Medical stents have made significant strides in development,however,creating a single manufacturing material that combines size adjustability,robust strength,and degradability remains a major challenge.Here,we develop...Medical stents have made significant strides in development,however,creating a single manufacturing material that combines size adjustability,robust strength,and degradability remains a major challenge.Here,we developed an elastomer designed for stent fabrication,featuring excellent thermo-responsive shape memory and fast self-healing.This elastomer is produced through supramolecular inter-actions between liquid crystal moieties,which exhibit strong orientation,and a polymer backbone.These supramolecular interactions provide the elastomer with remarkable mechanical strength(10.46 MPa).Interestingly,the elastomer shows excellent mesocrystalline stability and cyclability,thanks to multiple non-covalent bonds,allowing the crosslinked liquid crystalline phase to maintain integrity at temper-atures up to 285℃.Impressively,the elastomer can respond to stress and temperature changes,fully reverting to its original shape in just 25.7±0.94 s.When configured as a helical stent,its macroscopic dimensions can be adjusted to mimic the size of blood vessels in vitro.The stent exhibits rapid responsiveness at 37℃,achieving complete self-expansion within 10 s.Furthermore,it demonstrates excellent degradability,with a weight loss of only 2.75%±0.31%after 70 d.This innovation paves the way for new possibilities in the use of medical stents,particularly for the long-term treatment of coronary heart disease.展开更多
基金funded by the Natural Science Foundation of Liaoning Province(2024JH2/102600340&2024-BSLH-310)the support program for excellent young scholars at China Medical University.
文摘Medical stents have made significant strides in development,however,creating a single manufacturing material that combines size adjustability,robust strength,and degradability remains a major challenge.Here,we developed an elastomer designed for stent fabrication,featuring excellent thermo-responsive shape memory and fast self-healing.This elastomer is produced through supramolecular inter-actions between liquid crystal moieties,which exhibit strong orientation,and a polymer backbone.These supramolecular interactions provide the elastomer with remarkable mechanical strength(10.46 MPa).Interestingly,the elastomer shows excellent mesocrystalline stability and cyclability,thanks to multiple non-covalent bonds,allowing the crosslinked liquid crystalline phase to maintain integrity at temper-atures up to 285℃.Impressively,the elastomer can respond to stress and temperature changes,fully reverting to its original shape in just 25.7±0.94 s.When configured as a helical stent,its macroscopic dimensions can be adjusted to mimic the size of blood vessels in vitro.The stent exhibits rapid responsiveness at 37℃,achieving complete self-expansion within 10 s.Furthermore,it demonstrates excellent degradability,with a weight loss of only 2.75%±0.31%after 70 d.This innovation paves the way for new possibilities in the use of medical stents,particularly for the long-term treatment of coronary heart disease.
