In this paper,we investigate the following fractional Schrödinger-Poisson system with concave-convex nonlinearities and a steep potential well{(-Δ)^(s)u+V_(λ)(x)u+ϕu=f(x)|u|^(q-2)u+|u|^(p-2)u,in R^(3),(-Δ)^(t)...In this paper,we investigate the following fractional Schrödinger-Poisson system with concave-convex nonlinearities and a steep potential well{(-Δ)^(s)u+V_(λ)(x)u+ϕu=f(x)|u|^(q-2)u+|u|^(p-2)u,in R^(3),(-Δ)^(t)ϕ=u^(2),in R^(3),where s∈(3/4,1),t∈(0,1),q∈(1,2),p∈(4,2_(s)^(*)),2_(s)^(*):=6/3-2s is the fractional critical exponent in dimension 3,V_(λ)(x)=λV(x)+1 withλ>0.Under the case of steep potential well,we obtain the existence of the sign-changing solutions for the above system by using the constraint variational method and the quantitative deformation lemma.Furthermore,we prove that the energy of ground state sign-changing solution is strictly more than twice of the energy of the ground state solution.Our results improve the recent results in the literature.展开更多
For any s∈(0,1),let the nonlocal Sobolev space X^(s)(R^(N))be the linear space of Lebesgue measure functions from R^(N) to R such that any function u in X^(s)(R^(N))belongs to L2(R^(N))and the function(x,y)→(u(x)-u...For any s∈(0,1),let the nonlocal Sobolev space X^(s)(R^(N))be the linear space of Lebesgue measure functions from R^(N) to R such that any function u in X^(s)(R^(N))belongs to L2(R^(N))and the function(x,y)→(u(x)-u(y)√K(x-y)is in L^(2)(R^(N),R^(N)).First,we show,for a coercive function V(x),the subspace E:={u∈X^s(R^N):f_(R)^N}V(x)u^(2)dx<+∞}of X^(s)(R^(N))is embedded compactly into L^(p)(R^(N))for p\in[2,2_(s)^(*)),where 2_(s)^(*)is the fractional Sobolev critical exponent.In terms of applications,the existence of a least energy sign-changing solution and infinitely many sign-changing solutions of the nonlocal Schrödinger equation-L_(k)u+V(x)u=f(x,u),x∈R^N are obtained,where-L_(K)is an integro-differential operator and V is coercive at infinity.展开更多
In this article, we give a new proof on the existence of infinitely many sign- changing solutions for the following Brezis-Nirenberg problem with critical exponent and a Hardy potential -△u-μ（u/｜x｜^2）=λu＋｜u...In this article, we give a new proof on the existence of infinitely many sign- changing solutions for the following Brezis-Nirenberg problem with critical exponent and a Hardy potential -△u-μ（u/｜x｜^2）=λu＋｜u｜^2＊-2u inΩ, u=0 on eΩ,where Ω is a smooth open bounded domain of R^N which contains the origin, 2＊=2N/n-2 is the critical Sobolev exponent. More precisely, under the assumptions that N ≥ 7, μ ∈ [0, μ- 4）, and μ=（N-2）^2/4, we show that the problem admits infinitely many sign-changing solutions for each fixed λ 〉 0. Our proof is based on a combination of invariant sets method and Lj usternik-Schnirelman theory.展开更多
In this paper, we study the existence of least energy sign-changing solutions for aKirchhoff-type problem involving the fractional Laplacian operator. By using the constraintvariation method and quantitative deformati...In this paper, we study the existence of least energy sign-changing solutions for aKirchhoff-type problem involving the fractional Laplacian operator. By using the constraintvariation method and quantitative deformation lemma, we obtain a least energy nodal solu-tion ub for the given problem. Moreover, we show that the energy of ub is strictly larger thantwice the ground state energy. We also give a convergence property of ub as b O, where bis regarded as a positive parameter.展开更多
In this article, by using the method of invariant sets of descending flow, we obtain the existence of sign-changing solutions of p-biharmonic equations with Hardy potential in RN.
In this article, we study the existence of sign-changing solutions for the following SchrSdinger equation -△u ＋ λV（x）u = K（x）｜u｜^p-2u x∈R^N, u→0 as ｜x｜→ ＋∞, 2N where N ≥ 3, λ〉 0 is a parameter, 2 〈...In this article, we study the existence of sign-changing solutions for the following SchrSdinger equation -△u ＋ λV（x）u = K（x）｜u｜^p-2u x∈R^N, u→0 as ｜x｜→ ＋∞, 2N where N ≥ 3, λ〉 0 is a parameter, 2 〈 p 〈 2N/N-2, and the potentials V（x） and K（x） satisfy some suitable conditions. By using the method based on invariant sets of the descending flow, we obtain the existence of a positive ground state solution and a ground state sign-changing solution of the above equation for small λ, which is a complement of the results obtained by Wang and Zhou in [J. Math. Phys. 52, 113704, 2011].展开更多
In this paper,we consider the nonlinear Kirchhoff type equation with a steep potential well−(a+b∫_(R)^(3)|∇u|^(2 )dx)Δu+λV(x)u=f(u)in R^(3),where a,b>0 are constants,λ is a positive parameter,V∈C(R3,R)is a ste...In this paper,we consider the nonlinear Kirchhoff type equation with a steep potential well−(a+b∫_(R)^(3)|∇u|^(2 )dx)Δu+λV(x)u=f(u)in R^(3),where a,b>0 are constants,λ is a positive parameter,V∈C(R3,R)is a steep potential well and the nonlinearity f∈C(R,R)satisfies certain assumptions.By applying a signchanging Nehari manifold combined with the method of constructing a sign-changing(PS)C sequence,we obtain the existence of ground state sign-changing solutions with precisely two nodal domains when λ is large enough,and find that its energy is strictly larger than twice that of the ground state solutions.In addition,we also prove the concentration of ground state sign-changing solutions.展开更多
In this paper,we construct sign-changing radial solutions for a class of Schrodinger equations with saturable nonlinearity which arises from several models in mathematical physics.More precisely,for any given nonnegat...In this paper,we construct sign-changing radial solutions for a class of Schrodinger equations with saturable nonlinearity which arises from several models in mathematical physics.More precisely,for any given nonnegative integer k,by using a minimization argument,we first obtain a sign-changing minimizer with k nodes of a constrained minimization problem,and show,by a deformation lemma and Miranda's theorem,that the minimizer is the desired solution.展开更多
In this paper, we study the following quasilinear equation of choquard type: where A(x,t) is given real functions on R<sup>N</sup> × R and with N ≥ 3, 1 p N, max{N-2p,1} α N, , and ε > 0 is a sm...In this paper, we study the following quasilinear equation of choquard type: where A(x,t) is given real functions on R<sup>N</sup> × R and with N ≥ 3, 1 p N, max{N-2p,1} α N, , and ε > 0 is a small parameter, I<sub>α</sub> is the Riesz potential. We establish for small ε the existence of a sequence of sign-changing solutions concentrating near a given local minimum point of the bounded potential function V by using the method of invariant sets of descending flow, perturbation method and truncation technique. .展开更多
We investigate the bi-harmonic problem{Δ^(2)u-α▽·(f(▽u))-βΔ_(p)u=g(x,u) in Ω,δu/δn=0,δ(Δu)/δn=0 on δΩ,where Δ^(2)u=Δ(Δu),Δ_(p)u=div(|▽u|^(p-2)▽u)with p>2.Ω is a bounded smooth domain in R^...We investigate the bi-harmonic problem{Δ^(2)u-α▽·(f(▽u))-βΔ_(p)u=g(x,u) in Ω,δu/δn=0,δ(Δu)/δn=0 on δΩ,where Δ^(2)u=Δ(Δu),Δ_(p)u=div(|▽u|^(p-2)▽u)with p>2.Ω is a bounded smooth domain in R^(N),N≥1.By using a special function space with the constraint ∫_(Ω)udx=0,under suitable assumptions on f and g(x,u),we show the existence and multiplicity of sign-changing solutions to the above problem via the Mountain pass theorem and the Fountain theorem.Recent results from the literature are extended.展开更多
Using invariant sets of descending flow and variational methods, we establish some sufficient conditions on the existence of sign-changing solutions, positive solutions and negative solutions for second-order nonlinea...Using invariant sets of descending flow and variational methods, we establish some sufficient conditions on the existence of sign-changing solutions, positive solutions and negative solutions for second-order nonlinear difference equations with Dirichlet boundary value problem. Some results in the literature are improved.展开更多
By using the fixed point theorem under the case structure, we study the existence of sign-changing solutions of A class of second-order differential equations three-point boundary-value problems, and a positive soluti...By using the fixed point theorem under the case structure, we study the existence of sign-changing solutions of A class of second-order differential equations three-point boundary-value problems, and a positive solution and a negative solution are obtained respectively, so as to popularize and improve some results that have been known.展开更多
In this paper,we study the following Schrodinger-Poisson system with critical growth:■We establish the existence of a positive ground state solution and a least energy sign-changing solution,providing that the nonlin...In this paper,we study the following Schrodinger-Poisson system with critical growth:■We establish the existence of a positive ground state solution and a least energy sign-changing solution,providing that the nonlinearity f is super-cubic,subcritical and that the potential V(x)has a potential well.展开更多
In this paper,we study the elliptic system{-Δu+V(x)u=|v|^(p-2)v-λ_(2)|v|^(s2-2)v,-Δu+V(x)v=|u|^(p-2)u-λ_(1)|u|^(s1-2)u,u,v∈H^(1)(R^(N))with strongly indefinite structure and sign-changing nonlinearity.We overcome...In this paper,we study the elliptic system{-Δu+V(x)u=|v|^(p-2)v-λ_(2)|v|^(s2-2)v,-Δu+V(x)v=|u|^(p-2)u-λ_(1)|u|^(s1-2)u,u,v∈H^(1)(R^(N))with strongly indefinite structure and sign-changing nonlinearity.We overcome the absence of the upper semi-continuity assumption which is crucial in traditional variational methods for strongly indefinite problems.By some new tools and techniques we proved the existence of infinitely many geometrically distinct solutions if parametersλ_(1),λ_(2)>0 small enough.To the best of our knowledge,our result seems to be the first result about infinitely many solutions for Hamiltonian system involving sign-changing nonlinearity.展开更多
In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By ...In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By virtue of the variational method and the concentration compactness principle with the equivariant group action,we obtain some new type of nonradial,sign-changing solutions of(FCSE)in the energy space˙H^(s)(R^(N)).The key component is that we take the equivariant group action to construct several subspace of˙H^(s)(R^(N))with trivial intersection,then combine the concentration compactness argument in the Sobolev space with fractional order to show the compactness property of Palais-Smale sequences in each subspace and obtain the multiple solutions of(FCSE)in˙H^(s)(R^(N)).展开更多
In the present paper, the author studies the existence of sign-changing solutions for nonlinear elliptic equations, which have jumping nonlinearities, and may or may not be resonant with respect to Fucik spectrum, via...In the present paper, the author studies the existence of sign-changing solutions for nonlinear elliptic equations, which have jumping nonlinearities, and may or may not be resonant with respect to Fucik spectrum, via linking methods under Cerami condition.展开更多
This paper is concerned with the following non linear elliptic problem in- volving nearly critical exponent （Pεk）： （-△）ku = K（x）｜u｜（4k/（n-2k））-εu in Ω, △k-lu =… △u = u = 0 on δΩ, where Ω is a bo...This paper is concerned with the following non linear elliptic problem in- volving nearly critical exponent （Pεk）： （-△）ku = K（x）｜u｜（4k/（n-2k））-εu in Ω, △k-lu =… △u = u = 0 on δΩ, where Ω is a bounded smooth domain in Rn, n≥ 2k＋2, k≥ 1, ε is a small positive parameter and K is a smooth positive function in Ω. We construct sign- changing solutions of （pεk） having two bubbles and blowing up either at two different critical points of K with the same speed or at the same critical point.展开更多
Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhan...Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhancing patient prognosis.Obviously,non-participation of asymptomatic individuals in screening programs hampers early diagnosis and may adversely affect long-term outcomes for CRC patients.In this letter,we provide a comprehensive overview of the current status of early screening practices,while also thoroughly examine the dilemmas and potential solutions associated with early screening for CRC.In response to these issues,we proffer a set of recommendations directed at governmental authorities and the general public,which focus on augmenting financial investment,establishing standardized screening protocols,advancing technological capabilities,and bolstering public awareness campaigns.The importance of collaborative efforts from various stakeholders cannot be overstated in the quest to enhance early detection rates and alleviate the societal burden of CRC.展开更多
Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the t...Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.展开更多
基金supported by the Natural Science Foundation of Sichuan(No.2023NSFSC0073)。
文摘In this paper,we investigate the following fractional Schrödinger-Poisson system with concave-convex nonlinearities and a steep potential well{(-Δ)^(s)u+V_(λ)(x)u+ϕu=f(x)|u|^(q-2)u+|u|^(p-2)u,in R^(3),(-Δ)^(t)ϕ=u^(2),in R^(3),where s∈(3/4,1),t∈(0,1),q∈(1,2),p∈(4,2_(s)^(*)),2_(s)^(*):=6/3-2s is the fractional critical exponent in dimension 3,V_(λ)(x)=λV(x)+1 withλ>0.Under the case of steep potential well,we obtain the existence of the sign-changing solutions for the above system by using the constraint variational method and the quantitative deformation lemma.Furthermore,we prove that the energy of ground state sign-changing solution is strictly more than twice of the energy of the ground state solution.Our results improve the recent results in the literature.
基金supported by the NSFC(12261107)Yunnan Key Laboratory of Modern Analytical Mathematics and Applications(202302AN360007).
文摘For any s∈(0,1),let the nonlocal Sobolev space X^(s)(R^(N))be the linear space of Lebesgue measure functions from R^(N) to R such that any function u in X^(s)(R^(N))belongs to L2(R^(N))and the function(x,y)→(u(x)-u(y)√K(x-y)is in L^(2)(R^(N),R^(N)).First,we show,for a coercive function V(x),the subspace E:={u∈X^s(R^N):f_(R)^N}V(x)u^(2)dx<+∞}of X^(s)(R^(N))is embedded compactly into L^(p)(R^(N))for p\in[2,2_(s)^(*)),where 2_(s)^(*)is the fractional Sobolev critical exponent.In terms of applications,the existence of a least energy sign-changing solution and infinitely many sign-changing solutions of the nonlocal Schrödinger equation-L_(k)u+V(x)u=f(x,u),x∈R^N are obtained,where-L_(K)is an integro-differential operator and V is coercive at infinity.
基金supported by the Specialized Fund for the Doctoral Program of Higher Education and the National Natural Science Foundation of China
文摘In this article, we give a new proof on the existence of infinitely many sign- changing solutions for the following Brezis-Nirenberg problem with critical exponent and a Hardy potential -△u-μ（u/｜x｜^2）=λu＋｜u｜^2＊-2u inΩ, u=0 on eΩ,where Ω is a smooth open bounded domain of R^N which contains the origin, 2＊=2N/n-2 is the critical Sobolev exponent. More precisely, under the assumptions that N ≥ 7, μ ∈ [0, μ- 4）, and μ=（N-2）^2/4, we show that the problem admits infinitely many sign-changing solutions for each fixed λ 〉 0. Our proof is based on a combination of invariant sets method and Lj usternik-Schnirelman theory.
基金supported by the NSFC(11501231)the "Fundamental Research Funds for the Central Universities"(WUT2017IVA077,2018IB014)
文摘In this paper, we study the existence of least energy sign-changing solutions for aKirchhoff-type problem involving the fractional Laplacian operator. By using the constraintvariation method and quantitative deformation lemma, we obtain a least energy nodal solu-tion ub for the given problem. Moreover, we show that the energy of ub is strictly larger thantwice the ground state energy. We also give a convergence property of ub as b O, where bis regarded as a positive parameter.
基金Supported by NSFC 11361077Young Academic and Technical Leaders Program(2015HB028)Yunnan Normal University,Lian Da Scholar Program
文摘In this article, by using the method of invariant sets of descending flow, we obtain the existence of sign-changing solutions of p-biharmonic equations with Hardy potential in RN.
基金supported by the Fundamental Research Funds for the Central Universities(2014QNA67)
文摘In this article, we study the existence of sign-changing solutions for the following SchrSdinger equation -△u ＋ λV（x）u = K（x）｜u｜^p-2u x∈R^N, u→0 as ｜x｜→ ＋∞, 2N where N ≥ 3, λ〉 0 is a parameter, 2 〈 p 〈 2N/N-2, and the potentials V（x） and K（x） satisfy some suitable conditions. By using the method based on invariant sets of the descending flow, we obtain the existence of a positive ground state solution and a ground state sign-changing solution of the above equation for small λ, which is a complement of the results obtained by Wang and Zhou in [J. Math. Phys. 52, 113704, 2011].
基金the National Natural Science Foundation of China (11971393)。
文摘In this paper,we consider the nonlinear Kirchhoff type equation with a steep potential well−(a+b∫_(R)^(3)|∇u|^(2 )dx)Δu+λV(x)u=f(u)in R^(3),where a,b>0 are constants,λ is a positive parameter,V∈C(R3,R)is a steep potential well and the nonlinearity f∈C(R,R)satisfies certain assumptions.By applying a signchanging Nehari manifold combined with the method of constructing a sign-changing(PS)C sequence,we obtain the existence of ground state sign-changing solutions with precisely two nodal domains when λ is large enough,and find that its energy is strictly larger than twice that of the ground state solutions.In addition,we also prove the concentration of ground state sign-changing solutions.
基金supported by National Natural Science Foundation of China(11971147)China Postdoctoral Science Foundation(2019M662475)Henan Postdoctoral Research Grant(201902026).
文摘In this paper,we construct sign-changing radial solutions for a class of Schrodinger equations with saturable nonlinearity which arises from several models in mathematical physics.More precisely,for any given nonnegative integer k,by using a minimization argument,we first obtain a sign-changing minimizer with k nodes of a constrained minimization problem,and show,by a deformation lemma and Miranda's theorem,that the minimizer is the desired solution.
文摘In this paper, we study the following quasilinear equation of choquard type: where A(x,t) is given real functions on R<sup>N</sup> × R and with N ≥ 3, 1 p N, max{N-2p,1} α N, , and ε > 0 is a small parameter, I<sub>α</sub> is the Riesz potential. We establish for small ε the existence of a sequence of sign-changing solutions concentrating near a given local minimum point of the bounded potential function V by using the method of invariant sets of descending flow, perturbation method and truncation technique. .
文摘We investigate the bi-harmonic problem{Δ^(2)u-α▽·(f(▽u))-βΔ_(p)u=g(x,u) in Ω,δu/δn=0,δ(Δu)/δn=0 on δΩ,where Δ^(2)u=Δ(Δu),Δ_(p)u=div(|▽u|^(p-2)▽u)with p>2.Ω is a bounded smooth domain in R^(N),N≥1.By using a special function space with the constraint ∫_(Ω)udx=0,under suitable assumptions on f and g(x,u),we show the existence and multiplicity of sign-changing solutions to the above problem via the Mountain pass theorem and the Fountain theorem.Recent results from the literature are extended.
文摘Using invariant sets of descending flow and variational methods, we establish some sufficient conditions on the existence of sign-changing solutions, positive solutions and negative solutions for second-order nonlinear difference equations with Dirichlet boundary value problem. Some results in the literature are improved.
文摘By using the fixed point theorem under the case structure, we study the existence of sign-changing solutions of A class of second-order differential equations three-point boundary-value problems, and a positive solution and a negative solution are obtained respectively, so as to popularize and improve some results that have been known.
基金supported by the National NaturalScience Foundation of China(12071170,11961043,11931012,12271196)supported by the excellent doctoral dissertation cultivation grant(2022YBZZ034)from Central China Normal University。
文摘In this paper,we study the following Schrodinger-Poisson system with critical growth:■We establish the existence of a positive ground state solution and a least energy sign-changing solution,providing that the nonlinearity f is super-cubic,subcritical and that the potential V(x)has a potential well.
基金supported by the NSFC(11301297)the Hubei Provincial Natural Science Foundation of China(2024AFB730)+3 种基金the Yichang City Natural Science Foundation(A-24-3-008)the Open Research Fund of Key Laboratory of Nonlinear Analysis and Applications(Central China Normal University),Ministry of Education,P.R.China(NAA2024ORG003)Gu's research was supported by the Zhejiang Provincial Natural Science Foundation(LQ21A010014)the NFSC(12101577).
文摘In this paper,we study the elliptic system{-Δu+V(x)u=|v|^(p-2)v-λ_(2)|v|^(s2-2)v,-Δu+V(x)v=|u|^(p-2)u-λ_(1)|u|^(s1-2)u,u,v∈H^(1)(R^(N))with strongly indefinite structure and sign-changing nonlinearity.We overcome the absence of the upper semi-continuity assumption which is crucial in traditional variational methods for strongly indefinite problems.By some new tools and techniques we proved the existence of infinitely many geometrically distinct solutions if parametersλ_(1),λ_(2)>0 small enough.To the best of our knowledge,our result seems to be the first result about infinitely many solutions for Hamiltonian system involving sign-changing nonlinearity.
基金supported by National Key Research and Development Program of China(No.2020YFA0712900)NSFC(No.112371240 and No.12431008)supported by NSFC(No.12001284)。
文摘In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By virtue of the variational method and the concentration compactness principle with the equivariant group action,we obtain some new type of nonradial,sign-changing solutions of(FCSE)in the energy space˙H^(s)(R^(N)).The key component is that we take the equivariant group action to construct several subspace of˙H^(s)(R^(N))with trivial intersection,then combine the concentration compactness argument in the Sobolev space with fractional order to show the compactness property of Palais-Smale sequences in each subspace and obtain the multiple solutions of(FCSE)in˙H^(s)(R^(N)).
基金Project supported by the National Natural Science Foundation of China(No.10571123)the Shandong Provincial Natural Science Foundation of China(No.Y2006A04).
文摘In the present paper, the author studies the existence of sign-changing solutions for nonlinear elliptic equations, which have jumping nonlinearities, and may or may not be resonant with respect to Fucik spectrum, via linking methods under Cerami condition.
文摘This paper is concerned with the following non linear elliptic problem in- volving nearly critical exponent （Pεk）： （-△）ku = K（x）｜u｜（4k/（n-2k））-εu in Ω, △k-lu =… △u = u = 0 on δΩ, where Ω is a bounded smooth domain in Rn, n≥ 2k＋2, k≥ 1, ε is a small positive parameter and K is a smooth positive function in Ω. We construct sign- changing solutions of （pεk） having two bubbles and blowing up either at two different critical points of K with the same speed or at the same critical point.
文摘Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhancing patient prognosis.Obviously,non-participation of asymptomatic individuals in screening programs hampers early diagnosis and may adversely affect long-term outcomes for CRC patients.In this letter,we provide a comprehensive overview of the current status of early screening practices,while also thoroughly examine the dilemmas and potential solutions associated with early screening for CRC.In response to these issues,we proffer a set of recommendations directed at governmental authorities and the general public,which focus on augmenting financial investment,establishing standardized screening protocols,advancing technological capabilities,and bolstering public awareness campaigns.The importance of collaborative efforts from various stakeholders cannot be overstated in the quest to enhance early detection rates and alleviate the societal burden of CRC.
文摘Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.
