Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor therapy.However,effective regulation of PTT and PDT with optimal synergistic effects remains a challenge.To dat...Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor therapy.However,effective regulation of PTT and PDT with optimal synergistic effects remains a challenge.To date,there are only a few synergistic PTT and PDT methods with suitable collaborative effects due to the rarity of efficient nanoplatforms with good cascading properties.To overcome this limitation,a proof-of-concept of self-cascade PTT and PDT was developed for hypoxia-reversible tumor therapy.With the assembly of dimeric indocyanine green(DICG)with oxygen nanobubbles(O_(2)-NBs),DICG/O_(2)-NBs typically exhibit J-aggregates for significant PTT effects,with a high photothermal conversion efficiency of 51.45% under 880 nm light irradiation.Interestingly,the PTT performance of DICG/O_(2)-NBs can switch J-aggregates of DICG into DICG monomers with efficient O_(2) gas liberation,while producing hydroxyl radicals for type Ⅰ PDT.Additionally,the evolved DICG monomer reacts with the released O_(2) to generate plenty of 1O_(2) for efficient type Ⅱ PDT.With these advantages,the cascaded nanoplatform achieves good tumor targeting and biocompatibility,and thus has high tumor inhibition of 94.26%,with an obvious ability to reverse hypoxia.This work demonstrates the efficiency of self-cascade PTT and PDT nanomedicine for high-performance hypoxia-reversible tumor ablation,thus providing a new approach for the development of cascading phototheranostics in vivo.展开更多
The self-cascade(SC) method is an effective technique for chaos enhancement and complexity increasing in chaos maps.Additionally, the controllable self-cascade(CSC) method allows for more accurate control of Lyapunov ...The self-cascade(SC) method is an effective technique for chaos enhancement and complexity increasing in chaos maps.Additionally, the controllable self-cascade(CSC) method allows for more accurate control of Lyapunov exponents of the discrete map. In this work, the SC and CSC systems of the original map are derived, which enhance the chaotic performance while preserving the fundamental dynamical characteristics of the original map. Higher Lyapunov exponent of chaotic sequences corresponding to higher frequency are obtained in SC and CSC systems. Meanwhile, the Lyapunov exponent could be linearly controlled with greater flexibility in the CSC system. The verification of the numerical simulation and theoretical analysis is carried out based on the platform of CH32.展开更多
Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/pr...Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/promotion of wound healing combined treatment.Herein,we propose CS/MnO_(2)-GO_x (CMGO_x)nanocatalysts for the specific catalytic generation of ~·OH to inhibit tumors and bacteria in a hyperglycemic environment.The good biocompatible chitosan (CS),as a carrier for the catalyst,exhibits excellent antibacterial effect as well as promotes wound healing.Glucose oxidase (GO_x) is loaded on the surface of CS nanoparticles to generate H_(2)O_(2) and gluconic acid by consuming glucose (starvation therapy,ST) and O_(2).The MnO_(2) depletes glutathione (GSH) to produce Mn^(2+),amplifying oxidative stress and further promoting the activity of Mn^(2+)-mediated Fenton-like reaction to produce~·OH (chemodynamic therapy,CDT)in weak acidic environment.Moreover,the produced gluconic acid lowers the p H of the environment,enhancing chemodynamic therapy (ECDT).The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT.The MnO_(2) nanoparticles at neutral environment decomposes H_(2)O_(2) into O_(2),which cooperate with CS to promote healing.The self-enhanced cascade reaction of CMGO_x in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing,offering a promising integrated treatment for diabetic patients after tumor surgical resection.展开更多
基金supported by the National Key R&D Program of China(No.2023YFF0713600)the National Natural Science Foundation of China(Nos.62375138,and 52173135)+3 种基金the National Natural Science Innovative Research Group Project(No.61821002)the Frontier Fundamental Research Program of Jiangsu Province for Leading Technology(No.BK 20222002)the Natural Science Foundation of Jiangsu Province(No.BK 20231523)Jiangsu Specially Appointed Professorship.
文摘Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor therapy.However,effective regulation of PTT and PDT with optimal synergistic effects remains a challenge.To date,there are only a few synergistic PTT and PDT methods with suitable collaborative effects due to the rarity of efficient nanoplatforms with good cascading properties.To overcome this limitation,a proof-of-concept of self-cascade PTT and PDT was developed for hypoxia-reversible tumor therapy.With the assembly of dimeric indocyanine green(DICG)with oxygen nanobubbles(O_(2)-NBs),DICG/O_(2)-NBs typically exhibit J-aggregates for significant PTT effects,with a high photothermal conversion efficiency of 51.45% under 880 nm light irradiation.Interestingly,the PTT performance of DICG/O_(2)-NBs can switch J-aggregates of DICG into DICG monomers with efficient O_(2) gas liberation,while producing hydroxyl radicals for type Ⅰ PDT.Additionally,the evolved DICG monomer reacts with the released O_(2) to generate plenty of 1O_(2) for efficient type Ⅱ PDT.With these advantages,the cascaded nanoplatform achieves good tumor targeting and biocompatibility,and thus has high tumor inhibition of 94.26%,with an obvious ability to reverse hypoxia.This work demonstrates the efficiency of self-cascade PTT and PDT nanomedicine for high-performance hypoxia-reversible tumor ablation,thus providing a new approach for the development of cascading phototheranostics in vivo.
基金supported by the National Natural Science Foundation of China (Grant No. 61871230)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘The self-cascade(SC) method is an effective technique for chaos enhancement and complexity increasing in chaos maps.Additionally, the controllable self-cascade(CSC) method allows for more accurate control of Lyapunov exponents of the discrete map. In this work, the SC and CSC systems of the original map are derived, which enhance the chaotic performance while preserving the fundamental dynamical characteristics of the original map. Higher Lyapunov exponent of chaotic sequences corresponding to higher frequency are obtained in SC and CSC systems. Meanwhile, the Lyapunov exponent could be linearly controlled with greater flexibility in the CSC system. The verification of the numerical simulation and theoretical analysis is carried out based on the platform of CH32.
基金supported by the Laboratory Animal Welfare and Ethics Committee of the Clinical Center of Shanghai First People's Hospital (No. 2020AWS0065)financially supported by the National Natural Science Foundation of China (Nos. 21978165, 92156020)+1 种基金Science and Technology Commission of Shanghai (No. 20DZ2255900)Class Ⅲ Peak Discipline of Shanghai—Materials Science and Engineering (High-Energy Beam Intelligent Processing and Green Manufacturing)。
文摘Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/promotion of wound healing combined treatment.Herein,we propose CS/MnO_(2)-GO_x (CMGO_x)nanocatalysts for the specific catalytic generation of ~·OH to inhibit tumors and bacteria in a hyperglycemic environment.The good biocompatible chitosan (CS),as a carrier for the catalyst,exhibits excellent antibacterial effect as well as promotes wound healing.Glucose oxidase (GO_x) is loaded on the surface of CS nanoparticles to generate H_(2)O_(2) and gluconic acid by consuming glucose (starvation therapy,ST) and O_(2).The MnO_(2) depletes glutathione (GSH) to produce Mn^(2+),amplifying oxidative stress and further promoting the activity of Mn^(2+)-mediated Fenton-like reaction to produce~·OH (chemodynamic therapy,CDT)in weak acidic environment.Moreover,the produced gluconic acid lowers the p H of the environment,enhancing chemodynamic therapy (ECDT).The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT.The MnO_(2) nanoparticles at neutral environment decomposes H_(2)O_(2) into O_(2),which cooperate with CS to promote healing.The self-enhanced cascade reaction of CMGO_x in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing,offering a promising integrated treatment for diabetic patients after tumor surgical resection.
