Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 ...Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples.Here,solid-state nanochannels,modified with metal-organic frameworks(MOF)and specific aptamers,were engineered for highly sensitive detection of strontium ion(Sr^(2+)).The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr^(2+) by aptamers amplifies the difference in ionic current signals,enhancing detection sensitivity significantly.The MOF-modified nanochannels exhibit highly sensitive detection of Sr^(2+),with a limit of detection(LOD)being 0.03 nmol·L^(-1),whereas the LOD for anodized aluminum oxide(AAO)without the modified MOF nanosheets is only 1000 nmol·L^(-1).These findings indicate that the LOD of Sr^(2+) detected by the MOF-modified nanochannels is approximately 33,000 times higher than that by the nanochannels without MOF modification.Additionally,the highly reliable detection of Sr^(2+) in various water samples was achieved,with a recovery rate ranging from 94.00%to 118.70%.This study provides valuable insights into the rapidly advancing field of advanced nanochannel-based sensors and their diverse applications for analyzing complex samples,including environmental contaminant detection,food analysis,medical diagnostics,and more.展开更多
Aim to detect the characteristic weak magnetic field signal against the strong noises background. Methods In combination with a low-pass-filter, the correlation output of magne-* tic sensors between the magnetic field...Aim to detect the characteristic weak magnetic field signal against the strong noises background. Methods In combination with a low-pass-filter, the correlation output of magne-* tic sensors between the magnetic field and reference current was utilized to provide a DC output voltage proportional to the applied magnetic induction, computer simulation was* done to investigate the correlation output of the Hall-effect sensors. Results Some analysis results concerning the noise property, harmonic supppression and the sensitivity were given. Conclsion The minimum detection signal of the equipment evolved from the mentioned cor-* relation theory can be 10-6 T. In addition to the DC output, such sensors can also measure the phase of the detected magnetic induction and has good harmonic suppression as well as* noise elimination.展开更多
Hydrazine hydrate(DH)is an important fine chemical intermediate and as fuel for rockets,however,it also has serious toxic for humans and environment.Developing novel materials and methods for sensitive detection of DH...Hydrazine hydrate(DH)is an important fine chemical intermediate and as fuel for rockets,however,it also has serious toxic for humans and environment.Developing novel materials and methods for sensitive detection of DH in water and air is an important task.In order to effectively detect DH,a novel conductive supramolecular polymer metallogel(PQ-Ag)has been constructed by the coordination of bis-5-hydroxyquinoline functionalized pillar[5]arene(PQ5)with Ag+.The metallogel PQ-Ag could realize the multi-channel sensitive detection of DH through naked-eye,fluorescence,and electrochemical methods.The lowest limit of detection(LOD)is 0.1 mg/m^(3)in air and 2.68×10^(−8)mol/L in water,which is lower than the standard of the US Environmental Protection Agency(EPA)for DH of maximum allowable concentration in drinking water.More importantly,an electronic device for DH detection based on the metallogel PQ-Ag was designed and prepared,which can realize conveniently and efficiently multi-channel detection and alert of DH through sound and light alarms not only in water but also in air.展开更多
Picosecond optical parametric generation and amplification in the near-infrared region within 1.361-1.656 μm and the mid-infrared region within 2.976-4.875 μm is constructed on the basis of bulk MgO：LiNbO 3 crystal...Picosecond optical parametric generation and amplification in the near-infrared region within 1.361-1.656 μm and the mid-infrared region within 2.976-4.875 μm is constructed on the basis of bulk MgO：LiNbO 3 crystals pumped at 1.064 μm.The maximum pulse energy reaches 1.3 mJ at 1.464 μm and 0.47 mJ at 3.894 μm,corresponding to a pumpto-idler photon conversion efficiency of 25%.By seeding the hard-to-measure mid-infrared radiation as the idler in the optical parametric amplification and measuring the amplified and frequency up-converted signal in the near-infrared or even visible region,one can measure very week mid-infrared radiation with ordinary detectors,which are insensitive to mid-infrared radiation,with a very high gain.A maximum gain factor of about 7 脳 10 7 is achieved at the mid-infrared wavelength of 3.374 μm and the corresponding energy detection limit is as low as about 390 aJ per pulse.展开更多
Gallium nitride- （GaN） based high electron mobility transistors （HEMTs） provide a good platform for biological detection. In this work, both Au-gated AlInN/GaN HEMT and AlGaN/GaN HEMT biosensors are fabricated for...Gallium nitride- （GaN） based high electron mobility transistors （HEMTs） provide a good platform for biological detection. In this work, both Au-gated AlInN/GaN HEMT and AlGaN/GaN HEMT biosensors are fabricated for the detection of deoxyribonucleic acid （DNA） hybridization. The Au-gated AIInN/GaN HEMT biosensor exhibits higher sensitivity in comparison with the AlGaN/GaN HEMT biosensor. For the former, the drain-source current （VDS = 0.5 V） shows a clear decrease of 69μA upon the introduction of 1μmolL^-1 （μM） complimentary DNA to the probe DNA at the sensor area, while for the latter it is only 38 μA. This current reduction is a notable indication of the hybridization. The high sensitivity can be attributed to the thinner barrier of the AlInN/GaN heterostructure, which makes the two-dimensional electron gas channel more susceptible to a slight change of the surface charge.展开更多
A simple technique for sensitive detection of heroine based on surface- plasmonresonance has been theoretically and experimentally investigated. The experiment was realized by using an anti-MO monoclonal antibody and ...A simple technique for sensitive detection of heroine based on surface- plasmonresonance has been theoretically and experimentally investigated. The experiment was realized by using an anti-MO monoclonal antibody and a morphine (MO)-bovine serum albumin (MOBSA) conjugate (antigen). The reason for using MO-BSA in the detection of heroine was also discussed. MO-BSA was immobilized on a gold thin film of SPR sensor chip by physical adsorption. The configuration of the device is allowed to be further miniaturized, which is required for the construction of a portable SPR device in the application of in-situ analysis.展开更多
Polarization is an important attribute of light and can be artificially modulated as a versatile information carrier.Conventional polarization-sensitive photodetection relies on a combination of polarizing optical ele...Polarization is an important attribute of light and can be artificially modulated as a versatile information carrier.Conventional polarization-sensitive photodetection relies on a combination of polarizing optical elements and standard photodetectors,which requires a substantial amount of space and manufacturing expenses.Although onchip polarized photodetectors have been realized in recent years based on two-dimensional(2D)materials with lowsymmetry crystal structures,they are limited by the intrinsic anisotropic property and thus the optional range of materials,the operation wavelength,and more importantly,the low anisotropic ratio,hindering their practical applications.In this work,we construct a versatile platform that transcends the constraints of material anisotropy,by integrating WSe2-based photodetector with MoS2-based field-effect transistor,delivering high-performance broadband polarization detection capability with orders of magnitude improvement in anisotropic ratio and on/off ratio.The polarization arises from hot electron injection caused by the plasmonic metal electrode and is amplified by the transistor to raise the anisotropic ratio from 2 to an impressive value over 60 in the infrared(iR)band,reaching the level of existing applications.Meanwhile,the system achieves a significant improvement in photosensitivity,with an on/off ratio of over 1o3 in the IR band.Based on the above performance optimization,we demonstrated its polarization-modulated IR optical communication ability and polarized artificial vision applications with a high image recognition accuracy of~99%.The proposed platform provides a promising route for the development of the longsought minimized,high-performance,multifunctional optoelectronic systems.展开更多
Radioactive iodine gas detection has significant applications in the nuclear industry,particularly in nuclear accident scenarios and nuclear fuel reprocessing facilities.Herein,chemically stable metal-organic framewor...Radioactive iodine gas detection has significant applications in the nuclear industry,particularly in nuclear accident scenarios and nuclear fuel reprocessing facilities.Herein,chemically stable metal-organic frameworks(MOFs)with good affinity for iodine(including Zn(1,3-BDP),UiO-66,UiO-66-NH2,etc.)were computationally screened and drop-casted upon interdigitated electrodes(IDEs).These MOFs were used to develop advanced iodine sensors to achieve the direct electrical detection of I2 gas via impedance spectroscopy measurements.Upon exposure to I2 gas,a similar electrical response change has occurred for all the IDE sensors,despite in the different impedance ratio.In particular,UiO-66-coated sensors exhibited an impedance ratio>103 times,while the modification of amino groups(-NH2)enhanced the sensitivity,exceeding 104 times for UiO-66-NH2,and was accompanied by a better iodine uptake.Notably,the sensors fabricated from Zn(1,3-BDP),which also contained nitrogen atoms,exhibited excellent comprehensive sensing performance,including high sensitivity(with impedance ratio achieving 1.4×106 times),good recyclability,rapid response speed(with impedance change ratio of 250 times within 3 min),low detection limit(about 29 times under 300 ppm I2 vapor at 25°C),and high anti-interference ability.Our theoretical calculations revealed that the underlying I2 sensing mechanism could be attributed to a decreased band gap and enhanced electrical conductivity due to the new electronic states introduced by the adsorbed I2.This work proposes a novel and feasible method for investigating sensing materials and strategies to fabricate high-performance iodine gas sensors,providing a basis for developing nuclear radioactivity monitoring technology and emergency security safeguard equipment.展开更多
FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules dur...FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules during 30 min.Here,we constituted a novel nanodevice with a molecular rotary motor and a“battery”,FoF1-ATPase and chromatophore,and presented a novel method of sandwich type rotary biosensor based on εsubunit with one target-to-one motor,in which one target corresponds 105 ATP molecules as detection signals during 30 min.The target such as NT-proBNP detection demonstrated that this novel nanodevice has potential to be developed into an ultrasensitive biosensor to detect low expressed targets.展开更多
Smart agriculture is an inevitable trend in the modernization of agriculture.Achieving efficient and precise monitoring of trace pesticides is an important research direction in smart agriculture,with significant impl...Smart agriculture is an inevitable trend in the modernization of agriculture.Achieving efficient and precise monitoring of trace pesticides is an important research direction in smart agriculture,with significant implications for a safe food supply chain.However,highly sensitive and high-throughput determination of pesticides still faces formidable challenges.Herein,we demonstrate a kind of sensitive and highly selective organophosphorus pesticide device based on organic field-effect transistors(OFETs).The unique signal amplification capability of OFETs and acetylcholinesterase modification on the active channel layer enables the achievement of accurate analysis of chlorpyrifos,parathion-methyl,and omethoate at the ppb level.Moreover,the simultaneous analysis of multiple samples is realized via the preparation of multichannel devices.Additionally,a portable monitoring applet is developed,enabling real-time assessment of the pesticide contamination status of samples based on the current response.This work provides a new avenue for constructing highly sensitive,real-time,high-flux intelligent agriculture sensing technology.展开更多
As the key factor in brain development and fat metabolism,choline is widely present in foods,especially in health care and dairy products.In this study,a simple,rapid,sensitive,and cost-eff ective method was proposed ...As the key factor in brain development and fat metabolism,choline is widely present in foods,especially in health care and dairy products.In this study,a simple,rapid,sensitive,and cost-eff ective method was proposed for choline detection based on luminol derivate(L012)doped amino silica nanoparticles(L012@SiNPs-NH_(2)).L012@SiNPs-NH_(2)exhibited a 47-fold increase in the electrochemiluminescence(ECL)response and much better uniformity and dispersion compared with conventional luminol-doped silica nanoparticles(Luminol@SiNPs).We thus constructed an ECL biosensor based on the L012@SiNPs-NH_(2)/H_(2)O_(2)system,in which co-reactant H_(2)O_(2)is generated from dissolved oxygen during the process of oxidation of choline by choline oxidase.Significantly,the ECL biosensor shows a linear relationship between ECL intensity and choline concentration in the range of 1–5000μM,with a low limit of detection of 1μM.Additionally,the recovery tests from milk powders were conducted,demonstrating its practical application potential,which could be expanded to other oxidase-related analytes detection.It greatly broadened the application of L012 based nano-emitters in biological,food,and clinical analysis.展开更多
Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various applications.Herein,a novel POF is suc...Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various applications.Herein,a novel POF is successfully prepared via Friedel-Crafts reaction.Silver nanoparticles(AgNPs)are embedded in the prepared POF to generate an Ag@POF composite,which not only possesses high surface area,outstanding physicochemical stability and outstretchedπ-conjugation skeleton,but also exhibits preferable electrochemical stability and conductivity.This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor.Electrochemical impedance spectroscopy(EIS)is a commonly used technology to analyze the electrochemical signal variation.The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS.For instance theophylline as a research mode,the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness,high selectivity,remarkable stability,good repeatability and simple operability even in various real samples.Notably,this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/m L(1.06 pmol/L)in a wide concentration range of 5.0×10^(-4)–5.0 ng/m L(2.78×10^(-3)–27.8 nmol/L).展开更多
Optical wireless(OW)communication systems face significant challenges such as signal attenuation due to atmospheric absorption,scattering,and noise from hardware components,which degrade detection sensitivity.To addre...Optical wireless(OW)communication systems face significant challenges such as signal attenuation due to atmospheric absorption,scattering,and noise from hardware components,which degrade detection sensitivity.To address these challenges,we propose a digital processing algorithm that combines finite impulse response filtering with dynamic synchronization based on pulse addition and subtraction.Unlike conventional methods,which typically rely solely on hardware optimization or basic thresholding techniques,the proposed approach integrates filtering and synchronization to improve weak signal detection and reduce noise-induced errors.The proposed algorithm was implemented and verified using a field-programmable gate array.Experiments conducted in an indoor OW communication environment demonstrate that the proposed algorithm significantly improves detection sensitivity by approximately 6 dB and 5 dB at communication rates of 3.5 Mbps and 5.0 Mbps,respectively.Specifically,under darkroom conditions and a bit error rate of 1×10^(-7),the detection sensitivity was improved from-38.56 dBm to-44.77 dBm at 3.5 Mbps and from-37.12 dBm to-42.29 dBm at 5 Mbps.The proposed algorithm is crucial for future capture and tracking of signals at large dispersion angles and in underwater and long-distance communication scenarios.展开更多
In vitro detection method for the sensitivity of Magnaporthe grisea to tricyclazole was studied, and the potential resistance risk of blast disease to tricyclazole was assessed. Both EC50 of hyphal melanization (EC50-...In vitro detection method for the sensitivity of Magnaporthe grisea to tricyclazole was studied, and the potential resistance risk of blast disease to tricyclazole was assessed. Both EC50 of hyphal melanization (EC50-H) and minimum inhibitive concentration of melanization in appressorial (MIC-A) by inhibitor tricyclazole showed positive correlation to the EC50 of tricyclazole against blast disease tested in vivo, with relative co-efficiency (R5) of 0.8995 and 0.8244, respectively. However, stability and reproducibility of EC50-H were better than those of MIC-A, suggesting that it could be used to detect the sensitivity of M. grisea to tricyclazole in vitro. Tricyclazole sensitivity of the progenies derived from single spores of the most sensitive isolate DY2 and the least sensitive isolate GY6 detected in sensitivity monitoring in 2000 was not stable, with mean EC50 values of 4.4968 μg/mL and 5.4010 ug/mL, respectively, indicating that the difference in EC50 between DY2 and GY6 was not caused probably by resistance variation. EC50 of GY6 did not increase significantly when continuously selected for twenty generations under the selection pressure of tricyclazole in vivo. However, the sensitivity of DY2 was decreased by 10-fold after selected for twenty generations. The results suggested that tricyclazole was still low resistance risk for M. grisea in China.展开更多
Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of view.This photoelectric detection target brings about the problem of uneven detection sensi...Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of view.This photoelectric detection target brings about the problem of uneven detection sensitivity distribution in the detection screen.To improve the uneven detection sensitivity of this photoelectric detection target,this paper analyzes the distribution law of the uneven detection sensitivity of the photoelectric detection target using the multi-element array photoelectric detector,dissects the main factors affecting the detection sensitivity according to the photoelectric detection principle,establishes the calculation model of detection sensitivity of the photoelectric detection target in the different detection areas and proposes a method to improve the detection sensitivity by compensating the gain of each unit photoelectric detector.The analysis of simulation and experimental results show that the proposed method of photoelectric detection target can effectively improve the output signal amplitude of the projectile under the certain detection distance,in particular,the output signal amplitude of the projectile is significantly increased when the projectile passes through the detection blind area.The experimental results are consistent with the simulation results,which verify the effectiveness of the proposed improvement method.展开更多
We demonstrate a high performance GaAs/AlGaAs-based quantum-well photodetector(QWP)device with a peak response frequency of 4.3 THz.The negative differential resistance(NDR)phenomenon is found in the dark currentvolta...We demonstrate a high performance GaAs/AlGaAs-based quantum-well photodetector(QWP)device with a peak response frequency of 4.3 THz.The negative differential resistance(NDR)phenomenon is found in the dark currentvoltage(I-V)curve in the current sweeping measurement mode,from which the breakdown voltage is determined.The photocurrent spectra and blackbody current responsivities at different voltages are measured.Based on the experimental data,the peak responsivity of 0.3 A/W(at 0.15 V,8 K)is derived,and the detection sensitivity is higher than 10^(11)Jones,which is in the similar level as that of the commercialized liquid-helium-cooled silicon bolometers.We attribute the high detection performance of the device to the small ohmic contact resistance of-2Ωand the big breakdown bias.展开更多
Well-defined raspberry-like magnetic microbeads （RMMBs） as immunoassay solid carriers were pre- pared by chemicM covalent binding between Fe304 magnetic microspheres and SiO2 nanoparticles. These RMMBs were not as a...Well-defined raspberry-like magnetic microbeads （RMMBs） as immunoassay solid carriers were pre- pared by chemicM covalent binding between Fe304 magnetic microspheres and SiO2 nanoparticles. These RMMBs were not as agglomerative as nano-sized magnetie particles （〈 200 nm）, which was an advangtage for high efficient magnetic separation. When compared to Fe304@SiO2 core-shell magnetic microbeads （CMMBs） with smooth surface, RMMBs exhibited stronger capacity to bind biomolecules. Limit of blank （LOB） and limit of detection （LoD） of HBsAg detection using RMMBs as carriers via chemiluminiscence immunoassay （CLIA） were 0.472 and 1.022 μg/L, respectively, showing a notable improvement compared with CMMBs whose LoB and LoD were 1.017 and 1.988 μg/L, respectively. All these indicated a great potential of RMMBs in immunoassay application.展开更多
Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable electronics.However,most strain sensors cannot achieve highly-sensitive and wide-range detection of...Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable electronics.However,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high strains.Inspired by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic spinning.The microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal conversion.The microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good repeatability.The experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal conversion.By integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly constructed.The microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during phonation.This work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.展开更多
MicroRNAs(miRNAs)and short RNA fragments(18–25 nt)are crucial biomarkers in biological research and disease diagnostics.However,their accurate and rapid detection remains a challenge,largely due to their low abundanc...MicroRNAs(miRNAs)and short RNA fragments(18–25 nt)are crucial biomarkers in biological research and disease diagnostics.However,their accurate and rapid detection remains a challenge,largely due to their low abundance,short length,and sequence similarities.In this study,we report on a highly sensitive,one-step RNA O-circle amplification(ROA)assay for rapid and accurate miRNA detection.The ROA assay commences with the hybridization of a circular probe with the test RNA,followed by a linear rolling circle amplification(RCA)using dUTP.This amplification process is facilitated by U-nick reactions,which lead to an exponential amplification for readout.Under optimized conditions,assays can be completed within an hour,producing an amplification yield up to the microgram level,with a detection limit as low as 0.15 fmol(6 pM).Notably,the ROA assay requires only one step,and the results can be easily read visually,making it user-friendly.This ROA assay has proven effective in detecting various miRNAs and phage ssRNA.Overall,the ROA assay offers a user-friendly,rapid,and accurate solution for miRNA detection.展开更多
This study employs an N-carboxyanhydride ring-opening polymerization(NCA ROP)signal amplification strategy to construct a novel sensing system for the simple and rapid detection of tobacco mosaic virus RNA(tRNA).In th...This study employs an N-carboxyanhydride ring-opening polymerization(NCA ROP)signal amplification strategy to construct a novel sensing system for the simple and rapid detection of tobacco mosaic virus RNA(tRNA).In the developed fluorescent biosensor,carboxylated biomagnetic beads serve as carriers for target capture based on the complementary pairing of the aptamer bases.Subsequently,NCA ROP fluorescent peptides are utilized as highly biocompatible signal carriers to achieve sensitive detection of the target.Under the optimal conditions,the biosensor exhibits a broad linear detection range from 1 pM to 10 nM,with a detection limit as low as 0.085 pM.Furthermore,the fluorescent aptamer biosensor demonstrates robust affinity and reliability in recovery experiments involving healthy R ehmannia glutinosa leaf total RNA.This work establishes a robust platform for tRNA analysis,facilitating real-time and early diagnosis of various plant viruses.展开更多
基金supported by the National Natural Science Foundation of China(No.22090050,No.22090052,No.22176180)National Basic Research Program of China(No.2021YFA1200400)+1 种基金the Natural Science Foundation of Hubei Province(No.2024AFA001)Shenzhen Science and Technology Program(No.JCYJ20220530162406014)。
文摘Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples.Here,solid-state nanochannels,modified with metal-organic frameworks(MOF)and specific aptamers,were engineered for highly sensitive detection of strontium ion(Sr^(2+)).The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr^(2+) by aptamers amplifies the difference in ionic current signals,enhancing detection sensitivity significantly.The MOF-modified nanochannels exhibit highly sensitive detection of Sr^(2+),with a limit of detection(LOD)being 0.03 nmol·L^(-1),whereas the LOD for anodized aluminum oxide(AAO)without the modified MOF nanosheets is only 1000 nmol·L^(-1).These findings indicate that the LOD of Sr^(2+) detected by the MOF-modified nanochannels is approximately 33,000 times higher than that by the nanochannels without MOF modification.Additionally,the highly reliable detection of Sr^(2+) in various water samples was achieved,with a recovery rate ranging from 94.00%to 118.70%.This study provides valuable insights into the rapidly advancing field of advanced nanochannel-based sensors and their diverse applications for analyzing complex samples,including environmental contaminant detection,food analysis,medical diagnostics,and more.
文摘Aim to detect the characteristic weak magnetic field signal against the strong noises background. Methods In combination with a low-pass-filter, the correlation output of magne-* tic sensors between the magnetic field and reference current was utilized to provide a DC output voltage proportional to the applied magnetic induction, computer simulation was* done to investigate the correlation output of the Hall-effect sensors. Results Some analysis results concerning the noise property, harmonic supppression and the sensitivity were given. Conclsion The minimum detection signal of the equipment evolved from the mentioned cor-* relation theory can be 10-6 T. In addition to the DC output, such sensors can also measure the phase of the detected magnetic induction and has good harmonic suppression as well as* noise elimination.
基金supported by the National Natural Science Foundation of China(NSFC,Nos.22065031,22061039)the Top Leading Talents Project of Gansu Province,the Key R&D program of Gansu Province(No.21YF5GA066)+1 种基金Gansu Province College Industry Support Plan Project(No.2022CYZC-18)Natural Science Foundation of Gansu Province(Nos.2020-0405-JCC-630,20JR10RA088).
文摘Hydrazine hydrate(DH)is an important fine chemical intermediate and as fuel for rockets,however,it also has serious toxic for humans and environment.Developing novel materials and methods for sensitive detection of DH in water and air is an important task.In order to effectively detect DH,a novel conductive supramolecular polymer metallogel(PQ-Ag)has been constructed by the coordination of bis-5-hydroxyquinoline functionalized pillar[5]arene(PQ5)with Ag+.The metallogel PQ-Ag could realize the multi-channel sensitive detection of DH through naked-eye,fluorescence,and electrochemical methods.The lowest limit of detection(LOD)is 0.1 mg/m^(3)in air and 2.68×10^(−8)mol/L in water,which is lower than the standard of the US Environmental Protection Agency(EPA)for DH of maximum allowable concentration in drinking water.More importantly,an electronic device for DH detection based on the metallogel PQ-Ag was designed and prepared,which can realize conveniently and efficiently multi-channel detection and alert of DH through sound and light alarms not only in water but also in air.
基金Project supported by the National Natural Science Foundation of China (Grant No. 61078005)the National Basic ResearchProgram of China (Grant No. 2007CB613205)the China Postdoctoral Science Foundation
文摘Picosecond optical parametric generation and amplification in the near-infrared region within 1.361-1.656 μm and the mid-infrared region within 2.976-4.875 μm is constructed on the basis of bulk MgO：LiNbO 3 crystals pumped at 1.064 μm.The maximum pulse energy reaches 1.3 mJ at 1.464 μm and 0.47 mJ at 3.894 μm,corresponding to a pumpto-idler photon conversion efficiency of 25%.By seeding the hard-to-measure mid-infrared radiation as the idler in the optical parametric amplification and measuring the amplified and frequency up-converted signal in the near-infrared or even visible region,one can measure very week mid-infrared radiation with ordinary detectors,which are insensitive to mid-infrared radiation,with a very high gain.A maximum gain factor of about 7 脳 10 7 is achieved at the mid-infrared wavelength of 3.374 μm and the corresponding energy detection limit is as low as about 390 aJ per pulse.
基金Supported by the National Key Research and Development Program of China under Grant Nos 2016YFB0400104 and2016YFB0400301the National Natural Sciences Foundation of China under Grant No 61334002the National Science and Technology Major Project
文摘Gallium nitride- （GaN） based high electron mobility transistors （HEMTs） provide a good platform for biological detection. In this work, both Au-gated AlInN/GaN HEMT and AlGaN/GaN HEMT biosensors are fabricated for the detection of deoxyribonucleic acid （DNA） hybridization. The Au-gated AIInN/GaN HEMT biosensor exhibits higher sensitivity in comparison with the AlGaN/GaN HEMT biosensor. For the former, the drain-source current （VDS = 0.5 V） shows a clear decrease of 69μA upon the introduction of 1μmolL^-1 （μM） complimentary DNA to the probe DNA at the sensor area, while for the latter it is only 38 μA. This current reduction is a notable indication of the hybridization. The high sensitivity can be attributed to the thinner barrier of the AlInN/GaN heterostructure, which makes the two-dimensional electron gas channel more susceptible to a slight change of the surface charge.
文摘A simple technique for sensitive detection of heroine based on surface- plasmonresonance has been theoretically and experimentally investigated. The experiment was realized by using an anti-MO monoclonal antibody and a morphine (MO)-bovine serum albumin (MOBSA) conjugate (antigen). The reason for using MO-BSA in the detection of heroine was also discussed. MO-BSA was immobilized on a gold thin film of SPR sensor chip by physical adsorption. The configuration of the device is allowed to be further miniaturized, which is required for the construction of a portable SPR device in the application of in-situ analysis.
基金support of the National Natural Science Foundation of China(Nos.62334010,62121005,and 62304221)the National Key Researchand Development Program(2021YFA0717600)the International Fund Program of Changchun Institute of Optics,Fine Mechanics andPhysics,ChineseAcademyofSciences.
文摘Polarization is an important attribute of light and can be artificially modulated as a versatile information carrier.Conventional polarization-sensitive photodetection relies on a combination of polarizing optical elements and standard photodetectors,which requires a substantial amount of space and manufacturing expenses.Although onchip polarized photodetectors have been realized in recent years based on two-dimensional(2D)materials with lowsymmetry crystal structures,they are limited by the intrinsic anisotropic property and thus the optional range of materials,the operation wavelength,and more importantly,the low anisotropic ratio,hindering their practical applications.In this work,we construct a versatile platform that transcends the constraints of material anisotropy,by integrating WSe2-based photodetector with MoS2-based field-effect transistor,delivering high-performance broadband polarization detection capability with orders of magnitude improvement in anisotropic ratio and on/off ratio.The polarization arises from hot electron injection caused by the plasmonic metal electrode and is amplified by the transistor to raise the anisotropic ratio from 2 to an impressive value over 60 in the infrared(iR)band,reaching the level of existing applications.Meanwhile,the system achieves a significant improvement in photosensitivity,with an on/off ratio of over 1o3 in the IR band.Based on the above performance optimization,we demonstrated its polarization-modulated IR optical communication ability and polarized artificial vision applications with a high image recognition accuracy of~99%.The proposed platform provides a promising route for the development of the longsought minimized,high-performance,multifunctional optoelectronic systems.
基金supported by the National Key R&D Program of China(No.2016YFC1402504).
文摘Radioactive iodine gas detection has significant applications in the nuclear industry,particularly in nuclear accident scenarios and nuclear fuel reprocessing facilities.Herein,chemically stable metal-organic frameworks(MOFs)with good affinity for iodine(including Zn(1,3-BDP),UiO-66,UiO-66-NH2,etc.)were computationally screened and drop-casted upon interdigitated electrodes(IDEs).These MOFs were used to develop advanced iodine sensors to achieve the direct electrical detection of I2 gas via impedance spectroscopy measurements.Upon exposure to I2 gas,a similar electrical response change has occurred for all the IDE sensors,despite in the different impedance ratio.In particular,UiO-66-coated sensors exhibited an impedance ratio>103 times,while the modification of amino groups(-NH2)enhanced the sensitivity,exceeding 104 times for UiO-66-NH2,and was accompanied by a better iodine uptake.Notably,the sensors fabricated from Zn(1,3-BDP),which also contained nitrogen atoms,exhibited excellent comprehensive sensing performance,including high sensitivity(with impedance ratio achieving 1.4×106 times),good recyclability,rapid response speed(with impedance change ratio of 250 times within 3 min),low detection limit(about 29 times under 300 ppm I2 vapor at 25°C),and high anti-interference ability.Our theoretical calculations revealed that the underlying I2 sensing mechanism could be attributed to a decreased band gap and enhanced electrical conductivity due to the new electronic states introduced by the adsorbed I2.This work proposes a novel and feasible method for investigating sensing materials and strategies to fabricate high-performance iodine gas sensors,providing a basis for developing nuclear radioactivity monitoring technology and emergency security safeguard equipment.
基金This work is supported by the National Basic Research Program of China(973 Program)under grant No.2013CB932804the National Natural Science Foundation of China under Grant No.11574329 and 11322543+2 种基金the Science and Technology Planning Project of General Administration of Quality Supervision,Inspection and Quarantine(AQSIQ)of PR China under Grant No.2015IK011AQSIQ industrial public service scientific research project of the Ministry of Science and Technology of P.R.China under Grant No.201410049The YS101 type high sensitive detector of chemiluminescence was manufactured by Yishang Innovation Technology Co.,Ltd.
文摘FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules during 30 min.Here,we constituted a novel nanodevice with a molecular rotary motor and a“battery”,FoF1-ATPase and chromatophore,and presented a novel method of sandwich type rotary biosensor based on εsubunit with one target-to-one motor,in which one target corresponds 105 ATP molecules as detection signals during 30 min.The target such as NT-proBNP detection demonstrated that this novel nanodevice has potential to be developed into an ultrasensitive biosensor to detect low expressed targets.
基金supported by the National Key Research and Development Program of China(2023YFD1301500)the Natural Science Foundation of China(32172325 and 22305252)+2 种基金the China Postdoctoral Science Foundation(2023M743552 and 2023M733555)the China National Postdoctoral Program for Innovative Talents(BX20230372)and the Postdoctoral Fellowship Program of CPSF(GZB20230771).
文摘Smart agriculture is an inevitable trend in the modernization of agriculture.Achieving efficient and precise monitoring of trace pesticides is an important research direction in smart agriculture,with significant implications for a safe food supply chain.However,highly sensitive and high-throughput determination of pesticides still faces formidable challenges.Herein,we demonstrate a kind of sensitive and highly selective organophosphorus pesticide device based on organic field-effect transistors(OFETs).The unique signal amplification capability of OFETs and acetylcholinesterase modification on the active channel layer enables the achievement of accurate analysis of chlorpyrifos,parathion-methyl,and omethoate at the ppb level.Moreover,the simultaneous analysis of multiple samples is realized via the preparation of multichannel devices.Additionally,a portable monitoring applet is developed,enabling real-time assessment of the pesticide contamination status of samples based on the current response.This work provides a new avenue for constructing highly sensitive,real-time,high-flux intelligent agriculture sensing technology.
基金supported by Natural Science Foundation of Shandong Province(ZR2022QB033)National Natural Science Foundation of China(22304015)+5 种基金the Scientifi c Research Start-up Fund of Binzhou Medical University(BY2022KYQD43BY2021KYQD21)Taishan Scholars Program of Shandong Province(tsqn202103112)the Development Plan of Youth Innovation Team in Colleges and Universities of Shandong Province(2021KJ052)the Supporting Fund for Leading Talents above Provincial Level in Yantai(10073803)the Collaborative Innovation Program of Hefei Science Center(2022HSC-CIP012)。
文摘As the key factor in brain development and fat metabolism,choline is widely present in foods,especially in health care and dairy products.In this study,a simple,rapid,sensitive,and cost-eff ective method was proposed for choline detection based on luminol derivate(L012)doped amino silica nanoparticles(L012@SiNPs-NH_(2)).L012@SiNPs-NH_(2)exhibited a 47-fold increase in the electrochemiluminescence(ECL)response and much better uniformity and dispersion compared with conventional luminol-doped silica nanoparticles(Luminol@SiNPs).We thus constructed an ECL biosensor based on the L012@SiNPs-NH_(2)/H_(2)O_(2)system,in which co-reactant H_(2)O_(2)is generated from dissolved oxygen during the process of oxidation of choline by choline oxidase.Significantly,the ECL biosensor shows a linear relationship between ECL intensity and choline concentration in the range of 1–5000μM,with a low limit of detection of 1μM.Additionally,the recovery tests from milk powders were conducted,demonstrating its practical application potential,which could be expanded to other oxidase-related analytes detection.It greatly broadened the application of L012 based nano-emitters in biological,food,and clinical analysis.
基金financially supported by the National Natural Science Foundation of China(No.21801187)。
文摘Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various applications.Herein,a novel POF is successfully prepared via Friedel-Crafts reaction.Silver nanoparticles(AgNPs)are embedded in the prepared POF to generate an Ag@POF composite,which not only possesses high surface area,outstanding physicochemical stability and outstretchedπ-conjugation skeleton,but also exhibits preferable electrochemical stability and conductivity.This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor.Electrochemical impedance spectroscopy(EIS)is a commonly used technology to analyze the electrochemical signal variation.The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS.For instance theophylline as a research mode,the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness,high selectivity,remarkable stability,good repeatability and simple operability even in various real samples.Notably,this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/m L(1.06 pmol/L)in a wide concentration range of 5.0×10^(-4)–5.0 ng/m L(2.78×10^(-3)–27.8 nmol/L).
基金supported by National Key R&D Program of China under Grants No.2022YFB3902500,No.2022YFB2903402,and No.2021YFA0718804Natural Science Foundation of Jilin Province under Grant No.222621JC010297013Education Department of Jilin Province under Grant No.JJKH20220745KJ.
文摘Optical wireless(OW)communication systems face significant challenges such as signal attenuation due to atmospheric absorption,scattering,and noise from hardware components,which degrade detection sensitivity.To address these challenges,we propose a digital processing algorithm that combines finite impulse response filtering with dynamic synchronization based on pulse addition and subtraction.Unlike conventional methods,which typically rely solely on hardware optimization or basic thresholding techniques,the proposed approach integrates filtering and synchronization to improve weak signal detection and reduce noise-induced errors.The proposed algorithm was implemented and verified using a field-programmable gate array.Experiments conducted in an indoor OW communication environment demonstrate that the proposed algorithm significantly improves detection sensitivity by approximately 6 dB and 5 dB at communication rates of 3.5 Mbps and 5.0 Mbps,respectively.Specifically,under darkroom conditions and a bit error rate of 1×10^(-7),the detection sensitivity was improved from-38.56 dBm to-44.77 dBm at 3.5 Mbps and from-37.12 dBm to-42.29 dBm at 5 Mbps.The proposed algorithm is crucial for future capture and tracking of signals at large dispersion angles and in underwater and long-distance communication scenarios.
文摘In vitro detection method for the sensitivity of Magnaporthe grisea to tricyclazole was studied, and the potential resistance risk of blast disease to tricyclazole was assessed. Both EC50 of hyphal melanization (EC50-H) and minimum inhibitive concentration of melanization in appressorial (MIC-A) by inhibitor tricyclazole showed positive correlation to the EC50 of tricyclazole against blast disease tested in vivo, with relative co-efficiency (R5) of 0.8995 and 0.8244, respectively. However, stability and reproducibility of EC50-H were better than those of MIC-A, suggesting that it could be used to detect the sensitivity of M. grisea to tricyclazole in vitro. Tricyclazole sensitivity of the progenies derived from single spores of the most sensitive isolate DY2 and the least sensitive isolate GY6 detected in sensitivity monitoring in 2000 was not stable, with mean EC50 values of 4.4968 μg/mL and 5.4010 ug/mL, respectively, indicating that the difference in EC50 between DY2 and GY6 was not caused probably by resistance variation. EC50 of GY6 did not increase significantly when continuously selected for twenty generations under the selection pressure of tricyclazole in vivo. However, the sensitivity of DY2 was decreased by 10-fold after selected for twenty generations. The results suggested that tricyclazole was still low resistance risk for M. grisea in China.
基金supported by Project of the Xi’an Science and Technology Innovation talent service enterprise project(No.2020KJRC0041)National Natural Science Foundation of China(No.62073256)Key Programs of Shaanxi Science and Technology Department(No.2020GY-125)。
文摘Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of view.This photoelectric detection target brings about the problem of uneven detection sensitivity distribution in the detection screen.To improve the uneven detection sensitivity of this photoelectric detection target,this paper analyzes the distribution law of the uneven detection sensitivity of the photoelectric detection target using the multi-element array photoelectric detector,dissects the main factors affecting the detection sensitivity according to the photoelectric detection principle,establishes the calculation model of detection sensitivity of the photoelectric detection target in the different detection areas and proposes a method to improve the detection sensitivity by compensating the gain of each unit photoelectric detector.The analysis of simulation and experimental results show that the proposed method of photoelectric detection target can effectively improve the output signal amplitude of the projectile under the certain detection distance,in particular,the output signal amplitude of the projectile is significantly increased when the projectile passes through the detection blind area.The experimental results are consistent with the simulation results,which verify the effectiveness of the proposed improvement method.
基金Project supported by the National Key R&D Program of China(Grant No.2017YFF0106302)the National Basic Research Program of of China(Grant No.2014CB339803)+1 种基金the National Natural Science Foundation of China(Grant Nos.61404150,61405233,and 61604161)the Shanghai Municipal Commission of Science and Technology,China(Grant Nos.15JC1403800,17ZR1448300,and 17YF1429900)
文摘We demonstrate a high performance GaAs/AlGaAs-based quantum-well photodetector(QWP)device with a peak response frequency of 4.3 THz.The negative differential resistance(NDR)phenomenon is found in the dark currentvoltage(I-V)curve in the current sweeping measurement mode,from which the breakdown voltage is determined.The photocurrent spectra and blackbody current responsivities at different voltages are measured.Based on the experimental data,the peak responsivity of 0.3 A/W(at 0.15 V,8 K)is derived,and the detection sensitivity is higher than 10^(11)Jones,which is in the similar level as that of the commercialized liquid-helium-cooled silicon bolometers.We attribute the high detection performance of the device to the small ohmic contact resistance of-2Ωand the big breakdown bias.
基金the National Natural Science Foundation of China(No.21075082)the National High Technology Research and Development Program(863) of China(No.2012AA020103)+3 种基金the Shanghai Nano Program(No.11nm0505600)the Shanghai Jiao Tong University Funding(No.YG2012ZD03)the 2012 Shanghai Jiao Tong University and University of Michigan Collaborative Research Projects(No.12X120010007)the Shanghai Municipal Education Commission Project(No.14ZZ023)
文摘Well-defined raspberry-like magnetic microbeads （RMMBs） as immunoassay solid carriers were pre- pared by chemicM covalent binding between Fe304 magnetic microspheres and SiO2 nanoparticles. These RMMBs were not as agglomerative as nano-sized magnetie particles （〈 200 nm）, which was an advangtage for high efficient magnetic separation. When compared to Fe304@SiO2 core-shell magnetic microbeads （CMMBs） with smooth surface, RMMBs exhibited stronger capacity to bind biomolecules. Limit of blank （LOB） and limit of detection （LoD） of HBsAg detection using RMMBs as carriers via chemiluminiscence immunoassay （CLIA） were 0.472 and 1.022 μg/L, respectively, showing a notable improvement compared with CMMBs whose LoB and LoD were 1.017 and 1.988 μg/L, respectively. All these indicated a great potential of RMMBs in immunoassay application.
基金support from the National Natural Science Foundation of China(Nos.22278281 and 21991101)Sichuan University(2020SCUNG112)
文摘Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable electronics.However,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high strains.Inspired by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic spinning.The microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal conversion.The microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good repeatability.The experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal conversion.By integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly constructed.The microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during phonation.This work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.
基金supported the National Key R&D Program of China(2019YFA0707003 and 2022YFC3400300 to J.R.)the Innovation Program of Chinese Academy of Agricultural Sciences.
文摘MicroRNAs(miRNAs)and short RNA fragments(18–25 nt)are crucial biomarkers in biological research and disease diagnostics.However,their accurate and rapid detection remains a challenge,largely due to their low abundance,short length,and sequence similarities.In this study,we report on a highly sensitive,one-step RNA O-circle amplification(ROA)assay for rapid and accurate miRNA detection.The ROA assay commences with the hybridization of a circular probe with the test RNA,followed by a linear rolling circle amplification(RCA)using dUTP.This amplification process is facilitated by U-nick reactions,which lead to an exponential amplification for readout.Under optimized conditions,assays can be completed within an hour,producing an amplification yield up to the microgram level,with a detection limit as low as 0.15 fmol(6 pM).Notably,the ROA assay requires only one step,and the results can be easily read visually,making it user-friendly.This ROA assay has proven effective in detecting various miRNAs and phage ssRNA.Overall,the ROA assay offers a user-friendly,rapid,and accurate solution for miRNA detection.
基金supported by the Project of tacking of key scientifi c and technical problems in Henan Province(192102310033)。
文摘This study employs an N-carboxyanhydride ring-opening polymerization(NCA ROP)signal amplification strategy to construct a novel sensing system for the simple and rapid detection of tobacco mosaic virus RNA(tRNA).In the developed fluorescent biosensor,carboxylated biomagnetic beads serve as carriers for target capture based on the complementary pairing of the aptamer bases.Subsequently,NCA ROP fluorescent peptides are utilized as highly biocompatible signal carriers to achieve sensitive detection of the target.Under the optimal conditions,the biosensor exhibits a broad linear detection range from 1 pM to 10 nM,with a detection limit as low as 0.085 pM.Furthermore,the fluorescent aptamer biosensor demonstrates robust affinity and reliability in recovery experiments involving healthy R ehmannia glutinosa leaf total RNA.This work establishes a robust platform for tRNA analysis,facilitating real-time and early diagnosis of various plant viruses.
