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SLO1B1和CYP2C9联合突变对那格列奈降血糖效果的影响 被引量:3
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作者 李宝群 万丽娟 +2 位作者 程艳芬 刘刚 宋成军 《实用医学杂志》 CAS 北大核心 2010年第13期2311-2313,共3页
目的:研究SL0181521T〉C变异以及SL0181521T〉C和CYP2C9}3的联合突变对口服降糖药那格列奈的降血糖效果的影响。方法:对48名健康志愿者(12例SLC0181521TT/CYP2C9*1基因型,14例SLC0181521TT/CYP2C9*3基因型.12例SLC0181521TC/C... 目的:研究SL0181521T〉C变异以及SL0181521T〉C和CYP2C9}3的联合突变对口服降糖药那格列奈的降血糖效果的影响。方法:对48名健康志愿者(12例SLC0181521TT/CYP2C9*1基因型,14例SLC0181521TT/CYP2C9*3基因型.12例SLC0181521TC/CC/CYP2C9*1基因型.10例SLC0181521TC/CYP2C9*3基因型)单次口服120mg那格列奈,分别在给药前和给药后0.25、0.5、O,75、1、1.5、2、3、4、6、8h采血.用自动生化分析仪进行血糖浓度分析。结果:单一的SL0181521T〉C多态和CYP2C9{3多态对于那格列奈的降血糖效果与野生型对照组比较差异无显著性。联合突变组在最大血糖升高值,0~4h和0.8h的血糖浓度平均变化值与野生型组比较差异无显著性,但是在最大血糖降低值与野生型对照组和SL0181521T〉C突变组比较差异有显著性意义(P=0.027,P=0.048)。结论:在健康受试者,单一及联合的SL0181和CYP2C9多态性对那格列奈降血糖效果没有显著影响:但是在2型糖尿病患者中,有关影响需要进一步的研究。 展开更多
关键词 糖尿病 2 那格列奈 slo1B1 CYP2C9 多态性 血糖浓度
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Enhancing the water-resistance stability of CaS:Eu^(2+),Sm^(2+) phosphor with SiO_2-PMMA composite coating
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作者 张杰强 范艳伟 +5 位作者 陈朝阳 闫世友 王军华 赵鹏君 郝斌 盖敏强 《Journal of Rare Earths》 SCIE EI CAS CSCD 2015年第9期922-926,共5页
This work was aimed at improving the water-resistance stability of CaS:Eu2+,Sm2+ phosphor. An organic-inorganic com- posite coating method was adopted in order to obtain ideal phosphor. The phosphor was coated with... This work was aimed at improving the water-resistance stability of CaS:Eu2+,Sm2+ phosphor. An organic-inorganic com- posite coating method was adopted in order to obtain ideal phosphor. The phosphor was coated with SiO2 via sol-gel technique and it was also covered by polymethyl methacrylate (PMMA) via dissolution-cohesion technique. Powder X-ray diffraction (XRD) patterns, fluorescence spectroscopy and transmission electron microscopy (TEM) were employed to characterize the phase structures, emission spectrum and surface morphologies, respectively. In addition, the water-resistance stability of the phosphor was tested by soaking the phosphor into deionized water. The results showed that the phase structures remained the same as the uncoated phosphor and the po- sition of the fluorescence peak did not shift after surface treatment. Results showed that the water-resistance stability of the phosphor was improved to some degree. Moreover, the photoluminescence (PL) intensity of the coated phosphors reduced less than 10% of the original phosphors. Though being soaked into deionized water for 50 h, the phosphor coated with 10 wt.%SiO2-10 wt.%PMMA retained 85.9% PL intensity compared to that of the uncoated phosphor. Therefore, it could be concluded that the 10 wt.%SiO2-10 wt.%PMMA composite coating effectively improved the phosphor water resistance and retained its good optical properties. 展开更多
关键词 2 2+CaS:Eu Sin2 redphosphor slo2-pmmacompositecoating photouminescence pHvaoue water-resistancestabioity RAREEARTHS
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良、恶性骨肿瘤的MRI动态增强评价 被引量:1
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作者 郭亮 谢道海 +1 位作者 丁庆国 陈剑华 《江苏医药》 CAS CSCD 北大核心 2005年第7期507-509,480,共4页
目的评价MRI动态增强在良、恶性骨肿瘤鉴别诊断中的价值。方法对24例良、恶性骨肿瘤患者行MRISE序列的T1WI和FSE序列的T2WI、STIR序列、动态增强MRI以及常规增强扫描。重点分析动态增强参数早期动态增强最大斜率值(Slo)、病变边缘中心... 目的评价MRI动态增强在良、恶性骨肿瘤鉴别诊断中的价值。方法对24例良、恶性骨肿瘤患者行MRISE序列的T1WI和FSE序列的T2WI、STIR序列、动态增强MRI以及常规增强扫描。重点分析动态增强参数早期动态增强最大斜率值(Slo)、病变边缘中心向心强化程度比(Rrimcenter)及SITime曲线类型。结果良、恶性骨肿瘤在动态增强SITime曲线类型方面有差异(P<0.05)。恶性肿瘤SLo为每秒(4.33±2.70)%,良性肿瘤为每秒(1.46±0.97)%,两组间有显著性差异(P<0.01)。以每秒2.0%为界,Slo对肿瘤潜在恶性评价的敏感性、特异性和准确性分别为83.3%、77.8%和80.6%。恶性肿瘤的Rrimcenter为0.58±0.21,良性肿瘤为0.15±0.27,两组间有显著性差异(P<0.01)。以0.27为界,对肿瘤潜在恶性评价的敏感性、特异性和准确性分别为93.3%、72.8%和86.6%。Slo与肿瘤组织微血管密度之间呈正相关(P<0.05)。结论动态增强参数早期动态增强最大斜率值、病变边缘中心向心强化程度比为良、恶性骨肿瘤鉴别诊断提供了一种有价值的定量指标。 展开更多
关键词 恶性骨肿瘤 动态增强MRI 显著性差异 STIR序列 常规增强扫描 鉴别诊断 强化程度 恶性肿瘤 良性肿瘤 FSE序列 微血管密度 T2WI T1WI 肿瘤患者 肿瘤组织 定量指标 斜率值 敏感性 slo 准确性 特异性 slo 正相关 价值 早期
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The Arabidopsis thaliana RNA Editing FactorSLO2, which Affects the Mitochondrial ElectronTransport Chain, Participates in Multiple Stressand Hormone Resoonses 被引量:4
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《Molecular Plant》 SCIE CAS CSCD 2014年第2期290-310,共21页
Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show... Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show thatmutation in SL02 causes hypersensitivity to ABA and insensitivity to ethylene, suggesting a link with stress responses.Indeed, slo2 mutants are hypersensitive to salt and osmotic stress during the germination stage, while adult plantsshow increased drought and salt tolerance. Moreover, slo2 mutants are more susceptible to Botrytis cinerea infection.An increased expression of nuclear-encoded stress-responsive genes, as well as mitochondrial-encoded NAD genes ofcomplex I and genes of the alternative respiratory pathway, was observed in slo2 mutants, further enhanced by ABAtreatment. In addition, H202 accumulation and altered amino acid levels were recorded in slo2 mutants. We conclude thatSLO2 is required for plant sensitivity to ABA, ethylene, biotic, and abiotic stress. Although two stress-related RNA editingfactors were reported very recently, this study demonstrates a unique role of SLO2, and further supports a link betweenmitochondrial RNA editing events and stress response. 展开更多
关键词 ABA Arabidopsis THALIANA ethylene plant STRESS mitochondria RNA editing PPR protein slo2 STRESS
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