The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens ...The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.展开更多
利用光学和SAR遥感影像进行建筑高度估计对于理解城市形态和优化城市存量空间具有重要意义。然而,现有的数据集存在诸多局限:由于样本数量较少,难以满足基于深度学习的遥感信息提取需求,样本所覆盖的区域较为有限,无法提供足够的地理多...利用光学和SAR遥感影像进行建筑高度估计对于理解城市形态和优化城市存量空间具有重要意义。然而,现有的数据集存在诸多局限:由于样本数量较少,难以满足基于深度学习的遥感信息提取需求,样本所覆盖的区域较为有限,无法提供足够的地理多样性和空间特征代表性,特别是针对中国区域的大规模建筑高度数据集尤为缺乏。此外,数据集的开源性不足,限制了其在更广泛的研究中的应用和验证。为解决这些问题,本文构建了一个面向深度学习的基于Sentinel影像的建筑物高度数据集BHDSI(Building Height Estimation Dataset Based on Sentinel Imagery),该数据集涵盖了中国62个城市的中心城区,共有5606个样本,覆盖了城市,农村等场景,是目前中国区域覆盖面积最大的建筑高度数据集。该数据集包含哨兵一号和哨兵二号的遥感影像以及建筑高度的真实值,样本大小是256×256,相比于64×64大小的数据集,为建筑高度估计研究提供了一个重要的补充选择。相比其他数据集,该数据集具有样本数量大、覆盖范围广、可获取性、建筑高度分布合理等特点,能够更好地满足深度学习网络的训练需求。在此基础上,本文采用相同的深度学习网络对BHDSI数据集及其他类似数据集进行了评估,并对比了多个网络使用BHDSI数据集时在建筑高度回归任务中的表现,深入分析了各网络的优劣。结果表明,与其他数据集相比,BHDSI数据集在建筑高度回归任务中的表现更加优异。进一步分析发现,使用BHDSI数据集时,建筑高度较低的区域其估计精度相对较高。此外,U-Net解码器用于建筑高度估计网络训练能够取得更高的精度。综上,BHDSI数据集为未来建筑高度估计领域的研究提供了重要的支持。展开更多
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen...Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.展开更多
With the advancement of surgical techniques and enhanced management of early gastric cancer(EGC),minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians.Lap...With the advancement of surgical techniques and enhanced management of early gastric cancer(EGC),minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians.Laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery(LECSSNNS)has drawn increasing interest because of its dual benefits of minimal invasiveness and organ function preservation.However,robust evidence-based support for guiding clinical implementation remains limited.To address this gap,we systematically evaluated available studies on the clinical application of LECS-SNNS in EGC and integrated expert insights to formulate 20 recommendations.These included preoperative assessment,surgical techniques,intraoperative endoscopic procedures,pathological evaluation,postoperative care,and follow-up.This consensus aimed to provide comprehensive guidance for the standardized application of LECS-SNNS,thereby advancing precise,minimally invasive,and function-preserving treatment for EGC.展开更多
Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately m...Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).展开更多
For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the or...For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the original "sentinels" problem.展开更多
城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台...城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。展开更多
文摘The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.
文摘利用光学和SAR遥感影像进行建筑高度估计对于理解城市形态和优化城市存量空间具有重要意义。然而,现有的数据集存在诸多局限:由于样本数量较少,难以满足基于深度学习的遥感信息提取需求,样本所覆盖的区域较为有限,无法提供足够的地理多样性和空间特征代表性,特别是针对中国区域的大规模建筑高度数据集尤为缺乏。此外,数据集的开源性不足,限制了其在更广泛的研究中的应用和验证。为解决这些问题,本文构建了一个面向深度学习的基于Sentinel影像的建筑物高度数据集BHDSI(Building Height Estimation Dataset Based on Sentinel Imagery),该数据集涵盖了中国62个城市的中心城区,共有5606个样本,覆盖了城市,农村等场景,是目前中国区域覆盖面积最大的建筑高度数据集。该数据集包含哨兵一号和哨兵二号的遥感影像以及建筑高度的真实值,样本大小是256×256,相比于64×64大小的数据集,为建筑高度估计研究提供了一个重要的补充选择。相比其他数据集,该数据集具有样本数量大、覆盖范围广、可获取性、建筑高度分布合理等特点,能够更好地满足深度学习网络的训练需求。在此基础上,本文采用相同的深度学习网络对BHDSI数据集及其他类似数据集进行了评估,并对比了多个网络使用BHDSI数据集时在建筑高度回归任务中的表现,深入分析了各网络的优劣。结果表明,与其他数据集相比,BHDSI数据集在建筑高度回归任务中的表现更加优异。进一步分析发现,使用BHDSI数据集时,建筑高度较低的区域其估计精度相对较高。此外,U-Net解码器用于建筑高度估计网络训练能够取得更高的精度。综上,BHDSI数据集为未来建筑高度估计领域的研究提供了重要的支持。
文摘Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.
基金supported by National Key Research and Development Program of China(No.2023YFC2507406)National Natural Science Foundation of China(No.82300646)+6 种基金Beijing Natural Science Foundation(No.7232334)Beijing Municipal Administration of Hospitals Incubating Program(No.PX2024002,PX2020001)Capital Fund for Health Development Scientific Research(No.2024-2-2028)Beijing Municipal Science&Technology Commission AI+Health Collaborative Innovation Cultivation Project(No.Z241100007724004)Research Ward Excellence Program of Beijing Municipal Health Commission(No.BRWEP2024W162020100,BRWEP2024W162020112,BRWEP2024W162020114)Excellent Plan for Capital Medicine Scientific and Technological Innovation Achievement Transformation Promotion Plan(No.YC202401QX0824)Clinical Scientific Research Fund of Beijing Integrated Medical Association[No.ZHKY-2025-1869(B012)]。
文摘With the advancement of surgical techniques and enhanced management of early gastric cancer(EGC),minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians.Laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery(LECSSNNS)has drawn increasing interest because of its dual benefits of minimal invasiveness and organ function preservation.However,robust evidence-based support for guiding clinical implementation remains limited.To address this gap,we systematically evaluated available studies on the clinical application of LECS-SNNS in EGC and integrated expert insights to formulate 20 recommendations.These included preoperative assessment,surgical techniques,intraoperative endoscopic procedures,pathological evaluation,postoperative care,and follow-up.This consensus aimed to provide comprehensive guidance for the standardized application of LECS-SNNS,thereby advancing precise,minimally invasive,and function-preserving treatment for EGC.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82573747,82172873,W2421095,and 82503888)National Science and Technology Major Project(Grant No.2025ZD0543900)+2 种基金Natural Science Foundation of Shandong Province(Grant Nos.ZR2024LMB011 and ZR2024QH058)Taishan Scholars Program of Shandong Province(Grant No.tsqn202211337)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003).
文摘Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).
文摘For periodic distributed systems the author reduces the "entinels" problem to a problem of controllability type and uses suitable adaptations of of HUM (Hilbert Uniqueness Method) to gives olutions to the original "sentinels" problem.
文摘城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。
