In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration ...In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.展开更多
BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity va...BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity variables affect MDD.We hypothesize that high-level trait-and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of MDD.AIM To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up results.METHODS In this prospective study,281 MDD patients were enrolled from a tertiary care setting.High-level stress-sensitivity factors were classified as trait anxiety,state anxiety,perceived stress,and neuroticism,with a total score in the top quartile of the research cohort.The cumulative effects of stress-sensitivity factors on cognitive dysfunction,disability and functional impairment,suicide risk,and depressive and anxiety symptoms were examined using an analysis of variance with linear trend analysis.Correlations were investigated further using multiple regression analysis.RESULTS Regarding high-level stress-sensitivity factors,53.40%of patients had at least one at baseline,and 29.61%had two or more.Four high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline(all P<0.001).Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms(partialη^(2)=0.153;standardizedβ=0.195;P<0.05).The follow-up outcomes were significantly impacted only by the high-level trait-related components,mainly when it came to depressive symptoms and suicide risk,which were predicted by trait anxiety and neuroticism,respectively(partialη^(2)=0.204 and 0.156;standardizedβ=0.247 and 0.392;P<0.05).CONCLUSION To enhance outcomes of MDD and lower the suicide risk,screening for stress-sensitivity factors and considering multifaceted measures,mainly focusing on trait-related ones,should be addressed clinically.展开更多
Higher education is transitioning from mass expansion to high-quality development.In this process,mental health issues among college students have become increasingly prominent,encompassing not only academic stress-in...Higher education is transitioning from mass expansion to high-quality development.In this process,mental health issues among college students have become increasingly prominent,encompassing not only academic stress-induced anxiety but also complex challenges such as interpersonal adaptation difficulties and career planning confusion.Traditional“problem-oriented”intervention models have shown limitations in responsiveness and adaptability,often only passively addressing existing psychological crises rather than preventing them in advance.This study aims to explore an AI-powered“positive psychology”proactive intervention model through developing an intelligent system.The system automatically collects,filters,and personalizes recommendations for positive activities on campus.Using a randomized controlled trial design,we conducted an 8-week intervention study involving 126 college students at a university.The study found that AI-based“campus positive activity”recommendations effectively boost students’positive emotions and promote psychological capital development through cumulative micro-interventions.This provides universities with empirical evidence and innovative methods to implement low-cost,efficient,and scalable mental health promotion programs through smart technology.展开更多
In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic ...In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi （ST36） and Yanglingquan （GB34）. In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold （paw withdrawal latency） was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.展开更多
Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbr...Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbreak of the record-breaking extreme cold event can be attributed to a huge merging Ural blocking(UB)ridge over the Eurasian region.The sea-ice cover in the Kara and East Siberia Seas(KESS)in autumn was at its lowest value since 1979,which could have served as a precursor signal.Further analysis shows that several successive UB episodes occurred from 1 September 2020 to 10 January 2021.The persistent UB that occurred in late September/early October 2020 may have made an important contribution to the October historical minimum of sea ice in the KESS region.Our results also show that,after each UB episode in winter,significant upward propagation of wave activity occurred around 60°E,which resulted in weakening the stratospheric vortex.Meanwhile,each UB episode also caused a significant reduction in sea-ice extent in KESS and a significant weakening of the westerly jet in mid-high-latitude Eurasia.Results suggest that the Arctic vortex,which is supposed to enhance seasonally,became weaker and more unstable than the climatic mean under the seasonal cumulative effects of UB episodes,KESS warming,and long-lasting negative-phase North Atlantic Oscillation(NAO-).Those seasonal cumulative effects,combined with the impact of La Niña winter,led to the frequent occurrence of extreme cold events.展开更多
In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi （ST36） and Yanglingquan （GB34） once a day for 14 consecutive days in a rat model of chronic sciatic nerve ...In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi （ST36） and Yanglingquan （GB34） once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold （paw withdrawal latency） was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region.展开更多
BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations ...BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.展开更多
On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular ...On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular tube,which is inherently induced by the closed propagation feature of CGWs.An appropriate mode pair of primary-and double-frequency CGWs satisfying the phase velocity matching and nonzero energy flux is selected to ensure that the second harmonic generated by primary CGW propagation can accumulate along the circumference.Using a coherent superposition of multi-waves,a model of unidirectional CGW propagation is established for analyzing the enhancement effect of cumulative SHG of primary CGW mode selected.The theoretical analyses and numerical simulations performed directly demonstrate that the second harmonic generated does have a cumulative effect along the circumferential direction and the closed propagation feature of CGWs does enhance the magnitude of cumulative second harmonic generated.Potential applications of the enhancement effect of cumulative SHG of CGWs are considered and discussed.The theoretical analysis and numerical simulation perspective presented here yield an insight previously unavailable into the physical mechanism of the enhancement effect of cumulative SHG by closed propagation feature of CGWs in a circular tube.展开更多
The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparat...The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparatus. The blasting test was carried out for ten times at some tunnels of Changba Lead-Zinc Mine. The damage depth of surrounding rock caused by old blasting excavation （0.8-1.2 m） was confirmed. The relation between the cumulative damage degree and blast times was obtained. The results show that the sonic velocity decreases gradually with increasing blast times, hut the damage degree （D） increases. The damage cumulative law is non-linear. The damage degree caused by blast decreases with increasing distance, and damage effects become indistinct. The blasting damage of rock mass is anisotropic. The damage degree of rock mass within charging range is maximal. And the more the charge is, the more severe the damage degree of rock mass is. The test results provide references for researches of mechanical parameters of rock mass and dynamic stability analysis of underground chambers.展开更多
Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects an...Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.展开更多
Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial re...Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial regulation considering the ecological and environmental protection on energy and mineral resource development areas is an important aspect of realizing China’s sustainable development.In this study,we mapped,categorized,and analyzed the ecological cumulative effects of the Chinese 134 prefectural mining units based on the pressure-state-response model,which is demonstrated as impact of mining activities on ecological environment,ecological environmental fragility,and ecological function.This investigation developed a stress zoning typology of the mining units based on scores of three dimensions of the ecological cumulative effects and classified 134 prefectural mining units into eight types of stress zones.A series of regulation and policy suggestions have been proposed to different types of zones from three aspects:space control,intensity control,and development mode control.The application of this evaluation and spatial zoning system will contribute to the refined spatial management of China’s mining areas.展开更多
The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics o...The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics of the change in the lower reaches of the Jinsha River, China are analyzed based on long-term(1952–2015) hydrological and sedimentological data. The averaging coefficient, reservoir regulation coefficient(RRC), incoming sediment coefficient(ISC), and sediment transport modulus(STM), which reflect the variation of streamflow and sediment regimes, are defined and calculated. The results show that the construction and regulation of reservoirs reduces flow in flood season, increases flow in dry season, significantly altering the monthly discharge regimes. These alterations also led directly to changes in the timing of extreme flows at Pingshan Station. The monthly flow records at the basin outlet are reconstructed using stepwise regression, to reduce reservoir impacts. Comparisons of observed and reconstructed monthly flows demonstrate that the previous studies overestimated the cumulative effects of cascade reservoirs on flow processes. Furthermore, this study clearly illustrates that the reduction in sediment trapping and sediment transportation capacity together lead to the sharp reduction in annual sediment yield at the Pingshan Station. The earlier constructed reservoirs have more obvious effects on the ISC and STM than the more recent reservoirs and the effect of sediment trapping is related to reservoir location, on the main stream versus tributaries.展开更多
The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of aco...The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of acoustic waves at an interface. In general, the cumulative second-harmonic generation of a dispersive guided wave propagation does not occur. However, the present paper shows that the second-harmonic of Lamb wave propagation arising from the nonlinear interaction of the partial bulk acoustic waves and the restriction of the three boundaries of the solid plates does have a cumulative growth effect if some conditions are satisfied. Through boundary condition and initial condition of excitation, the analytical expression of cumulative second-harmonic of Lamb waves propagation is determined. Numerical results show the cumulative effect of Lamb waves on second-harmonic field patterns.展开更多
BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients...BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients shrink significantly during this treatment,leading to improved short-term efficacy.AIM To investigate the relationship between the shrinkage of hepatic arteries and the short-term effect of HAIC plus lenvatinib treatment.METHODS Sixty-seven participants with uHCC were enrolled in this retrospective study.The patients received HAIC every 3 wk,followed by oral lenvatinib after the first HAIC course.Hepatic artery diameters were measured on CT before treatment and after 1 and 2 mo of treatment.Meanwhile,the changes in tumor capillaries were also examined on pathological specimens before and after 1 mo of treatment.The antitumor response after 1,3,and 6 mo of treatment was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST).The relationship between the changes in vessel diameters and the short-term effect of the combination treatment was evaluated by receiver-operating characteristic and logistic regression analyses.RESULTS The hepatic artery diameters were all significantly decreased after 1 and 2 mo of treatment(P<0.001),but there was no difference in the vessel diameters between 1 and 2 mo(P>0.05).The microvessel density in the tumor lesions decreased significantly after 1 mo of combination treatment(P<0.001).According to mRECIST,46,41,and 24 patients had complete or partial responses after 1,3,and 6 mo of treatment,respectively,whereas 21,21,and 32 patients had a stable or progressive disease at these times,respectively.Shrinkage of the tumor-feeding artery was significantly associated with the tumor response after 1,3,and 6 mo of treatment(P<0.001,P=0.004,and P=0.023,respectively);however,changes in other hepatic arteries were not significantly associated with the tumor response.Furthermore,shrinkage of the tumor-feeding artery was an independent factor for treatment efficacy(P=0.001,P=0.001,and P=0.002 and 1,3,and 6 mo,respectively).CONCLUSION The hepatic arteries shrank rapidly after treatment with HAIC plus lenvatinib,and shrinkage of the tumor-feeding artery diameter was closely related to improved short-term efficacy.展开更多
To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical ca...To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical calculations,this study proposed magnification of the Arias intensity(MIa)to characterize the overall local deformation damage of the tunnel lining in terms of the deformation characteristics,frequency domain,and energy.Using the time‐domain analysis method,the plastic effect coefficient(PEC)was proposed to characterize the degree of plastic deformation,and the applicability of the seismic cumulative failure effect(SCFE)was discussed.The results show that the low‐frequency component(f1 and f2≤10 Hz)and the high‐frequency component(f3 and f4>10 Hz)acceleration mainly cause global and local deformation of the tunnel lining.The local deformation caused by the high‐frequency wave has an important effect on the seismic damage of the lining.The physical meaning of PEC is more clearly defined than that of the residual strain,and the SCFE of the tunnel lining can also be defined.The SCFE of the tunnel lining includes the elastic deformation effect stage(<0.15g),the elastic–plastic deformation effect stage(0.15g–0.30g),and the plastic deformation effect stage(0.30g–0.40g).This study can provide valuable theoretical and technical support for the construction of traffic tunnels in high‐intensity earthquake areas.展开更多
Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ...Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level展开更多
Since the London fog in 1952, numerous epidemioLogical studies have revealed that both short-term and long-term exposure to air pollutants is associated with the development of diseases[1]. Up to date, the assessment ...Since the London fog in 1952, numerous epidemioLogical studies have revealed that both short-term and long-term exposure to air pollutants is associated with the development of diseases[1]. Up to date, the assessment of air quality on health and air quality standard establishment in developing countries were mainly relied on extrapolation based on the results from long-term cohort studies conducted in Europe and North America.展开更多
AIM:To quantify cumulative effective dose of intensive care unit(ICU)patients attributable to diagnostic imaging.METHODS:This was a prospective,interdisciplinary study conducted in the ICU of a large tertiary referral...AIM:To quantify cumulative effective dose of intensive care unit(ICU)patients attributable to diagnostic imaging.METHODS:This was a prospective,interdisciplinary study conducted in the ICU of a large tertiary referral and level 1 trauma center.Demographic and clinical data including age,gender,date of ICU admission,primary reason for ICU admission,APACHE Ⅱ score,length of stay,number of days intubated,date of death or discharge,and re-admission data was collected on all patients admitted over a 1-year period.The overall radiation exposure was quantified by the cumulative effective radiation dose(CED)in millisieverts(mS v)and calculated using reference effective doses published by the United Kingdom National Radiation Protection Board.Pediatric patients were selected for subgroupanalysis.RESULTS:A total of 2737 studies were performedin 421 patients.The total CED was 1704 m Sv with a median CED of 1.5 mS v(IQR 0.04-6.6 mS v).Total CED in pediatric patients was 74.6 mS v with a median CED of 0.07 mS v(IQR 0.01-4.7 mS v).Chest radiography was the most commonly performed examination accounting for 83% of all studies but only 2.7% of total CED.Computed tomography(CT)accounted for 16% of all studies performed and contributed 97% of total CED.Trauma patients received a statistically significant higher dose [median CED 7.7 mS v(IQR 3.5-13.8 mS v)] than medical [median CED 1.4 m Sv(IQR 0.05-5.4 m Sv)] and surgical [median CED 1.6 mS v(IQR 0.04-7.5 mS v)] patients.Length of stay in ICU [OR = 1.12(95%CI:1.079-1.157)] was identified as an independent predictor of receiving a CED greater than 15 mS v.CONCLUSION:Trauma patients and patients with extended ICU admission times are at increased risk of higher CEDs.CED should be minimized where feasible,especially in young patients.展开更多
<span style="font-family:Verdana;">The subjects of this study were to observe the improved short-term effects of anti-tumor purified Chinese medicine injection Ai-Jing for 138 cases with malignant tumo...<span style="font-family:Verdana;">The subjects of this study were to observe the improved short-term effects of anti-tumor purified Chinese medicine injection Ai-Jing for 138 cases with malignant tumors. This was a multi-center clinical study, and a total of 138 patients include</span><span style="font-family:Verdana;">d</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> 96 males and 42 females, with the age from 60 to 76 years. </span><span style="font-family:Verdana;">Ai-Jing has obtained the Chinese invention patent since 2008</span><span style="font-family:Verdana;"> (ZL991-03528.3). A novel technique acupoint injection method was adopted. Except for lung cancer, patients with other malignant tumors were injected once every other day, 2</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">ml each time. A course of treatment needs 6 Ai-Jing injections, lung cancer patients need 10</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">20 Ai-Jing injections. At the same time, patients were treated with traditional medicine decoction. Due to the limited number of cases, cure rate, recovery rate and remission rate were calculated as a whole, respectively</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">18.12%, 44.20% and 32.15%. All the invalid patients were lung cancer, accounting for 16.67% of the patients treated with lung cancer, and the total treatment inefficiency was 6.52%. Conclusion: Chinese Medicine Injection Ai-Jing extracts the effective components of anti-cancer and tumorig</span><span style="font-family:Verdana;">enesis, and has the effects of anti-cancer and tumorigenesis, anti-infl</span><span style="font-family:Verdana;">am</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">matory and analgesic, and repairing body damage, with small toxic and side effects and low cost.</span>展开更多
Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the in...Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed展开更多
基金Supported by the National Science Foundation of China(41675046)
文摘In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.
基金Supported by Science and Technology Innovation 2030-Major Projects,No.2021ZD0202000National Key Research and Development Program of China,No.2019YFA0706200+2 种基金National Natural Science Foundation of China,No.82371535Science and Technology Innovation Program of Hunan Province,No.2023RC3083Fundamental Research Funds for the Central Universities of Central South University,No.2023ZZTS0838.
文摘BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity variables affect MDD.We hypothesize that high-level trait-and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of MDD.AIM To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up results.METHODS In this prospective study,281 MDD patients were enrolled from a tertiary care setting.High-level stress-sensitivity factors were classified as trait anxiety,state anxiety,perceived stress,and neuroticism,with a total score in the top quartile of the research cohort.The cumulative effects of stress-sensitivity factors on cognitive dysfunction,disability and functional impairment,suicide risk,and depressive and anxiety symptoms were examined using an analysis of variance with linear trend analysis.Correlations were investigated further using multiple regression analysis.RESULTS Regarding high-level stress-sensitivity factors,53.40%of patients had at least one at baseline,and 29.61%had two or more.Four high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline(all P<0.001).Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms(partialη^(2)=0.153;standardizedβ=0.195;P<0.05).The follow-up outcomes were significantly impacted only by the high-level trait-related components,mainly when it came to depressive symptoms and suicide risk,which were predicted by trait anxiety and neuroticism,respectively(partialη^(2)=0.204 and 0.156;standardizedβ=0.247 and 0.392;P<0.05).CONCLUSION To enhance outcomes of MDD and lower the suicide risk,screening for stress-sensitivity factors and considering multifaceted measures,mainly focusing on trait-related ones,should be addressed clinically.
文摘Higher education is transitioning from mass expansion to high-quality development.In this process,mental health issues among college students have become increasingly prominent,encompassing not only academic stress-induced anxiety but also complex challenges such as interpersonal adaptation difficulties and career planning confusion.Traditional“problem-oriented”intervention models have shown limitations in responsiveness and adaptability,often only passively addressing existing psychological crises rather than preventing them in advance.This study aims to explore an AI-powered“positive psychology”proactive intervention model through developing an intelligent system.The system automatically collects,filters,and personalizes recommendations for positive activities on campus.Using a randomized controlled trial design,we conducted an 8-week intervention study involving 126 college students at a university.The study found that AI-based“campus positive activity”recommendations effectively boost students’positive emotions and promote psychological capital development through cumulative micro-interventions.This provides universities with empirical evidence and innovative methods to implement low-cost,efficient,and scalable mental health promotion programs through smart technology.
基金supported by the National Natural Science Foundation of China,No.30472241,90709031 and 30973796the National Basic Research Program of China for Traditional Chinese Medicine Theory("973" Program),No.2007CB512505+1 种基金the Natural Foundation of Hainan Province(No.310054)a grant from the Health Department of Hainan Province(QiongWei 2010-45)
文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi （ST36） and Yanglingquan （GB34）. In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold （paw withdrawal latency） was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.
基金the financial support from the National Natural Science Foundation of China(Grants Nos. 41975068, 41790473, and 41975099)the Chinese Academy of Sciences Strategic Priority Research Program (Grant No. XDA19070403).
文摘Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbreak of the record-breaking extreme cold event can be attributed to a huge merging Ural blocking(UB)ridge over the Eurasian region.The sea-ice cover in the Kara and East Siberia Seas(KESS)in autumn was at its lowest value since 1979,which could have served as a precursor signal.Further analysis shows that several successive UB episodes occurred from 1 September 2020 to 10 January 2021.The persistent UB that occurred in late September/early October 2020 may have made an important contribution to the October historical minimum of sea ice in the KESS region.Our results also show that,after each UB episode in winter,significant upward propagation of wave activity occurred around 60°E,which resulted in weakening the stratospheric vortex.Meanwhile,each UB episode also caused a significant reduction in sea-ice extent in KESS and a significant weakening of the westerly jet in mid-high-latitude Eurasia.Results suggest that the Arctic vortex,which is supposed to enhance seasonally,became weaker and more unstable than the climatic mean under the seasonal cumulative effects of UB episodes,KESS warming,and long-lasting negative-phase North Atlantic Oscillation(NAO-).Those seasonal cumulative effects,combined with the impact of La Niña winter,led to the frequent occurrence of extreme cold events.
基金supported by the National Natural Science Foundation of China,No.30472241,90709031 and 30973796the Ministry of Science and Technology of China("973"Project),No.2007CB512505+1 种基金provided by the Foundation of Hainan Province,No.310054the Health Department of Hainan Province,Qiong-Wei-45
文摘In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi （ST36） and Yanglingquan （GB34） once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold （paw withdrawal latency） was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region.
基金National Natural Science Foundation of China,No.72101236China Postdoctoral Science Foundation,No.2022M722900+1 种基金Collaborative Innovation Project of Zhengzhou City,No.XTCX2023006Nursing Team Project of the First Affiliated Hospital of Zhengzhou University,No.HLKY2023005.
文摘BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11834008,11704410,11632004,11474361,and U1930202).
文摘On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular tube,which is inherently induced by the closed propagation feature of CGWs.An appropriate mode pair of primary-and double-frequency CGWs satisfying the phase velocity matching and nonzero energy flux is selected to ensure that the second harmonic generated by primary CGW propagation can accumulate along the circumference.Using a coherent superposition of multi-waves,a model of unidirectional CGW propagation is established for analyzing the enhancement effect of cumulative SHG of primary CGW mode selected.The theoretical analyses and numerical simulations performed directly demonstrate that the second harmonic generated does have a cumulative effect along the circumferential direction and the closed propagation feature of CGWs does enhance the magnitude of cumulative second harmonic generated.Potential applications of the enhancement effect of cumulative SHG of CGWs are considered and discussed.The theoretical analysis and numerical simulation perspective presented here yield an insight previously unavailable into the physical mechanism of the enhancement effect of cumulative SHG by closed propagation feature of CGWs in a circular tube.
基金Project (50490272) supported by the National Natural Science Foundation of ChinaProject(040109) supported by the Doctor Degree Paper Innovation Engineering of Central South University
文摘The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparatus. The blasting test was carried out for ten times at some tunnels of Changba Lead-Zinc Mine. The damage depth of surrounding rock caused by old blasting excavation （0.8-1.2 m） was confirmed. The relation between the cumulative damage degree and blast times was obtained. The results show that the sonic velocity decreases gradually with increasing blast times, hut the damage degree （D） increases. The damage cumulative law is non-linear. The damage degree caused by blast decreases with increasing distance, and damage effects become indistinct. The blasting damage of rock mass is anisotropic. The damage degree of rock mass within charging range is maximal. And the more the charge is, the more severe the damage degree of rock mass is. The test results provide references for researches of mechanical parameters of rock mass and dynamic stability analysis of underground chambers.
基金supported by the National Natural Science Foundation of China(Grant No.12372356)Postgraduate Scientific Research In-novation Project of Hunan Province(Grant No.CX20221044).
文摘Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.
基金Under the auspices of the Strategic Priority Research Program(A)of the Chinese Academy of Sciences(No.XDA19040403)National Natural Science Foundation of China(No.42071158,72050001)。
文摘Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial regulation considering the ecological and environmental protection on energy and mineral resource development areas is an important aspect of realizing China’s sustainable development.In this study,we mapped,categorized,and analyzed the ecological cumulative effects of the Chinese 134 prefectural mining units based on the pressure-state-response model,which is demonstrated as impact of mining activities on ecological environment,ecological environmental fragility,and ecological function.This investigation developed a stress zoning typology of the mining units based on scores of three dimensions of the ecological cumulative effects and classified 134 prefectural mining units into eight types of stress zones.A series of regulation and policy suggestions have been proposed to different types of zones from three aspects:space control,intensity control,and development mode control.The application of this evaluation and spatial zoning system will contribute to the refined spatial management of China’s mining areas.
基金financially supported by the National 973 Program of China (2015CB452701)the National Natural Science Foundation of China (Grant No. 51579161)
文摘The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics of the change in the lower reaches of the Jinsha River, China are analyzed based on long-term(1952–2015) hydrological and sedimentological data. The averaging coefficient, reservoir regulation coefficient(RRC), incoming sediment coefficient(ISC), and sediment transport modulus(STM), which reflect the variation of streamflow and sediment regimes, are defined and calculated. The results show that the construction and regulation of reservoirs reduces flow in flood season, increases flow in dry season, significantly altering the monthly discharge regimes. These alterations also led directly to changes in the timing of extreme flows at Pingshan Station. The monthly flow records at the basin outlet are reconstructed using stepwise regression, to reduce reservoir impacts. Comparisons of observed and reconstructed monthly flows demonstrate that the previous studies overestimated the cumulative effects of cascade reservoirs on flow processes. Furthermore, this study clearly illustrates that the reduction in sediment trapping and sediment transportation capacity together lead to the sharp reduction in annual sediment yield at the Pingshan Station. The earlier constructed reservoirs have more obvious effects on the ISC and STM than the more recent reservoirs and the effect of sediment trapping is related to reservoir location, on the main stream versus tributaries.
基金Project supported by the Shanghai Leading Academic Discipline Project, China (Grant No B503)
文摘The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of acoustic waves at an interface. In general, the cumulative second-harmonic generation of a dispersive guided wave propagation does not occur. However, the present paper shows that the second-harmonic of Lamb wave propagation arising from the nonlinear interaction of the partial bulk acoustic waves and the restriction of the three boundaries of the solid plates does have a cumulative growth effect if some conditions are satisfied. Through boundary condition and initial condition of excitation, the analytical expression of cumulative second-harmonic of Lamb waves propagation is determined. Numerical results show the cumulative effect of Lamb waves on second-harmonic field patterns.
文摘BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients shrink significantly during this treatment,leading to improved short-term efficacy.AIM To investigate the relationship between the shrinkage of hepatic arteries and the short-term effect of HAIC plus lenvatinib treatment.METHODS Sixty-seven participants with uHCC were enrolled in this retrospective study.The patients received HAIC every 3 wk,followed by oral lenvatinib after the first HAIC course.Hepatic artery diameters were measured on CT before treatment and after 1 and 2 mo of treatment.Meanwhile,the changes in tumor capillaries were also examined on pathological specimens before and after 1 mo of treatment.The antitumor response after 1,3,and 6 mo of treatment was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST).The relationship between the changes in vessel diameters and the short-term effect of the combination treatment was evaluated by receiver-operating characteristic and logistic regression analyses.RESULTS The hepatic artery diameters were all significantly decreased after 1 and 2 mo of treatment(P<0.001),but there was no difference in the vessel diameters between 1 and 2 mo(P>0.05).The microvessel density in the tumor lesions decreased significantly after 1 mo of combination treatment(P<0.001).According to mRECIST,46,41,and 24 patients had complete or partial responses after 1,3,and 6 mo of treatment,respectively,whereas 21,21,and 32 patients had a stable or progressive disease at these times,respectively.Shrinkage of the tumor-feeding artery was significantly associated with the tumor response after 1,3,and 6 mo of treatment(P<0.001,P=0.004,and P=0.023,respectively);however,changes in other hepatic arteries were not significantly associated with the tumor response.Furthermore,shrinkage of the tumor-feeding artery was an independent factor for treatment efficacy(P=0.001,P=0.001,and P=0.002 and 1,3,and 6 mo,respectively).CONCLUSION The hepatic arteries shrank rapidly after treatment with HAIC plus lenvatinib,and shrinkage of the tumor-feeding artery diameter was closely related to improved short-term efficacy.
基金National Key R&D Program of China,Grant/Award Number:2018YFC1504901Science and technology program of Gansu Province,Grant/Award Numbers:21JR7RA738,21JR7RA739+1 种基金Science and Technology Development Project of China Railway Research Institute Co.Ltd,Grant/Award Number:2017‐KJ008‐Z008‐XBNatural Science Foundation of Gansu Province,Grant/Award Number:145RJZA068。
文摘To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical calculations,this study proposed magnification of the Arias intensity(MIa)to characterize the overall local deformation damage of the tunnel lining in terms of the deformation characteristics,frequency domain,and energy.Using the time‐domain analysis method,the plastic effect coefficient(PEC)was proposed to characterize the degree of plastic deformation,and the applicability of the seismic cumulative failure effect(SCFE)was discussed.The results show that the low‐frequency component(f1 and f2≤10 Hz)and the high‐frequency component(f3 and f4>10 Hz)acceleration mainly cause global and local deformation of the tunnel lining.The local deformation caused by the high‐frequency wave has an important effect on the seismic damage of the lining.The physical meaning of PEC is more clearly defined than that of the residual strain,and the SCFE of the tunnel lining can also be defined.The SCFE of the tunnel lining includes the elastic deformation effect stage(<0.15g),the elastic–plastic deformation effect stage(0.15g–0.30g),and the plastic deformation effect stage(0.30g–0.40g).This study can provide valuable theoretical and technical support for the construction of traffic tunnels in high‐intensity earthquake areas.
文摘Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level
基金supported by the National Basic Research Program (973 program) of China (2011CB503802)the Gong-Yi Program of the Chinese Ministry of Environmental Protection (201209008)+2 种基金Shanghai Municipal Committee of Science and Technology (12dz1202602)Shanghai Health Bureau (GWDTR201212)the Scholarship Award for Excellent Doctoral Student granted by Ministry of Education (2011)
文摘Since the London fog in 1952, numerous epidemioLogical studies have revealed that both short-term and long-term exposure to air pollutants is associated with the development of diseases[1]. Up to date, the assessment of air quality on health and air quality standard establishment in developing countries were mainly relied on extrapolation based on the results from long-term cohort studies conducted in Europe and North America.
文摘AIM:To quantify cumulative effective dose of intensive care unit(ICU)patients attributable to diagnostic imaging.METHODS:This was a prospective,interdisciplinary study conducted in the ICU of a large tertiary referral and level 1 trauma center.Demographic and clinical data including age,gender,date of ICU admission,primary reason for ICU admission,APACHE Ⅱ score,length of stay,number of days intubated,date of death or discharge,and re-admission data was collected on all patients admitted over a 1-year period.The overall radiation exposure was quantified by the cumulative effective radiation dose(CED)in millisieverts(mS v)and calculated using reference effective doses published by the United Kingdom National Radiation Protection Board.Pediatric patients were selected for subgroupanalysis.RESULTS:A total of 2737 studies were performedin 421 patients.The total CED was 1704 m Sv with a median CED of 1.5 mS v(IQR 0.04-6.6 mS v).Total CED in pediatric patients was 74.6 mS v with a median CED of 0.07 mS v(IQR 0.01-4.7 mS v).Chest radiography was the most commonly performed examination accounting for 83% of all studies but only 2.7% of total CED.Computed tomography(CT)accounted for 16% of all studies performed and contributed 97% of total CED.Trauma patients received a statistically significant higher dose [median CED 7.7 mS v(IQR 3.5-13.8 mS v)] than medical [median CED 1.4 m Sv(IQR 0.05-5.4 m Sv)] and surgical [median CED 1.6 mS v(IQR 0.04-7.5 mS v)] patients.Length of stay in ICU [OR = 1.12(95%CI:1.079-1.157)] was identified as an independent predictor of receiving a CED greater than 15 mS v.CONCLUSION:Trauma patients and patients with extended ICU admission times are at increased risk of higher CEDs.CED should be minimized where feasible,especially in young patients.
文摘<span style="font-family:Verdana;">The subjects of this study were to observe the improved short-term effects of anti-tumor purified Chinese medicine injection Ai-Jing for 138 cases with malignant tumors. This was a multi-center clinical study, and a total of 138 patients include</span><span style="font-family:Verdana;">d</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> 96 males and 42 females, with the age from 60 to 76 years. </span><span style="font-family:Verdana;">Ai-Jing has obtained the Chinese invention patent since 2008</span><span style="font-family:Verdana;"> (ZL991-03528.3). A novel technique acupoint injection method was adopted. Except for lung cancer, patients with other malignant tumors were injected once every other day, 2</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">ml each time. A course of treatment needs 6 Ai-Jing injections, lung cancer patients need 10</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">20 Ai-Jing injections. At the same time, patients were treated with traditional medicine decoction. Due to the limited number of cases, cure rate, recovery rate and remission rate were calculated as a whole, respectively</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">18.12%, 44.20% and 32.15%. All the invalid patients were lung cancer, accounting for 16.67% of the patients treated with lung cancer, and the total treatment inefficiency was 6.52%. Conclusion: Chinese Medicine Injection Ai-Jing extracts the effective components of anti-cancer and tumorig</span><span style="font-family:Verdana;">enesis, and has the effects of anti-cancer and tumorigenesis, anti-infl</span><span style="font-family:Verdana;">am</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">matory and analgesic, and repairing body damage, with small toxic and side effects and low cost.</span>
文摘Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed
