The authors regret that in Fig.2Aa of the article,the images for TPUPPy and TPU-aa in the first column were mistakenly duplicated due to a formatting error.The correct version of Fig.2 is provided below,along with the...The authors regret that in Fig.2Aa of the article,the images for TPUPPy and TPU-aa in the first column were mistakenly duplicated due to a formatting error.The correct version of Fig.2 is provided below,along with the original data for reference.The authors confirm that the rest of the article remains unaffected.展开更多
Conventional antibiotic strategies often fail to consistently suppress escaping planktonic bacteria and even induce antibiotic resistance,allowing implant-associated infections(IAIs)to persist.In this study,we demonst...Conventional antibiotic strategies often fail to consistently suppress escaping planktonic bacteria and even induce antibiotic resistance,allowing implant-associated infections(IAIs)to persist.In this study,we demonstrated an antibiotic-free coating engineered with an herbal bioheterojunction featuring a shell-in-shell structure where Cu_(2)O forms the core,strontium(Sr)is loaded in the inner shell,and curcumin(Cur)is nucleated in situ at the outer heterointerface(Cu_(2)O-Sr/Cur).Ultrasound-triggered reactive oxygen species(ROS)generation by the outer heterostructure(Cu_(2)O/Cur),coupled with Cu(Ⅰ)-induced cuproptosis-like bacterial death,achieved antibacterial rates of 99.56%against S.aureus and 99.43%against E.coli.When ultrasonication ceases,the released Cu(Ⅰ)undergoes disproportionation reactions to form Cu(Ⅱ),which can chelate with Cur to form Cu-Cur metal complexes.These complexes exhibit enhanced antioxidative properties through self-catalytic regulation,the scavenging of ROS,and the activation of anti-inflammatory M2 macrophage phenotype.Moreover,strontium release from the inner shell simultaneously suppressed osteoclast activity and promoted osteogenesis,resulting in trabecular number and thickness increases of 129.03%and 56.71%,respectively,compared with those in control group.Therefore,our work establishes a sequential treatment strategy for the antibacterial properties and osteointegration ability of IAIs.展开更多
A new type regulating valve with the cooling mode of constant temperature difference water supply, temperature difference self operated regulating valve, was introduced into blast furnace cooling system to overcome s...A new type regulating valve with the cooling mode of constant temperature difference water supply, temperature difference self operated regulating valve, was introduced into blast furnace cooling system to overcome shortcomings of the cooling mode of constant flow rate water supply. The results show that the temperature difference between inlet and outlet water of cooling wall can be decreased greatly and steadily, and the water supply for blast furnace cooling can be reduced considerably.展开更多
文摘The authors regret that in Fig.2Aa of the article,the images for TPUPPy and TPU-aa in the first column were mistakenly duplicated due to a formatting error.The correct version of Fig.2 is provided below,along with the original data for reference.The authors confirm that the rest of the article remains unaffected.
基金supported by the National Natural Science Foundations of China(No.U22A20280,No.82102542,No.82172394,No.32271392 No.82472402)the Sichuan Science and Technology Program(No.2023YFQ0039,No.2023ZYD0070)+1 种基金the National Key Research and Development Program of China(No.2022YFC2503100 and 2022YFC2503104)the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD23033,No.ZYJC21066).
文摘Conventional antibiotic strategies often fail to consistently suppress escaping planktonic bacteria and even induce antibiotic resistance,allowing implant-associated infections(IAIs)to persist.In this study,we demonstrated an antibiotic-free coating engineered with an herbal bioheterojunction featuring a shell-in-shell structure where Cu_(2)O forms the core,strontium(Sr)is loaded in the inner shell,and curcumin(Cur)is nucleated in situ at the outer heterointerface(Cu_(2)O-Sr/Cur).Ultrasound-triggered reactive oxygen species(ROS)generation by the outer heterostructure(Cu_(2)O/Cur),coupled with Cu(Ⅰ)-induced cuproptosis-like bacterial death,achieved antibacterial rates of 99.56%against S.aureus and 99.43%against E.coli.When ultrasonication ceases,the released Cu(Ⅰ)undergoes disproportionation reactions to form Cu(Ⅱ),which can chelate with Cur to form Cu-Cur metal complexes.These complexes exhibit enhanced antioxidative properties through self-catalytic regulation,the scavenging of ROS,and the activation of anti-inflammatory M2 macrophage phenotype.Moreover,strontium release from the inner shell simultaneously suppressed osteoclast activity and promoted osteogenesis,resulting in trabecular number and thickness increases of 129.03%and 56.71%,respectively,compared with those in control group.Therefore,our work establishes a sequential treatment strategy for the antibacterial properties and osteointegration ability of IAIs.
文摘A new type regulating valve with the cooling mode of constant temperature difference water supply, temperature difference self operated regulating valve, was introduced into blast furnace cooling system to overcome shortcomings of the cooling mode of constant flow rate water supply. The results show that the temperature difference between inlet and outlet water of cooling wall can be decreased greatly and steadily, and the water supply for blast furnace cooling can be reduced considerably.
