A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their stru...A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their structures were identified as negunfurol （1）, schensianol A （2）, artemine （3）, erivanin （4）, 1,5-diepi-artemin （5）, acetylartemin （6）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy） decahydro-9a-hydroxy-3,Sa-dimethyl-9-methylene-（3S,3aS,5aS,6S,9aS, ghS） （7）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy）- 3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,Sa,9-trimethyl- （3S,3aS, SaR,6S, SS,9bS） （8）, isoerivanin （9）, harrelierin （10）, （11S）-1- oxoeudesm-4（14）-eno-13,6a-lactone （11）, 1-epi-dehydroisoeranin （12）, respectively. All of these compounds were isolated from Artemisia vestita for the first time, and compounds 1 and 2 were isolated from the genus Artemisia for the first time.展开更多
Two new beta-dihydroagarofuran sesquiterpenes were isolated from Euonymus phellomana Loes. and their structures were established on the basis of spectral analysis.
Three new sesquiterpenes, namely schensianol A （1）, schensianolside A （2） and schensianolside B （3） were isolated from the stems and leaves of Euonymus schensianus Maxim. Their structures were established by che...Three new sesquiterpenes, namely schensianol A （1）, schensianolside A （2） and schensianolside B （3） were isolated from the stems and leaves of Euonymus schensianus Maxim. Their structures were established by chemical methods and spectroscopic techniques including 2D NMR. ？ 2009 Wei Sheng Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Three new humulane-type sesquiterpenes,antrodols A–C(1–3),were isolated from cultures of the fungus Antrodiella albocinnamomea.Their structures were elucidated on the basis of extensive spectroscopic analysis.Antrod...Three new humulane-type sesquiterpenes,antrodols A–C(1–3),were isolated from cultures of the fungus Antrodiella albocinnamomea.Their structures were elucidated on the basis of extensive spectroscopic analysis.Antrodols A–C(1–3)are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi,and antrodol A(1)was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3.All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.展开更多
Two new steroids,3a,17a,19,20-tetrahydroxy-4a-methylpregn-8-ene(1)and 3a,12a,17a,20-tetrahydroxy-4amethylpregn-8-ene(2)and three new sesquiterpenoids,12-hydroxy-a-cadinol(3),3a,12-dihydroxy-d-cadinol(4),and 3a,6a-dih...Two new steroids,3a,17a,19,20-tetrahydroxy-4a-methylpregn-8-ene(1)and 3a,12a,17a,20-tetrahydroxy-4amethylpregn-8-ene(2)and three new sesquiterpenoids,12-hydroxy-a-cadinol(3),3a,12-dihydroxy-d-cadinol(4),and 3a,6a-dihydroxyspiroax-4-ene(5),have been isolated from cultures of the fungus Phellinus igniarius.Their structures were characterized based on extensive spectroscopic data.In preliminary in vitro assays,compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0%and 7.0%at 3910-4 M,respectively.展开更多
Two new eremophilane derivatives and one new nor-sesquiterpene were isolated from Ligularia veitchiana.Their structures were elucidated by spectroscopic methods and 2D-NMR tech- niques and shown to be 1β,10β-epoxy-6...Two new eremophilane derivatives and one new nor-sesquiterpene were isolated from Ligularia veitchiana.Their structures were elucidated by spectroscopic methods and 2D-NMR tech- niques and shown to be 1β,10β-epoxy-6β-(2′—semialdehyde acetal hydroxymethylacryloyloxy)- 8β-ethoxy-eremophil-7(11)-en-12,8α-olide(1),1β-hydroxy-Δ~6,Δ~9-8-oxo- eremophil-(12)-oic-acid(2)and 1β-hydroxy-Δ~6,Δ~9-8-oxo-11-nor-11-hydroxy- eremophiladiene(3).展开更多
Two new beta-dihydroagarofuran sesquiterpene polyol esters were isolated from Celastrus paniculatus.subsp.paniculatus. Their Structures were deduced on the basis of spectral analyses including 2D NMR. CO2 supercritica...Two new beta-dihydroagarofuran sesquiterpene polyol esters were isolated from Celastrus paniculatus.subsp.paniculatus. Their Structures were deduced on the basis of spectral analyses including 2D NMR. CO2 supercritical fluid was used in separation.展开更多
This study evaluated toxic efficacy of Eupatorium adenophorum extracts,against the Kunming mice.In acute study,we firstly tested median lethal dose(LD50)in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9...This study evaluated toxic efficacy of Eupatorium adenophorum extracts,against the Kunming mice.In acute study,we firstly tested median lethal dose(LD50)in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA),9-oxo-agerophorone(OA)and 9-oxo-10,11-dehydro-agerophorone(ODA)from Eupatorium adenophorum(Ea).DAOA(215–4640 mg/kg BW,given orally)showed lowest LD50 at 926 mg/kg BW for male mice in contrast with OA(1470 mg/kg BW)and ODA(1470 mg/kg BW).In sub-acute study,repeated doses(75–300 mg/kg BW,for 7 days)of DAOA/OA increased blood parameters,liver and spleen index in dose dependent relationship,along with decrease in thymus index.The blood biochemical and histopathological examination showed that DAOA/OA dose 300 mg/kg BW significantly causes pathological changes of hepatic lobules and hepatocytes,which are consistent with cholestasis and hepatic injury.75 mg/kg dose of DAOA/OA was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters.Cadinene sesquiterpenes guarantee low risk to environment as a type of low toxic botanical components,which may find potential application in biopesticides development field.展开更多
Three naturally new sesquiterpenes named 10-hydroxyepiaplysin, 10-hydroxyaplysin and 10-hydroxybromoepiaplysin have been isolated from Laurencia tristicha. On the basis of the spectroscopic techniques their structures...Three naturally new sesquiterpenes named 10-hydroxyepiaplysin, 10-hydroxyaplysin and 10-hydroxybromoepiaplysin have been isolated from Laurencia tristicha. On the basis of the spectroscopic techniques their structures were elucidated as （3S, 3αR, 8βS）-（-）-2, 3, 3α, 8β3-tetra- hydro-7-bromo-3-hydroxy-3, 3α, 6,8β-tetramethyl-lH-cyclopenta[b]benzofuran, （3R, 3αR, 8βS）- （-）-2,3,3α, 8β-tetrahydro-7-bromo-3-hydroxy-3, 3α,6,8β-tetramethyl-lH-cyclopenta[b]benzofuran and （3S, 3αR, 8βS）-（-）-2, 3,3R, 8β-tetrahydro-3-hydroxy-3,3α,6,8β-tetramethyl-lH-cyclopenta[b]- benzofuran, respectively.展开更多
In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and ...In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.展开更多
Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyl...Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.展开更多
A facile synthetic route to two seco-eudesmane, 4, 5-dioxo-10-epi-4, 5-seco-γ- eudesmane (1) and 4, 5-dioxo-10-epi-4, 5-seco-γ-eudesmol (2) from (+)-dihydrocarvone has been described. Avoiding expensive reagents, th...A facile synthetic route to two seco-eudesmane, 4, 5-dioxo-10-epi-4, 5-seco-γ- eudesmane (1) and 4, 5-dioxo-10-epi-4, 5-seco-γ-eudesmol (2) from (+)-dihydrocarvone has been described. Avoiding expensive reagents, this highly economic method especially suits for the synthesis of 4, 5-seco-eudesman-type and ophianon-type sesquiterpenes with a double bond at position 11 and 12.展开更多
Several bisabolane sesquiterpenes,（±）-curcumene,（±）-curcuphenol,（±）-curcudiol and（±）-curcuhydroquinone,have been synthesized in racemic form and fully characterized.The salient characterist...Several bisabolane sesquiterpenes,（±）-curcumene,（±）-curcuphenol,（±）-curcudiol and（±）-curcuhydroquinone,have been synthesized in racemic form and fully characterized.The salient characteristic of our approach is that a Johnson-Claisen arrangement was involved as a key step.展开更多
We are grateful for financial support from the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)a...We are grateful for financial support from the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)awarded to Professor S.M.N.Efange and Medicines for Malaria Venture(MMV),Geneva,Switzerland.The US Fulbright Council for International Exchange of Scholars(CIES)is acknowledged for grant to Kennedy D.Nyongbela to carry-out research at the University of Minnesota.We wish to thank M.Campbell and A.Powell from the Centre for Drug Candidate Optimisation(CDCO),Monash University for the DMPK data.Fidele Ntie-Kang is currently a Georg Forster fellow of the Alexander von Humboldt Foundation,Germany.We are equally grateful to Schro¨dinger Inc.for the academic license to use the QikProp software.展开更多
Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from A...Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide （1）, alismol （2）, orientalol B （3）, oplopanone （4）, gibberodione （5）, and 7a, lOa-epoxy-salvialan-1Ofl-ol （6）, respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.展开更多
Four new sesquiterpenes were isolated from the roots of Ligularia virgaurea, and identified as furanomexicanane-9-ene-8-one(1), 9β, 10β-epoxyfuranomexicanane-8-one(2), virgauride(3) and virgaurin A(4) by spectral me...Four new sesquiterpenes were isolated from the roots of Ligularia virgaurea, and identified as furanomexicanane-9-ene-8-one(1), 9β, 10β-epoxyfuranomexicanane-8-one(2), virgauride(3) and virgaurin A(4) by spectral methods.展开更多
A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone（1）, 1β,6α-dihydroxyeudesma-4（15）-en...A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone（1）, 1β,6α-dihydroxyeudesma-4（15）-ene（2）, carainterol A（3）, oplodiol（4）, douglanin（5）, 1α-hydroxyisodauc-4-en-15-al（6）, 3α,6α-dihydroxybisabola-4,10-diene（7）, 4α,5β-dihydroxybisabola-2,10-diene（8）, opposit-4（15）-ene-1β,7-diol（9）, and saniculamoid D（10）, respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.展开更多
Four new eremophilane type sesquiterpenes were isolated from the roots of Cacalia roborowskii (Maxim) Ling. Their structures were established as 8-oxo-eremophila-6, 9-dien-12-oic acid (1), 3 beta-acetoxyl-8-oxo-eremop...Four new eremophilane type sesquiterpenes were isolated from the roots of Cacalia roborowskii (Maxim) Ling. Their structures were established as 8-oxo-eremophila-6, 9-dien-12-oic acid (1), 3 beta-acetoxyl-8-oxo-eremophila-6, 9-dien-12-oic acid (2), 3 beta-angeloyoxyl-8-oxo-eremophilad, 9-dien-12-oic acid (3) and 3 beta-(2-methylbutyryloxyl)-8-oxo-eremophilia-6,9-dien-12-oic acid (4) by means of 1D and 2D NMR spectroscopy.展开更多
Two new eudesmane sesquiterpene lactones were isolated from the stalk of Lactuca sativa vat anagustata L and their structures were elucidated by means of spectroscopic methods, including 2D NMR （1H-1H COSY, HMBC and ...Two new eudesmane sesquiterpene lactones were isolated from the stalk of Lactuca sativa vat anagustata L and their structures were elucidated by means of spectroscopic methods, including 2D NMR （1H-1H COSY, HMBC and NOESY） as 1β-O-β-D- glucopyranosyl-4α-hydroxyl-5α, 6β, 11βH-eudesma-12, 6α-olide （1） and 1β-hydroxyl-15-O-（p-methoxyphenylacetyl）-5α, 6β, 11 βH-eudesma-3-en- 12, 6a-olide （2）.展开更多
基金National Natural Science Foundation of China(Grant No.30973629)National Key Technology R&D Program "New Drug Innovation" of China(Grant No.2012ZX09301002-002-002,2012ZX09304-005)
文摘A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their structures were identified as negunfurol （1）, schensianol A （2）, artemine （3）, erivanin （4）, 1,5-diepi-artemin （5）, acetylartemin （6）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy） decahydro-9a-hydroxy-3,Sa-dimethyl-9-methylene-（3S,3aS,5aS,6S,9aS, ghS） （7）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy）- 3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,Sa,9-trimethyl- （3S,3aS, SaR,6S, SS,9bS） （8）, isoerivanin （9）, harrelierin （10）, （11S）-1- oxoeudesm-4（14）-eno-13,6a-lactone （11）, 1-epi-dehydroisoeranin （12）, respectively. All of these compounds were isolated from Artemisia vestita for the first time, and compounds 1 and 2 were isolated from the genus Artemisia for the first time.
文摘Two new beta-dihydroagarofuran sesquiterpenes were isolated from Euonymus phellomana Loes. and their structures were established on the basis of spectral analysis.
文摘Three new sesquiterpenes, namely schensianol A （1）, schensianolside A （2） and schensianolside B （3） were isolated from the stems and leaves of Euonymus schensianus Maxim. Their structures were established by chemical methods and spectroscopic techniques including 2D NMR. ？ 2009 Wei Sheng Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金National Natural Science Foundation of China(U1132607,81373289,81102346)Youth Innovation Promotion Association of CAS(2011312D11019).
文摘Three new humulane-type sesquiterpenes,antrodols A–C(1–3),were isolated from cultures of the fungus Antrodiella albocinnamomea.Their structures were elucidated on the basis of extensive spectroscopic analysis.Antrodols A–C(1–3)are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi,and antrodol A(1)was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3.All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.
基金the National Natural Sciences Foundation of China(U1132607,81102346)Natural Sciences Foundation of Yunnan Province(2011FB099).
文摘Two new steroids,3a,17a,19,20-tetrahydroxy-4a-methylpregn-8-ene(1)and 3a,12a,17a,20-tetrahydroxy-4amethylpregn-8-ene(2)and three new sesquiterpenoids,12-hydroxy-a-cadinol(3),3a,12-dihydroxy-d-cadinol(4),and 3a,6a-dihydroxyspiroax-4-ene(5),have been isolated from cultures of the fungus Phellinus igniarius.Their structures were characterized based on extensive spectroscopic data.In preliminary in vitro assays,compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0%and 7.0%at 3910-4 M,respectively.
文摘Two new eremophilane derivatives and one new nor-sesquiterpene were isolated from Ligularia veitchiana.Their structures were elucidated by spectroscopic methods and 2D-NMR tech- niques and shown to be 1β,10β-epoxy-6β-(2′—semialdehyde acetal hydroxymethylacryloyloxy)- 8β-ethoxy-eremophil-7(11)-en-12,8α-olide(1),1β-hydroxy-Δ~6,Δ~9-8-oxo- eremophil-(12)-oic-acid(2)and 1β-hydroxy-Δ~6,Δ~9-8-oxo-11-nor-11-hydroxy- eremophiladiene(3).
文摘Two new beta-dihydroagarofuran sesquiterpene polyol esters were isolated from Celastrus paniculatus.subsp.paniculatus. Their Structures were deduced on the basis of spectral analyses including 2D NMR. CO2 supercritical fluid was used in separation.
基金Special Nonprofit Agricultural Industrial Research Fund(20080321,201103027)of China.
文摘This study evaluated toxic efficacy of Eupatorium adenophorum extracts,against the Kunming mice.In acute study,we firstly tested median lethal dose(LD50)in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA),9-oxo-agerophorone(OA)and 9-oxo-10,11-dehydro-agerophorone(ODA)from Eupatorium adenophorum(Ea).DAOA(215–4640 mg/kg BW,given orally)showed lowest LD50 at 926 mg/kg BW for male mice in contrast with OA(1470 mg/kg BW)and ODA(1470 mg/kg BW).In sub-acute study,repeated doses(75–300 mg/kg BW,for 7 days)of DAOA/OA increased blood parameters,liver and spleen index in dose dependent relationship,along with decrease in thymus index.The blood biochemical and histopathological examination showed that DAOA/OA dose 300 mg/kg BW significantly causes pathological changes of hepatic lobules and hepatocytes,which are consistent with cholestasis and hepatic injury.75 mg/kg dose of DAOA/OA was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters.Cadinene sesquiterpenes guarantee low risk to environment as a type of low toxic botanical components,which may find potential application in biopesticides development field.
基金financially supported by NNSFC(Grant No.20432030)National“863”Project(Grant No.2004AA625030,2001AA620503)the Key Innovative Project of the Chinese Academy of Sciences(Grant No.KZCX3-SW-215).
文摘Three naturally new sesquiterpenes named 10-hydroxyepiaplysin, 10-hydroxyaplysin and 10-hydroxybromoepiaplysin have been isolated from Laurencia tristicha. On the basis of the spectroscopic techniques their structures were elucidated as （3S, 3αR, 8βS）-（-）-2, 3, 3α, 8β3-tetra- hydro-7-bromo-3-hydroxy-3, 3α, 6,8β-tetramethyl-lH-cyclopenta[b]benzofuran, （3R, 3αR, 8βS）- （-）-2,3,3α, 8β-tetrahydro-7-bromo-3-hydroxy-3, 3α,6,8β-tetramethyl-lH-cyclopenta[b]benzofuran and （3S, 3αR, 8βS）-（-）-2, 3,3R, 8β-tetrahydro-3-hydroxy-3,3α,6,8β-tetramethyl-lH-cyclopenta[b]- benzofuran, respectively.
基金supported by the National Natural Science Foundation of China (Nos. 31360081 and 31400303)the Basic Research Foundation of Yunnan Province (Nos. 2014FB163 and 2014FD078)the Product Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (No. 2014CP01)
文摘In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.
文摘Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.
基金This work was financially supported by the National Natural Science Foundation of China(No.20272021).
文摘A facile synthetic route to two seco-eudesmane, 4, 5-dioxo-10-epi-4, 5-seco-γ- eudesmane (1) and 4, 5-dioxo-10-epi-4, 5-seco-γ-eudesmol (2) from (+)-dihydrocarvone has been described. Avoiding expensive reagents, this highly economic method especially suits for the synthesis of 4, 5-seco-eudesman-type and ophianon-type sesquiterpenes with a double bond at position 11 and 12.
基金Financial support from Program for Excellent Young Talents in Northwest A&F University(No.2111020712) as well as the National Natural Science Foundation of China(No.20802058) is greatly appreciated.
文摘Several bisabolane sesquiterpenes,（±）-curcumene,（±）-curcuphenol,（±）-curcudiol and（±）-curcuhydroquinone,have been synthesized in racemic form and fully characterized.The salient characteristic of our approach is that a Johnson-Claisen arrangement was involved as a key step.
基金the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)awarded to Professor S.M.N.Efange and Medicines for Malaria Venture(MMV)Geneva,Switzerland.The US Fulbright Council for International Exchange of Scholars(CIES)is acknowledged for grant to Kennedy D.Nyongbela to carry-out research at the University of Minnesota.
文摘We are grateful for financial support from the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)awarded to Professor S.M.N.Efange and Medicines for Malaria Venture(MMV),Geneva,Switzerland.The US Fulbright Council for International Exchange of Scholars(CIES)is acknowledged for grant to Kennedy D.Nyongbela to carry-out research at the University of Minnesota.We wish to thank M.Campbell and A.Powell from the Centre for Drug Candidate Optimisation(CDCO),Monash University for the DMPK data.Fidele Ntie-Kang is currently a Georg Forster fellow of the Alexander von Humboldt Foundation,Germany.We are equally grateful to Schro¨dinger Inc.for the academic license to use the QikProp software.
基金The National Science and Technology Major Project of“Technological study on the safety and standards of Chinese materia medica”(Grant No.2014ZX09304307-001-011)Chinese materia medica supporting program of“Quality control base construction of Chinese material medica including Isatidis Radix,Carthami Flos,etc”by Ministry of Industry and Information Technology of Peoples Republic of China
文摘Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide （1）, alismol （2）, orientalol B （3）, oplopanone （4）, gibberodione （5）, and 7a, lOa-epoxy-salvialan-1Ofl-ol （6）, respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.
文摘Four new sesquiterpenes were isolated from the roots of Ligularia virgaurea, and identified as furanomexicanane-9-ene-8-one(1), 9β, 10β-epoxyfuranomexicanane-8-one(2), virgauride(3) and virgaurin A(4) by spectral methods.
基金National Natural Science Foundation of China(NSFC,Grant No.81373294)National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2018ZX09711001-008-003)
文摘A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone（1）, 1β,6α-dihydroxyeudesma-4（15）-ene（2）, carainterol A（3）, oplodiol（4）, douglanin（5）, 1α-hydroxyisodauc-4-en-15-al（6）, 3α,6α-dihydroxybisabola-4,10-diene（7）, 4α,5β-dihydroxybisabola-2,10-diene（8）, opposit-4（15）-ene-1β,7-diol（9）, and saniculamoid D（10）, respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.
文摘Four new eremophilane type sesquiterpenes were isolated from the roots of Cacalia roborowskii (Maxim) Ling. Their structures were established as 8-oxo-eremophila-6, 9-dien-12-oic acid (1), 3 beta-acetoxyl-8-oxo-eremophila-6, 9-dien-12-oic acid (2), 3 beta-angeloyoxyl-8-oxo-eremophilad, 9-dien-12-oic acid (3) and 3 beta-(2-methylbutyryloxyl)-8-oxo-eremophilia-6,9-dien-12-oic acid (4) by means of 1D and 2D NMR spectroscopy.
基金financed by the Science Foundation of Zhejiang Sci-Tech University(No.0613266-Y)the Talents Training Foundation of Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Zhejiang Sci-Tech University),Ministry of Education(No.2006QN04)
文摘Two new eudesmane sesquiterpene lactones were isolated from the stalk of Lactuca sativa vat anagustata L and their structures were elucidated by means of spectroscopic methods, including 2D NMR （1H-1H COSY, HMBC and NOESY） as 1β-O-β-D- glucopyranosyl-4α-hydroxyl-5α, 6β, 11βH-eudesma-12, 6α-olide （1） and 1β-hydroxyl-15-O-（p-methoxyphenylacetyl）-5α, 6β, 11 βH-eudesma-3-en- 12, 6a-olide （2）.
