Empirical evidence suggests that the stability of personality itself contributes to successful ageing and is associated with longer life. The aim of this study was to investigate the association between personality tr...Empirical evidence suggests that the stability of personality itself contributes to successful ageing and is associated with longer life. The aim of this study was to investigate the association between personality traits and the self-perceived health status, stratified by medical conditions in a representative sample of non-institutionalized elderly people in Chile. The data used for this study come from the fourth waves (2009) of the Chilean Social Protection Survey (SPS-2009). Included were a total of 2655 subjects aged 65 and over. The results showed that higher scores of all five personality factors were associated with good health. Those with the perception of poor health were more likely to be female, with lower education level and older than those with good health. With the exception of agreeableness, strong and significant associations with self-perceived health were demonstrated for extraversion, conscientiousness, emotional stability and openness, among elderly with medical conditions. Among elderly without medical problems, significant associations with self-perceived health were demonstrated only for extraversion, agreeableness and emotional stability. This study has shown that there is a consistent association between personality factors and self-perceived health throughout the older population. Our results suggest that extraversion and openness traits could be acting as “protector” factors and agreeableness and conscientiousness traits as “resilient” factors, facing to the health problems among elderly people.展开更多
BACKGROUND Lung resection represents the main curative treatment modality of non-small cell lung cancer.Patients with high-risk to develop postoperative pulmonary complications have been classified as“high-risk patie...BACKGROUND Lung resection represents the main curative treatment modality of non-small cell lung cancer.Patients with high-risk to develop postoperative pulmonary complications have been classified as“high-risk patients.”Characterizing this population could be important to improve their approach and rehabilitation.AIM To identify the differences between high and low-risk patients in exercise capacity and self-perceived health status after hospitalization.METHODS A longitudinal observational prospective cohort study was carried out.Patients undergoing lung resection were recruited from the“Hospital Virgen de las Nieves”(Granada)and divided into two groups according to the risk profile criteria(age≥70 years,forced expiratory volume in 1 s≤70%predicted,carbon monoxide diffusion capacity≤70%predicted or scheduled pneumonectomy).Outcomes included were exercise capacity(Fatigue Severity Scale,Unsupported Upper-Limb Exercise,handgrip dynamometry,Five Sit-to-stand test,and quadriceps hand-held dynamometry)and patient-reported outcome(Euroqol-5 dimensions 5 Levels Visual Analogue Scale).RESULTS In total,115 participants were included in the study and divided into three groups:high-risk,low-risk and control group.At discharge high-risk patients presented a poorer exercise capacity and a worse self-perceived health status(P<0.05).One month after discharge patients in the high-risk group maintained these differences compared to the other groups.CONCLUSION Our results show a poorer recovery in high-risk patients at discharge and 1 mo after surgery,with lower self-perceived health status and a poorer upper and lower limb exercise capacity.These results are important in the rehabilitation field.展开更多
BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receivi...BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receiving maintenance hemodia-lysis(MHD)is limited.AIM To investigate the correlation between anxiety,depression,SPB,and PR in pati-ents with CRF on MHD.METHODS This study included 225 patients with CRF on MHD who were admitted between June 2021 and June 2024.The anxiety level was evaluated using the Self-Rating Anxiety Scale(SAS);the depression status was assessed using the Self-Rating Depression Scale(SDS);the SPB was measured using the SPB Scale(SPBS);and the PR was determined using the Connor–Davidson Resilience Scale(CD-RISC).The correlations among the SAS,SDS,SPB,and CD-RISC were analyzed using Pearson’s correlation coefficients.Univariate and multivariate analyses were performed to identify the factors that influence the PR of patients with CRF on MHD.RESULTS The SAS,SDS,SPB,and CD-RISC scores of the 225 patients were 45.25±15.36,54.81±14.68,32.31±11.52,and 66.48±9.18,respectively.Significant negative correlations were observed between SAS,SDS,SPB,and CD-RISC.Furthermore,longer dialysis vintage(P=0.015),the absence of religious beliefs(P=0.020),lower monthly income(P=0.008),higher SAS score(P=0.013),and higher SDS score(P=0.006)were all independent factors that adversely affected the PR of patients with CRF on MHD.CONCLUSION Patients with CRF on MHD present with varying degrees of anxiety,depression,and SPB,all of which exhibit a significant negative correlation with their PR.Moreover,longer dialysis vintage,the absence of religious beliefs,lower monthly income,higher SAS score,and higher SDS score were factors that negatively affected the PR of patients with CRF on MHD.展开更多
BACKGROUND Diabetes is becoming increasingly common and has become an important global health issue.In addition to physical damage,diabetes often leads to psychological complications,such as depressive symptoms.Self-c...BACKGROUND Diabetes is becoming increasingly common and has become an important global health issue.In addition to physical damage,diabetes often leads to psychological complications,such as depressive symptoms.Self-care is considered to be the cornerstone of type 2 diabetes mellitus(T2DM)management.This research evaluated depression and explored the associations between self-care activities,self-perceived burden,and depression among T2DM patients in China.AIM To investigate the self-care activities and the association between depression and self-perceived burden among Chinese inpatients with T2DM.METHODS A cross-sectional study was conducted in participants with T2DM.The data collected encompassed basic characteristics,diabetes self-care activities,depre-ssion levels,and self-perceived burdens.Bootstrapping was utilized to assess the mediating role of diabetes self-care activities.RESULTS There were 599 T2DM patients in the survey,and 71.8%had been diagnosed with the disease for 1–10 years.There were significant correlations between self-care activities,depression,and self-perceived burden.The significant coefficients for paths a(B=-0.281,P<0.001)and b(B=-0.041,P<0.05)suggested negative associations between self-perceived burden and self-care behavior and between self-care activities and depression.The indirect effect(path a×b)of self-perceived burden on depression through self-care behaviors was significant(B=0.020,P<0.05),with a 95%bias-corrected bootstrap confidence interval of 0.007–0.036.CONCLUSION The mediating model presented here highlights the role of self-care activities in exerting both direct and indirect effects on depression in participants with T2DM.展开更多
Analysis Method of ^(131)I Activity in Carbon Cartridge and Internal Dose Assessment for Nuclear Medicine Workers.Shuo Wang1,Fei Tuo1,Jian-feng Zhang1,Xiao-liang Li1,Bao-lu Yang1,Qiang Zhou1,Ze-shu Li1,Shu-ying Kong1,...Analysis Method of ^(131)I Activity in Carbon Cartridge and Internal Dose Assessment for Nuclear Medicine Workers.Shuo Wang1,Fei Tuo1,Jian-feng Zhang1,Xiao-liang Li1,Bao-lu Yang1,Qiang Zhou1,Ze-shu Li1,Shu-ying Kong1,and Wei-hao Qin1(1.National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing,100088,China.)展开更多
Healthy behavior has long been linked to mental health outcomes.However,the role of artificial intelligence(AI)literacy in shaping healthy behaviors and its potential impact on mental health remains underexplored.This...Healthy behavior has long been linked to mental health outcomes.However,the role of artificial intelligence(AI)literacy in shaping healthy behaviors and its potential impact on mental health remains underexplored.This paper presents a scoping review offering a novel perspective on the intersection of healthy behaviors,mental health,and AI literacy.By examining how individuals’understanding of AI influences their choices regarding nutrition and their susceptibility to mental health issues,the current study explores emerging trends in health behavior decision-making.This emphasizes the need for integrating AI literacy into mental health and health behaviors education,as well as the development of AI-driven tools to support healthier behavior choices.It highlights that individuals with low AI literacy may misinterpret or overly depend on AI guidance,resulting in maladaptive health choices,while those with high AI literacy may be more likely to engage reflectively and sustain positive behaviors.The paper outlines the importance of inclusive education,user-centered design,and community-based support systems to enhance AI literacy for digitally marginalized groups.AI literacy may be positioned as a key determinant of health equity,better allowing for interdisciplinary strategies that empower individuals to make informed,autonomous decisions that promote both physical and mental health.展开更多
Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By...Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.展开更多
Social determinants of health(SDOH)affect quality of life.We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plemen...Social determinants of health(SDOH)affect quality of life.We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plementary studies:a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021.Resilience was assessed through CD-RISC10 score(range 0–40,higher scores reflect greater self-perceived resilience)and interview responses.Sociodemographic and SDOH(education,employment,living situa-tion,monetary stability,financial dependency,area deprivation index)data were collected by healthcare record review and self-report.We used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview data.Survey participants(N=127)mean age was 42±14 years;51%were female,87%white.ACHD was moderate(75%)or complex(25%);41%functional class C or D.Resilience(mean 30±7)varied by monetary stability:compared to people with difficulty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,p<0.001)for people reporting having enough money and 14.2 points higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough money.Interview participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%white.ACHD was moderate(56%)or complex(44%);76%functional class C or D.Participants discussed factors affecting resilience aligned with each of the major SDOH,prominently,economic stability and healthcare access and quality.Financial stability may be important for supporting self-perceived resi-lience in ACHD.This knowledge can inform the development of resilience interventions for this population.展开更多
Academic journals,consulting firms,and mainstream media have often published“predictions”about the future develop-ment of medical and health care.These publications often emphasize the potential of cutting-edge scie...Academic journals,consulting firms,and mainstream media have often published“predictions”about the future develop-ment of medical and health care.These publications often emphasize the potential of cutting-edge scientific or technical breakthroughs.Health Care Science looks at the problem from another perspective.We focus on how these changes enter the health system,how they operate in the real world,and how they reshape the organization and governance of medical services.At the beginning of 2026,we envision the following three major shifts that will reshape healthcare.展开更多
Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine.Here,we provide a detailed atlas of 2,920 plasma proteins linking to diseases(406 prevalent and 660 incid...Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine.Here,we provide a detailed atlas of 2,920 plasma proteins linking to diseases(406 prevalent and 660 incident)and 986 health-related traits in 53,026 individuals(median follow-up:14.8 years)from the UK Biobank,representing the most comprehensive proteome profiles to date.This atlas revealed 168,100 protein-disease associations and 554,488 protein-trait associations.展开更多
Recently,inflammatory cytokine profiles have been linked to suicide risk in adolescents with non-suicidal self-injury,highlighting a promising biological dimension of suicide risk assessment.Clinical translation of th...Recently,inflammatory cytokine profiles have been linked to suicide risk in adolescents with non-suicidal self-injury,highlighting a promising biological dimension of suicide risk assessment.Clinical translation of the cytokine profiles into practice will require frontline engagement of the workforce.Mental health nurses are frequently the most accessible professionals in schools,communities,and low-resource settings and are prime candidates to bridge this gap.By integrating psychosocial evaluation with emerging biomarker data,they can deliver systematic risk assessment,continuous monitoring,and timely intervention.This role would not replace psychiatric expertise;it would extend the reach of psychiatric services,embedding suicide prevention across the continuum of care.For health systems,nurse-led integration may enhance capacity,equity,and resilience in responding to adolescent suicide risk.This editorial demonstrates that empowering nurses to operationalize biomarker-informed strategies is needed for advancing effective and sustainable suicide prevention in this vulnerable population.展开更多
Background:Mental health concerns among doctoral students have become increasingly prominent,with consistently low levels of well-being making this issue a critical focus in higher education research.This study aims t...Background:Mental health concerns among doctoral students have become increasingly prominent,with consistently low levels of well-being making this issue a critical focus in higher education research.This study aims to synthesize existing evidence on the mental health and well-being of doctoral students and to identify key factors and intervention strategies reported in the literature.Methods:A systematic review was conducted to examine the determinants and interventions related to doctoral students’mental health and well-being.Relevant studies were comprehensively searched in Web of Science,PubMed,Scopus,and EBSCO,with the final search conducted on September 19,2025.Records were screened according to predefined criteria:empirical studies on doctoral students’mental health or well-being published in English were included,while non-empirical,non-English,and non-doctoral-student-focused studies were excluded.A total of 56 studies were included after rigorous screening.Results:Doctoral students’mental health and well-being are shaped by multiple interacting factors across individual,academic,interpersonal,organizational,and environmental levels.Moreover,variations in gender,identity,discipline,study stage,and institutional context may further exacerbate or mitigate psychological distress.Existing intervention studies primarily focus on three approaches:psychologically oriented training,practice-based behavioral and learning programs,and relationship-or support network-based initiatives.Conclusion:This review offers integrated evidence on doctoral students’mental health and well-being and highlights the need for universities to assume greater responsibility in developing systematic and responsive support mechanisms.Current research remains limited by insufficient cross-cultural comparison,a lack of intersectional perspectives,and a scarcity of large-scale,long-term evaluations of intervention effectiveness.Future studies should give greater attention to institutional contexts and vulnerable groups while expanding the scope and rigor of intervention research.展开更多
Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered...Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.展开更多
Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss...Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.展开更多
Objective: The purpose of the study is to investigate the degree and influencing factors of self-perceived burden in elderly patients with essential hypertension in China's Mainland. Methods:The study used the cro...Objective: The purpose of the study is to investigate the degree and influencing factors of self-perceived burden in elderly patients with essential hypertension in China's Mainland. Methods:The study used the cross-sectional investigation method and the patients were recruited from six tertiary hospitals in Chengdu, China. A convenience sample of 451 elderly patients with essential hypertension was included in this study. Multiple linear regression analysis was performed as well. Results: Results showed that the score of elderly essential hypertension patients’self-perceived burden was 27.96 ± 6.04, which was at medium degree. According to Spearman's r test the anxiety, depression and medication compliance with Self-perceived burden (SPB) of elderly hypertension patients were statistically significant (r=0.372, 0.899,0.438,P=0.000,respectively). Single factor analysis showed that the difference of patients’ gender, place of residence, monthly per capita income, marital status, whether can afford medical expenses and number of complications in SPB scores was statistically significant (P<0.05). Multiple regression analysis also showed that anxiety, medication compliance, age and marital status were the main influencing factor of SPB of elderly hypertension patients (P<0.05). Conclusion: Our care workers should pay attention to the self-perceived burden of elderly patients with essential hypertension, and omnibearing, systematic nursing should be supplied to decrease the self-perceived burden of them.展开更多
To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail stee...To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail steel arch bridge.An initial statistical comparison of sensor data distributions reveals clear temporal variations in stress redistribution patterns.XGBoost(eXtreme Gradient Boosting),a gradient-boosting machine learning(ML)algorithm,was employed not only for predictive modeling but also to uncover the underlying mechanisms of stress evolution.Unlike traditional numerical models that rely on extensive assumptions and idealizations,XGBoost effectively captures nonlinear and time-varying relationships between stress states and operational/environmental factors,such as temperature,traffic load,and structural geometry.This approach allows for the identification of critical periods and conditions under which stress redistribution becomes significant.Results indicate a clear shift of stress concentrations frombeamends toward mid-span regions following the commencement of metro operations,reflecting both structural adaptation and localized overstress near arch ribs.Furthermore,the model generates robust predictions of stress evolution,demonstrating potential applications in early warning systems and fatigue risk assessment.This work represents the first application of interpretable gradient-boosting techniques to stress redistribution modeling in double-deck bridges.In addition,a Stress Redistribution Index(SRI)is proposed,derived from this monitoring study and finite-element-based transverse load distributions,to quantify temporal stress shifts between midspan and edge beams.The results provide both theoretical contributions and practical guidance for the design,inspection,and maintenance of complex bridge structures.展开更多
Background:Intrinsic capacity reflects the overall health status of older adults and decline in intrinsic abilities can lead to adverse health outcomes.However,empirical studies examining the association between digit...Background:Intrinsic capacity reflects the overall health status of older adults and decline in intrinsic abilities can lead to adverse health outcomes.However,empirical studies examining the association between digital health literacy,health-promoting lifestyles and intrinsic capacity are scarce.Methods:A cross-sectional study was conducted.Using convenience sampling method,371 older adults were recruited from communities.Multidimensional intrinsic capacity,digital health literacy,health promoting lifestyle and sociodemographic information were measured.Results:The intrinsic capacity of older adults scored 3.75±1.10.The prevalences of declined cognitive capacity,psychological capacity,sensory capacity,vitality,and locomotor capacity were 13.7%,24.3%,19.1%,14.8%,53.1%,respectively.The multiple regression analysis revealed that age(β=−0.253),only living with children and/or grandchildren(β=0.249),current working status(β=−0.132),number of chronic diseases(β=−0.149),frequency of Internet usage(β=0.193),the domain of ability to acquire and evaluate digital health information(β=0.197)in digital health literacy,and the domain of nutrition(β=0.171)in health-promoting lifestyle were the significant factors influencing intrinsic capacity,explaining 27.1%of the variance.Conclusion:Digital health literacy and health-promoting lifestyle have a significant impact on intrinsic capacity.Enhancing digital health literacy and advocating a health-promoting lifestyle are critical to promoting intrinsic capacity for community-dwelling older adults.展开更多
Objectives:In recent years,mental health has emerged as a pressing public health concern in China,driven by mounting societal pressures and fast-paced urban lifestyles.Physical activity,a well-established means of enh...Objectives:In recent years,mental health has emerged as a pressing public health concern in China,driven by mounting societal pressures and fast-paced urban lifestyles.Physical activity,a well-established means of enhancing psychological well-being,has received growing scholarly and policy attention.This study uses panel data from the 2020 and 2022 waves of the China Family Panel Studies(CFPS)to examine the impact of exercise frequency on mental health(with indicators such as CESD-8 depression scores)among college students and young employees,thereby providing empirical support for targeted mental health interventions.Methods:This study examines the relationship between individual exercise frequency and mental health among college students and young employees,using panel data from the 2020 and 2022 waves of the China Family Panel Studies(CFPS),with the Chinese version of the 8-item Center for Epidemiologic Studies Depression Scale(CESD-8)depression scores,self-rated health,and life satisfaction as outcome variables.Specifically,this study tests three hypotheses:(H1)increased exercise frequency significantly reduces depression symptoms and enhances well-being;(H2)the effects of exercise vary by social roles,with stronger mental health benefits among employed individuals and those with lower education;and(H3)lifestyle factors such as smoking amount,sleep duration,and Body Mass Index(BMI)partially mediate the relationship between exercise and mental health.Employing a two-way fixed effects model,baseline results indicate that a one-unit increase in exercise frequency significantly reduces the CESD-8 score by 0.183 points.To address potential endogeneity and spurious regression concerns,an instrumental variable(IV)approach is further applied.The heterogeneity analysis differentiates between students and employed individuals.Results:Among students,the effects of exercise on mental health are not statistically significant,regardless of education level.In contrast,for the employed,exercise demonstrates a significant positive impact on mental health,with particularly pronounced effects among those with lower educational attainment.These findings underscore the importance of promoting exercise as part of comprehensive mental health strategies.Mediation analysis indicates that the beneficial effect of exercise on mental health is partially transmitted through reductions in adverse health behaviors,especially smoking.Conclusions:Policymakers should integrate physical activity promotion into health interventions,prioritizing vulnerable groups to enhance psychological resilience and foster inclusive,health-oriented development.展开更多
Background Maternal obesity during pregnancy can lead to increased risk for metabolic disease in offspring during adulthood,helping fuel the worldwide increase in obesity.Fortunately,studies in rodent models have esta...Background Maternal obesity during pregnancy can lead to increased risk for metabolic disease in offspring during adulthood,helping fuel the worldwide increase in obesity.Fortunately,studies in rodent models have established that female dams(F0)that perform voluntary wheel running exercise during pregnancy have first-generation(F1)offspring with improved glucose tolerance,suggesting a potential means to reduce the burden of generational metabolic disease transmission.We have shown that maternal exercise also affects F1 male offspring as sires,as their progeny(F2)have similarly improved metabolic health.Whether maternal exercise can affect F1 females in a manner that improves F2 offspring metabolism is not known.Here,we determined whether voluntary exercise by F0 grandmothers,via their F1 female progeny,produced F2 male and female offspring with an improved metabolic phenotype.Methods Six-week-old C57BL/6 N female mice(F0)were fed a chow diet and either kept sedentary or exercise trained by voluntary wheel running for 2 weeks preconception and during pregnancy.Chow-fed sedentary F1 female offspring at 8 weeks of age were bred with age-matched untreated virgin males to generate F2 offspring.F2 were kept sedentary and chow fed and studied up to 52 weeks of age.Metabolic parameters were assessed,including food intake,body weight,body composition,glucose tolerance,systemic glucose and insulin levels,and liver metabolism.Results Grandmaternal exercise did not significantly alter male and female F2 offspring body weights measured throughout the first year of life,nor was there an effect of grandmaternal exercise on F2 offspring fat mass or lean mass.Remarkably,despite the lack of effect on body weight parameters,grandmaternal exercise resulted in improved glucose tolerance and homeostatic model assessment for insulin resistance(HOMA-IR)in F2 offspring at 52 weeks of age,effects that were more pronounced in male F2 offspring.Conclusion Voluntary wheel running exercise in female mice during pregnancy leads to metabolic improvements in her grand offspring,despite no direct intervention of the intermediate maternal generation.Maternal physical activity during pregnancy may reduce metabolic diseases in later generations.展开更多
This study aims to explore the impact of combined health education and dietary guidance on the speed of postoperative recovery in patients with gastrointestinal polyps.A specific number of patients who underwent gastr...This study aims to explore the impact of combined health education and dietary guidance on the speed of postoperative recovery in patients with gastrointestinal polyps.A specific number of patients who underwent gastrointestinal polyp resection were selected and randomly divided into a control group and an experimental group.The control group received routine nursing,while the experimental group implemented combined health education and dietary guidance on this basis.By comparing the recovery indicators of the two groups,it was found that the recovery speed of the experimental group was significantly faster than that of the control group,indicating that this combined intervention method can effectively promote patient recovery.展开更多
文摘Empirical evidence suggests that the stability of personality itself contributes to successful ageing and is associated with longer life. The aim of this study was to investigate the association between personality traits and the self-perceived health status, stratified by medical conditions in a representative sample of non-institutionalized elderly people in Chile. The data used for this study come from the fourth waves (2009) of the Chilean Social Protection Survey (SPS-2009). Included were a total of 2655 subjects aged 65 and over. The results showed that higher scores of all five personality factors were associated with good health. Those with the perception of poor health were more likely to be female, with lower education level and older than those with good health. With the exception of agreeableness, strong and significant associations with self-perceived health were demonstrated for extraversion, conscientiousness, emotional stability and openness, among elderly with medical conditions. Among elderly without medical problems, significant associations with self-perceived health were demonstrated only for extraversion, agreeableness and emotional stability. This study has shown that there is a consistent association between personality factors and self-perceived health throughout the older population. Our results suggest that extraversion and openness traits could be acting as “protector” factors and agreeableness and conscientiousness traits as “resilient” factors, facing to the health problems among elderly people.
文摘BACKGROUND Lung resection represents the main curative treatment modality of non-small cell lung cancer.Patients with high-risk to develop postoperative pulmonary complications have been classified as“high-risk patients.”Characterizing this population could be important to improve their approach and rehabilitation.AIM To identify the differences between high and low-risk patients in exercise capacity and self-perceived health status after hospitalization.METHODS A longitudinal observational prospective cohort study was carried out.Patients undergoing lung resection were recruited from the“Hospital Virgen de las Nieves”(Granada)and divided into two groups according to the risk profile criteria(age≥70 years,forced expiratory volume in 1 s≤70%predicted,carbon monoxide diffusion capacity≤70%predicted or scheduled pneumonectomy).Outcomes included were exercise capacity(Fatigue Severity Scale,Unsupported Upper-Limb Exercise,handgrip dynamometry,Five Sit-to-stand test,and quadriceps hand-held dynamometry)and patient-reported outcome(Euroqol-5 dimensions 5 Levels Visual Analogue Scale).RESULTS In total,115 participants were included in the study and divided into three groups:high-risk,low-risk and control group.At discharge high-risk patients presented a poorer exercise capacity and a worse self-perceived health status(P<0.05).One month after discharge patients in the high-risk group maintained these differences compared to the other groups.CONCLUSION Our results show a poorer recovery in high-risk patients at discharge and 1 mo after surgery,with lower self-perceived health status and a poorer upper and lower limb exercise capacity.These results are important in the rehabilitation field.
基金Supported by Key Research Fund of Wannan Medical College,No.WK2021ZF15Research Foundation for Advanced Talents of Wannan Medical College,No.YR202213+3 种基金Foundation of Anhui Educational Committee,No.2023AH051759Excellent Youth Research Project of Anhui UniversitiesNo.2023AH030107Horizontal Project of Wannan Medical College,No.622202504003 and No.662202404013.
文摘BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receiving maintenance hemodia-lysis(MHD)is limited.AIM To investigate the correlation between anxiety,depression,SPB,and PR in pati-ents with CRF on MHD.METHODS This study included 225 patients with CRF on MHD who were admitted between June 2021 and June 2024.The anxiety level was evaluated using the Self-Rating Anxiety Scale(SAS);the depression status was assessed using the Self-Rating Depression Scale(SDS);the SPB was measured using the SPB Scale(SPBS);and the PR was determined using the Connor–Davidson Resilience Scale(CD-RISC).The correlations among the SAS,SDS,SPB,and CD-RISC were analyzed using Pearson’s correlation coefficients.Univariate and multivariate analyses were performed to identify the factors that influence the PR of patients with CRF on MHD.RESULTS The SAS,SDS,SPB,and CD-RISC scores of the 225 patients were 45.25±15.36,54.81±14.68,32.31±11.52,and 66.48±9.18,respectively.Significant negative correlations were observed between SAS,SDS,SPB,and CD-RISC.Furthermore,longer dialysis vintage(P=0.015),the absence of religious beliefs(P=0.020),lower monthly income(P=0.008),higher SAS score(P=0.013),and higher SDS score(P=0.006)were all independent factors that adversely affected the PR of patients with CRF on MHD.CONCLUSION Patients with CRF on MHD present with varying degrees of anxiety,depression,and SPB,all of which exhibit a significant negative correlation with their PR.Moreover,longer dialysis vintage,the absence of religious beliefs,lower monthly income,higher SAS score,and higher SDS score were factors that negatively affected the PR of patients with CRF on MHD.
基金Supported by the Hunan Provincial Natural Science Foundation of China,No.2025JJ80413.
文摘BACKGROUND Diabetes is becoming increasingly common and has become an important global health issue.In addition to physical damage,diabetes often leads to psychological complications,such as depressive symptoms.Self-care is considered to be the cornerstone of type 2 diabetes mellitus(T2DM)management.This research evaluated depression and explored the associations between self-care activities,self-perceived burden,and depression among T2DM patients in China.AIM To investigate the self-care activities and the association between depression and self-perceived burden among Chinese inpatients with T2DM.METHODS A cross-sectional study was conducted in participants with T2DM.The data collected encompassed basic characteristics,diabetes self-care activities,depre-ssion levels,and self-perceived burdens.Bootstrapping was utilized to assess the mediating role of diabetes self-care activities.RESULTS There were 599 T2DM patients in the survey,and 71.8%had been diagnosed with the disease for 1–10 years.There were significant correlations between self-care activities,depression,and self-perceived burden.The significant coefficients for paths a(B=-0.281,P<0.001)and b(B=-0.041,P<0.05)suggested negative associations between self-perceived burden and self-care behavior and between self-care activities and depression.The indirect effect(path a×b)of self-perceived burden on depression through self-care behaviors was significant(B=0.020,P<0.05),with a 95%bias-corrected bootstrap confidence interval of 0.007–0.036.CONCLUSION The mediating model presented here highlights the role of self-care activities in exerting both direct and indirect effects on depression in participants with T2DM.
文摘Analysis Method of ^(131)I Activity in Carbon Cartridge and Internal Dose Assessment for Nuclear Medicine Workers.Shuo Wang1,Fei Tuo1,Jian-feng Zhang1,Xiao-liang Li1,Bao-lu Yang1,Qiang Zhou1,Ze-shu Li1,Shu-ying Kong1,and Wei-hao Qin1(1.National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing,100088,China.)
文摘Healthy behavior has long been linked to mental health outcomes.However,the role of artificial intelligence(AI)literacy in shaping healthy behaviors and its potential impact on mental health remains underexplored.This paper presents a scoping review offering a novel perspective on the intersection of healthy behaviors,mental health,and AI literacy.By examining how individuals’understanding of AI influences their choices regarding nutrition and their susceptibility to mental health issues,the current study explores emerging trends in health behavior decision-making.This emphasizes the need for integrating AI literacy into mental health and health behaviors education,as well as the development of AI-driven tools to support healthier behavior choices.It highlights that individuals with low AI literacy may misinterpret or overly depend on AI guidance,resulting in maladaptive health choices,while those with high AI literacy may be more likely to engage reflectively and sustain positive behaviors.The paper outlines the importance of inclusive education,user-centered design,and community-based support systems to enhance AI literacy for digitally marginalized groups.AI literacy may be positioned as a key determinant of health equity,better allowing for interdisciplinary strategies that empower individuals to make informed,autonomous decisions that promote both physical and mental health.
文摘Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.
基金This study is supported by K23HL15180(NIH/NHLBI,Steiner)a grant from the American College of Cardiology Foundation.
文摘Social determinants of health(SDOH)affect quality of life.We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plementary studies:a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021.Resilience was assessed through CD-RISC10 score(range 0–40,higher scores reflect greater self-perceived resilience)and interview responses.Sociodemographic and SDOH(education,employment,living situa-tion,monetary stability,financial dependency,area deprivation index)data were collected by healthcare record review and self-report.We used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview data.Survey participants(N=127)mean age was 42±14 years;51%were female,87%white.ACHD was moderate(75%)or complex(25%);41%functional class C or D.Resilience(mean 30±7)varied by monetary stability:compared to people with difficulty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,p<0.001)for people reporting having enough money and 14.2 points higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough money.Interview participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%white.ACHD was moderate(56%)or complex(44%);76%functional class C or D.Participants discussed factors affecting resilience aligned with each of the major SDOH,prominently,economic stability and healthcare access and quality.Financial stability may be important for supporting self-perceived resi-lience in ACHD.This knowledge can inform the development of resilience interventions for this population.
文摘Academic journals,consulting firms,and mainstream media have often published“predictions”about the future develop-ment of medical and health care.These publications often emphasize the potential of cutting-edge scientific or technical breakthroughs.Health Care Science looks at the problem from another perspective.We focus on how these changes enter the health system,how they operate in the real world,and how they reshape the organization and governance of medical services.At the beginning of 2026,we envision the following three major shifts that will reshape healthcare.
文摘Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine.Here,we provide a detailed atlas of 2,920 plasma proteins linking to diseases(406 prevalent and 660 incident)and 986 health-related traits in 53,026 individuals(median follow-up:14.8 years)from the UK Biobank,representing the most comprehensive proteome profiles to date.This atlas revealed 168,100 protein-disease associations and 554,488 protein-trait associations.
文摘Recently,inflammatory cytokine profiles have been linked to suicide risk in adolescents with non-suicidal self-injury,highlighting a promising biological dimension of suicide risk assessment.Clinical translation of the cytokine profiles into practice will require frontline engagement of the workforce.Mental health nurses are frequently the most accessible professionals in schools,communities,and low-resource settings and are prime candidates to bridge this gap.By integrating psychosocial evaluation with emerging biomarker data,they can deliver systematic risk assessment,continuous monitoring,and timely intervention.This role would not replace psychiatric expertise;it would extend the reach of psychiatric services,embedding suicide prevention across the continuum of care.For health systems,nurse-led integration may enhance capacity,equity,and resilience in responding to adolescent suicide risk.This editorial demonstrates that empowering nurses to operationalize biomarker-informed strategies is needed for advancing effective and sustainable suicide prevention in this vulnerable population.
文摘Background:Mental health concerns among doctoral students have become increasingly prominent,with consistently low levels of well-being making this issue a critical focus in higher education research.This study aims to synthesize existing evidence on the mental health and well-being of doctoral students and to identify key factors and intervention strategies reported in the literature.Methods:A systematic review was conducted to examine the determinants and interventions related to doctoral students’mental health and well-being.Relevant studies were comprehensively searched in Web of Science,PubMed,Scopus,and EBSCO,with the final search conducted on September 19,2025.Records were screened according to predefined criteria:empirical studies on doctoral students’mental health or well-being published in English were included,while non-empirical,non-English,and non-doctoral-student-focused studies were excluded.A total of 56 studies were included after rigorous screening.Results:Doctoral students’mental health and well-being are shaped by multiple interacting factors across individual,academic,interpersonal,organizational,and environmental levels.Moreover,variations in gender,identity,discipline,study stage,and institutional context may further exacerbate or mitigate psychological distress.Existing intervention studies primarily focus on three approaches:psychologically oriented training,practice-based behavioral and learning programs,and relationship-or support network-based initiatives.Conclusion:This review offers integrated evidence on doctoral students’mental health and well-being and highlights the need for universities to assume greater responsibility in developing systematic and responsive support mechanisms.Current research remains limited by insufficient cross-cultural comparison,a lack of intersectional perspectives,and a scarcity of large-scale,long-term evaluations of intervention effectiveness.Future studies should give greater attention to institutional contexts and vulnerable groups while expanding the scope and rigor of intervention research.
基金supported by the Fund for Health Promotion from Osaka Prefecture。
文摘Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.
基金supported by the National Institutes of Health for the Kansas Center for Metabolism and Obesity Research(award No.P20GM144269)support from the Center for Advancing Translational Sciences of the National Institutes of Health(award No.KL2TR002367)supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(award No.TL1TR002368)。
文摘Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.
文摘Objective: The purpose of the study is to investigate the degree and influencing factors of self-perceived burden in elderly patients with essential hypertension in China's Mainland. Methods:The study used the cross-sectional investigation method and the patients were recruited from six tertiary hospitals in Chengdu, China. A convenience sample of 451 elderly patients with essential hypertension was included in this study. Multiple linear regression analysis was performed as well. Results: Results showed that the score of elderly essential hypertension patients’self-perceived burden was 27.96 ± 6.04, which was at medium degree. According to Spearman's r test the anxiety, depression and medication compliance with Self-perceived burden (SPB) of elderly hypertension patients were statistically significant (r=0.372, 0.899,0.438,P=0.000,respectively). Single factor analysis showed that the difference of patients’ gender, place of residence, monthly per capita income, marital status, whether can afford medical expenses and number of complications in SPB scores was statistically significant (P<0.05). Multiple regression analysis also showed that anxiety, medication compliance, age and marital status were the main influencing factor of SPB of elderly hypertension patients (P<0.05). Conclusion: Our care workers should pay attention to the self-perceived burden of elderly patients with essential hypertension, and omnibearing, systematic nursing should be supplied to decrease the self-perceived burden of them.
基金supported by the Key Technologies Research and Development Program under Grant 2021YFB1600300.
文摘To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail steel arch bridge.An initial statistical comparison of sensor data distributions reveals clear temporal variations in stress redistribution patterns.XGBoost(eXtreme Gradient Boosting),a gradient-boosting machine learning(ML)algorithm,was employed not only for predictive modeling but also to uncover the underlying mechanisms of stress evolution.Unlike traditional numerical models that rely on extensive assumptions and idealizations,XGBoost effectively captures nonlinear and time-varying relationships between stress states and operational/environmental factors,such as temperature,traffic load,and structural geometry.This approach allows for the identification of critical periods and conditions under which stress redistribution becomes significant.Results indicate a clear shift of stress concentrations frombeamends toward mid-span regions following the commencement of metro operations,reflecting both structural adaptation and localized overstress near arch ribs.Furthermore,the model generates robust predictions of stress evolution,demonstrating potential applications in early warning systems and fatigue risk assessment.This work represents the first application of interpretable gradient-boosting techniques to stress redistribution modeling in double-deck bridges.In addition,a Stress Redistribution Index(SRI)is proposed,derived from this monitoring study and finite-element-based transverse load distributions,to quantify temporal stress shifts between midspan and edge beams.The results provide both theoretical contributions and practical guidance for the design,inspection,and maintenance of complex bridge structures.
基金funded by the College Students’Innovation and Entrepreneurship Program(X2024110650385).
文摘Background:Intrinsic capacity reflects the overall health status of older adults and decline in intrinsic abilities can lead to adverse health outcomes.However,empirical studies examining the association between digital health literacy,health-promoting lifestyles and intrinsic capacity are scarce.Methods:A cross-sectional study was conducted.Using convenience sampling method,371 older adults were recruited from communities.Multidimensional intrinsic capacity,digital health literacy,health promoting lifestyle and sociodemographic information were measured.Results:The intrinsic capacity of older adults scored 3.75±1.10.The prevalences of declined cognitive capacity,psychological capacity,sensory capacity,vitality,and locomotor capacity were 13.7%,24.3%,19.1%,14.8%,53.1%,respectively.The multiple regression analysis revealed that age(β=−0.253),only living with children and/or grandchildren(β=0.249),current working status(β=−0.132),number of chronic diseases(β=−0.149),frequency of Internet usage(β=0.193),the domain of ability to acquire and evaluate digital health information(β=0.197)in digital health literacy,and the domain of nutrition(β=0.171)in health-promoting lifestyle were the significant factors influencing intrinsic capacity,explaining 27.1%of the variance.Conclusion:Digital health literacy and health-promoting lifestyle have a significant impact on intrinsic capacity.Enhancing digital health literacy and advocating a health-promoting lifestyle are critical to promoting intrinsic capacity for community-dwelling older adults.
文摘Objectives:In recent years,mental health has emerged as a pressing public health concern in China,driven by mounting societal pressures and fast-paced urban lifestyles.Physical activity,a well-established means of enhancing psychological well-being,has received growing scholarly and policy attention.This study uses panel data from the 2020 and 2022 waves of the China Family Panel Studies(CFPS)to examine the impact of exercise frequency on mental health(with indicators such as CESD-8 depression scores)among college students and young employees,thereby providing empirical support for targeted mental health interventions.Methods:This study examines the relationship between individual exercise frequency and mental health among college students and young employees,using panel data from the 2020 and 2022 waves of the China Family Panel Studies(CFPS),with the Chinese version of the 8-item Center for Epidemiologic Studies Depression Scale(CESD-8)depression scores,self-rated health,and life satisfaction as outcome variables.Specifically,this study tests three hypotheses:(H1)increased exercise frequency significantly reduces depression symptoms and enhances well-being;(H2)the effects of exercise vary by social roles,with stronger mental health benefits among employed individuals and those with lower education;and(H3)lifestyle factors such as smoking amount,sleep duration,and Body Mass Index(BMI)partially mediate the relationship between exercise and mental health.Employing a two-way fixed effects model,baseline results indicate that a one-unit increase in exercise frequency significantly reduces the CESD-8 score by 0.183 points.To address potential endogeneity and spurious regression concerns,an instrumental variable(IV)approach is further applied.The heterogeneity analysis differentiates between students and employed individuals.Results:Among students,the effects of exercise on mental health are not statistically significant,regardless of education level.In contrast,for the employed,exercise demonstrates a significant positive impact on mental health,with particularly pronounced effects among those with lower educational attainment.These findings underscore the importance of promoting exercise as part of comprehensive mental health strategies.Mediation analysis indicates that the beneficial effect of exercise on mental health is partially transmitted through reductions in adverse health behaviors,especially smoking.Conclusions:Policymakers should integrate physical activity promotion into health interventions,prioritizing vulnerable groups to enhance psychological resilience and foster inclusive,health-oriented development.
基金supported by NIH awards R01 DK101043 to LJG and P30 DK036836 to Joslin Diabetes Centersupported by American Diabetes Association Grant No.1-17-PMF-009+1 种基金supported by American Diabetes Association(Grant No.1-25-PDF-67)supported by fellowships from Sunstar Foundation,Japan Society for the Promotion of Science(JSPS),Kanae Foundation,and Meiji Yasuda Life Foundation of Health and Welfare.
文摘Background Maternal obesity during pregnancy can lead to increased risk for metabolic disease in offspring during adulthood,helping fuel the worldwide increase in obesity.Fortunately,studies in rodent models have established that female dams(F0)that perform voluntary wheel running exercise during pregnancy have first-generation(F1)offspring with improved glucose tolerance,suggesting a potential means to reduce the burden of generational metabolic disease transmission.We have shown that maternal exercise also affects F1 male offspring as sires,as their progeny(F2)have similarly improved metabolic health.Whether maternal exercise can affect F1 females in a manner that improves F2 offspring metabolism is not known.Here,we determined whether voluntary exercise by F0 grandmothers,via their F1 female progeny,produced F2 male and female offspring with an improved metabolic phenotype.Methods Six-week-old C57BL/6 N female mice(F0)were fed a chow diet and either kept sedentary or exercise trained by voluntary wheel running for 2 weeks preconception and during pregnancy.Chow-fed sedentary F1 female offspring at 8 weeks of age were bred with age-matched untreated virgin males to generate F2 offspring.F2 were kept sedentary and chow fed and studied up to 52 weeks of age.Metabolic parameters were assessed,including food intake,body weight,body composition,glucose tolerance,systemic glucose and insulin levels,and liver metabolism.Results Grandmaternal exercise did not significantly alter male and female F2 offspring body weights measured throughout the first year of life,nor was there an effect of grandmaternal exercise on F2 offspring fat mass or lean mass.Remarkably,despite the lack of effect on body weight parameters,grandmaternal exercise resulted in improved glucose tolerance and homeostatic model assessment for insulin resistance(HOMA-IR)in F2 offspring at 52 weeks of age,effects that were more pronounced in male F2 offspring.Conclusion Voluntary wheel running exercise in female mice during pregnancy leads to metabolic improvements in her grand offspring,despite no direct intervention of the intermediate maternal generation.Maternal physical activity during pregnancy may reduce metabolic diseases in later generations.
文摘This study aims to explore the impact of combined health education and dietary guidance on the speed of postoperative recovery in patients with gastrointestinal polyps.A specific number of patients who underwent gastrointestinal polyp resection were selected and randomly divided into a control group and an experimental group.The control group received routine nursing,while the experimental group implemented combined health education and dietary guidance on this basis.By comparing the recovery indicators of the two groups,it was found that the recovery speed of the experimental group was significantly faster than that of the control group,indicating that this combined intervention method can effectively promote patient recovery.
