The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens ...The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.展开更多
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen...Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.展开更多
Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately m...Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).展开更多
For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the or...For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the original "sentinels" problem.展开更多
城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台...城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。展开更多
The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagn...The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.展开更多
Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation project...Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation projects but lacks comprehensive assessments and monitoring related to land cover changes.This study aimed to(1)investigate land cover changes in the Banlaem mangrove from 1995 to 2023,and(2)generate a predictive model for future land cover changes.For land cover assessment,satellite imagery from multiple sources,including Sentinel-2(Level 2A)and Landsat(Collection 2 Level 2),was utilized to examine and classify changes in mangrove cover within the Banlaem mangrove forest from 1995 to 2023,using supervised classification with the maximum likelihood algorithm.Various regression models were analysed to develop a predictive model based on area size and time.The mangrove area in the Banlaem mangrove forest steadily grew throughout the study period,with the total area increasing from 56.16 ha in 1995 to 527.55 ha in 2023.This study represents the first analysis of changes in the Banlaem mangrove cover.Throughout the tested models,they reveal an unclear pattern of mangrove expansion,yet they indicate a high rate of expansion in the Banlaem mangrove forest.In addition,these results are expected to encourage greater community involvement in the monitoring and management of the Banlaem mangrove.We recommend establishing a community monitoring network to engage local residents in tracking changes in mangrove cover,supported by training and resources.展开更多
文摘The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.
文摘Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82573747,82172873,W2421095,and 82503888)National Science and Technology Major Project(Grant No.2025ZD0543900)+2 种基金Natural Science Foundation of Shandong Province(Grant Nos.ZR2024LMB011 and ZR2024QH058)Taishan Scholars Program of Shandong Province(Grant No.tsqn202211337)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003).
文摘Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).
文摘For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the original "sentinels" problem.
文摘城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.81672638 and W2421095)National Natural Science Foundation of Shandong Province(Grant No.ZR2024LMB011)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003)。
文摘The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.
文摘Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation projects but lacks comprehensive assessments and monitoring related to land cover changes.This study aimed to(1)investigate land cover changes in the Banlaem mangrove from 1995 to 2023,and(2)generate a predictive model for future land cover changes.For land cover assessment,satellite imagery from multiple sources,including Sentinel-2(Level 2A)and Landsat(Collection 2 Level 2),was utilized to examine and classify changes in mangrove cover within the Banlaem mangrove forest from 1995 to 2023,using supervised classification with the maximum likelihood algorithm.Various regression models were analysed to develop a predictive model based on area size and time.The mangrove area in the Banlaem mangrove forest steadily grew throughout the study period,with the total area increasing from 56.16 ha in 1995 to 527.55 ha in 2023.This study represents the first analysis of changes in the Banlaem mangrove cover.Throughout the tested models,they reveal an unclear pattern of mangrove expansion,yet they indicate a high rate of expansion in the Banlaem mangrove forest.In addition,these results are expected to encourage greater community involvement in the monitoring and management of the Banlaem mangrove.We recommend establishing a community monitoring network to engage local residents in tracking changes in mangrove cover,supported by training and resources.
