Background and Objectives: This study aimed to evaluate the role of selenium intake on the correlation between obesity and sex hormone levels in children and adolescents. Methods and Study Design: Children and adolesc...Background and Objectives: This study aimed to evaluate the role of selenium intake on the correlation between obesity and sex hormone levels in children and adolescents. Methods and Study Design: Children and adolescents(6-19-year-old) with complete body mass index(BMI), selenium intake, and sex hormone level data were included. Applying weighted linear regression model to analyze the relationships of obesity and selenium intake with testosterone, estradiol, and sex hormone-binding globulin(SHBG) levels. Then, interaction terms for different selenium intake levels(<Q1, ≥Q1) and obesity(no, yes) were constructed, to investigate the moderating effect of selenium intake on the correlation between obesity and sex hormones. Results: A total of 3,380 participants were enrolled. Although selenium intake showed no direct relationship with testosterone, estradiol, or SHBG levels in any group(p > 0.05), it demonstrated a significant interaction with obesity in terms of sex hormone levels. In females aged less than 12 years, there was an interaction between obesity and selenium intake on testosterone levels(pinteraction = 0.007). The interaction of obesity and selenium intake on SHBG levels was observed in both males and females(all pinteraction <0.001). Moreover, a trend was observed for the effects of these interaction terms on testosterone, estradiol and SHBG levels(all ptrend <0.05). Conclusions: Selenium intake may play a moderating effect in the relationship between obesity and sex hormones.展开更多
The human dietary selenium requirement in China has been estimated by various methods. The minimum dietary selenium requircment for the prevention of Keshan disease (KD) was found to be around 17 μg/d. On the other h...The human dietary selenium requirement in China has been estimated by various methods. The minimum dietary selenium requircment for the prevention of Keshan disease (KD) was found to be around 17 μg/d. On the other hand, an intake of 40 μg/d is required to maintain the plasma glutathione peroxidase (GPx) activity at plateau. Hence 40 μg/d is considered as the adequate dietary selenium requirement. Studies conducted in a chronic selenosis area indicate thai the toxic dietary selenlum inlake (adverse effect level), which would maintain the characteristic fingernail changes, was approximately 1600 μg/d. The mean value of dietary selenium intakes, which enabled the five patients to recover from fingernail lesions, was found to be 819 ±126μg/d. At a 95% confidence limit, the lower limit is around 600μg/d. Therefore, 600 and 400μg/d were suggested as the individual daily maximum safe selenium intake and the safe dietary selenium intake, respectively,The results were used in the prevention of Se-related endemic KD and Kashin-Beck disease (KBD)展开更多
文摘Background and Objectives: This study aimed to evaluate the role of selenium intake on the correlation between obesity and sex hormone levels in children and adolescents. Methods and Study Design: Children and adolescents(6-19-year-old) with complete body mass index(BMI), selenium intake, and sex hormone level data were included. Applying weighted linear regression model to analyze the relationships of obesity and selenium intake with testosterone, estradiol, and sex hormone-binding globulin(SHBG) levels. Then, interaction terms for different selenium intake levels(<Q1, ≥Q1) and obesity(no, yes) were constructed, to investigate the moderating effect of selenium intake on the correlation between obesity and sex hormones. Results: A total of 3,380 participants were enrolled. Although selenium intake showed no direct relationship with testosterone, estradiol, or SHBG levels in any group(p > 0.05), it demonstrated a significant interaction with obesity in terms of sex hormone levels. In females aged less than 12 years, there was an interaction between obesity and selenium intake on testosterone levels(pinteraction = 0.007). The interaction of obesity and selenium intake on SHBG levels was observed in both males and females(all pinteraction <0.001). Moreover, a trend was observed for the effects of these interaction terms on testosterone, estradiol and SHBG levels(all ptrend <0.05). Conclusions: Selenium intake may play a moderating effect in the relationship between obesity and sex hormones.
文摘The human dietary selenium requirement in China has been estimated by various methods. The minimum dietary selenium requircment for the prevention of Keshan disease (KD) was found to be around 17 μg/d. On the other hand, an intake of 40 μg/d is required to maintain the plasma glutathione peroxidase (GPx) activity at plateau. Hence 40 μg/d is considered as the adequate dietary selenium requirement. Studies conducted in a chronic selenosis area indicate thai the toxic dietary selenlum inlake (adverse effect level), which would maintain the characteristic fingernail changes, was approximately 1600 μg/d. The mean value of dietary selenium intakes, which enabled the five patients to recover from fingernail lesions, was found to be 819 ±126μg/d. At a 95% confidence limit, the lower limit is around 600μg/d. Therefore, 600 and 400μg/d were suggested as the individual daily maximum safe selenium intake and the safe dietary selenium intake, respectively,The results were used in the prevention of Se-related endemic KD and Kashin-Beck disease (KBD)
