The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show...The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show clinical potential,their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity(R^(2)>0.99 up to 1 MPa)in conventional designs.Inspired by the tactile sensing mechanism of human skin,where dermal stratification enables wide-range pressure adaptation and ion-channelregulated signaling maintains linear electrical responses,we developed a dual-mechanism flexible iontronic pressure sensor(FIPS).This innovative design synergistically combines two bioinspired components:interdigitated fabric microstructures enabling pressure-proportional contact area expansion(αP1/3)and iontronic film facilitating self-adaptive ion concentration modulation(αP^(2/3)),which together generate a linear capacitance-pressure response(CαP).The FIPS achieves breakthrough performance:242 kPa^(-1)sensitivity with 0.997linearity across 0-1 MPa,yielding a record linear sensing factor(LSF=242,000).The design is validated across various substrates and ionic materials,demonstrating its versatility.Finally,the FIPS-driven design enables a smart insole demonstrating 1.8%error in tibial load assessment during gait analysis,outperforming nonlinear counterparts(6.5%error)in early fracture-risk prediction.The biomimetic design framework establishes a universal approach for developing high-performance linear sensors,establishing generalized principles for medical-grade wearable devices.展开更多
Intense bacterial infection,long-term inflammatory infiltration,and inadequate vascularization make diabetic wounds non-healing.Endogenous electric fields are the basis of bioelectric signal conduction and have been s...Intense bacterial infection,long-term inflammatory infiltration,and inadequate vascularization make diabetic wounds non-healing.Endogenous electric fields are the basis of bioelectric signal conduction and have been shown to be the primary signal guiding cell migration and promoting tissue repair.Still,the disorder microenvironment of diabetic wounds may affect the functions of endogenous electric fields.Traditional wound dressings,such as gauzes and bandages,lead to unsatisfactory repair due to their limited infection management and inability to couple with endogenous electrical fields.In this study,we develop the PMQG hydrogel,a multifunctional hydrogel dressing with effective antibacterial properties and good electroactivity,made from acrylic acid,quaternary ammonium chitosan,and MXene nanosheets.Inspired by skin,the PMQG hydrogels have flexible mechanical properties matched to the skin,strong tissue adhesion,broad-spectrum antibacterial activity,and desirable conductivity,which could transmit electrical signals,facilitating cell migration,and thus promoting the process of wound repair.The PMQG hydrogels exhibited good antibacterial properties against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and methicillin-resistant S.aureus(MRSA),effectively controlling the infection-induced inflammation.Furthermore,incorporating MXene nanosheets into the hydrogel network enhances its reactive oxygen species scavenging ability and provides biomimetic conductivity.These anti-inflammatory properties,combined with its conductivity,help regulate the microenvironment and rebuild the endogenous electric fields,facilitating cell migration,angiogenesis,and collagen deposition,leading to a remarkable 98%wound closure by day 15 in diabetic rats,thus demonstrating superior efficacy.This novel wound dressing is expected to be an ideal therapeutic strategy for diabetic wound healing.展开更多
Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-in...Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-inspired structured surfaces have been explored,the incorporation of mucus on the structured surfaces has been largely ignored.Inspired by the skin of Osteichthyes fishes,a Janus hydrogel coating(JHC)is successfully prepared by a two-step UV light irradiation at room temperature.The bottom side of JHC(STH)achieves a shear adhesive strength of 103.3±17.5 kPa and can strongly adhere to a large variety of surfaces,including metals,ceramic and polymers.The top surface of JHC(SLH)replicates the structure of cycloid scales,while the nature of hydrogel mimics the mucus on fish skin.SLH possesses prominent mechanical,anti-swelling,anti-fouling and drag reduction properties.The design strategy for JHC has potential applications in numerous fields,like,pipeline transportation,bioengineering,and shipping industry.展开更多
Electronic skin has showcased superior sensing capabilities inspired from human skin.However,most preceding studies focused on the dermis of the skin rather than the epidermis.In particular,the pseudo-porous structura...Electronic skin has showcased superior sensing capabilities inspired from human skin.However,most preceding studies focused on the dermis of the skin rather than the epidermis.In particular,the pseudo-porous structural domain of the epidermis increases the skin's tolerance while ensuring its susceptibility to touch.Yet,most endeavors on the porous structures failed to replicate the superior sensing performance of skin-like counterparts in terms of sensitivity and/or detection range.Stimulated by the strategy that the epidermis of the skin absorbs energy while producing ionic conduction to the nerves,this work initiatively introduced an easy-to-produce,and low-cost pressure sensor based on ionic-gel foam,and achieved a high sensitivity(2893 kPa^(-1))within a wide pressure range(up to~1 MPa),which ranked among the best cases thus far.Moreover,the factors affecting the sensor performance were explored while the sensing principles were enriched.Inspiringly,the plantar pressure measurement by harnessing the as-prepared sensor unveiled an ultra-broad detection range(100 Pa-1 MPa),thus delivering a huge application potential in the field of robot and health monitoring.展开更多
基金supported by the National Natural Science Foundation of China(NSFC 52175281,52475315)Youth Innovation Promotion Association of CAS(2021382)。
文摘The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show clinical potential,their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity(R^(2)>0.99 up to 1 MPa)in conventional designs.Inspired by the tactile sensing mechanism of human skin,where dermal stratification enables wide-range pressure adaptation and ion-channelregulated signaling maintains linear electrical responses,we developed a dual-mechanism flexible iontronic pressure sensor(FIPS).This innovative design synergistically combines two bioinspired components:interdigitated fabric microstructures enabling pressure-proportional contact area expansion(αP1/3)and iontronic film facilitating self-adaptive ion concentration modulation(αP^(2/3)),which together generate a linear capacitance-pressure response(CαP).The FIPS achieves breakthrough performance:242 kPa^(-1)sensitivity with 0.997linearity across 0-1 MPa,yielding a record linear sensing factor(LSF=242,000).The design is validated across various substrates and ionic materials,demonstrating its versatility.Finally,the FIPS-driven design enables a smart insole demonstrating 1.8%error in tibial load assessment during gait analysis,outperforming nonlinear counterparts(6.5%error)in early fracture-risk prediction.The biomimetic design framework establishes a universal approach for developing high-performance linear sensors,establishing generalized principles for medical-grade wearable devices.
基金supported by the Natural Science Foundation of Jilin Province(SKL202302002)Ministry of Science,Technological Development and Innovation of the Republic of Serbia(45103-66/2024-03/200017)。
文摘Intense bacterial infection,long-term inflammatory infiltration,and inadequate vascularization make diabetic wounds non-healing.Endogenous electric fields are the basis of bioelectric signal conduction and have been shown to be the primary signal guiding cell migration and promoting tissue repair.Still,the disorder microenvironment of diabetic wounds may affect the functions of endogenous electric fields.Traditional wound dressings,such as gauzes and bandages,lead to unsatisfactory repair due to their limited infection management and inability to couple with endogenous electrical fields.In this study,we develop the PMQG hydrogel,a multifunctional hydrogel dressing with effective antibacterial properties and good electroactivity,made from acrylic acid,quaternary ammonium chitosan,and MXene nanosheets.Inspired by skin,the PMQG hydrogels have flexible mechanical properties matched to the skin,strong tissue adhesion,broad-spectrum antibacterial activity,and desirable conductivity,which could transmit electrical signals,facilitating cell migration,and thus promoting the process of wound repair.The PMQG hydrogels exhibited good antibacterial properties against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and methicillin-resistant S.aureus(MRSA),effectively controlling the infection-induced inflammation.Furthermore,incorporating MXene nanosheets into the hydrogel network enhances its reactive oxygen species scavenging ability and provides biomimetic conductivity.These anti-inflammatory properties,combined with its conductivity,help regulate the microenvironment and rebuild the endogenous electric fields,facilitating cell migration,angiogenesis,and collagen deposition,leading to a remarkable 98%wound closure by day 15 in diabetic rats,thus demonstrating superior efficacy.This novel wound dressing is expected to be an ideal therapeutic strategy for diabetic wound healing.
基金supported by Joint Fund of Ministry of Education for Equipment Pre-research(8091B022230)the Fundamental Research Funds for the Central Universities(2042022kf1220)+1 种基金National Natural Science Foundation of China(62161160311,51973165)Open Fund of Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration(Wuhan University)(EMPI2023020).
文摘Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-inspired structured surfaces have been explored,the incorporation of mucus on the structured surfaces has been largely ignored.Inspired by the skin of Osteichthyes fishes,a Janus hydrogel coating(JHC)is successfully prepared by a two-step UV light irradiation at room temperature.The bottom side of JHC(STH)achieves a shear adhesive strength of 103.3±17.5 kPa and can strongly adhere to a large variety of surfaces,including metals,ceramic and polymers.The top surface of JHC(SLH)replicates the structure of cycloid scales,while the nature of hydrogel mimics the mucus on fish skin.SLH possesses prominent mechanical,anti-swelling,anti-fouling and drag reduction properties.The design strategy for JHC has potential applications in numerous fields,like,pipeline transportation,bioengineering,and shipping industry.
基金supported the Chongqing Natural Science Foundation(CSTB2023NSCQ-MSX0459&CSTB2023NSCQ-MSX0231)the Graduate Research and Innovation Foundation of Chongqing,China(CYB23048)+1 种基金the Fundamental Research Program under Grant(JCKY2022603C017)National Natural Science Foundation of China(NSFC 52175281).
文摘Electronic skin has showcased superior sensing capabilities inspired from human skin.However,most preceding studies focused on the dermis of the skin rather than the epidermis.In particular,the pseudo-porous structural domain of the epidermis increases the skin's tolerance while ensuring its susceptibility to touch.Yet,most endeavors on the porous structures failed to replicate the superior sensing performance of skin-like counterparts in terms of sensitivity and/or detection range.Stimulated by the strategy that the epidermis of the skin absorbs energy while producing ionic conduction to the nerves,this work initiatively introduced an easy-to-produce,and low-cost pressure sensor based on ionic-gel foam,and achieved a high sensitivity(2893 kPa^(-1))within a wide pressure range(up to~1 MPa),which ranked among the best cases thus far.Moreover,the factors affecting the sensor performance were explored while the sensing principles were enriched.Inspiringly,the plantar pressure measurement by harnessing the as-prepared sensor unveiled an ultra-broad detection range(100 Pa-1 MPa),thus delivering a huge application potential in the field of robot and health monitoring.
