Regional development strategies that align with urban characteristics and the sci-entific allocation of construction land indicators can effectively guide the high-quality coordi-nated development of urban agglomerati...Regional development strategies that align with urban characteristics and the sci-entific allocation of construction land indicators can effectively guide the high-quality coordi-nated development of urban agglomerations.However,the issue of whether urbanization matches the development strategy has always lacked an in-depth response in geography.Moreover,along with the urbanization process,the land limitation for agricultural and eco-logical spaces becomes increasingly strict,and the availability of construction land indicators is increasingly constrained.The construction land allocation is thus critical for the distribution of regional resources and the development goals of urban agglomeration.Based on the prin-ciples of development geography and the core-periphery theory,this study comprehensively considered three subsystems of urbanization(population,economy,and land)and the spatial link intensity among cities within a certain region to analyze the impacts of"siphon"and"ra-diation"effects on regional development,and assessed whether China's two major regional urbanization strategies aligned the comprehensive development characteristics.Furthermore,the quantitative construction land allocation in Beijing-Tianjin-Hebei(BTH)and Yangtze River Delta(YRD)urban agglomerations was completed.The results showed that the urban com-prehensive level index(UCL)in core cities(Beijing and Tianjin)and peripheral cities differed significantly in BTH,demonstrating a clear core-periphery structure.Along with urbanization,the"siphon"effect in BTH was weakening.Beijing's urban primacy decreased and the growth rate of UCL decreased from 53.89%in the first five years to 18.37%in the last five years during the study period(2020-2019).In contrast,the"radiation"effect in YRD was more ob-vious,exhibiting a development pattern driven by multiple growth poles.Temporally,the BTH indicated a coordinated development trend,while the integration level of YRD continued to strengthen.Compared to the top-down construction land allocated by the government,the results of quantitative allocation in this study reduced volatility.This study confirms the scientific basis of the coordinated development for BTH and the integrated regional development strategy for YRD from the perspective of development geography.It also provides a practical reference fortheconstructionland allocation.展开更多
In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how fac...In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how factors such as the difference in water level,sediment concentration,and pipeline layout affected the sediment discharge effect.The results show that the sediment discharge device can effectively discharge sediment under diverse operating conditions and show adaptability to different environmental conditions,which indicates that it is suitable for various types of reservoir environments.展开更多
The editorial discusses the impact of liver metastasis on immunotherapy efficacy in gastric cancer(GC)patients.Liver metastasis can hinder the effectiveness of immunotherapy by altering the immune microenvironment,lea...The editorial discusses the impact of liver metastasis on immunotherapy efficacy in gastric cancer(GC)patients.Liver metastasis can hinder the effectiveness of immunotherapy by altering the immune microenvironment,leading to systemic loss of T-cells and reduced treatment response.Studies suggest that liver meta-stases serve as a negative baseline factor for immunotherapy efficacy,resulting in poorer progression-free survival and objective response rates.Strategies such as liver-mediated radiotherapy may help improve treatment outcomes by reshaping the liver’s immune microenvironment and reducing T-cell depletion.Understand-ing the complex interplay between liver metastasis and immunotherapy response is crucial for optimising patient care in GC.展开更多
Solar-driven desalination is a promising way to alleviate the freshwater shortage,while is facing challenges posed by low evaporation rates and severe salt accumulation.Herein,a high-performance twodimensional(2D) sol...Solar-driven desalination is a promising way to alleviate the freshwater shortage,while is facing challenges posed by low evaporation rates and severe salt accumulation.Herein,a high-performance twodimensional(2D) solar absorber with Co_(3)O_(4) nanoneedle arrays(Co_(3)O_(4)-NN) grown on the surface of reduced graphene oxide-coated pyrolyzed silk cloth(Co_(3)O_(4)-NN/rGO/PSC) was prepared,and a salt-free evaporator system was assembled based on the composite material and siphonage-the flowing water delivery.It is revealed that the evaporation enthalpy of water can be reduced over the 2D solar absorber grown with Co_(3)O_(4)-NN_T enabling an evaporation rate of up to 2.35 kg m^(-2) h^(-1) in DI water under one solar irradiation.The desalination process can be carried out continuously even with salt concentration up to 20 wt%,due to the timely removal of concentrated brine from the interface with the assistance of directed flowing water.Moreover,the 2D structure and the flowing water also provide an opportunity to convert waste solar heat into electricity in the evaporator based on the seebeck effect,ensuring simultaneous freshwater production and power generation.It is believed that this work provides insights into designing hybrid systems with high evaporation rate,salt resistance,and electricity generation.展开更多
Accelerating green innovation is crucial for achieving high-quality development in China.Despite this importance,empirical evidence on the harmonization techniques in the context of carbon-trading policies has been re...Accelerating green innovation is crucial for achieving high-quality development in China.Despite this importance,empirical evidence on the harmonization techniques in the context of carbon-trading policies has been remarkably thin.To address this gap,we employed the difference-in-difference(DID)and spatial difference-in-difference(S-DID)models using panel data from 2007 to 2017 for 30 Chinese provinces.Our findings reveal that the carbon-trading policy contributes significantly to the coordinated advancement of green technologies across Chinese provinces and exhibits a local siphoning effect.Specifically,the pilot areas of the policy have attracted talent from neighboring regions,which has fostered local cooperation and promoted coordinated innovation in green technologies within the region.展开更多
Soxhlet extraction is a common method of sample preparation. However, there has been no discussion about the efficiency of Soxhlet extraction from different batches and the factors that cause content fluctuation. In t...Soxhlet extraction is a common method of sample preparation. However, there has been no discussion about the efficiency of Soxhlet extraction from different batches and the factors that cause content fluctuation. In this study, Panax ginseng was selected as a model sample. Soxhlet extraction by means of a water bath, which has always been neglected, was identified as a novel key factor in the poor repeat- ability in different batches of Soxhlet extraction, as it can affect the siphon times and reflux time, which have been positively correlated with the ginsenoside contents. By substituting round bottom flasks in the same column, the relative standard deviation of the most fluctuated compound, ginsenoside Rbl, was decreased from 24.6% to 5.02%. Scanning electron microscopy analysis confirmed that the breakdown of the surface of the ginseng powder in the Soxhlet extraction led to a better dissolution of ginsenosides, indicating that chloroform may promote the extraction of ginsenosides by disrupting the cell structure. Moreover, 70% methanol was regarded as the better solvent for extracting the ginsenosides. Overall, this work offers a practical and effective protocol for improving the accuracy and repeatability of Soxhlet extraction methodology for ginsenosides and other analytes.展开更多
The siphon drainage is an effective measure for the slope groundwater control. However,for the traditional siphon drainage, limitations such as siphon lift restriction and poor reliability in longterm service prevent ...The siphon drainage is an effective measure for the slope groundwater control. However,for the traditional siphon drainage, limitations such as siphon lift restriction and poor reliability in longterm service prevent it from being widely used. In this study, an improved siphon drainage method with inclined borehole penetrating the deep part of the slope is proposed to overcome the limitations suffered by the traditional method. Through experimental research, theoretical analysis and engineering practice,the reliability and capability of the proposed method are investigated. The results demonstrate that with the inclined pipe the height difference between the control point of the groundwater level and the orifice can be controlled to be less than the height of the water column corresponding to the local atmospheric pressure. As a result, deep drainage can be achieved.In addition, by controlling the diameter of siphon drainage pipe not larger than 4 mm, a plug flow can be formed in the siphon pipe, which can prevent air accumulation in the siphon process and a continuous and effective siphon drainage is achieved. Through a practical project running smoothly since September 2013, it is found that the proposed method can effectively drain the groundwater deep in the slope and the maximum drawdown of groundwater level in boreholes can reach 8.5 m with an average drainage flow of 5.5 m3/d. The practical results also illustrate that 4 mm siphon pipe can be used to realize deep slope drainage and restart siphon automatically.展开更多
To improve the efficiency of backwashing in upflow biological aerated filter （BAF）, a novel backwashing process named air-water siphon backwashing （AWSB） was proposed and applied on laboratory scale. The effects o...To improve the efficiency of backwashing in upflow biological aerated filter （BAF）, a novel backwashing process named air-water siphon backwashing （AWSB） was proposed and applied on laboratory scale. The effects of backwashing on turbidity and suspended solid （SS） in backwashing efluent using this new backwashing process were compared with those of traditional backwashing process, namely air-water backwashing （AWB）. In AWB, the turbidity of backwashing efluent maintained 100 NUT when consumed 60 min and 10.5 L water. However, in AWSB, it declined to 44 NUT, consumed 40 min, and 7 L water. The COD removal of BAF after backwashing was also analyzed. The average removal rate of COD in the reactor backwashed by AWB and AWSB was 89.34% and 90.91%, respectively. Compared with AWB, the backwashing interval had been prolonged 35%. The volume of backwashing water in that AWSB was only 66.7% of that in AWB. The results demonstrated that AWSB required less water and took shorter backwashing timerelative to AWB to achieve the same turbidity of backwashing efluent, and AWSB was more effective in removing fouling than that of AWB. More significant advantage of AWSB was that the backwashing interval was effectively prolonged展开更多
Based on the characteristics of large flow rate , low head , short annual operation time , and high reliability of the city flood-control pumping stations , a new-type shaft tubular pumping system featuring a shaft su...Based on the characteristics of large flow rate , low head , short annual operation time , and high reliability of the city flood-control pumping stations , a new-type shaft tubular pumping system featuring a shaft suction box and a siphon-type discharge passage with a vacuum breaker as the cutoff device was developed , which possesses such advantages as simple structure , reliable cutoff , and high energy performance.Taking some pumping stations as the case studies , in the light of the specified operation conditions , the hydraulic optimal design of the shaft-type tubular pumping system was determined and the optimized shape of the system was recommended.The performance prediction based on the computational fluid dynamics methodology was determined and the model test verification was conducted.The results show that the predicted data agree with the experimental head and efficiency so that both methods can be used to determine the performance of a real pumping station.Finally , the in-situ measurements of a pumping station during the commissioning period further verified that the shaft-type tubular pumping station with a siphon discharge passage is of higher efficiency , more reliable and stable.展开更多
Deadlock resolution strategies based on siphon control are widely investigated.Their computational efficiency largely depends on siphon computation.Mixed-integer programming(MIP)can be utilized for the computation of ...Deadlock resolution strategies based on siphon control are widely investigated.Their computational efficiency largely depends on siphon computation.Mixed-integer programming(MIP)can be utilized for the computation of an emptiable siphon in a Petri net(PN).Based on it,deadlock resolution strategies can be designed without requiring complete siphon enumeration that has exponential complexity.Due to this reason,various MIP methods are proposed for various subclasses of PNs.This work proposes an innovative MIP method to compute an emptiable minimal siphon(EMS)for a subclass of PNs named S^(4)PR.In particular,many particular structural characteristics of EMS in S4 PR are formalized as constraints,which greatly reduces the solution space.Experimental results show that the proposed MIP method has higher computational efficiency.Furthermore,the proposed method allows one to determine the liveness of an ordinary S^(4)PR.展开更多
High-lift siphon drainage by 4-mm internal diameter siphon hoses is a real-time, free-power, and long-term approach for slope drainage. The conventional hydraulics formula for pressurized pipe flow is generally used t...High-lift siphon drainage by 4-mm internal diameter siphon hoses is a real-time, free-power, and long-term approach for slope drainage. The conventional hydraulics formula for pressurized pipe flow is generally used to calculate the single-phase velocity of siphon flow. However, an intensive cavitation phenomenon occurs in the high-lift siphon hose and then a two-phase flow is formed. Research on the velocity of high-lift siphon flow is a prerequisite for the application of siphon drainage with a 4-mm siphon hose. Few investigations of this subject have been carried out. Hence, experiments on the high-lift （8 m〈H0〈10.3 m） siphon drainage in a 4-mm siphon hose were performed. The characteristics of siphon flow under different conditions were ob- served and test data were obtained. Comparisons between test results and calculated results showed that significant errors were given by the hydraulics formula. It is demonstrated that the effect of gas in a siphon hose should be included in the calculation of flow velocity. The findings can be used to determine the number of siphon hoses and layout of siphon drainage holes, and provide valuable information for geotechnical companies.展开更多
A new anchor-siphon drainage combined method used for slope stabilization is proposed in this paper.It includes an anchoring section and a siphon drainage section.The novelty of the anchor-siphon drainage combined met...A new anchor-siphon drainage combined method used for slope stabilization is proposed in this paper.It includes an anchoring section and a siphon drainage section.The novelty of the anchor-siphon drainage combined method is the realization of the drainage and anchoring in the one inclined borehole.The engineering cost of drilling and the resulting disturbance to the slope is reduced.To validate the feasibility of the proposed method,a numerical method that combines the pore water pressure distribution after siphon drainage and the anchoring force of the anchoring section is used to evaluate the safety of the slope with the anchor-siphon drainage method.The proposed method was illustrated and validated with the Hongpu Village landslide,in Tonglu County,Zhejiang Province,in China.Compared with the common anchor bar with the same length in the anchoring section,the factor of safety(FOS)for Hongpu Village slope with anchorsiphon drainage is increased by 0.085.The calculation method of the optimal length ratio between the drainage section and the anchoring section and its influencing factors were studied.For the different design parameters,there is always an optimal length ratio of the drainage section.Compared with the siphon drainage and full-length anchor bar with the same borehole length,the anchor-siphon drainage combined method shows better landslide prevention ability.Moreover,when the optimized parameters with a bond strength of 560kPa,a borehole inclination of 35°,and no reduction in length are used,the calculated safety factor is 1.316,which is significantly higher than the FOS of 1.131 for the slope with siphon drainage.展开更多
A large amount of research has shown the vitality of siphon enumeration in the analysis and control of deadlocks in various resource-allocation systems modeled by Petri nets(PNs).In this paper,we propose an algorithm ...A large amount of research has shown the vitality of siphon enumeration in the analysis and control of deadlocks in various resource-allocation systems modeled by Petri nets(PNs).In this paper,we propose an algorithm for the enumeration of minimal siphons in PN based on problem decomposition.The proposed algorithm is an improved version of the global partitioning minimal-siphon enumeration(GPMSE)proposed by Cordone et al.(2005)in IEEE Transactions on Systems,Man,and Cybernetics-Part A:Systems and Humans,which is widely used in the literature to compute minimal siphons.The experimental results show that the proposed algorithm consumes lower computational time and memory compared with GPMSE,which becomes more evident when the size of the handled net grows.展开更多
Actin is a ubiquitous protein and plays essential roles on cellular structure maintenance and cellular motility in both muscle and non-muscle tissues.Multiple genes encoding muscle actin have been identified from the ...Actin is a ubiquitous protein and plays essential roles on cellular structure maintenance and cellular motility in both muscle and non-muscle tissues.Multiple genes encoding muscle actin have been identified from the ascidians,including those expressed in the larval tail muscle,the adult body-wall muscle,and adult heart muscle.In this study,a novel striated non-tail muscle actin gene was identified from the RNA-seq data of Ciona savignyi embryos.Phylogenetic analysis,alignment of the N-terminal amino acid sequences and comparation of diagnostic residues provided evidence that it had high similarity with vertebrate cardiac and skeletal muscle actin.In situ hybridization and promoter-driven GFP reporter assay revealed that it was specifically expressed in the primordia of the oral and atrial siphon.We hereby defined it as siphon-specific muscle actin coding gene(Cs-SMA).A 201 bp(−1350 bp to−1150 bp)sequence containing T-box and Six1/2 binding motif within the upstream region of Cs-SMA confined the expression of GFP in the siphons of electroporated embryos.Six1/2 binding motif was experimentally confirmed to play indispensable role in controlling the siphon-specific expression of Cs-SMA.The tissue-specific expression of Cs-SMA in the siphon primordia indicated its potential crucial roles in Ciona embryogenesis and organogenesis.展开更多
Siphonic roof drainage systems (SRDS’s) have been widespread used now for approximately 40 years and are an efficient method of removing rainwater rapidly from roofs. SRDS’s are designed to run full-bore, resulting ...Siphonic roof drainage systems (SRDS’s) have been widespread used now for approximately 40 years and are an efficient method of removing rainwater rapidly from roofs. SRDS’s are designed to run full-bore, resulting in sub-atmospheric system pressures with high hydraulic driving heads and higher system flow velocities than conventionally guttered systems. Hence, SRDS’s normally require far fewer downpipes, and the depressurised conditions also mean that much of the collection pipework can be routed at a high level, thus reducing the extent of any underground pipework. But, they work properly at only one roof run-off rate and therefore suffer from sizing and operational problems including noise and vibration which limit their performance and adoption rate. Climate change is creating situations where normal ranges of rainfall intensity are being frequently exceeded, so the typical:storm ratios (rTS) are large increasing. Current SRDS’s typically operate within a small rTS range of 2. This may have an impact on the future uptake of SRDS’s. This paper describes the development of a novel SRDS which includes a small mobile cap at the roof of outlet appears to offer benefits and avoids sizing problems associated with current SRDS’s. The cap has the potential to avoid noise associated with making and breaking siphonic action through flow modulation. Laboratory scale tests demonstrate the basic feasibility of the cap system and indicate that the cap functions reliably. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Basic on sizing and design optimiza-tion factors are suggested. The rTS range is increased from approximately 2 to approximately 6.展开更多
AIM:To evaluate whether narrowing of internal carotid artery siphon(ICAS)may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy(NAION).METHODS:Totally 30 consecutive patients who had uni...AIM:To evaluate whether narrowing of internal carotid artery siphon(ICAS)may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy(NAION).METHODS:Totally 30 consecutive patients who had unilateral NAION and 30 gender-matched control subjects were recruited in the present study.The diameter of ICAS of all the participants were measured using head-and-neck computed tomographic angiography(CTA).Color doppler flow imaging(CDI)was used to measure the haemodynamics parameters of ICAS and short posterior ciliary arteries(SPCAs)in all subjects.Comparison of parameters between the NAION patients and controls as well as between the two sides within the patients were performed.The correlation between the diameter of ICAS and NAION was analyzed.RESULTS:A comparison of parameters between the affected side of the NAION patients and the controls,including the diameter of ICAS,the resistance index(RI)of ICAS,the blood flow velocities of SPCAs and RI of SPCAs,showed significantly difference(P<0.01),while there was no significant difference in terms of the mean blood flow velocity(Vm)of ICAS;Similar results were found while comparing all the measurements of the affected and unaffected side of patients(P for RI of SPCAs<0.05).No marked difference was detected in nearly all parameters except for RI of ICAS and SPCAs between the unaffected side of the NAION patients and the controls(P<0.05).The diameter of ICAS were significantly positive correlated with both peak systolic velocity(PSV)of SPCAs and end diastolic velocity(EDV)of SPCAs in patients with NAION(r=0.514,P<0.01 and r=0.418,P<0.05,respectively).CONCLUSION:Narrowing of ICAS may increase the risk of developing NAION.展开更多
In order to further clarify the spraying performance of siphonic nozzle, the spray rate of siponic cone nozzle with aperture of 1.0 mm was determined at 15 different air pressure levels and 12 gravity drop levels, and...In order to further clarify the spraying performance of siphonic nozzle, the spray rate of siponic cone nozzle with aperture of 1.0 mm was determined at 15 different air pressure levels and 12 gravity drop levels, and DPS and SPSS were used to make the difference analysis and modeling, which clarified the relationship between the spray rate of the siphonic cone nozzle with aperture of 1.0 mm and air pressure and gravity drop, getting the regression equation of Y=406.854P＋ 1.904G＋77.524. The study could provide a theoretical basis for the optimization and improvement of plant protection spraying equipment.展开更多
For responsiveness, in the Petri nets theory framework deadlock prevention policies based elementary siphons control are often utilized to deal with deadlocks caused by the sharing of resources in flexible manufacturi...For responsiveness, in the Petri nets theory framework deadlock prevention policies based elementary siphons control are often utilized to deal with deadlocks caused by the sharing of resources in flexible manufacturing system (FMS) which is developing the theory of efficient strict minimal siphons of an S3PR. Analyzer of Petri net models and their P-invariant analysis, and deadlock control are presented as tools for modelling, efficiency structure analysis, control, and investigation of the FMSs when different policies can be implemented for the deadlock prevention. We are to show an effective deadlock prevention policy of a special class of Petri nets namely elementary siphons. As well, both structural analysis and reachability graph analysis and simulation are used for analysis and control of Petri nets. This work is successfully applied Petri nets to deadlock analysis using the concept of elementary siphons, for design of supervisors of some supervisory control problems of FMS and simulation of Petri net tool with MATLAB.展开更多
Based on the present simultaneous hydrometeorological data and the analysis of the actual materials obtained by our studies, we can suppose the fact of the occurrence of powerful underground floodings in the hydrodyna...Based on the present simultaneous hydrometeorological data and the analysis of the actual materials obtained by our studies, we can suppose the fact of the occurrence of powerful underground floodings in the hydrodynamic system of the Tskaltubo Cave. The simultaneous records of the water levels (discharges) of the underground rivers and atmospheric precipitation show that there are importantly clear peaks in the hydrographs, when the diurnal sums of precipitations reach or exceed 50 mm in all observation points (in all surface catchment basins defined by us). Though, a long-term observation revealed that only 50 mm of precipitation diurnal sum is not enough for the formation of strong underground flooding in the cave hydrodynamic system;a rainy period of several days should precede such kind of precipitation so that the soil was well saturated with water. Only under these conditions is expected a powerful flooding. As the analysis of the dangerous flooding formation mechanism showed, what is important is not the abundance of diurnal precipitation and their intensity, but the combination of factors such as: the total amount and duration of precipitation of the predecessor period, precipitation amount during the flooding maximum development days and the coverage rate of the cave system’s surface water catchment area.展开更多
基金National Natural Science Foundation of China,No.42071415Xinyang Academy of Ecological Research Open Foundation,No.2023XYMS01Central Plains Youth Top Talent Project。
文摘Regional development strategies that align with urban characteristics and the sci-entific allocation of construction land indicators can effectively guide the high-quality coordi-nated development of urban agglomerations.However,the issue of whether urbanization matches the development strategy has always lacked an in-depth response in geography.Moreover,along with the urbanization process,the land limitation for agricultural and eco-logical spaces becomes increasingly strict,and the availability of construction land indicators is increasingly constrained.The construction land allocation is thus critical for the distribution of regional resources and the development goals of urban agglomeration.Based on the prin-ciples of development geography and the core-periphery theory,this study comprehensively considered three subsystems of urbanization(population,economy,and land)and the spatial link intensity among cities within a certain region to analyze the impacts of"siphon"and"ra-diation"effects on regional development,and assessed whether China's two major regional urbanization strategies aligned the comprehensive development characteristics.Furthermore,the quantitative construction land allocation in Beijing-Tianjin-Hebei(BTH)and Yangtze River Delta(YRD)urban agglomerations was completed.The results showed that the urban com-prehensive level index(UCL)in core cities(Beijing and Tianjin)and peripheral cities differed significantly in BTH,demonstrating a clear core-periphery structure.Along with urbanization,the"siphon"effect in BTH was weakening.Beijing's urban primacy decreased and the growth rate of UCL decreased from 53.89%in the first five years to 18.37%in the last five years during the study period(2020-2019).In contrast,the"radiation"effect in YRD was more ob-vious,exhibiting a development pattern driven by multiple growth poles.Temporally,the BTH indicated a coordinated development trend,while the integration level of YRD continued to strengthen.Compared to the top-down construction land allocated by the government,the results of quantitative allocation in this study reduced volatility.This study confirms the scientific basis of the coordinated development for BTH and the integrated regional development strategy for YRD from the perspective of development geography.It also provides a practical reference fortheconstructionland allocation.
基金Supported by the National Undergraduate Innovation Training Program(Project No.202211437036).
文摘In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how factors such as the difference in water level,sediment concentration,and pipeline layout affected the sediment discharge effect.The results show that the sediment discharge device can effectively discharge sediment under diverse operating conditions and show adaptability to different environmental conditions,which indicates that it is suitable for various types of reservoir environments.
文摘The editorial discusses the impact of liver metastasis on immunotherapy efficacy in gastric cancer(GC)patients.Liver metastasis can hinder the effectiveness of immunotherapy by altering the immune microenvironment,leading to systemic loss of T-cells and reduced treatment response.Studies suggest that liver meta-stases serve as a negative baseline factor for immunotherapy efficacy,resulting in poorer progression-free survival and objective response rates.Strategies such as liver-mediated radiotherapy may help improve treatment outcomes by reshaping the liver’s immune microenvironment and reducing T-cell depletion.Understand-ing the complex interplay between liver metastasis and immunotherapy response is crucial for optimising patient care in GC.
基金the financial support from the National Natural Science Foundation of China (Grant No. 52172038, 22179017)National Key Research and Development Program of China (Nos. 2022YFB4101600, 2022YFB4101601)。
文摘Solar-driven desalination is a promising way to alleviate the freshwater shortage,while is facing challenges posed by low evaporation rates and severe salt accumulation.Herein,a high-performance twodimensional(2D) solar absorber with Co_(3)O_(4) nanoneedle arrays(Co_(3)O_(4)-NN) grown on the surface of reduced graphene oxide-coated pyrolyzed silk cloth(Co_(3)O_(4)-NN/rGO/PSC) was prepared,and a salt-free evaporator system was assembled based on the composite material and siphonage-the flowing water delivery.It is revealed that the evaporation enthalpy of water can be reduced over the 2D solar absorber grown with Co_(3)O_(4)-NN_T enabling an evaporation rate of up to 2.35 kg m^(-2) h^(-1) in DI water under one solar irradiation.The desalination process can be carried out continuously even with salt concentration up to 20 wt%,due to the timely removal of concentrated brine from the interface with the assistance of directed flowing water.Moreover,the 2D structure and the flowing water also provide an opportunity to convert waste solar heat into electricity in the evaporator based on the seebeck effect,ensuring simultaneous freshwater production and power generation.It is believed that this work provides insights into designing hybrid systems with high evaporation rate,salt resistance,and electricity generation.
基金National Social Science Foundation of China(Grant No.:23BJL108).
文摘Accelerating green innovation is crucial for achieving high-quality development in China.Despite this importance,empirical evidence on the harmonization techniques in the context of carbon-trading policies has been remarkably thin.To address this gap,we employed the difference-in-difference(DID)and spatial difference-in-difference(S-DID)models using panel data from 2007 to 2017 for 30 Chinese provinces.Our findings reveal that the carbon-trading policy contributes significantly to the coordinated advancement of green technologies across Chinese provinces and exhibits a local siphoning effect.Specifically,the pilot areas of the policy have attracted talent from neighboring regions,which has fostered local cooperation and promoted coordinated innovation in green technologies within the region.
基金financial support of the key project at the central government level:The Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(No.2060302)the Independent Research Grant of National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences(No.ZZXT201608)the National Natural Science Foundation of China(No.81603293)
文摘Soxhlet extraction is a common method of sample preparation. However, there has been no discussion about the efficiency of Soxhlet extraction from different batches and the factors that cause content fluctuation. In this study, Panax ginseng was selected as a model sample. Soxhlet extraction by means of a water bath, which has always been neglected, was identified as a novel key factor in the poor repeat- ability in different batches of Soxhlet extraction, as it can affect the siphon times and reflux time, which have been positively correlated with the ginsenoside contents. By substituting round bottom flasks in the same column, the relative standard deviation of the most fluctuated compound, ginsenoside Rbl, was decreased from 24.6% to 5.02%. Scanning electron microscopy analysis confirmed that the breakdown of the surface of the ginseng powder in the Soxhlet extraction led to a better dissolution of ginsenosides, indicating that chloroform may promote the extraction of ginsenosides by disrupting the cell structure. Moreover, 70% methanol was regarded as the better solvent for extracting the ginsenosides. Overall, this work offers a practical and effective protocol for improving the accuracy and repeatability of Soxhlet extraction methodology for ginsenosides and other analytes.
基金financially supported by the National Key R&D Program of China (Grant No. 2018YFC1504704)the National Natural Science Foundation of China (Grant No. 41772276)Key R&D project of Zhejiang Province (Grant No. 2017C03006)
文摘The siphon drainage is an effective measure for the slope groundwater control. However,for the traditional siphon drainage, limitations such as siphon lift restriction and poor reliability in longterm service prevent it from being widely used. In this study, an improved siphon drainage method with inclined borehole penetrating the deep part of the slope is proposed to overcome the limitations suffered by the traditional method. Through experimental research, theoretical analysis and engineering practice,the reliability and capability of the proposed method are investigated. The results demonstrate that with the inclined pipe the height difference between the control point of the groundwater level and the orifice can be controlled to be less than the height of the water column corresponding to the local atmospheric pressure. As a result, deep drainage can be achieved.In addition, by controlling the diameter of siphon drainage pipe not larger than 4 mm, a plug flow can be formed in the siphon pipe, which can prevent air accumulation in the siphon process and a continuous and effective siphon drainage is achieved. Through a practical project running smoothly since September 2013, it is found that the proposed method can effectively drain the groundwater deep in the slope and the maximum drawdown of groundwater level in boreholes can reach 8.5 m with an average drainage flow of 5.5 m3/d. The practical results also illustrate that 4 mm siphon pipe can be used to realize deep slope drainage and restart siphon automatically.
基金supported by the National Natural Science Foundation of China (No. 30700010)the Eleventh Five-Year Plan National Key Technology R&D Program of China (No. 2006BAD07A01)+1 种基金the National Gongyixing Hangye Kejizhuanxiang (No. 200803033)the Special Program for Water Pollution Control of Taihu Lake in Jiangsu Province (No. BK2007741)
文摘To improve the efficiency of backwashing in upflow biological aerated filter （BAF）, a novel backwashing process named air-water siphon backwashing （AWSB） was proposed and applied on laboratory scale. The effects of backwashing on turbidity and suspended solid （SS） in backwashing efluent using this new backwashing process were compared with those of traditional backwashing process, namely air-water backwashing （AWB）. In AWB, the turbidity of backwashing efluent maintained 100 NUT when consumed 60 min and 10.5 L water. However, in AWSB, it declined to 44 NUT, consumed 40 min, and 7 L water. The COD removal of BAF after backwashing was also analyzed. The average removal rate of COD in the reactor backwashed by AWB and AWSB was 89.34% and 90.91%, respectively. Compared with AWB, the backwashing interval had been prolonged 35%. The volume of backwashing water in that AWSB was only 66.7% of that in AWB. The results demonstrated that AWSB required less water and took shorter backwashing timerelative to AWB to achieve the same turbidity of backwashing efluent, and AWSB was more effective in removing fouling than that of AWB. More significant advantage of AWSB was that the backwashing interval was effectively prolonged
基金support by the 11th Five Year Key Project of China’s National Scientific Supporting Plan(Grant No.2006BAB04A03)the Hydraulic Engineering Project from the Water Resources Department of Jiangsu Province(Grant No.2010023)
文摘Based on the characteristics of large flow rate , low head , short annual operation time , and high reliability of the city flood-control pumping stations , a new-type shaft tubular pumping system featuring a shaft suction box and a siphon-type discharge passage with a vacuum breaker as the cutoff device was developed , which possesses such advantages as simple structure , reliable cutoff , and high energy performance.Taking some pumping stations as the case studies , in the light of the specified operation conditions , the hydraulic optimal design of the shaft-type tubular pumping system was determined and the optimized shape of the system was recommended.The performance prediction based on the computational fluid dynamics methodology was determined and the model test verification was conducted.The results show that the predicted data agree with the experimental head and efficiency so that both methods can be used to determine the performance of a real pumping station.Finally , the in-situ measurements of a pumping station during the commissioning period further verified that the shaft-type tubular pumping station with a siphon discharge passage is of higher efficiency , more reliable and stable.
基金supported in part by Zhejiang Provincial Key Research and Development Program(2018C01084)Zhejiang Natural Science Foundation(LQ20F020009)Zhejiang Gongshang University,Zhejiang Provincial Key Laboratory of New Network Standards and Technologies(2013E10012)。
文摘Deadlock resolution strategies based on siphon control are widely investigated.Their computational efficiency largely depends on siphon computation.Mixed-integer programming(MIP)can be utilized for the computation of an emptiable siphon in a Petri net(PN).Based on it,deadlock resolution strategies can be designed without requiring complete siphon enumeration that has exponential complexity.Due to this reason,various MIP methods are proposed for various subclasses of PNs.This work proposes an innovative MIP method to compute an emptiable minimal siphon(EMS)for a subclass of PNs named S^(4)PR.In particular,many particular structural characteristics of EMS in S4 PR are formalized as constraints,which greatly reduces the solution space.Experimental results show that the proposed MIP method has higher computational efficiency.Furthermore,the proposed method allows one to determine the liveness of an ordinary S^(4)PR.
基金Project supported by the National ＂Twelfth Five-Year＂ Plan for Science ＆ Technology Support Program of China （No. 2012BAK10B06） and the National Natural Science Foundation of China （No. 41272336）
文摘High-lift siphon drainage by 4-mm internal diameter siphon hoses is a real-time, free-power, and long-term approach for slope drainage. The conventional hydraulics formula for pressurized pipe flow is generally used to calculate the single-phase velocity of siphon flow. However, an intensive cavitation phenomenon occurs in the high-lift siphon hose and then a two-phase flow is formed. Research on the velocity of high-lift siphon flow is a prerequisite for the application of siphon drainage with a 4-mm siphon hose. Few investigations of this subject have been carried out. Hence, experiments on the high-lift （8 m〈H0〈10.3 m） siphon drainage in a 4-mm siphon hose were performed. The characteristics of siphon flow under different conditions were ob- served and test data were obtained. Comparisons between test results and calculated results showed that significant errors were given by the hydraulics formula. It is demonstrated that the effect of gas in a siphon hose should be included in the calculation of flow velocity. The findings can be used to determine the number of siphon hoses and layout of siphon drainage holes, and provide valuable information for geotechnical companies.
基金the financial support of the National Natural Science Foundation of China(Key Project)(No.42230702)National Natural Science Foundation of China(No.42277129)Natural Science Foundation of Zhejiang Province(No.LY21D020001)。
文摘A new anchor-siphon drainage combined method used for slope stabilization is proposed in this paper.It includes an anchoring section and a siphon drainage section.The novelty of the anchor-siphon drainage combined method is the realization of the drainage and anchoring in the one inclined borehole.The engineering cost of drilling and the resulting disturbance to the slope is reduced.To validate the feasibility of the proposed method,a numerical method that combines the pore water pressure distribution after siphon drainage and the anchoring force of the anchoring section is used to evaluate the safety of the slope with the anchor-siphon drainage method.The proposed method was illustrated and validated with the Hongpu Village landslide,in Tonglu County,Zhejiang Province,in China.Compared with the common anchor bar with the same length in the anchoring section,the factor of safety(FOS)for Hongpu Village slope with anchorsiphon drainage is increased by 0.085.The calculation method of the optimal length ratio between the drainage section and the anchoring section and its influencing factors were studied.For the different design parameters,there is always an optimal length ratio of the drainage section.Compared with the siphon drainage and full-length anchor bar with the same borehole length,the anchor-siphon drainage combined method shows better landslide prevention ability.Moreover,when the optimized parameters with a bond strength of 560kPa,a borehole inclination of 35°,and no reduction in length are used,the calculated safety factor is 1.316,which is significantly higher than the FOS of 1.131 for the slope with siphon drainage.
基金supported in part by the Zhejiang Natural Science Foundation(LQ20F020009)the Zhejiang Provincial Key Laboratory of New Network Standards and Technologies(2013E10012)the Public Technology Research Plan of Zhejiang Province(LGJ21F030001)。
文摘A large amount of research has shown the vitality of siphon enumeration in the analysis and control of deadlocks in various resource-allocation systems modeled by Petri nets(PNs).In this paper,we propose an algorithm for the enumeration of minimal siphons in PN based on problem decomposition.The proposed algorithm is an improved version of the global partitioning minimal-siphon enumeration(GPMSE)proposed by Cordone et al.(2005)in IEEE Transactions on Systems,Man,and Cybernetics-Part A:Systems and Humans,which is widely used in the literature to compute minimal siphons.The experimental results show that the proposed algorithm consumes lower computational time and memory compared with GPMSE,which becomes more evident when the size of the handled net grows.
基金funded by the National Key Research and Development Program of China(Nos.2019YFE0190900,2018YFD0900705).
文摘Actin is a ubiquitous protein and plays essential roles on cellular structure maintenance and cellular motility in both muscle and non-muscle tissues.Multiple genes encoding muscle actin have been identified from the ascidians,including those expressed in the larval tail muscle,the adult body-wall muscle,and adult heart muscle.In this study,a novel striated non-tail muscle actin gene was identified from the RNA-seq data of Ciona savignyi embryos.Phylogenetic analysis,alignment of the N-terminal amino acid sequences and comparation of diagnostic residues provided evidence that it had high similarity with vertebrate cardiac and skeletal muscle actin.In situ hybridization and promoter-driven GFP reporter assay revealed that it was specifically expressed in the primordia of the oral and atrial siphon.We hereby defined it as siphon-specific muscle actin coding gene(Cs-SMA).A 201 bp(−1350 bp to−1150 bp)sequence containing T-box and Six1/2 binding motif within the upstream region of Cs-SMA confined the expression of GFP in the siphons of electroporated embryos.Six1/2 binding motif was experimentally confirmed to play indispensable role in controlling the siphon-specific expression of Cs-SMA.The tissue-specific expression of Cs-SMA in the siphon primordia indicated its potential crucial roles in Ciona embryogenesis and organogenesis.
文摘Siphonic roof drainage systems (SRDS’s) have been widespread used now for approximately 40 years and are an efficient method of removing rainwater rapidly from roofs. SRDS’s are designed to run full-bore, resulting in sub-atmospheric system pressures with high hydraulic driving heads and higher system flow velocities than conventionally guttered systems. Hence, SRDS’s normally require far fewer downpipes, and the depressurised conditions also mean that much of the collection pipework can be routed at a high level, thus reducing the extent of any underground pipework. But, they work properly at only one roof run-off rate and therefore suffer from sizing and operational problems including noise and vibration which limit their performance and adoption rate. Climate change is creating situations where normal ranges of rainfall intensity are being frequently exceeded, so the typical:storm ratios (rTS) are large increasing. Current SRDS’s typically operate within a small rTS range of 2. This may have an impact on the future uptake of SRDS’s. This paper describes the development of a novel SRDS which includes a small mobile cap at the roof of outlet appears to offer benefits and avoids sizing problems associated with current SRDS’s. The cap has the potential to avoid noise associated with making and breaking siphonic action through flow modulation. Laboratory scale tests demonstrate the basic feasibility of the cap system and indicate that the cap functions reliably. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Basic on sizing and design optimiza-tion factors are suggested. The rTS range is increased from approximately 2 to approximately 6.
基金Supported by Start Funding of Beijing Friendship Hospital(No.yyqdkt2016-8)the Capital Health Research and Development of Special(No.2018-1-2021)。
文摘AIM:To evaluate whether narrowing of internal carotid artery siphon(ICAS)may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy(NAION).METHODS:Totally 30 consecutive patients who had unilateral NAION and 30 gender-matched control subjects were recruited in the present study.The diameter of ICAS of all the participants were measured using head-and-neck computed tomographic angiography(CTA).Color doppler flow imaging(CDI)was used to measure the haemodynamics parameters of ICAS and short posterior ciliary arteries(SPCAs)in all subjects.Comparison of parameters between the NAION patients and controls as well as between the two sides within the patients were performed.The correlation between the diameter of ICAS and NAION was analyzed.RESULTS:A comparison of parameters between the affected side of the NAION patients and the controls,including the diameter of ICAS,the resistance index(RI)of ICAS,the blood flow velocities of SPCAs and RI of SPCAs,showed significantly difference(P<0.01),while there was no significant difference in terms of the mean blood flow velocity(Vm)of ICAS;Similar results were found while comparing all the measurements of the affected and unaffected side of patients(P for RI of SPCAs<0.05).No marked difference was detected in nearly all parameters except for RI of ICAS and SPCAs between the unaffected side of the NAION patients and the controls(P<0.05).The diameter of ICAS were significantly positive correlated with both peak systolic velocity(PSV)of SPCAs and end diastolic velocity(EDV)of SPCAs in patients with NAION(r=0.514,P<0.01 and r=0.418,P<0.05,respectively).CONCLUSION:Narrowing of ICAS may increase the risk of developing NAION.
基金Supported by the Special Key Fund for Science and Technology of Anhui Province(15CZZ03132)the Special Fund for Talent Development of Anhui Province(13C1109)the Agricultural Science and Technology Innovation Fund Project of Anhui Province(16A1132)~~
文摘In order to further clarify the spraying performance of siphonic nozzle, the spray rate of siponic cone nozzle with aperture of 1.0 mm was determined at 15 different air pressure levels and 12 gravity drop levels, and DPS and SPSS were used to make the difference analysis and modeling, which clarified the relationship between the spray rate of the siphonic cone nozzle with aperture of 1.0 mm and air pressure and gravity drop, getting the regression equation of Y=406.854P＋ 1.904G＋77.524. The study could provide a theoretical basis for the optimization and improvement of plant protection spraying equipment.
文摘For responsiveness, in the Petri nets theory framework deadlock prevention policies based elementary siphons control are often utilized to deal with deadlocks caused by the sharing of resources in flexible manufacturing system (FMS) which is developing the theory of efficient strict minimal siphons of an S3PR. Analyzer of Petri net models and their P-invariant analysis, and deadlock control are presented as tools for modelling, efficiency structure analysis, control, and investigation of the FMSs when different policies can be implemented for the deadlock prevention. We are to show an effective deadlock prevention policy of a special class of Petri nets namely elementary siphons. As well, both structural analysis and reachability graph analysis and simulation are used for analysis and control of Petri nets. This work is successfully applied Petri nets to deadlock analysis using the concept of elementary siphons, for design of supervisors of some supervisory control problems of FMS and simulation of Petri net tool with MATLAB.
文摘Based on the present simultaneous hydrometeorological data and the analysis of the actual materials obtained by our studies, we can suppose the fact of the occurrence of powerful underground floodings in the hydrodynamic system of the Tskaltubo Cave. The simultaneous records of the water levels (discharges) of the underground rivers and atmospheric precipitation show that there are importantly clear peaks in the hydrographs, when the diurnal sums of precipitations reach or exceed 50 mm in all observation points (in all surface catchment basins defined by us). Though, a long-term observation revealed that only 50 mm of precipitation diurnal sum is not enough for the formation of strong underground flooding in the cave hydrodynamic system;a rainy period of several days should precede such kind of precipitation so that the soil was well saturated with water. Only under these conditions is expected a powerful flooding. As the analysis of the dangerous flooding formation mechanism showed, what is important is not the abundance of diurnal precipitation and their intensity, but the combination of factors such as: the total amount and duration of precipitation of the predecessor period, precipitation amount during the flooding maximum development days and the coverage rate of the cave system’s surface water catchment area.
