BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult....BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult.Identifying the factors associated with spinal infection and early intervention can reduce the occurrence of the disease.At present,the research mainly focuses on the accurate diagnosis and treatment of spinal infection,and there are few studies on the prevention of spinal infection.The concept of"preventive treatment of diseases"in traditional Chinese medicine may help identify the causes and reduce the occurrence of NOSI.AIM To determine the association of age,bowel movements,and sleep patterns with NOSI.METHODS Data of 69 NOSI patients and 84 healthy controls in a tertiary hospital from January 2019 to June 2024 were collected.Patients with NOSI had imaging evidence(magnetic resonance imaging)of spinal infections(including infections caused by tuberculosis,brucopathy,and other pathogens)and had no history of spinal surgery in the last 1 year were included in the analysis.Patients with spinalinfection due to spinal surgery are excluded in the study.Data including age,sex,place of residence,sleeping status,and bowel movements were collected.SPSS22.0 was used for correlation analysis of all data.RESULTS The mean age of the NOSI group and the control group was 63.55±14.635 years and 59.18±17.111 years,respectively,without statistical difference(P=0.096).There was also no statistically significant difference in gender between the two groups.In the NOSI group,45(65.22%)were over 60 years old,and 44(63.77%)were rural residents.Compared with the control group,the NOSI group had more patients with sleep disorder and defecation disorder,accounting for 69.57%and 68.12%,respectively,with significant statistical difference(both P<0.001).Regression analysis showed that defecation and sleep disorders were closely related to NOSI(both P<0.001).CONCLUSION Most patients with NOSI are older and have sleep disorders and abnormal defecation.展开更多
In this paper, we reviewed the developing history of delaying senility of acupunctureand moxibustion, summarized 41 reports about the effects of acupuncture and moxibustion on elderly,normal subject and the "defi...In this paper, we reviewed the developing history of delaying senility of acupunctureand moxibustion, summarized 41 reports about the effects of acupuncture and moxibustion on elderly,normal subject and the "deficiency syndrome" model animal, and expounded the rnechanisms in the aspects of immunology, endocrinology and biology. In addition, we also discussed the influence fac-tors and the developing trends of delaying senility of acupuncture and moxibustion in corning years.展开更多
The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic prote...The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins identified to date and is associated with a group of highly debilitating and life-threatening disorders called TTR amyloidosis(ATTR).ATTR comprises senile systemic amyloidosis,which is linked to wild-type(WT)TTR aggregation,and hereditary ATTR,a dominantly inherited disorder caused by the deposition of one of over 130 TTR genetic variants.Senile systemic amyloidosis is a prevalent age-related amyloidosis,affecting up to 25%of the population over 80 years of age,and is characterized by the build-up of TTR fibrils in the myocardium.Regarding hereditary ATTR,the clinical presentation is highly heterogeneous,primarily affecting the peripheral nervous system(familial amyloid polyneuropathy-FAP)or the heart(familial amyloid cardiomyopathy).In rare cases,aggregation develops in the central nervous system,giving rise to a phenotype known as familial leptomeningeal amyloidosis(Carroll et al.,2022).展开更多
Eighty elderly men with symptoms of senility due to deficiency syndrome of the Kidney,but otherwise healthy. were randomly divided into two groups. one group was treated with Wuzi YanzongSolution (WXYZS) and the other...Eighty elderly men with symptoms of senility due to deficiency syndrome of the Kidney,but otherwise healthy. were randomly divided into two groups. one group was treated with Wuzi YanzongSolution (WXYZS) and the other with a placebo, each for five weeks. Affer treatment, the symptoms ofsenility were arneliorated as judged by using a scoring method. the activity of the erythrocyte superoxidedismutase was increased. the plasma lipid peroxide content was reduced, the plasma testosterone levelwas raised and the plasma estradiol/testosterone ratio was decreased in the WZYZS group, while nochanges were noticed in the placebo group. The results suggest that WZYZS retards senility in the aged,probably through its action of eliminating free radicals, reducing plasma lipid peroxide levels, elevatingerythrocyte superoxide dismutase activity and regulating sex hormone levels.展开更多
Objective:To investigate the risk factors for deep vein thrombosis(DVT)following total hip arthroplasty in elderly patients with femoral neck fractures during the winter.Methods:A total of 162 patients who underwent t...Objective:To investigate the risk factors for deep vein thrombosis(DVT)following total hip arthroplasty in elderly patients with femoral neck fractures during the winter.Methods:A total of 162 patients who underwent total hip arthroplasty were categorized based on the development of DVT within 7 days postoperatively:28 patients formed the DVT group and 134 patients the non-DVT group.Collected data included age,gender,history of glucocorticoid use,diabetes,hypertension,body mass index(BMI),triglyceride(TG)levels,cholesterol(CHOL)levels at admission,operative time,and postoperative bed rest duration.D-dimer(D-D)and fibrinogen(Fg)levels,along with the D-D/Fg ratio,were recorded on the first postoperative day.Group comparisons were performed using t-tests.Logistic regression analysis was conducted to identify independent risk factors,and the predictive value of these factors was evaluated using receiver operating characteristic(ROC)curve analysis.Results:In the DVT group,18 patients had diabetes.Levels of TG(1.78±0.44 mmol/L),CHOL(4.70±1.84 mmol/L),D-D(0.40±0.17 mg/L),and the D-D/Fg ratio(0.24±0.07)were significantly higher than in the non-DVT group(P<0.05).Logistic regression identified TG,CHOL,D-D,and the D-D/Fg ratio as independent risk factors for DVT,with odds ratios of 0.987,2.395,0.8,4.992,and 9.004,respectively(P<0.05).ROC curve analysis yielded areas under the curve(AUCs)of 0.715,0.69,0.614,and 0.726 for TG,CHOL,D-D,and the D-D/Fg ratio,respectively.Sensitivities were 0.643,0.500,0.429,and 0.857,and specificities were 0.694,0.978,0.918,and 0.537,respectively.Conclusion:Elevated levels of TG,CHOL,D-D,and the D-D/Fg ratio are independent risk factors for DVT following total hip arthroplasty in elderly patients.Among these,the D-D/Fg ratio demonstrated the highest sensitivity and may serve as an effective marker for early-stage DVT screening.展开更多
Objective:To explore the application value of the extended nursing intervention mode in senile dementia patients.Methods:A total of 60 cases of Alzheimer’s disease patients were selected as the research subjects and ...Objective:To explore the application value of the extended nursing intervention mode in senile dementia patients.Methods:A total of 60 cases of Alzheimer’s disease patients were selected as the research subjects and divided using the random number table method into the control group and the observation group,each with 30 cases.The control group adopted conventional nursing,while the observation group adopted the extended nursing model of this study.The self-care ability,quality of life,cognitive function,and the frequency of unsafe behaviors were compared between the two groups.Results:After 6 months of intervention,the results showed that the scores of all dimensions in the relevant data tables such as the activity of daily living(ADL)scale,simple intelligence scale,and health survey scale in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The incidence of unsafe behaviors in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=5.963,P<0.05).Conclusion:Extended nursing plays a positive role in the nursing of Alzheimer’s patients,including improving their cognitive function and restoring their self-care ability,so as to significantly improve their quality of life and reduce the occurrence of unsafe behaviors.It can be seen that the extended nursing intervention mode can be vigorously promoted in clinical practice.展开更多
Fighting against mental deterioration in ageing lt’s commonly accepted by scientists that if the extension of life is possible,the secrets of senility must be uncovered.
One of the outstanding features of neuron is that axon lacks the ability to synthesize proteins. The structural and functional materials needed for axonal growing and regeneration have to be prepared in its cell body,...One of the outstanding features of neuron is that axon lacks the ability to synthesize proteins. The structural and functional materials needed for axonal growing and regeneration have to be prepared in its cell body, and then supplied by axoplasmic transport. In our previous work, we have found that the transport rate of some slow-transported proteins is accelerated during regeneration. Because some changes展开更多
Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by the deposition of amyloid-β(Aβ),neurofibrillary tangles,neuroinflammation,and neurodegeneration in the brain.In recent years,con...Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by the deposition of amyloid-β(Aβ),neurofibrillary tangles,neuroinflammation,and neurodegeneration in the brain.In recent years,considering the unsatisfied benefits of pharmacological therapies,non-pharmacological therapy has become a research hotspot for AD intervention.Terahertz(THz)waves with a range between microwave and infrared regions in the electromagnetic spectrum and high permeability to a wide range of materials have great potential in the bioengineering field.However,its biological impacts on the central nervous system,under either physiological or pathological conditions,are poorly investigated.In this study,we first measured the 0.14 THz waves penetration across the skull of a C57BL/6 mouse and found the percentage of THz penetration to be~70%,guaranteeing that THz waves can reach the relevant brain regions.We then exposed the APPSWE/PS1DE9 mouse model of AD to repeated low-frequency THz waves on the head.We demonstrated that THz waves treatment significantly improved the cognitive impairment and alleviated AD neuropathology including Aβdeposition and tau hyperphosphorylation in the AD mice.Moreover,THz waves treatment effectively attenuated mitochondrial impairment,neuroinflammation,and neuronal loss in the AD mouse brain.Our findings reveal previously unappreciated beneficial effects of THz waves treatment in AD and suggest that THz waves may have the potential to be used as a novel therapeutic intervention for this devastating disease.展开更多
Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron disease.There is currently no cure and approximately 90% of cases are sporadic.ALS share...Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron disease.There is currently no cure and approximately 90% of cases are sporadic.ALS shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile dementia.ALS and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).展开更多
BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after diagnosis.However,there is limited research on the stigma ...BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after diagnosis.However,there is limited research on the stigma experienced by these patients and the factors that may contribute to it.AIM To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing factors.METHODS A retrospective analysis was conducted using clinical data obtained from questionnaire surveys,interviews,and the medical records of older patients with leukemia admitted to the Hengyang Medical School from June 2020 to June 2023.The data obtained included participants’basic demographic information,medical history,leukemia type,family history of leukemia,average monthly family income,pension,and tendency to conceal illness.The Chinese versions of the Social Impact Scale(SIS),Perceived Social Support Scale(PSSS),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess indicators related to stigma,social support,and mental health status.We used Pearson’s correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale,and regression analysis to explore the factors related to the stigma of older patients with leukemia after diagnosis.RESULTS Data from 120 patients with leukemia aged 65-80 years were analyzed.The total score on the SIS and PSSS was 43.60±4.07 and 37.06±2.87,respectively.The SAS score was 58.35±8.32 and the SDS score was 60.58±5.97.The stigma experienced by older leukemia patients was negatively correlated with social support(r=-0.691,P<0.05)and positively correlated with anxiety and depression(r=0.506,0.382,P<0.05).Age,education level,smoking status,average monthly family income,pension,and tendency to conceal illness were significantly associated with the participants’level of stigma(P<0.05).Age,smoking status,social support,anxiety,and depression were predictive factors of stigmatization among older leukemia patients after diagnosis(all P<0.05),with a coefficient of determination(R2)of 0.644 and an adjusted R2 of 0.607.CONCLUSION Older patients commonly experience stigmatization after being diagnosed with leukemia.Factors such as age,smoking status,social support,and psychological well-being may influence older patients’reported experience of stigma.展开更多
Background:Both simvastatin and metformin have demonstrated potential efficacy in osteoporosis(OP)treatment.However,there is a lack of systematic studies comparing their anti-osteoporotic effects.This study aims to co...Background:Both simvastatin and metformin have demonstrated potential efficacy in osteoporosis(OP)treatment.However,there is a lack of systematic studies comparing their anti-osteoporotic effects.This study aims to compare the effects of simvastatin and metformin on OP through Mendelian randomization(MR)studies and animal experiments.Methods:Initially,we will analyze the causal impact of simvastatin or metformin treatment on OP prevalence and three common clinical OP diagnostic markers(bone mineral density(BMD),serum osteocalcin(OCN),and tartrate-resistant acid phosphatase(TRAP)levels)using genome-wide association study(GWAS)summary statistics.Additionally,we established animal models to further analyze and compare the anti-osteoporosis effects of simvastatin and metformin.8 male C57BL/6J mice(3-month-old)and 24 male C57BL/6J mice(18-month-old)were treated with simvastatin or metformin for 12 weeks.OP pathology was assessed using histology,immunohistochemistry,biomechanical tests,micro-computed tomography,and osteogenic differentiation assays.Results:In the MR analysis,metformin treatment was significantly associated with lower OP prevalence(OR(95%CI)=0.933(0.902–0.965),β=-0.0694,P<0.001)and higher BMD(OR(95%CI)=3.719(1.750–7.908),β=1.3136,P<0.001).In the animal experiment,both drugs increased bone mass,improved bone microstructure,and promoted osteoblast differentiation.However,metformin appeared more effective in several aspects.It significantly inhibited bone marrow adipocyte and osteoclast differentiation in aged mice compared to simvastatin.Additionally,metformin better promoted the expression of osteoprotegerin(OPG)and collagen type I(Col-I)in bone tissue and maintained the structure and biomechanical properties of cancellous bone.Conclusion:Both drugs significantly preserved bone homeostasis.Particularly,compared with simvastatin,metformin exhibited superior effects in inhibiting adipogenesis,enhancing the OPG/RANKL pathway,and promoting cancellous bone reconstruction.Metformin may serve as a valuable adjunct in preventing and treating OP in the elderly.展开更多
Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the...Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects.The patients were divided into two groups based on different treatment methods:the control group(treated with memantine hydrochloride,34 cases)and the treatment group(treated with sodium oligomannate+memantine hydrochloride,34 cases).Cognitive function,activities of daily living,neurotransmitters,serum intestinal flora metabolic markers,inflammatory factors,neurotrophic factors,and adverse reactions were compared between the two groups.Results:The treatment group showed better cognitive function,quality of life scores,and levels of relevant metabolic markers in the body compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions between the two groups(treatment group:2%;control group:4%)was not statistically significant(χ^(2)=0.731,P=0.393).Conclusion:Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia.It significantly improves and restores cognitive function and daily living abilities,benefits neurotransmitter secretion and internal regulation,upregulates the expression of neurotrophic factors,and has fewer adverse reactions,making it a treatment worthy of further clinical promotion and application.展开更多
Objective The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer’s disease （AD）. However,...Objective The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer’s disease （AD）. However, there remains an argument as to their importance in the onset of AD.Recent studies have shown that axonopathy is considered as an early stage of AD. However, the exact relationship between axonopathy and the origin and development of classic neuropathological changes such as senile plaques （SPs） and neurofibrillary tangles （NFTs） is unclear. The present study aimed to investigate this relationship. Methods Postmortem tracing, combined with the immunohistochemical or immunofluo-rescence staining, was used to detect axonopathy and the formation of SPs and NFTs. Results ＂Axonal leakage＂–a novel type of axonopathy, was usually accompanied with the extensive swollen axons and varicosities, and was associated with the origin and development of Aβ plaques and hyperphosphorylated tau in the brains of AD patients. Conclusion Axonopathy, particularly axonal leakage, might be a key event in the initiation of the neuropathological processes in AD.展开更多
AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previousl...AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function test.AM was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow eyes.RESULTS:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P【0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P【0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P【0.001).The more severity of amblyopia,the poorer levels of contrast sensitivity.Most pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously impaired.CONCLUSION:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.展开更多
Objective To compare the therapeutic effect differences of senile osteoarthritis treated by the combined therapy of acupuncture and Chinese medicine and western medication.Methods Eightytwo cases of senile osteoarthri...Objective To compare the therapeutic effect differences of senile osteoarthritis treated by the combined therapy of acupuncture and Chinese medicine and western medication.Methods Eightytwo cases of senile osteoarthritis were randomly divided into 2 groups.In observation group（42 cases）,puncture at Shènshū （肾俞 BL 23）,Yāoyángguān （腰阳关 GV 3）,Fēngchí（风池 GB 20） and Dàzhuī（大 椎 GV 14） etc.combining with Chinese medicine of Bushen Zhuanggu Decoction for oral administration was applied;in control group （40 cases）,routine western medicine was applied.Pain score and theraputic effect of both groups were observed before and after treatment.Results The total effective rate was 88.1%（37/42） in observation group,and 60.0%（24/40） in control group.The therapeutic effect in observation group was superior to that in control group （P0.01）.The pain score was improved by both therapies （P0.05,P0.01） after treatment,and the improvement in observation group was superior to that in control group （P0.05）.Conclusion The therapeutic effect of senile osteoarthritis by combined therapy of both acupuncture and Bushen Zhuanggu Decoction for oral administration is superior to that by western medication.展开更多
The purpose of this study is to determine whether advancing age andheart failure are independent predictors of increased mortality afrer acutemyocardial infarction(AMI)We reviewed the clinical data of 1068 in-patients...The purpose of this study is to determine whether advancing age andheart failure are independent predictors of increased mortality afrer acutemyocardial infarction(AMI)We reviewed the clinical data of 1068 in-patients(344 senile/724 nonsenile)with AMI.The results showed atypicalpresentations of infarction-related symptoms in the elderly are common,with consequent delay in the diagnosis and treatment The elderly patientshad a high proportion of systemic hypertension(43.9%),non Q wave AM/(36%)and heart failure(35.5%),On the contrast,the proportion of that innonsenile patients were 33%,8Vo and 16.4% respectively.In elderlypatients,several complications:of AMI are more common,asinterventricular septum perforation(2%),cardiogenic shock(19.8%),arthythmia(61.9%).Heart failure was more frequent in patients with leftventricular ejection fraction(LVEF)≤35%,previous heart failure ormyocardial infarction,and anterior location infarction.Those with severecongestive heart failure had a mortality of 33.2% compared with 24.5% forthose with moderate heart failure and 13.51% for those with no heart failurein the first eight weeks.The following factors were associated with anincreased risk of death:older age,longer delay before admission to hospital,no prescription of beta-blaekers and a previous history of infarctionOur data suggested that the prognosis after AMI was directly related toadvaneeing age and the severity of congestive heart failure.Thedevelopment of congestive heart failure was an independent predictor ofdeath.The increasing incidence and mortality were closely related toimpaired myocardial reserve.The present benefits,as pointed out by therecent progress in AMI therapy,must be employed in the treatment of olderinfarcted patients More aggressive management in elderly patients shouldoe evaluated for its potential to reduce mortality.展开更多
The present paper reports a clinical observation of the effect of health-preservingmoxibustion in the aged people without apparent organic diseases. Results show that the health-preserving moxibustion has an evident a...The present paper reports a clinical observation of the effect of health-preservingmoxibustion in the aged people without apparent organic diseases. Results show that the health-preserving moxibustion has an evident action in lessening aging symptoms and improving physio-logic functions of the senile body. It is held in traditional Chinese medicine that from the middle-aged period on, the decline of kidney Qi is an important cause of senility and deficiency of thespleen and blood stasis also play a role in some degree. Health-preserving moxibustion ofShenque and Zusanli has actions in warming Yang, reinforcing Qi and promoting blood circulationto remove obstruction in meridians. It is thus a method for self health protection.展开更多
文摘BACKGROUND Non-operative spinal infections(NOSI)are caused by tuberculosis,brucella,and other specific bacteria.The etiology of the disease is insidious,the onset is slow and the diagnosis and treatment are difficult.Identifying the factors associated with spinal infection and early intervention can reduce the occurrence of the disease.At present,the research mainly focuses on the accurate diagnosis and treatment of spinal infection,and there are few studies on the prevention of spinal infection.The concept of"preventive treatment of diseases"in traditional Chinese medicine may help identify the causes and reduce the occurrence of NOSI.AIM To determine the association of age,bowel movements,and sleep patterns with NOSI.METHODS Data of 69 NOSI patients and 84 healthy controls in a tertiary hospital from January 2019 to June 2024 were collected.Patients with NOSI had imaging evidence(magnetic resonance imaging)of spinal infections(including infections caused by tuberculosis,brucopathy,and other pathogens)and had no history of spinal surgery in the last 1 year were included in the analysis.Patients with spinalinfection due to spinal surgery are excluded in the study.Data including age,sex,place of residence,sleeping status,and bowel movements were collected.SPSS22.0 was used for correlation analysis of all data.RESULTS The mean age of the NOSI group and the control group was 63.55±14.635 years and 59.18±17.111 years,respectively,without statistical difference(P=0.096).There was also no statistically significant difference in gender between the two groups.In the NOSI group,45(65.22%)were over 60 years old,and 44(63.77%)were rural residents.Compared with the control group,the NOSI group had more patients with sleep disorder and defecation disorder,accounting for 69.57%and 68.12%,respectively,with significant statistical difference(both P<0.001).Regression analysis showed that defecation and sleep disorders were closely related to NOSI(both P<0.001).CONCLUSION Most patients with NOSI are older and have sleep disorders and abnormal defecation.
文摘In this paper, we reviewed the developing history of delaying senility of acupunctureand moxibustion, summarized 41 reports about the effects of acupuncture and moxibustion on elderly,normal subject and the "deficiency syndrome" model animal, and expounded the rnechanisms in the aspects of immunology, endocrinology and biology. In addition, we also discussed the influence fac-tors and the developing trends of delaying senility of acupuncture and moxibustion in corning years.
基金funded by the Spanish Ministry of Science and Innovation(PDC2021-120914-I00)the Universitat Autònoma de Barcelona(PROOF OF CONCEPT 2020)ICREA,ICREA-Academia 2015 and 2020(to SV).
文摘The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins identified to date and is associated with a group of highly debilitating and life-threatening disorders called TTR amyloidosis(ATTR).ATTR comprises senile systemic amyloidosis,which is linked to wild-type(WT)TTR aggregation,and hereditary ATTR,a dominantly inherited disorder caused by the deposition of one of over 130 TTR genetic variants.Senile systemic amyloidosis is a prevalent age-related amyloidosis,affecting up to 25%of the population over 80 years of age,and is characterized by the build-up of TTR fibrils in the myocardium.Regarding hereditary ATTR,the clinical presentation is highly heterogeneous,primarily affecting the peripheral nervous system(familial amyloid polyneuropathy-FAP)or the heart(familial amyloid cardiomyopathy).In rare cases,aggregation develops in the central nervous system,giving rise to a phenotype known as familial leptomeningeal amyloidosis(Carroll et al.,2022).
文摘Eighty elderly men with symptoms of senility due to deficiency syndrome of the Kidney,but otherwise healthy. were randomly divided into two groups. one group was treated with Wuzi YanzongSolution (WXYZS) and the other with a placebo, each for five weeks. Affer treatment, the symptoms ofsenility were arneliorated as judged by using a scoring method. the activity of the erythrocyte superoxidedismutase was increased. the plasma lipid peroxide content was reduced, the plasma testosterone levelwas raised and the plasma estradiol/testosterone ratio was decreased in the WZYZS group, while nochanges were noticed in the placebo group. The results suggest that WZYZS retards senility in the aged,probably through its action of eliminating free radicals, reducing plasma lipid peroxide levels, elevatingerythrocyte superoxide dismutase activity and regulating sex hormone levels.
基金supported by grants from the Youth TCM scientific research Project of Heilongjiang Province TCM Administration(ZHY2024-283)the Health and Family Planning Commission of Heilongjiang Province(20240404070039)+1 种基金Heilongjiang Postdoctoral Fund(NO.LBH-Z23257)the Innovative Science Research Fund of Harbin Medical University(also known as Heilongjiang Provincial University's Project of Graduate Scientific Research Business Fees)(2024,Xin Zhang)and the Postdoctoral Program of Heilongjiang Province(NO.LBH-Z23234).
文摘Objective:To investigate the risk factors for deep vein thrombosis(DVT)following total hip arthroplasty in elderly patients with femoral neck fractures during the winter.Methods:A total of 162 patients who underwent total hip arthroplasty were categorized based on the development of DVT within 7 days postoperatively:28 patients formed the DVT group and 134 patients the non-DVT group.Collected data included age,gender,history of glucocorticoid use,diabetes,hypertension,body mass index(BMI),triglyceride(TG)levels,cholesterol(CHOL)levels at admission,operative time,and postoperative bed rest duration.D-dimer(D-D)and fibrinogen(Fg)levels,along with the D-D/Fg ratio,were recorded on the first postoperative day.Group comparisons were performed using t-tests.Logistic regression analysis was conducted to identify independent risk factors,and the predictive value of these factors was evaluated using receiver operating characteristic(ROC)curve analysis.Results:In the DVT group,18 patients had diabetes.Levels of TG(1.78±0.44 mmol/L),CHOL(4.70±1.84 mmol/L),D-D(0.40±0.17 mg/L),and the D-D/Fg ratio(0.24±0.07)were significantly higher than in the non-DVT group(P<0.05).Logistic regression identified TG,CHOL,D-D,and the D-D/Fg ratio as independent risk factors for DVT,with odds ratios of 0.987,2.395,0.8,4.992,and 9.004,respectively(P<0.05).ROC curve analysis yielded areas under the curve(AUCs)of 0.715,0.69,0.614,and 0.726 for TG,CHOL,D-D,and the D-D/Fg ratio,respectively.Sensitivities were 0.643,0.500,0.429,and 0.857,and specificities were 0.694,0.978,0.918,and 0.537,respectively.Conclusion:Elevated levels of TG,CHOL,D-D,and the D-D/Fg ratio are independent risk factors for DVT following total hip arthroplasty in elderly patients.Among these,the D-D/Fg ratio demonstrated the highest sensitivity and may serve as an effective marker for early-stage DVT screening.
文摘Objective:To explore the application value of the extended nursing intervention mode in senile dementia patients.Methods:A total of 60 cases of Alzheimer’s disease patients were selected as the research subjects and divided using the random number table method into the control group and the observation group,each with 30 cases.The control group adopted conventional nursing,while the observation group adopted the extended nursing model of this study.The self-care ability,quality of life,cognitive function,and the frequency of unsafe behaviors were compared between the two groups.Results:After 6 months of intervention,the results showed that the scores of all dimensions in the relevant data tables such as the activity of daily living(ADL)scale,simple intelligence scale,and health survey scale in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The incidence of unsafe behaviors in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=5.963,P<0.05).Conclusion:Extended nursing plays a positive role in the nursing of Alzheimer’s patients,including improving their cognitive function and restoring their self-care ability,so as to significantly improve their quality of life and reduce the occurrence of unsafe behaviors.It can be seen that the extended nursing intervention mode can be vigorously promoted in clinical practice.
文摘Fighting against mental deterioration in ageing lt’s commonly accepted by scientists that if the extension of life is possible,the secrets of senility must be uncovered.
文摘One of the outstanding features of neuron is that axon lacks the ability to synthesize proteins. The structural and functional materials needed for axonal growing and regeneration have to be prepared in its cell body, and then supplied by axoplasmic transport. In our previous work, we have found that the transport rate of some slow-transported proteins is accelerated during regeneration. Because some changes
基金supported by the National Natural Science Foundation of China(32220103006 and 82271524).
文摘Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by the deposition of amyloid-β(Aβ),neurofibrillary tangles,neuroinflammation,and neurodegeneration in the brain.In recent years,considering the unsatisfied benefits of pharmacological therapies,non-pharmacological therapy has become a research hotspot for AD intervention.Terahertz(THz)waves with a range between microwave and infrared regions in the electromagnetic spectrum and high permeability to a wide range of materials have great potential in the bioengineering field.However,its biological impacts on the central nervous system,under either physiological or pathological conditions,are poorly investigated.In this study,we first measured the 0.14 THz waves penetration across the skull of a C57BL/6 mouse and found the percentage of THz penetration to be~70%,guaranteeing that THz waves can reach the relevant brain regions.We then exposed the APPSWE/PS1DE9 mouse model of AD to repeated low-frequency THz waves on the head.We demonstrated that THz waves treatment significantly improved the cognitive impairment and alleviated AD neuropathology including Aβdeposition and tau hyperphosphorylation in the AD mice.Moreover,THz waves treatment effectively attenuated mitochondrial impairment,neuroinflammation,and neuronal loss in the AD mouse brain.Our findings reveal previously unappreciated beneficial effects of THz waves treatment in AD and suggest that THz waves may have the potential to be used as a novel therapeutic intervention for this devastating disease.
基金supported by grants from the UK Medical Research Council (MR/R022666/1)Alzheimer’s Disease Society (AlzSoc-28 7)+4 种基金Alzheimer’s Research UK (ARUK-PG2017B-3 and ARUK-DC2019-009) to CCJMa Motor Neurone Disease Association Fellowship to PGS and a King’s College Guy’s and St Thomas’s studentship to NHPGSis supported by an MSCA-Sealof Excellence-HEALTH fellowship (IHMC22/00025) from the Instituto de Salud CarlosⅢ(ISCⅢ)funded by the"Mecanismo para la Recuperacion y la Resiliencia"(MRR) program from The NextGenerationEU funds (European Union)by Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas-lnstituto de Salud CarlosⅢ(CIBER-CIBERNED-ISCⅢ)(CB06/05/0041)。
文摘Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron disease.There is currently no cure and approximately 90% of cases are sporadic.ALS shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile dementia.ALS and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).
文摘BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after diagnosis.However,there is limited research on the stigma experienced by these patients and the factors that may contribute to it.AIM To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing factors.METHODS A retrospective analysis was conducted using clinical data obtained from questionnaire surveys,interviews,and the medical records of older patients with leukemia admitted to the Hengyang Medical School from June 2020 to June 2023.The data obtained included participants’basic demographic information,medical history,leukemia type,family history of leukemia,average monthly family income,pension,and tendency to conceal illness.The Chinese versions of the Social Impact Scale(SIS),Perceived Social Support Scale(PSSS),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess indicators related to stigma,social support,and mental health status.We used Pearson’s correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale,and regression analysis to explore the factors related to the stigma of older patients with leukemia after diagnosis.RESULTS Data from 120 patients with leukemia aged 65-80 years were analyzed.The total score on the SIS and PSSS was 43.60±4.07 and 37.06±2.87,respectively.The SAS score was 58.35±8.32 and the SDS score was 60.58±5.97.The stigma experienced by older leukemia patients was negatively correlated with social support(r=-0.691,P<0.05)and positively correlated with anxiety and depression(r=0.506,0.382,P<0.05).Age,education level,smoking status,average monthly family income,pension,and tendency to conceal illness were significantly associated with the participants’level of stigma(P<0.05).Age,smoking status,social support,anxiety,and depression were predictive factors of stigmatization among older leukemia patients after diagnosis(all P<0.05),with a coefficient of determination(R2)of 0.644 and an adjusted R2 of 0.607.CONCLUSION Older patients commonly experience stigmatization after being diagnosed with leukemia.Factors such as age,smoking status,social support,and psychological well-being may influence older patients’reported experience of stigma.
基金funded by the Applied Basic Research Foundation of Tianjin(22JCQNJC00230)the Beijing-Tianjin-Hebei Basic Research Cooperation Project(23JCZXJC00050/J230007)the Tianjin Health and Technology Project(TJWJ2024QN056)。
文摘Background:Both simvastatin and metformin have demonstrated potential efficacy in osteoporosis(OP)treatment.However,there is a lack of systematic studies comparing their anti-osteoporotic effects.This study aims to compare the effects of simvastatin and metformin on OP through Mendelian randomization(MR)studies and animal experiments.Methods:Initially,we will analyze the causal impact of simvastatin or metformin treatment on OP prevalence and three common clinical OP diagnostic markers(bone mineral density(BMD),serum osteocalcin(OCN),and tartrate-resistant acid phosphatase(TRAP)levels)using genome-wide association study(GWAS)summary statistics.Additionally,we established animal models to further analyze and compare the anti-osteoporosis effects of simvastatin and metformin.8 male C57BL/6J mice(3-month-old)and 24 male C57BL/6J mice(18-month-old)were treated with simvastatin or metformin for 12 weeks.OP pathology was assessed using histology,immunohistochemistry,biomechanical tests,micro-computed tomography,and osteogenic differentiation assays.Results:In the MR analysis,metformin treatment was significantly associated with lower OP prevalence(OR(95%CI)=0.933(0.902–0.965),β=-0.0694,P<0.001)and higher BMD(OR(95%CI)=3.719(1.750–7.908),β=1.3136,P<0.001).In the animal experiment,both drugs increased bone mass,improved bone microstructure,and promoted osteoblast differentiation.However,metformin appeared more effective in several aspects.It significantly inhibited bone marrow adipocyte and osteoclast differentiation in aged mice compared to simvastatin.Additionally,metformin better promoted the expression of osteoprotegerin(OPG)and collagen type I(Col-I)in bone tissue and maintained the structure and biomechanical properties of cancellous bone.Conclusion:Both drugs significantly preserved bone homeostasis.Particularly,compared with simvastatin,metformin exhibited superior effects in inhibiting adipogenesis,enhancing the OPG/RANKL pathway,and promoting cancellous bone reconstruction.Metformin may serve as a valuable adjunct in preventing and treating OP in the elderly.
基金Clinical Special Project of Fujian University of Traditional Chinese Medicine(Project Number:XB2023027)。
文摘Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects.The patients were divided into two groups based on different treatment methods:the control group(treated with memantine hydrochloride,34 cases)and the treatment group(treated with sodium oligomannate+memantine hydrochloride,34 cases).Cognitive function,activities of daily living,neurotransmitters,serum intestinal flora metabolic markers,inflammatory factors,neurotrophic factors,and adverse reactions were compared between the two groups.Results:The treatment group showed better cognitive function,quality of life scores,and levels of relevant metabolic markers in the body compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions between the two groups(treatment group:2%;control group:4%)was not statistically significant(χ^(2)=0.731,P=0.393).Conclusion:Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia.It significantly improves and restores cognitive function and daily living abilities,benefits neurotransmitter secretion and internal regulation,upregulates the expression of neurotrophic factors,and has fewer adverse reactions,making it a treatment worthy of further clinical promotion and application.
基金supported by an"Excellent Project"of the China Ministry of Human Resources for Return Overseas Chinese Scholarshippartly by the Research Foundation for"Key Laboratory of Neu-roscience and Neuroengineering"of South-Central University for Nationalities(No.XJS09001)the National Natural Science Foundation of China(No.31070961)
文摘Objective The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer’s disease （AD）. However, there remains an argument as to their importance in the onset of AD.Recent studies have shown that axonopathy is considered as an early stage of AD. However, the exact relationship between axonopathy and the origin and development of classic neuropathological changes such as senile plaques （SPs） and neurofibrillary tangles （NFTs） is unclear. The present study aimed to investigate this relationship. Methods Postmortem tracing, combined with the immunohistochemical or immunofluo-rescence staining, was used to detect axonopathy and the formation of SPs and NFTs. Results ＂Axonal leakage＂–a novel type of axonopathy, was usually accompanied with the extensive swollen axons and varicosities, and was associated with the origin and development of Aβ plaques and hyperphosphorylated tau in the brains of AD patients. Conclusion Axonopathy, particularly axonal leakage, might be a key event in the initiation of the neuropathological processes in AD.
基金Zhejiang Province Science Foundation of Health Bureau of China(No.2012KYA102)
文摘AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function test.AM was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow eyes.RESULTS:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P【0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P【0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P【0.001).The more severity of amblyopia,the poorer levels of contrast sensitivity.Most pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously impaired.CONCLUSION:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.
文摘Objective To compare the therapeutic effect differences of senile osteoarthritis treated by the combined therapy of acupuncture and Chinese medicine and western medication.Methods Eightytwo cases of senile osteoarthritis were randomly divided into 2 groups.In observation group（42 cases）,puncture at Shènshū （肾俞 BL 23）,Yāoyángguān （腰阳关 GV 3）,Fēngchí（风池 GB 20） and Dàzhuī（大 椎 GV 14） etc.combining with Chinese medicine of Bushen Zhuanggu Decoction for oral administration was applied;in control group （40 cases）,routine western medicine was applied.Pain score and theraputic effect of both groups were observed before and after treatment.Results The total effective rate was 88.1%（37/42） in observation group,and 60.0%（24/40） in control group.The therapeutic effect in observation group was superior to that in control group （P0.01）.The pain score was improved by both therapies （P0.05,P0.01） after treatment,and the improvement in observation group was superior to that in control group （P0.05）.Conclusion The therapeutic effect of senile osteoarthritis by combined therapy of both acupuncture and Bushen Zhuanggu Decoction for oral administration is superior to that by western medication.
文摘The purpose of this study is to determine whether advancing age andheart failure are independent predictors of increased mortality afrer acutemyocardial infarction(AMI)We reviewed the clinical data of 1068 in-patients(344 senile/724 nonsenile)with AMI.The results showed atypicalpresentations of infarction-related symptoms in the elderly are common,with consequent delay in the diagnosis and treatment The elderly patientshad a high proportion of systemic hypertension(43.9%),non Q wave AM/(36%)and heart failure(35.5%),On the contrast,the proportion of that innonsenile patients were 33%,8Vo and 16.4% respectively.In elderlypatients,several complications:of AMI are more common,asinterventricular septum perforation(2%),cardiogenic shock(19.8%),arthythmia(61.9%).Heart failure was more frequent in patients with leftventricular ejection fraction(LVEF)≤35%,previous heart failure ormyocardial infarction,and anterior location infarction.Those with severecongestive heart failure had a mortality of 33.2% compared with 24.5% forthose with moderate heart failure and 13.51% for those with no heart failurein the first eight weeks.The following factors were associated with anincreased risk of death:older age,longer delay before admission to hospital,no prescription of beta-blaekers and a previous history of infarctionOur data suggested that the prognosis after AMI was directly related toadvaneeing age and the severity of congestive heart failure.Thedevelopment of congestive heart failure was an independent predictor ofdeath.The increasing incidence and mortality were closely related toimpaired myocardial reserve.The present benefits,as pointed out by therecent progress in AMI therapy,must be employed in the treatment of olderinfarcted patients More aggressive management in elderly patients shouldoe evaluated for its potential to reduce mortality.
文摘The present paper reports a clinical observation of the effect of health-preservingmoxibustion in the aged people without apparent organic diseases. Results show that the health-preserving moxibustion has an evident action in lessening aging symptoms and improving physio-logic functions of the senile body. It is held in traditional Chinese medicine that from the middle-aged period on, the decline of kidney Qi is an important cause of senility and deficiency of thespleen and blood stasis also play a role in some degree. Health-preserving moxibustion ofShenque and Zusanli has actions in warming Yang, reinforcing Qi and promoting blood circulationto remove obstruction in meridians. It is thus a method for self health protection.
