The key point in studying or teaching the history of Chinese medicine is on the doctrines underlying it and on its perception of the body,physiology,pathology,and its treatment.Namely,there is often a tendency to focu...The key point in studying or teaching the history of Chinese medicine is on the doctrines underlying it and on its perception of the body,physiology,pathology,and its treatment.Namely,there is often a tendency to focus on reading and analysing the classical canons and therapy-related texts including formularies and materia medica collections.However,focusing on these sources provides us with a one-sided presentation of Chinese medicine.These primary sources lack the clinical down-to-earth know-how that encompasses medical treatment,which are represented,for instance,in the clinical rounds of modern medical schools.Our traditional focus on the medical canons and formularies provides almost no clinical knowledge,leaving us with a one-sided narrative that ignores how medicine and healing are actually practiced in the field.This paper focuses on the latter aspect of medicine from a historical perspective.Using written and visual sources dating to the Song dynasty,clinical encounters between doctors and patients including their families are depicted based on case records recorded by a physician,members of the patient’s family,and bystanders.This array of case records or case stories will enable us to narrate the interaction between physicians and patients both from the clinical perspective and from the social interaction.This paper will also discuss visual depictions of the medical encounter to provide another perspective for narrating medicine during the Song dynasty.Medical case records and paintings depicting medical encounters are exemplary of the potential of Chinese primary sources for narrative medicine.展开更多
Objective To explore the mechanism of Shuwei Decoction(SWD)on functional dyspepsia(FD)rats with Gan stagnation and Pi deficiency syndrome(GSPDS)basedonPI3K/AKTTsignalingpathwayyand the proliferation of Cajal interstit...Objective To explore the mechanism of Shuwei Decoction(SWD)on functional dyspepsia(FD)rats with Gan stagnation and Pi deficiency syndrome(GSPDS)basedonPI3K/AKTTsignalingpathwayyand the proliferation of Cajal interstitial cells(ICCs)in gastric antrum.Methods Forty SD rats were divided into the control group,model group,SWD group(7.56 g/kg),and Mosapride group(1.35×10-3 g/kg)using a random number table,with 10 rats in each group.Except those in the control group,FD rats with GSPDS in the remaining groups were established using an enhanced composite etiology model(encompassing chronic restraint stress,tail-clamping,excessive fatigue,and dietary disturbances).After 21 days of modeling,rats in the control and the model groups were given normal saline by gavage,rats in the SWD and Mosapride group were administered with the corresponding drugs by gavage for 14 days.Body weight changes,gastric emptying rate and small intestinal propulsive rate were detected.Behavioral changes were evaluated using the elevated plus-maze test.The pathological injury degrees of gastric antral tissue was observed by HE staining,and the protein expression levelsof phosphatidyli-nositol-3 kinase(PI3K),proteinkinase B(AKT),p-AKT,and anoctamin-1(ANO1)were detected by Western Blot.Additionally,the mRNA expression levels of PI3K,p-AKT,and ANO1 were detected in gastric sinus using RT-qPCR.The c-kit expression level was detected by immunofluorescence colocalization,while the proliferative activity of ICCs was evaluated with CCK8,along with apoptosis rate of ICCs was measured by flow cytometry.Results Compared with the'control group,the model group exhibited a decrease in body weight,gastric emptying rate,and small intestinal propulsive rate,as well as a decrease in proteins and mRNA expression levels of PI3K,p-AKT,ANO1(P<0.05),a decrease in the expression of c-kit and proliferative rate of ICCs(P<0.05),and an increase in level of apoptosis(P<0.05).Compared with the model group,the SWD and Mosapride groups showed an increase in body weight,gastric emptying rate,and small intestinal propulsive rate,an increase in proteins and mRNA expression levels of PI3K,p-AKT,ANO1(P<0.05),an increase in the expressions of c-kit and propulsive rate of ICCs(P<0.05),and a decrease in apoptosis levels(P<0.05).Conclusion SWD could enhance gastric emptying rate and small intestinal propulsive rate,reduce the apoptosis of ICCs and gastric sinusoidal cells,and improve the gastrointestinal motility in FD rats with GSPDS.Its mechanisms might be related to regulating ICCs via the PI3K/AKT signaling pathway.展开更多
Objective: To explore the clinical effectiveness and therapeutic mechanism of Shuwei Decoction (舒胃汤) in treating functional dyspepsia (FD). Methods: A total of 124 FD patients were randomly divided into two groups:...Objective: To explore the clinical effectiveness and therapeutic mechanism of Shuwei Decoction (舒胃汤) in treating functional dyspepsia (FD). Methods: A total of 124 FD patients were randomly divided into two groups: Shuwei Decoction group (60 cases) and the control group (64 cases) treated with cisapride. After one month treatment, all patients were examined with motilin and electrogastrography (EGG). Results: The therapeutic effectiveness of Shuwei Decoction group was much better than that of the control group ( P <0.05), while the changes on motilin and EGG in the two groups were relatively similar ( P <0.05). Conclusion: Shuwei Decoction could effectively raise motilin level, promote gastric movement and improve the clinical symptoms in FD patients.展开更多
目的:观察舒胃汤对功能性消化不良(FD)大鼠胃排空、血清一氧化氮(NO)、干细胞因子(SCF)的影响,探讨其可能的作用机制。方法:大鼠随机分为空白组、模型组、木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组,每组10只。通过夹尾刺激方法建...目的:观察舒胃汤对功能性消化不良(FD)大鼠胃排空、血清一氧化氮(NO)、干细胞因子(SCF)的影响,探讨其可能的作用机制。方法:大鼠随机分为空白组、模型组、木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组,每组10只。通过夹尾刺激方法建立FD模型,除空白组外其余5组每天夹尾4次,连续7 d。造模后第3天,各给药组大鼠给予相应药液ig治疗,共14 d。检测大鼠胃排空、血清NO、SCF含量变化。结果:模型组与空白组比较胃排空延迟,血清SCF含量明显减少而NO明显升高(均P<0.05)。用药组(木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组)与模型组比较胃排空(%)改善(58.35±8.71,78.17±10.74,60.39±3.48,76.80±6.96 vs 48.20±10.17,均P<0.05),血清中SCF含量(μmol.L-1)明显升高(19.78±2.83,26.13±4.91,19.48±1.74,24.19±3.40 vs 14.96±2.60,均P<0.05),NO(μmol.L-1)降低(0.18±0.01,0.16±0.01,0.18±0.01,0.16±0.01 vs 0.22±0.01,均P<0.05)。舒高组与木香顺气丸组、舒低组比较,胃排空改善(P<0.05),血清SCF含量明显升高(P<0.05),NO降低(P<0.05).结论:舒胃汤恢复胃肠道运动功可能通过调节血清NO,SCF水平的变化,促进胃排空有关。展开更多
基金This study is financed by the grants from Israel Science Foundation(No.ISF-1199/16)Chiang Ching-kuo Foundation for International Scholarly Exchange(No.RG001-U-19).
文摘The key point in studying or teaching the history of Chinese medicine is on the doctrines underlying it and on its perception of the body,physiology,pathology,and its treatment.Namely,there is often a tendency to focus on reading and analysing the classical canons and therapy-related texts including formularies and materia medica collections.However,focusing on these sources provides us with a one-sided presentation of Chinese medicine.These primary sources lack the clinical down-to-earth know-how that encompasses medical treatment,which are represented,for instance,in the clinical rounds of modern medical schools.Our traditional focus on the medical canons and formularies provides almost no clinical knowledge,leaving us with a one-sided narrative that ignores how medicine and healing are actually practiced in the field.This paper focuses on the latter aspect of medicine from a historical perspective.Using written and visual sources dating to the Song dynasty,clinical encounters between doctors and patients including their families are depicted based on case records recorded by a physician,members of the patient’s family,and bystanders.This array of case records or case stories will enable us to narrate the interaction between physicians and patients both from the clinical perspective and from the social interaction.This paper will also discuss visual depictions of the medical encounter to provide another perspective for narrating medicine during the Song dynasty.Medical case records and paintings depicting medical encounters are exemplary of the potential of Chinese primary sources for narrative medicine.
文摘Objective To explore the mechanism of Shuwei Decoction(SWD)on functional dyspepsia(FD)rats with Gan stagnation and Pi deficiency syndrome(GSPDS)basedonPI3K/AKTTsignalingpathwayyand the proliferation of Cajal interstitial cells(ICCs)in gastric antrum.Methods Forty SD rats were divided into the control group,model group,SWD group(7.56 g/kg),and Mosapride group(1.35×10-3 g/kg)using a random number table,with 10 rats in each group.Except those in the control group,FD rats with GSPDS in the remaining groups were established using an enhanced composite etiology model(encompassing chronic restraint stress,tail-clamping,excessive fatigue,and dietary disturbances).After 21 days of modeling,rats in the control and the model groups were given normal saline by gavage,rats in the SWD and Mosapride group were administered with the corresponding drugs by gavage for 14 days.Body weight changes,gastric emptying rate and small intestinal propulsive rate were detected.Behavioral changes were evaluated using the elevated plus-maze test.The pathological injury degrees of gastric antral tissue was observed by HE staining,and the protein expression levelsof phosphatidyli-nositol-3 kinase(PI3K),proteinkinase B(AKT),p-AKT,and anoctamin-1(ANO1)were detected by Western Blot.Additionally,the mRNA expression levels of PI3K,p-AKT,and ANO1 were detected in gastric sinus using RT-qPCR.The c-kit expression level was detected by immunofluorescence colocalization,while the proliferative activity of ICCs was evaluated with CCK8,along with apoptosis rate of ICCs was measured by flow cytometry.Results Compared with the'control group,the model group exhibited a decrease in body weight,gastric emptying rate,and small intestinal propulsive rate,as well as a decrease in proteins and mRNA expression levels of PI3K,p-AKT,ANO1(P<0.05),a decrease in the expression of c-kit and proliferative rate of ICCs(P<0.05),and an increase in level of apoptosis(P<0.05).Compared with the model group,the SWD and Mosapride groups showed an increase in body weight,gastric emptying rate,and small intestinal propulsive rate,an increase in proteins and mRNA expression levels of PI3K,p-AKT,ANO1(P<0.05),an increase in the expressions of c-kit and propulsive rate of ICCs(P<0.05),and a decrease in apoptosis levels(P<0.05).Conclusion SWD could enhance gastric emptying rate and small intestinal propulsive rate,reduce the apoptosis of ICCs and gastric sinusoidal cells,and improve the gastrointestinal motility in FD rats with GSPDS.Its mechanisms might be related to regulating ICCs via the PI3K/AKT signaling pathway.
文摘Objective: To explore the clinical effectiveness and therapeutic mechanism of Shuwei Decoction (舒胃汤) in treating functional dyspepsia (FD). Methods: A total of 124 FD patients were randomly divided into two groups: Shuwei Decoction group (60 cases) and the control group (64 cases) treated with cisapride. After one month treatment, all patients were examined with motilin and electrogastrography (EGG). Results: The therapeutic effectiveness of Shuwei Decoction group was much better than that of the control group ( P <0.05), while the changes on motilin and EGG in the two groups were relatively similar ( P <0.05). Conclusion: Shuwei Decoction could effectively raise motilin level, promote gastric movement and improve the clinical symptoms in FD patients.
文摘目的:观察舒胃汤对功能性消化不良(FD)大鼠胃排空、血清一氧化氮(NO)、干细胞因子(SCF)的影响,探讨其可能的作用机制。方法:大鼠随机分为空白组、模型组、木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组,每组10只。通过夹尾刺激方法建立FD模型,除空白组外其余5组每天夹尾4次,连续7 d。造模后第3天,各给药组大鼠给予相应药液ig治疗,共14 d。检测大鼠胃排空、血清NO、SCF含量变化。结果:模型组与空白组比较胃排空延迟,血清SCF含量明显减少而NO明显升高(均P<0.05)。用药组(木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组)与模型组比较胃排空(%)改善(58.35±8.71,78.17±10.74,60.39±3.48,76.80±6.96 vs 48.20±10.17,均P<0.05),血清中SCF含量(μmol.L-1)明显升高(19.78±2.83,26.13±4.91,19.48±1.74,24.19±3.40 vs 14.96±2.60,均P<0.05),NO(μmol.L-1)降低(0.18±0.01,0.16±0.01,0.18±0.01,0.16±0.01 vs 0.22±0.01,均P<0.05)。舒高组与木香顺气丸组、舒低组比较,胃排空改善(P<0.05),血清SCF含量明显升高(P<0.05),NO降低(P<0.05).结论:舒胃汤恢复胃肠道运动功可能通过调节血清NO,SCF水平的变化,促进胃排空有关。
