In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on...In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on human skin samples combined with in vivo administration of JAKi in individuals with TEN,demonstrating rapid reepithelization and recovery of patients.1 As TEN has a high mortality rate(30-50%),2 this study offers a new avenue for targeted treatment.展开更多
文摘In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on human skin samples combined with in vivo administration of JAKi in individuals with TEN,demonstrating rapid reepithelization and recovery of patients.1 As TEN has a high mortality rate(30-50%),2 this study offers a new avenue for targeted treatment.
