BACKGROUND Burnout,musculoskeletal pain,and sharps injuries(SIs)affect medical workers.AIM To establish a model between SIs,burnout,and the risk factors to assess the extent to which burnout affects SIs.METHODS This q...BACKGROUND Burnout,musculoskeletal pain,and sharps injuries(SIs)affect medical workers.AIM To establish a model between SIs,burnout,and the risk factors to assess the extent to which burnout affects SIs.METHODS This questionnaire was used for an observational and cross-sectional study,which was based on members at a hospital affiliated with a medical university in Taichung,Taiwan,in 2020.The valid responses constituted 68.5%(1734 of 2531).The items were drawn from the Nordic Musculoskeletal Questionnaire and Copenhagen burnout inventory and concerned work experience,occupational category,presence of chronic diseases,sleep duration,overtime work,and work schedule.Factor analysis,chi-square test,Fisher exact test,Multiple linear,logistic regression and Sobel test were conducted.The present analyses were performed using SAS Enterprise Guide 6.1 software(SAS Institute Inc.,Cary,NC,United States),and significance was set at P<0.05.RESULTS Personal and work-related burnout ranks, sex, work experience ranks, occupationalgroups, drinking in the past month, sleep duration per day, presence ofchronic diseases, overtime work ranks, and work schedule were associated withSIs. Frequent upper limb and lower limb pain (pain occurring every day or once aweek) determined to be related to SIs. High personal burnout (> Q3) and highwork-related burnout (> Q3) mediated the relationship between SIs and frequentlower limb pain. Similarly, frequent lower limb pain mediated the relationship ofSIs with high personal and high work-related burnout. High personal and highwork-related burnout mediated the relationships of SIs with overtime work andirregular shift work. The mediating model provides strong evidence of anassociation between mental health and SIs.CONCLUSIONBurnout was determined to contribute to SIs occurrence;specifically, it mediatedthe relationships of SIs with frequent musculoskeletal pain, overtime work, andirregular shift work.展开更多
In this research work, we consider the below inequalities: (1.1). The researchers attempt to find an answer as to what are the best possible parameters <i><i>α</i></i>, <i><i&...In this research work, we consider the below inequalities: (1.1). The researchers attempt to find an answer as to what are the best possible parameters <i><i>α</i></i>, <i><i>β</i></i> that (1.1) can be held? The main tool is the optimization of some suitable functions that we seek to find out. Without loss of generality, we have assumed that <i>a</i> > <i>b</i> and let <img src="Edit_26c0f99b-93dd-48ff-acdb-f1c8047744f1.bmp" alt="" /> for 1) and <i>a</i> < <i>b</i>, <img src="Edit_15c32a7a-e9ae-41d3-8f49-c6b9c01c7ece.bmp" alt="" />(<i>t</i> small) for 2) to determine the condition for <i><i>α</i></i> and <i><i>β</i></i> to become <i>f</i>(<i>t</i>) ≤ 0 and <i>g</i>(<i>t</i>) ≥ 0.展开更多
The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of ...The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of Navier slip conditions on exchange flows within a long channel connecting two large reservoirs of differing salinity.These horizontal density gradients drive the flow.We modify the recent one-dimensional theory,developed to avoid runaway stratification,to account for the presence of uniform slip walls.By adjusting the parameters of the horizontal density gradient based on the slip factor,we resolve analytically various flow regimes ranging from high diffusion to transitional high advection.These regimes are governed by physical parameters like channel aspect ratio,slip factor,Schmidt number,and gravitational Reynolds number.Our solutions align perfectly with ones in the no-slip limit.More importantly,under the conditions of no net flow across the channel and high Schmidt number(where stratification is concentrated near the channel’s mid-layer),we derive a closed-form solution for the slip parameter,aspect ratio,and gravitational Reynolds number that describes the interface’s behavior as a sharp interface separating two distinct zones.This interface,arising from hydrostatic wall gradients,ultimately detaches the low-and high-density regimes throughout the channel when the gravitational Reynolds number is inversely proportional to the aspect ratio for a fixed slip parameter.This phenomenon,observed previously in 2D numerical simulations with no-slip walls in the literature,is thus confirmed by our theoretical results.Our findings further demonstrate that wall slip leads to distinct and diverse flow regimes.展开更多
Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Ou...Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.展开更多
BACKGROUND Sharp foreign body ingestion can cause gastrointestinal tract mucosa injury and requires proper endoscopic removal.Typically,protective devices are used to reduce mucosal damage.This case presents an altern...BACKGROUND Sharp foreign body ingestion can cause gastrointestinal tract mucosa injury and requires proper endoscopic removal.Typically,protective devices are used to reduce mucosal damage.This case presents an alternative approach for the endoscopic removal of a large,irregular,and sharp foreign body(chicken bone)when traditional protective devices are inadequate,thus contributing to the management of such ingestions.CASE SUMMARY A 57-year-old male presented with a history of swallowing an irregular and sharp-pointed chicken bone.Emergent endoscopy showed it was tightly embedded in the esophageal wall,with minor bleeding.The chicken bone was grasped and moved cautiously using a foreign forceps.It was loosened after repeated attempts but could not pass through the pharynx.Considering possible mucosal damage,it was carefully pushed into the stomach cavity and then wrapped in a condom.The chicken bone was retrieved uneventfully by grasping the open edge of the condom with foreign forceps.No additional damage was found,except for primary esophageal injuries caused by the embedded chicken bone.The patient was discharged on the following day.Our experience demonstrated that condoms can be an alternative as a protective device under such conditions.CONCLUSION Condoms can serve as an alternative when traditional protective devices are unsuitable.Because of its smooth and oily nature,it can provide mucosal protection and lubrication during endoscopic removal.展开更多
This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neuro...This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neurons in the hippocampal CA3 region and examine how strong coupling parameters modulate memory consolidation processes.Employing bifurcation analysis,we systematically characterize the model's complex dynamical behaviors.Subsequently,a characteristic waveform recognition algorithm enables precise feature extraction and automated detection of hippocampal sharp-wave ripples(SWRs).Our results demonstrate that neuronal rhythms exhibit a propensity for abrupt transitions near bifurcation points,facilitating the emergence of SWRs.Critically,temporal rhythmic analysis reveals that the occurrence of a bifurcation is not always sufficient for SWR formation.By integrating one-parameter bifurcation analysis with extremum analysis,we demonstrate that large-amplitude membrane potential oscillations near bifurcation points are highly conducive to SWR generation.This research elucidates the mechanistic link between changes in neuronal self-connection parameters and the evolution of rhythmic characteristics,providing deeper insights into the role of dynamical behavior in memory consolidation.展开更多
One of the most notable developments in the asset management industry in recent decades has been the growth of algorithmic trading.At the same time,significant structural changes in the industry have occurred,with pas...One of the most notable developments in the asset management industry in recent decades has been the growth of algorithmic trading.At the same time,significant structural changes in the industry have occurred,with passive investing gaining momentum.The intersection of these two major trends poses special challenges during market downturns,magnifying portfolio losses and leading to significant outflows.Emerging market(EM)investors have seen two major downturn events in the 2020s,namely the COVID-19 pandemic and the Russia-Ukraine conflict,both of which have strongly affected EM portfolios’risk-return profiles and increased their correlations with their developed market counterparts,eliminating much or all of EMs’diversification benefits.This has led to major capital outflows from EM countries,further destabilizing these fragile economies.Against this backdrop,we argue that capital need not exit these riskier markets during periods of turmoil and support this by developing a second-generation Automated Adaptive Trading System(AATS)back-tested on a relevant,diversified EM portfolio that tracks the Morgan Stanley Capital International(MSCI)Emerging Markets Index during a volatile period characterized by negative returns,high risk,and a high correlation with global markets for the buy-and-hold EM portfolio.The system incorporates an Autoregressive Moving Average-Generalized AutoRegressive Conditional Heteroskedasticity model that offers an interpretability advantage over machine-learning methods.The main strength of the AATS is its ability to allow the embedded hybrid forecasting model to adapt to the changing environments that characterize EMs.This is done by implementing a recursive window technique and running a user-specified fitness function to dynamically optimize the mean equation parameters throughout the lead time.Back-testing several configurations of the flexible AATS consistently reveals its superiority while assuring the robustness of the results.We conclude that with the right investment tools,EMs continue to offer compelling opportunities that should not be overlooked.The novel AATS proposed in this study is such a tool,providing active EM investors with substantial value-added through its ability to generate abnormal returns,and can help to enhance the resilience of EMs by mitigating the cost of crises for those countries.展开更多
In this paper,the authors study the multilinear commutators generated by a class of multilinear singular integral operators with generalized kernels and Lipschitz functions.By establishing the sharp maximal estimates,...In this paper,the authors study the multilinear commutators generated by a class of multilinear singular integral operators with generalized kernels and Lipschitz functions.By establishing the sharp maximal estimates,the boundedness of this kind of multilinear commutators on product of weighted Lebesgue spaces can be obtained.展开更多
Objective To compare the impact of different reconstruction algorithms on the image quality of 60 kVp head and neck CT angiography(CTA)using subjective and objective metrics,with a focus on vessel edge sharpness.Metho...Objective To compare the impact of different reconstruction algorithms on the image quality of 60 kVp head and neck CT angiography(CTA)using subjective and objective metrics,with a focus on vessel edge sharpness.Methods This prospective study enrolled 45 patients who underwent ultra-low-voltage(60 kVp)head and neck CTA.Image datasets were reconstructed with filtered back-projection(FBP),ClearView(CV)and ClearInfinity(CI)algorithms at low(30%),medium(50%),and high(70%)strengths.Image quality was assessed subjectively and objectively via the Kruskal‒Wallis test for multiple comparisons.Objective parameters,including edge rise slope(ERS)and edge rise distance(ERD),were analyzed via the Friedman test of multiple comparisons statistics.Results Subjective assessments favored the CI50 reconstruction algorithm,demonstrating superior or satisfactory results compared to the other algorithms,with significantly better vessel delineation,edge definition and diagnostic confidence(all P<0.05).Objective analysis revealed that the CV50 and CV70 algorithms significantly reduced ERS and/or elevated ERD(both P<0.05).However,the CI50 algorithm maintained comparable vessel edge sharpness(P>0.05)across all evaluated head and neck vascular segments when compared with the FBP algorithm.Conclusions The CI50 reconstruction algorithm optimizes image quality in 60 kVp head and neck CTA.It provides vessel edge sharpness comparable to FBP while offering superior vessel delineation,edge definition,and diagnostic confidence compared to FBP and CV algorithm.These findings suggest that CI50 has the potential to improve diagnostic accuracy in low-dose vascular imaging.展开更多
Heterointerfaces have been pivotal in unveiling extraordinary interfacial properties and enabling multifunctional material platforms.Despite extensive research on all-oxide interfaces,heterointerfaces between differen...Heterointerfaces have been pivotal in unveiling extraordinary interfacial properties and enabling multifunctional material platforms.Despite extensive research on all-oxide interfaces,heterointerfaces between different material classes,such as oxides and nitrides,remain underexplored.Here we present the fabrication of atomically sharp heterointerfaces between antiperovskite Ni_(3)InN and perovskite SrVO_(3).Leveraging layer-resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we identified pronounced charge transfer across the well-ordered interface.First-principles calculations confirmed our experimental observations and further predicted an emergent magnetic moment within the Ni_(3)InN layer due to the charge transfer.These findings pave the way for novel electronic and spintronic applications by enabling tunable interfacial properties in nitride/oxide systems.展开更多
In sharp contrast to Western urbanization models, the distinctive feature of China's rapid urbanization lies in the production of space. This is not only a crucial entry point for comprehending China's urbaniz...In sharp contrast to Western urbanization models, the distinctive feature of China's rapid urbanization lies in the production of space. This is not only a crucial entry point for comprehending China's urbanization path but also provides a new orientation for global urban studies.展开更多
Physics-informed neural networks(PINNs)have prevailed as differentiable simulators to investigate flow in porous media.Despite recent progress PINNs have achieved,practical geotechnical scenarios cannot be readily sim...Physics-informed neural networks(PINNs)have prevailed as differentiable simulators to investigate flow in porous media.Despite recent progress PINNs have achieved,practical geotechnical scenarios cannot be readily simulated because conventional PINNs fail in discontinuous heterogeneous porous media or multi-layer strata when labeled data are missing.This work aims to develop a universal network structure to encode the mass continuity equation and Darcy’s law without labeled data.The finite element approximation,which can decompose a complex heterogeneous domain into simpler ones,is adopted to build the differentiable network.Without conventional DNNs,physics-encoded finite element network(PEFEN)can avoid spectral bias and learn high-frequency functions with sharp/steep gradients.PEFEN rigorously encodes Dirichlet and Neumann boundary conditions without training.Benefiting from its discretized formulation,the discontinuous heterogeneous hydraulic conductivity is readily embedded into the network.Three typical cases are reproduced to corroborate PEFEN’s superior performance over conventional PINNs and the PINN with mixed formulation.PEFEN is sparse and demonstrated to be capable of dealing with heterogeneity with much fewer training iterations(less than 1/30)than the improved PINN with mixed formulation.Thus,PEFEN saves energy and contributes to low-carbon AI for science.The last two cases focus on common geotechnical settings of impermeable sheet pile in singlelayer and multi-layer strata.PEFEN solves these cases with high accuracy,circumventing costly labeled data,extra computational burden,and additional treatment.Thus,this study warrants the further development and application of PEFEN as a novel differentiable network in porous flow of practical geotechnical engineering.展开更多
传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预...传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预期不足ES(Expected Shortfall)来替代投资收益的标准差,从而对传统Sharpe比率进行了调整。这里对VaR和ES进行计算时,运用了经验非参数估计和非参数平滑核估计两种方法。此外,本文还考虑了基金收益随时间波动的动态性,用广义自回归异方差GARCH模型对收益波动进行模拟,考察动态的VaR和ES,在实践中以动态的VaR和ES评价风险收益更加灵活。在实证研究中,本文用传统的Sharpe比率、基于VaR和ES的Sharpe比率以及基于条件VaR和条件ES的条件Sharpe比率对国内证券市场上所有26只封闭式基金在2005-2009年间的业绩进行了实证分析,分析了基金在不同指标下所体现的风险控制能力和收益水平的差别,并基于不同指标对所有基金进行了排名。此外,本文还运用协整检验考察基金收益率与市场基准指数是否存在联动关系,检验证明两者并不存在长期的均衡关系。展开更多
文摘BACKGROUND Burnout,musculoskeletal pain,and sharps injuries(SIs)affect medical workers.AIM To establish a model between SIs,burnout,and the risk factors to assess the extent to which burnout affects SIs.METHODS This questionnaire was used for an observational and cross-sectional study,which was based on members at a hospital affiliated with a medical university in Taichung,Taiwan,in 2020.The valid responses constituted 68.5%(1734 of 2531).The items were drawn from the Nordic Musculoskeletal Questionnaire and Copenhagen burnout inventory and concerned work experience,occupational category,presence of chronic diseases,sleep duration,overtime work,and work schedule.Factor analysis,chi-square test,Fisher exact test,Multiple linear,logistic regression and Sobel test were conducted.The present analyses were performed using SAS Enterprise Guide 6.1 software(SAS Institute Inc.,Cary,NC,United States),and significance was set at P<0.05.RESULTS Personal and work-related burnout ranks, sex, work experience ranks, occupationalgroups, drinking in the past month, sleep duration per day, presence ofchronic diseases, overtime work ranks, and work schedule were associated withSIs. Frequent upper limb and lower limb pain (pain occurring every day or once aweek) determined to be related to SIs. High personal burnout (> Q3) and highwork-related burnout (> Q3) mediated the relationship between SIs and frequentlower limb pain. Similarly, frequent lower limb pain mediated the relationship ofSIs with high personal and high work-related burnout. High personal and highwork-related burnout mediated the relationships of SIs with overtime work andirregular shift work. The mediating model provides strong evidence of anassociation between mental health and SIs.CONCLUSIONBurnout was determined to contribute to SIs occurrence;specifically, it mediatedthe relationships of SIs with frequent musculoskeletal pain, overtime work, andirregular shift work.
文摘In this research work, we consider the below inequalities: (1.1). The researchers attempt to find an answer as to what are the best possible parameters <i><i>α</i></i>, <i><i>β</i></i> that (1.1) can be held? The main tool is the optimization of some suitable functions that we seek to find out. Without loss of generality, we have assumed that <i>a</i> > <i>b</i> and let <img src="Edit_26c0f99b-93dd-48ff-acdb-f1c8047744f1.bmp" alt="" /> for 1) and <i>a</i> < <i>b</i>, <img src="Edit_15c32a7a-e9ae-41d3-8f49-c6b9c01c7ece.bmp" alt="" />(<i>t</i> small) for 2) to determine the condition for <i><i>α</i></i> and <i><i>β</i></i> to become <i>f</i>(<i>t</i>) ≤ 0 and <i>g</i>(<i>t</i>) ≥ 0.
文摘The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of Navier slip conditions on exchange flows within a long channel connecting two large reservoirs of differing salinity.These horizontal density gradients drive the flow.We modify the recent one-dimensional theory,developed to avoid runaway stratification,to account for the presence of uniform slip walls.By adjusting the parameters of the horizontal density gradient based on the slip factor,we resolve analytically various flow regimes ranging from high diffusion to transitional high advection.These regimes are governed by physical parameters like channel aspect ratio,slip factor,Schmidt number,and gravitational Reynolds number.Our solutions align perfectly with ones in the no-slip limit.More importantly,under the conditions of no net flow across the channel and high Schmidt number(where stratification is concentrated near the channel’s mid-layer),we derive a closed-form solution for the slip parameter,aspect ratio,and gravitational Reynolds number that describes the interface’s behavior as a sharp interface separating two distinct zones.This interface,arising from hydrostatic wall gradients,ultimately detaches the low-and high-density regimes throughout the channel when the gravitational Reynolds number is inversely proportional to the aspect ratio for a fixed slip parameter.This phenomenon,observed previously in 2D numerical simulations with no-slip walls in the literature,is thus confirmed by our theoretical results.Our findings further demonstrate that wall slip leads to distinct and diverse flow regimes.
基金supported by the National Natural Science Foundation of China(32270296)the Shenzhen Postdoctoral Scientific Research,China(77000-42100004)+1 种基金the Key Basic Research and Development Program of Hubei Province,China(2020BBA052)the Natural Science Foundation of Guangdong Province,China(2024A1515010498)and the Fundamental Research Funds for the Central Universities,Sun Yat-sen University,China.
文摘Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.
文摘BACKGROUND Sharp foreign body ingestion can cause gastrointestinal tract mucosa injury and requires proper endoscopic removal.Typically,protective devices are used to reduce mucosal damage.This case presents an alternative approach for the endoscopic removal of a large,irregular,and sharp foreign body(chicken bone)when traditional protective devices are inadequate,thus contributing to the management of such ingestions.CASE SUMMARY A 57-year-old male presented with a history of swallowing an irregular and sharp-pointed chicken bone.Emergent endoscopy showed it was tightly embedded in the esophageal wall,with minor bleeding.The chicken bone was grasped and moved cautiously using a foreign forceps.It was loosened after repeated attempts but could not pass through the pharynx.Considering possible mucosal damage,it was carefully pushed into the stomach cavity and then wrapped in a condom.The chicken bone was retrieved uneventfully by grasping the open edge of the condom with foreign forceps.No additional damage was found,except for primary esophageal injuries caused by the embedded chicken bone.The patient was discharged on the following day.Our experience demonstrated that condoms can be an alternative as a protective device under such conditions.CONCLUSION Condoms can serve as an alternative when traditional protective devices are unsuitable.Because of its smooth and oily nature,it can provide mucosal protection and lubrication during endoscopic removal.
基金supported by the National Natural Science Foundation of China(Grant Nos.12272002 and 12372061)the R&D Program of Beijing Municipal Education Commission(Grant No.KM202310009004)+1 种基金the North China University of Technology(Grant No.2023XN075-01)the Youth Research Special Project of the North China University of Technology(Grant No.2025NCUTYRSP051)。
文摘This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neurons in the hippocampal CA3 region and examine how strong coupling parameters modulate memory consolidation processes.Employing bifurcation analysis,we systematically characterize the model's complex dynamical behaviors.Subsequently,a characteristic waveform recognition algorithm enables precise feature extraction and automated detection of hippocampal sharp-wave ripples(SWRs).Our results demonstrate that neuronal rhythms exhibit a propensity for abrupt transitions near bifurcation points,facilitating the emergence of SWRs.Critically,temporal rhythmic analysis reveals that the occurrence of a bifurcation is not always sufficient for SWR formation.By integrating one-parameter bifurcation analysis with extremum analysis,we demonstrate that large-amplitude membrane potential oscillations near bifurcation points are highly conducive to SWR generation.This research elucidates the mechanistic link between changes in neuronal self-connection parameters and the evolution of rhythmic characteristics,providing deeper insights into the role of dynamical behavior in memory consolidation.
基金funded by the EU’s NextGenerationEU instrument through the National Recovery and Resilience Plan of Romania-Pillar Ⅲ-C9-I8,managed by the Ministry of Research,Innovation and Digitalization,within the project entitled,Non-Gaussian self-similar processes:Enhancing mathematical tools and financial models for capturing complex market dynamics,contract no.760243/28.12.2023,code CF 194/31.07.2023’.
文摘One of the most notable developments in the asset management industry in recent decades has been the growth of algorithmic trading.At the same time,significant structural changes in the industry have occurred,with passive investing gaining momentum.The intersection of these two major trends poses special challenges during market downturns,magnifying portfolio losses and leading to significant outflows.Emerging market(EM)investors have seen two major downturn events in the 2020s,namely the COVID-19 pandemic and the Russia-Ukraine conflict,both of which have strongly affected EM portfolios’risk-return profiles and increased their correlations with their developed market counterparts,eliminating much or all of EMs’diversification benefits.This has led to major capital outflows from EM countries,further destabilizing these fragile economies.Against this backdrop,we argue that capital need not exit these riskier markets during periods of turmoil and support this by developing a second-generation Automated Adaptive Trading System(AATS)back-tested on a relevant,diversified EM portfolio that tracks the Morgan Stanley Capital International(MSCI)Emerging Markets Index during a volatile period characterized by negative returns,high risk,and a high correlation with global markets for the buy-and-hold EM portfolio.The system incorporates an Autoregressive Moving Average-Generalized AutoRegressive Conditional Heteroskedasticity model that offers an interpretability advantage over machine-learning methods.The main strength of the AATS is its ability to allow the embedded hybrid forecasting model to adapt to the changing environments that characterize EMs.This is done by implementing a recursive window technique and running a user-specified fitness function to dynamically optimize the mean equation parameters throughout the lead time.Back-testing several configurations of the flexible AATS consistently reveals its superiority while assuring the robustness of the results.We conclude that with the right investment tools,EMs continue to offer compelling opportunities that should not be overlooked.The novel AATS proposed in this study is such a tool,providing active EM investors with substantial value-added through its ability to generate abnormal returns,and can help to enhance the resilience of EMs by mitigating the cost of crises for those countries.
基金Supported by the National Natural Science Foundation of China(11671397,11571160,12071052)the Yue Qi Young Scholar of China University of Mining and Technology(Beijing)。
文摘In this paper,the authors study the multilinear commutators generated by a class of multilinear singular integral operators with generalized kernels and Lipschitz functions.By establishing the sharp maximal estimates,the boundedness of this kind of multilinear commutators on product of weighted Lebesgue spaces can be obtained.
基金the Grant from the National Key Research and Development Program of China(No.2024YFC2419300)the National Natural Science Foundation of China(No.82471967)+1 种基金the Hubei Provincial Key Research and Development Program(No.2024BCB008)the Hubei Provincial Natural Science Foundation of China(No.2025AFB733).
文摘Objective To compare the impact of different reconstruction algorithms on the image quality of 60 kVp head and neck CT angiography(CTA)using subjective and objective metrics,with a focus on vessel edge sharpness.Methods This prospective study enrolled 45 patients who underwent ultra-low-voltage(60 kVp)head and neck CTA.Image datasets were reconstructed with filtered back-projection(FBP),ClearView(CV)and ClearInfinity(CI)algorithms at low(30%),medium(50%),and high(70%)strengths.Image quality was assessed subjectively and objectively via the Kruskal‒Wallis test for multiple comparisons.Objective parameters,including edge rise slope(ERS)and edge rise distance(ERD),were analyzed via the Friedman test of multiple comparisons statistics.Results Subjective assessments favored the CI50 reconstruction algorithm,demonstrating superior or satisfactory results compared to the other algorithms,with significantly better vessel delineation,edge definition and diagnostic confidence(all P<0.05).Objective analysis revealed that the CV50 and CV70 algorithms significantly reduced ERS and/or elevated ERD(both P<0.05).However,the CI50 algorithm maintained comparable vessel edge sharpness(P>0.05)across all evaluated head and neck vascular segments when compared with the FBP algorithm.Conclusions The CI50 reconstruction algorithm optimizes image quality in 60 kVp head and neck CTA.It provides vessel edge sharpness comparable to FBP while offering superior vessel delineation,edge definition,and diagnostic confidence compared to FBP and CV algorithm.These findings suggest that CI50 has the potential to improve diagnostic accuracy in low-dose vascular imaging.
基金supported by the Beijing Natural Science Foundation(Grant No.JQ24002)the National Key Basic Research Program of China(Grant No.2020YFA0309100)+3 种基金the National Natural Science Foundation of China(Grant Nos.U22A20263,52250308,12304158,12325401,12274069,12404102,and 12474096)the Chinese Academy of Sciences(CAS)Project for Young Scientists in Basic Research(Grant No.YSBR-084)the CAS Youth Interdisciplinary Team,the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022B1515120014)the Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology,and the International Young Scientist Fellowship of Institute of Physics,CAS.
文摘Heterointerfaces have been pivotal in unveiling extraordinary interfacial properties and enabling multifunctional material platforms.Despite extensive research on all-oxide interfaces,heterointerfaces between different material classes,such as oxides and nitrides,remain underexplored.Here we present the fabrication of atomically sharp heterointerfaces between antiperovskite Ni_(3)InN and perovskite SrVO_(3).Leveraging layer-resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we identified pronounced charge transfer across the well-ordered interface.First-principles calculations confirmed our experimental observations and further predicted an emergent magnetic moment within the Ni_(3)InN layer due to the charge transfer.These findings pave the way for novel electronic and spintronic applications by enabling tunable interfacial properties in nitride/oxide systems.
文摘In sharp contrast to Western urbanization models, the distinctive feature of China's rapid urbanization lies in the production of space. This is not only a crucial entry point for comprehending China's urbanization path but also provides a new orientation for global urban studies.
基金supported by the National Natural Science Foundation of China(Grant Nos.42272338 and 41827807)Department of Transportation of Zhejiang Province,China(Grant No.202213).
文摘Physics-informed neural networks(PINNs)have prevailed as differentiable simulators to investigate flow in porous media.Despite recent progress PINNs have achieved,practical geotechnical scenarios cannot be readily simulated because conventional PINNs fail in discontinuous heterogeneous porous media or multi-layer strata when labeled data are missing.This work aims to develop a universal network structure to encode the mass continuity equation and Darcy’s law without labeled data.The finite element approximation,which can decompose a complex heterogeneous domain into simpler ones,is adopted to build the differentiable network.Without conventional DNNs,physics-encoded finite element network(PEFEN)can avoid spectral bias and learn high-frequency functions with sharp/steep gradients.PEFEN rigorously encodes Dirichlet and Neumann boundary conditions without training.Benefiting from its discretized formulation,the discontinuous heterogeneous hydraulic conductivity is readily embedded into the network.Three typical cases are reproduced to corroborate PEFEN’s superior performance over conventional PINNs and the PINN with mixed formulation.PEFEN is sparse and demonstrated to be capable of dealing with heterogeneity with much fewer training iterations(less than 1/30)than the improved PINN with mixed formulation.Thus,PEFEN saves energy and contributes to low-carbon AI for science.The last two cases focus on common geotechnical settings of impermeable sheet pile in singlelayer and multi-layer strata.PEFEN solves these cases with high accuracy,circumventing costly labeled data,extra computational burden,and additional treatment.Thus,this study warrants the further development and application of PEFEN as a novel differentiable network in porous flow of practical geotechnical engineering.
文摘传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预期不足ES(Expected Shortfall)来替代投资收益的标准差,从而对传统Sharpe比率进行了调整。这里对VaR和ES进行计算时,运用了经验非参数估计和非参数平滑核估计两种方法。此外,本文还考虑了基金收益随时间波动的动态性,用广义自回归异方差GARCH模型对收益波动进行模拟,考察动态的VaR和ES,在实践中以动态的VaR和ES评价风险收益更加灵活。在实证研究中,本文用传统的Sharpe比率、基于VaR和ES的Sharpe比率以及基于条件VaR和条件ES的条件Sharpe比率对国内证券市场上所有26只封闭式基金在2005-2009年间的业绩进行了实证分析,分析了基金在不同指标下所体现的风险控制能力和收益水平的差别,并基于不同指标对所有基金进行了排名。此外,本文还运用协整检验考察基金收益率与市场基准指数是否存在联动关系,检验证明两者并不存在长期的均衡关系。
