The catalytic asymmetric synthesis of atropisomers incorporating both axial and central chirality represents an attractive but formidable challenge in synthetic chemistry.We disclose herein a nickel-catalyzed diastere...The catalytic asymmetric synthesis of atropisomers incorporating both axial and central chirality represents an attractive but formidable challenge in synthetic chemistry.We disclose herein a nickel-catalyzed diastereo-and enantioselective silacycloaddition that achieves the atroposelective assembly of multistereogenic aromatic amide-derived atropisomers.This transformation combines dynamic kinetic resolution of racemic aromatic amide atropisomers with asymmetric Si-C bond activation of benzosilacyclobutenes.展开更多
基金supported by the grants of National Natural Science Foundation of China(NSFC,Nos.22371060 and 22361162606)Zhejiang Provincial Natural Science Foundation of China(No.LZ23B020002)+1 种基金"Pioneer and Leading Goose+X"R&D Program of Zhejiang Province(2025C01159)The Interdisciplinary Research Project of Hangzhou Normal University(2025JCXK02)is also gratefully acknowledged。
文摘The catalytic asymmetric synthesis of atropisomers incorporating both axial and central chirality represents an attractive but formidable challenge in synthetic chemistry.We disclose herein a nickel-catalyzed diastereo-and enantioselective silacycloaddition that achieves the atroposelective assembly of multistereogenic aromatic amide-derived atropisomers.This transformation combines dynamic kinetic resolution of racemic aromatic amide atropisomers with asymmetric Si-C bond activation of benzosilacyclobutenes.
