relationship between sleep disorders and chronic kidney disease(CKD) remain relatively little investigated. This article presents an overview of sleep disorders in patients with CKD, with emphasis on relevant pathophysiologic underpinnings and clinical presentations. Evidence-based interventions will be discussed, in the context of individual sleep disorders, namely sleep apnea, insomnia, restless leg syndrome and excessive daytime sleepiness. Limitations of the current knowledge as well as future research directions will be highlighted, with a final discussion of different conceptual frameworks of the relationship between sleep disorders and CKD.展开更多
Studies have shown that non-alcoholic fatty liver disease(NAFLD)may be associated with sleep disorders.In order to explore the explicit relationship between the two,we systematically reviewed the effects of sleep diso...Studies have shown that non-alcoholic fatty liver disease(NAFLD)may be associated with sleep disorders.In order to explore the explicit relationship between the two,we systematically reviewed the effects of sleep disorders,especially obstructive sleep apnea(OSA),on the incidence of NAFLD,and analyzed the possible mechanisms after adjusting for confounding factors.NAFLD is independently associated with sleep disorders.Different sleep disorders may be the cause of the onset and aggravation of NAFLD.An excessive or insufficient sleep duration,poor sleep quality,insomnia,sleep-wake disorders,and OSA may increase the incidence of NAFLD.Despite that some research suggests a unidirectional causal link between the two,specifically,the onset of NAFLD is identified as a result of changes in sleep characteristics,and the reverse relationship does not hold true.Nevertheless,there is still a lack of specific research elucidating the reasons behind the higher risk of developing sleep disorders in individuals with NAFLD.Further research is needed to establish a clear relationship between NAFLD and sleep disorders.This will lay the groundwork for earlier identification of potential patients,which is crucial for earlier monitoring,diagnosis,effective prevention,and treatment of NAFLD.展开更多
Introduction: Sleep disorders (SD) are common dialysis patients and can impact their quality of life. In previous studies, black ethnicity was associated with higher incidence of SD but a few data are available in Afr...Introduction: Sleep disorders (SD) are common dialysis patients and can impact their quality of life. In previous studies, black ethnicity was associated with higher incidence of SD but a few data are available in African patients. This study aimed to describe prevalence and risk factors of SD among Senegalese dialysis patients. Methods: We performed a cross-sectional study between February 15th and April 30th 2012 including 127 patients (75 males and 52 females) aged 46.8 ± 16.9 (16 - 85 years) and dialysed since >6 months in three dialysis centres. For each patient, we assessed insomnia according to international definition, obstructive sleep apnea syndrome (OSAS) with the Berlin questionnaire, restless leg syndrome (RLS) using abridged version of Cambridge-Hopkins RLS questionnaire, and excessive daytime sleepiness (EDS) with Epworth sleepiness scale. Logistic multivariate regression was used to identify factors associated with different SD. Results: Overall prevalence of SD was 88% comprising: insomnia (64.3%), OSAS (49.1%), RLS (24.1%) and EDS (20.5%). Forty-two patients presented at least two disorders. No difference was noticed in prevalence of SD between genders (p = 0.14). Level of blood pressure were not different across patients with and without SD. Insomnia correlated with anemia, inflammation and EDS. OSAS was associated with age ≥50 years, EDS and neck circumference ≥25 cm. RLS correlated with anemia and EDS. Other parameters such as gender, dialysis vintage, KT/V, obesity, diabetes status and hypoalbuminemia were not associated with the different SD. The majority of patients had not been diagnosed before the survey and none of them was under treatment. Conclusions: Our findings are compatible with high prevalence of sleep disorders reported in other populations. Insomnia and OSAS are the most frequent SD but some patients combined many disorders. Nephrologists should be more aware of these SD in order to detect them early and provide efficient treatment.展开更多
In this paper we will discuss on sleep disorders in older adults and aged people following the catastrophes and stressful life events, and then note very shortly some treatments. Sleep disorders, accompanied with head...In this paper we will discuss on sleep disorders in older adults and aged people following the catastrophes and stressful life events, and then note very shortly some treatments. Sleep disorders, accompanied with headache, have been known throughout the history of humanity and traditional medicine. In our time, diverse psychosocial and environmental factors such as wars also some psycho-socio-political events, acts of terrorism and others have shocked the world with numerous material, human, damages and victims. Many of these catastrophic acts and stressful life events, with their pathological effects, can bring consequently anxiety and depression. Sleep disorders and insomnia resulting from anxiety and depression, are very common, underdiagnosed, and become a significant source of major pain complaints in older adults and geriatric population. Some modifications in sleep patterns, during normal ageing process, as well as in retired people, may not be considered a part of pathological process of ageing; however, some factors like psychosomatical problems, death of spouse or loss of a child or other dear member family etc. can be related to pathological processes, and produce disturbances in circadian rhythm and consequently lead to sleep disorder. Based on his teaching experiences and clinical observations at Mental Health Centres, as well as theoretical studies （particularly during these three last decades） the author presents the results of his clinical researches. Our studies and lectures in University Hospitals： （Ste Anne, Lariboisière and La Salpêtrière） have enriched this research. The experiences and researches have shown that anxiety and depression exert pathological effects, not only on the cognitive system as noted elsewhere and harmful influences on the cardiovascular system, but have also pathological effects on the pineal gland and its “melatonin” hormone secretion which is considered as stimulator system （pace-maker-like） to regulate the rhythm of wake-sleep. Major depression, anxiety and trauma, resulting of catastrophic stressful life event, such as wars, acts of terrorism or others, when accumulating and occurring together, can perturb not only the circadian rhythm system, but in some extreme situations （such as inability to cope with stress or suffering, facing economic crisis and failure etc.） in some cases as noted elsewhere, they can also engender behaviour and personality disorders and finally lead to suicide. Concerning current treatments, the efficacy of melatonin to improve the quality of sleep is well established however the author would propose if possible, to maximize the dosage.展开更多
In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation wa...In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation was assessed using the Pittsburgh Sleep Quality Index（PSQI）, and the Epworth Sleepiness Scale（ESS）. It was found that poor sleep quality（77.11%） and excessive daytime sleepiness（32.34%） were commonly seen in PD patients and positively correlated with disease severity. Then 70 out of the 201 PD patients and 70 age- and sex-matched controls underwent a polysomnographic recording. The parameters were compared between PD group and control group and the influencing factors of sleep in PD patients were analyzed. The results showed that sleep efficiency（SE） was significantly decreased（P〈0.01）, and sleep latency（SL） and the arousal index（AI） were increased（P〈0.05） in the PD group as compared with those in the control group. SE and total sleep time（TST） were positively correlated with the Hoehn and Yahr（H＆Y） stage. There was significant difference in the extent of hypopnea and hypoxemia between the PD group and the control group（P〈0.05）. Our results indicate that PD patients have an overall poor sleep quality and a high prevalence of sleep disorder, which may be correlated with the disease severity. Respiratory function and oxygen supply are also affected to a certain degree in PD patients.展开更多
Sleep accounts for a third of one＇s lifetime, partial or complete deprivation of sleep could elicit sever disorders of body function. Previous studies have reported the higher prevalence of sleep disorders in glaucom...Sleep accounts for a third of one＇s lifetime, partial or complete deprivation of sleep could elicit sever disorders of body function. Previous studies have reported the higher prevalence of sleep disorders in glaucoma patients, but the definite mechanism for this phenomenon is unknown. On the other hand, it is well known by us that the intrinsically photosensitive retinal ganglion cells（ip RGCs） serve additional ocular functions, called non-image-forming（NIF） functions, in the regulation of circadian rhythm, melatonin secretion, sleep, mood and others. Specifically, ip RGCs can directly or indirectly innervate the central areas such as suprachiasmatic nucleus（SCN）, downstream pineal gland（the origin of melatonin）, sleep and wake-inducing centers and mood regulation areas, making NIF functions of ip RGCs relate to sleep. The more interesting thing is that previous research showed glaucoma not only affected visual functions such as the degeneration of classical retinal ganglion cells（RGCs）, but also affected ip RGCs. Therefore, we hypothesize that higher prevalence of sleep disorders in glaucoma patients maybe result from the underlying glaucomatous injuries of ip RGCs leading to the abnormalities of diverse NIF functions corresponding to sleep.展开更多
Sleep disorders affect an individual’s ability to sleep well on a regular and natural basis. Inadequate sleep can have adverse outcomes for health and safety. Electroencephalogram (EEG) has been presented as an authe...Sleep disorders affect an individual’s ability to sleep well on a regular and natural basis. Inadequate sleep can have adverse outcomes for health and safety. Electroencephalogram (EEG) has been presented as an authentic indicator to monitor brain activities. In this review paper, different procedures of EEG tests for recording and monitoring brain activity during sleep such as the EEG electrodes system and the Dreem headband (DH) have been introduced. Also, the processes of recording and analyzing the data have been discussed and compared with each other. The results of various stages of sleep from EEG tests help sleep specialists diagnose or evaluate sleep disorders accurately and choose appropriate strategies. Sleep disorder management is integral to provide patients with a safe sleeping environment.展开更多
[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective t...[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective traditional Chinese medicine monomer compounds that intervene in the core targets of nonorganic sleep disorders, and molecular docking technology was used to verify the traditional Chinese medicine monomer compounds that meet the expected goals.[Results] Based on the storm related targets of nonorganic sleep disorders, five monomer compounds of traditional Chinese medicine were screened, namely paeoniflorin, chlorogenic acid, quercetin, baicalin, and ginsenoside Rg1. These monomer compounds of traditional Chinese medicine act on multiple targets such as CASP8, IKBKB, IL1B, IL6, CXCL8, etc. , thereby playing a role in calming the mind and improving sleep.[Conclusions] These monomer compounds of traditional Chinese medicine had potential pharmacological effects on nonorganic sleep disorders and high value in subsequent experiments and clinical applications.展开更多
Objective: to explore and analyze the effect of targeted nursing on depression patients with sleep disorders. Methods: 72 patients with depression and sleep disorder were selected from our hospital. From March 2018 to...Objective: to explore and analyze the effect of targeted nursing on depression patients with sleep disorders. Methods: 72 patients with depression and sleep disorder were selected from our hospital. From March 2018 to September 2020, patients were divided into groups according to random number table. The control group (36 cases) received routine nursing, and the observation group (36 cases) received targeted nursing. Results: the sleep improvement of the two groups was better than that of the control group (P < 0.05);The improvement of depression symptoms in the observation group was better than that in the reference group (P < 0.05). Conclusion: the implementation of targeted nursing for patients with depression and sleep disorders has a satisfactory effect, which can significantly enhance the sleep quality of patients, and greatly improve the depressive symptoms of patients, which is worthy of clinical promotion.展开更多
Sleep disorders and memory impairments are prevalent in clinical practice and often coexist,significantly impacting individuals’physical,emotional,and cognitive health.The comorbidity between these conditions is mult...Sleep disorders and memory impairments are prevalent in clinical practice and often coexist,significantly impacting individuals’physical,emotional,and cognitive health.The comorbidity between these conditions is multifactorial,involving neurobiological,endocrine,and metabolic factors.Structural brain changes,neuroinflammation,oxidative stress,and neurotransmitter imbalances exacerbate impairments in both sleep and memory function.This paper reviews current combination therapy strategies for managing comorbid sleep and memory disorders,analyzing the effectiveness of pharmacological treatments(such as benzodiazepines and cholinesterase inhibitors)and non-pharmacological interventions(such as Cognitive Behavioral Therapy for Insomnia(CBT-I)and cognitive training).While combination therapies show promising potential,challenges such as drug interactions and patient adherence remain.Future research should focus on exploring underlying mechanisms,developing personalized treatment approaches,and integrating novel therapeutic strategies.展开更多
文摘BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s disease.The disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is unclear.AIM To explore the near-infrared brain function characteristics of MCI with sleep disorders.METHODS A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were selected.All subjects underwent the functional near-infrared spec-troscopy test.Collect baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task period.The relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<0.05.CONCLUSION Patients with MCI and sleep disorders have lower near-infrared brain function than normal people,which is related to sleep quality.Clinically,a comprehensive assessment of the near-infrared brain function of patients should be carried out to guide targeted treatment and improve curative effect.
文摘Recent studies have revealed that patients with septic shock and acute skin failure(ASF)exhibit significantly higher levels of inflammatory cytokines,lactate,and C-reactive protein,along with elevated skin mottling score;modified early warning score(MEWS);and anxiety,depression,and Pittsburgh sleep quality index scores compared to those without ASF.Notably,these indicators are significantly correlated.Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9,indicating severe disease progression.Therefore,it is ess-ential to not only manage septic shock but also mitigate anxiety,depression,sleep disorders,and disturbances of consciousness.This article explores the impact of severe anxiety,depression,and sleep disorders on the prognosis of septic shock and discusses intervention strategies.
基金Supported by the Key Think Tank Research Project of the Shaanxi Federation of Social Sciences,No.2023ZD1080。
文摘BACKGROUND Doctoral students often encounter mental health challenges,including stress,anxiety,depression,and sleep disorders.It is important to explore effective intervention methods to enhance their overall physical and mental well-being.It is anticipated that targeted exercise will lead to a significant reduction in stress,anxiety,and depression levels as well as an improvement in sleep quality.AIM To assess the feasibility and potential benefits of both intervention models in enhancing the sleep quality of doctoral students while alleviating stress,anxiety,and depression.METHODS A retrospective analysis of health data from 64 doctoral students across three universities in Shenyang during the 2024-2025 academic year was conducted.The participants were divided into a targeted exercise group and a Tai Chi group.The study employed the Epworth Sleepiness Scale,Insomnia Severity Index,Pittsburgh Sleep Quality Index,Perceived Stress Scale-10,Generalized Anxiety Disorder Scale-7,and Patient Health Questionnaire-9 to evaluate the impact of the two interventions on reducing stress,anxiety,depression,and sleep disorders.RESULTS The primary results of the study indicated that targeted exercise interventions are significantly effective in alleviating symptoms of anxiety,stress,and depression,as well as in improving sleep quality.Compared to Tai Chi interventions,this approach demonstrates greater durability of effects.Although the efficacy of targeted interventions may gradually diminish over time,the overall research findings suggest that targeted exercise remains a more effective therapeutic approach than Tai Chi interventions.CONCLUSION The impact of targeted exercise on stress,anxiety,depression,and sleep disorders was greater than that of Tai Chi,confirming the potential benefits for psychological health intervention for doctoral students.
基金Supported by National Natural Science Foundation of China,No.82270634.
文摘As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,cirrhosis)and aflatoxin exposure.However,with evolving lifestyles and environmental changes,sleep disorders have become increasingly prevalent.Emerging evidence suggest that sleep disorders may contribute to hepatocarcinogenesis through multiple mechanisms,including immunity environment disorder,oxidative stress,metabolic dysregulation,disruption of gut microbiota,and circadian rhythm disruption,thereby influencing disease progression and patient prognosis.This review summarizes epidemiological evidence on the relationship between sleep disorders and HCC incidence,explores the underlying mechanisms through which sleep disorders contribute to HCC,and discusses clinical challenges and potential intervention strategies.Our objective is to provide novel insights into HCC prevention and therapeutic approaches.
文摘Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.
基金supported by grants from the National Key Research and Development Program of China(Nos.2023YFC2508002&2023YFC2508403)the National Natural Science Foundation of China(Nos.82371168 and 82171152)the Hubei Provincial Key Research and Development Program(No.2023BCB027).
文摘Recent years have seen a burgeoning interest in elucidating the intricate relationship between vestibular dysfunction and sleep disorders,owing to their substantial impact on daily functioning and overall health.Despite significant advancements,the precise mechanisms underpinning this interplay remain elusive.This review aims to synthesize the current literature on the association between vestibular dysfunction and sleep disorders,focusing on potential causal mechanisms and therapeutic implications.We systematically examine various sleep disorders,including insomnia,circadian rhythm disorders,and sleep apnea,in association with specific vestibular dysfunctions,such as Meniere’s disease(MD),vestibular migraine(VM),benign paroxysmal positional vertigo(BPPV),vestibular neuritis(VN),and persistent postural perceptual dizziness(PPPD).By exploring these complex interactions,our goal is to provide a comprehensive understanding that contributes to the ongoing discourse in this field.We seek to encourage further investigations into innovative diagnostic and therapeutic strategies,ultimately aiming to improve the clinical management and enhance the quality of life for patients affected by both vestibular dysfunction and sleep disorders.
基金National Natural Science Foundation of China:Study on the Mechanism of Cooling Blood and Tranquilizing Mind in the Treatment of Psoriasis with Sleep Disorder based on the Regulation of Oxidative Stress by Melatonin (No. 82074436)。
文摘OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathway. METHODS:Forty Sprague-Dawley rats were randomly divided into four groups, and administered distilled water, XYAS and its two different disassembly prescriptions by gavage respectively. Four types of drug-containing serums corresponding to the four groups were then prepared. Tumor necrosis factor(TNF)-α stimulated Ha Ca T was used to establish a psoriasis cell model, and the serums and the retinoid related orphan receptor alpha(RORα) inverse agonist were used respectively to intervene in the model. Enzyme-linked immunosorbent assay was used to detect the levels of interleukin(IL)-6 and melatonin in each group;flow cytometry was used to detect the levels of reactive oxygen species(ROS), mitochondrial membrane potential, and apoptosis;Western blot was used to evaluate the levels of superoxide dismutase 2(SOD2), cytochrome-c(Cyt-c), inhibitor of kappa-B alpha(IκBα), p65 and phosphorylated p65. RESULTS:XYAS and its disassembly prescriptions inhibited the secretion of inflammatory factors such as IL-6, reduced the ROS content and Cyt-c expression, increased the mitochondrial membrane potential and SOD2 content, promoted the apoptosis in Ha Ca T cells and inhibited the activation of the NF-κB pathway. XYAS was also found increase the melatonin content. The above effects are beneficial in the treatment of psoriasis combined with sleep disorders. Meanwhile, XYAS no longer had a significant ameliorative effect after applying the RORα inverse agonist, suggesting that the therapeutic effect of XYAS is related to RORα. CONCLUSIONS:The results of this study confirm that XYAS can be utilized for the treatment of psoriasis combined with sleep disorders via inhibiting the NF-κB pathway, anti-inflammatory, antioxidant and proapoptotic, which is in part related to the regulatory role of melatonin and its receptor RORα.
文摘Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that discrepancies can occur between subjective data regarding sleep disturbances and the impact of insomnia and objective assays, and surrogate markers of sleep and sleep disturbances. Both objective and subjective measures should be incorporated into clinic studies. It seems likely that sleep quality is represented by a combination of more than one subjective sleep parameter. Objective and subjective assessments of sleep quality may relate to different parameters. Future studies incorporated both subjective and objective measures could help to address the sleep disorders.
文摘BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult.Identifying the factors associated with spinal infection and early intervention can reduce the occurrence of the disease.At present,the research mainly focuses on the accurate diagnosis and treatment of spinal infection,and there are few studies on the prevention of spinal infection.The concept of"preventive treatment of diseases"in traditional Chinese medicine may help identify the causes and reduce the occurrence of NOSI.AIM To determine the association of age,bowel movements,and sleep patterns with NOSI.METHODS Data of 69 NOSI patients and 84 healthy controls in a tertiary hospital from January 2019 to June 2024 were collected.Patients with NOSI had imaging evidence(magnetic resonance imaging)of spinal infections(including infections caused by tuberculosis,brucopathy,and other pathogens)and had no history of spinal surgery in the last 1 year were included in the analysis.Patients with spinalinfection due to spinal surgery are excluded in the study.Data including age,sex,place of residence,sleeping status,and bowel movements were collected.SPSS22.0 was used for correlation analysis of all data.RESULTS The mean age of the NOSI group and the control group was 63.55±14.635 years and 59.18±17.111 years,respectively,without statistical difference(P=0.096).There was also no statistically significant difference in gender between the two groups.In the NOSI group,45(65.22%)were over 60 years old,and 44(63.77%)were rural residents.Compared with the control group,the NOSI group had more patients with sleep disorder and defecation disorder,accounting for 69.57%and 68.12%,respectively,with significant statistical difference(both P<0.001).Regression analysis showed that defecation and sleep disorders were closely related to NOSI(both P<0.001).CONCLUSION Most patients with NOSI are older and have sleep disorders and abnormal defecation.
基金This work was funded by the National Natural Science Foundation of China, Nos. 81660151 (to FFH), 81660751 (to SLY).
文摘Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s disease.Sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-βand tau in patients with Alzheimer’s disease.At present,sleep disorders are considered as a risk factor for,and may be a predictor of,Alzheimer’s disease development.Given that sleep disorders are encountered in other types of dementia and psychiatric conditions,sleep-related biomarkers to predict Alzheimer’s disease need to have high specificity and sensitivity.Here,we summarize the major Alzheimer’s disease-specific sleep changes,including abnormal non-rapid eye movement sleep,sleep fragmentation,and sleep-disordered breathing,and describe their ability to predict the onset of Alzheimer’s disease at its earliest stages.Understanding the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer’s disease.This paper therefore explores some potential mechanisms that may contribute to sleep disorders,including dysregulation of the orexinergic,glutamatergic,andγ-aminobutyric acid systems and the circadian rhythm,together with amyloid-βaccumulation.This review could provide a theoretical basis for the development of drugs to treat Alzheimer’s disease based on sleep disorders in future work.
基金Supported by a NIH grant to Dr.Cukor(MD006875)(in part)
文摘Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morbidity and mortality burden. The complex and dynamic relationship between sleep disorders and chronic kidney disease(CKD) remain relatively little investigated. This article presents an overview of sleep disorders in patients with CKD, with emphasis on relevant pathophysiologic underpinnings and clinical presentations. Evidence-based interventions will be discussed, in the context of individual sleep disorders, namely sleep apnea, insomnia, restless leg syndrome and excessive daytime sleepiness. Limitations of the current knowledge as well as future research directions will be highlighted, with a final discussion of different conceptual frameworks of the relationship between sleep disorders and CKD.
基金Supported by National Natural Science Foundation of China,No.82360880,and 82060661Jiangxi Provincial Natural Science Foundation of China,No.20232ACB206057+3 种基金Key project of Jiangxi Provincial Department of Education,No.GJJ218104Teaching reform research project of Jiangxi Province of China,No.JXJG-22-130-1National Natural Science Foundation of China,No.81660151Jiangxi Provincial Natural Science Foundation of China,No.20212BAB206092.
文摘Studies have shown that non-alcoholic fatty liver disease(NAFLD)may be associated with sleep disorders.In order to explore the explicit relationship between the two,we systematically reviewed the effects of sleep disorders,especially obstructive sleep apnea(OSA),on the incidence of NAFLD,and analyzed the possible mechanisms after adjusting for confounding factors.NAFLD is independently associated with sleep disorders.Different sleep disorders may be the cause of the onset and aggravation of NAFLD.An excessive or insufficient sleep duration,poor sleep quality,insomnia,sleep-wake disorders,and OSA may increase the incidence of NAFLD.Despite that some research suggests a unidirectional causal link between the two,specifically,the onset of NAFLD is identified as a result of changes in sleep characteristics,and the reverse relationship does not hold true.Nevertheless,there is still a lack of specific research elucidating the reasons behind the higher risk of developing sleep disorders in individuals with NAFLD.Further research is needed to establish a clear relationship between NAFLD and sleep disorders.This will lay the groundwork for earlier identification of potential patients,which is crucial for earlier monitoring,diagnosis,effective prevention,and treatment of NAFLD.
文摘Introduction: Sleep disorders (SD) are common dialysis patients and can impact their quality of life. In previous studies, black ethnicity was associated with higher incidence of SD but a few data are available in African patients. This study aimed to describe prevalence and risk factors of SD among Senegalese dialysis patients. Methods: We performed a cross-sectional study between February 15th and April 30th 2012 including 127 patients (75 males and 52 females) aged 46.8 ± 16.9 (16 - 85 years) and dialysed since >6 months in three dialysis centres. For each patient, we assessed insomnia according to international definition, obstructive sleep apnea syndrome (OSAS) with the Berlin questionnaire, restless leg syndrome (RLS) using abridged version of Cambridge-Hopkins RLS questionnaire, and excessive daytime sleepiness (EDS) with Epworth sleepiness scale. Logistic multivariate regression was used to identify factors associated with different SD. Results: Overall prevalence of SD was 88% comprising: insomnia (64.3%), OSAS (49.1%), RLS (24.1%) and EDS (20.5%). Forty-two patients presented at least two disorders. No difference was noticed in prevalence of SD between genders (p = 0.14). Level of blood pressure were not different across patients with and without SD. Insomnia correlated with anemia, inflammation and EDS. OSAS was associated with age ≥50 years, EDS and neck circumference ≥25 cm. RLS correlated with anemia and EDS. Other parameters such as gender, dialysis vintage, KT/V, obesity, diabetes status and hypoalbuminemia were not associated with the different SD. The majority of patients had not been diagnosed before the survey and none of them was under treatment. Conclusions: Our findings are compatible with high prevalence of sleep disorders reported in other populations. Insomnia and OSAS are the most frequent SD but some patients combined many disorders. Nephrologists should be more aware of these SD in order to detect them early and provide efficient treatment.
文摘In this paper we will discuss on sleep disorders in older adults and aged people following the catastrophes and stressful life events, and then note very shortly some treatments. Sleep disorders, accompanied with headache, have been known throughout the history of humanity and traditional medicine. In our time, diverse psychosocial and environmental factors such as wars also some psycho-socio-political events, acts of terrorism and others have shocked the world with numerous material, human, damages and victims. Many of these catastrophic acts and stressful life events, with their pathological effects, can bring consequently anxiety and depression. Sleep disorders and insomnia resulting from anxiety and depression, are very common, underdiagnosed, and become a significant source of major pain complaints in older adults and geriatric population. Some modifications in sleep patterns, during normal ageing process, as well as in retired people, may not be considered a part of pathological process of ageing; however, some factors like psychosomatical problems, death of spouse or loss of a child or other dear member family etc. can be related to pathological processes, and produce disturbances in circadian rhythm and consequently lead to sleep disorder. Based on his teaching experiences and clinical observations at Mental Health Centres, as well as theoretical studies （particularly during these three last decades） the author presents the results of his clinical researches. Our studies and lectures in University Hospitals： （Ste Anne, Lariboisière and La Salpêtrière） have enriched this research. The experiences and researches have shown that anxiety and depression exert pathological effects, not only on the cognitive system as noted elsewhere and harmful influences on the cardiovascular system, but have also pathological effects on the pineal gland and its “melatonin” hormone secretion which is considered as stimulator system （pace-maker-like） to regulate the rhythm of wake-sleep. Major depression, anxiety and trauma, resulting of catastrophic stressful life event, such as wars, acts of terrorism or others, when accumulating and occurring together, can perturb not only the circadian rhythm system, but in some extreme situations （such as inability to cope with stress or suffering, facing economic crisis and failure etc.） in some cases as noted elsewhere, they can also engender behaviour and personality disorders and finally lead to suicide. Concerning current treatments, the efficacy of melatonin to improve the quality of sleep is well established however the author would propose if possible, to maximize the dosage.
基金supported by grants from the National Natural Science Foundation of China(No.30700244)the Natural Science Foundation of Hubei Province(No.2012FFB02501)
文摘In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation was assessed using the Pittsburgh Sleep Quality Index（PSQI）, and the Epworth Sleepiness Scale（ESS）. It was found that poor sleep quality（77.11%） and excessive daytime sleepiness（32.34%） were commonly seen in PD patients and positively correlated with disease severity. Then 70 out of the 201 PD patients and 70 age- and sex-matched controls underwent a polysomnographic recording. The parameters were compared between PD group and control group and the influencing factors of sleep in PD patients were analyzed. The results showed that sleep efficiency（SE） was significantly decreased（P〈0.01）, and sleep latency（SL） and the arousal index（AI） were increased（P〈0.05） in the PD group as compared with those in the control group. SE and total sleep time（TST） were positively correlated with the Hoehn and Yahr（H＆Y） stage. There was significant difference in the extent of hypopnea and hypoxemia between the PD group and the control group（P〈0.05）. Our results indicate that PD patients have an overall poor sleep quality and a high prevalence of sleep disorder, which may be correlated with the disease severity. Respiratory function and oxygen supply are also affected to a certain degree in PD patients.
基金Supported by the National Natural Science Foundation of China(No.81200687)the National Major Scientific Equipment Program(No.2012YQ12008005)the Young Scholar for the Doctoral Program of Higher Education of China(No.20120181120014)
文摘Sleep accounts for a third of one＇s lifetime, partial or complete deprivation of sleep could elicit sever disorders of body function. Previous studies have reported the higher prevalence of sleep disorders in glaucoma patients, but the definite mechanism for this phenomenon is unknown. On the other hand, it is well known by us that the intrinsically photosensitive retinal ganglion cells（ip RGCs） serve additional ocular functions, called non-image-forming（NIF） functions, in the regulation of circadian rhythm, melatonin secretion, sleep, mood and others. Specifically, ip RGCs can directly or indirectly innervate the central areas such as suprachiasmatic nucleus（SCN）, downstream pineal gland（the origin of melatonin）, sleep and wake-inducing centers and mood regulation areas, making NIF functions of ip RGCs relate to sleep. The more interesting thing is that previous research showed glaucoma not only affected visual functions such as the degeneration of classical retinal ganglion cells（RGCs）, but also affected ip RGCs. Therefore, we hypothesize that higher prevalence of sleep disorders in glaucoma patients maybe result from the underlying glaucomatous injuries of ip RGCs leading to the abnormalities of diverse NIF functions corresponding to sleep.
文摘Sleep disorders affect an individual’s ability to sleep well on a regular and natural basis. Inadequate sleep can have adverse outcomes for health and safety. Electroencephalogram (EEG) has been presented as an authentic indicator to monitor brain activities. In this review paper, different procedures of EEG tests for recording and monitoring brain activity during sleep such as the EEG electrodes system and the Dreem headband (DH) have been introduced. Also, the processes of recording and analyzing the data have been discussed and compared with each other. The results of various stages of sleep from EEG tests help sleep specialists diagnose or evaluate sleep disorders accurately and choose appropriate strategies. Sleep disorder management is integral to provide patients with a safe sleeping environment.
基金Supported by the Key Project of TCM in Hubei Province(ZY2023F074).
文摘[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective traditional Chinese medicine monomer compounds that intervene in the core targets of nonorganic sleep disorders, and molecular docking technology was used to verify the traditional Chinese medicine monomer compounds that meet the expected goals.[Results] Based on the storm related targets of nonorganic sleep disorders, five monomer compounds of traditional Chinese medicine were screened, namely paeoniflorin, chlorogenic acid, quercetin, baicalin, and ginsenoside Rg1. These monomer compounds of traditional Chinese medicine act on multiple targets such as CASP8, IKBKB, IL1B, IL6, CXCL8, etc. , thereby playing a role in calming the mind and improving sleep.[Conclusions] These monomer compounds of traditional Chinese medicine had potential pharmacological effects on nonorganic sleep disorders and high value in subsequent experiments and clinical applications.
文摘Objective: to explore and analyze the effect of targeted nursing on depression patients with sleep disorders. Methods: 72 patients with depression and sleep disorder were selected from our hospital. From March 2018 to September 2020, patients were divided into groups according to random number table. The control group (36 cases) received routine nursing, and the observation group (36 cases) received targeted nursing. Results: the sleep improvement of the two groups was better than that of the control group (P < 0.05);The improvement of depression symptoms in the observation group was better than that in the reference group (P < 0.05). Conclusion: the implementation of targeted nursing for patients with depression and sleep disorders has a satisfactory effect, which can significantly enhance the sleep quality of patients, and greatly improve the depressive symptoms of patients, which is worthy of clinical promotion.
文摘Sleep disorders and memory impairments are prevalent in clinical practice and often coexist,significantly impacting individuals’physical,emotional,and cognitive health.The comorbidity between these conditions is multifactorial,involving neurobiological,endocrine,and metabolic factors.Structural brain changes,neuroinflammation,oxidative stress,and neurotransmitter imbalances exacerbate impairments in both sleep and memory function.This paper reviews current combination therapy strategies for managing comorbid sleep and memory disorders,analyzing the effectiveness of pharmacological treatments(such as benzodiazepines and cholinesterase inhibitors)and non-pharmacological interventions(such as Cognitive Behavioral Therapy for Insomnia(CBT-I)and cognitive training).While combination therapies show promising potential,challenges such as drug interactions and patient adherence remain.Future research should focus on exploring underlying mechanisms,developing personalized treatment approaches,and integrating novel therapeutic strategies.
