The precise control of supramolecular assembly to achieve multifunctional integration remains a significant challenge in materials science.In this study,we synthesized a novel,previously unreported AIE-active molecule...The precise control of supramolecular assembly to achieve multifunctional integration remains a significant challenge in materials science.In this study,we synthesized a novel,previously unreported AIE-active molecule(BA)through an exceptionally simple procedure.Subsequently,we constructed two cucurbituril-mediated assemblies(Q[8]-BA and Q[10]-BA)using BA as the building block.These assemblies were systematically investigated for their differences in ion recognition,cellular imaging,and cytotoxicity.The Q[8]-BA assembly exhibited enhanced fluorescence intensity,pH sensitivity,and high specificity for Co2+detection(LOD=4.8×10^(-7) M),making it a promising candidate for environmental sensing and cell imaging.In contrast,theQ[10]-BA assembly demonstrated selective cytotoxicity toward melanoma cells while protecting normal cells,highlighting its potential in cancer theranostics.These findings reveal the critical role of cavity size and assembly mode in regulating material properties,providing new insights for designing multifunctional supramolecular systems with tailored functionalities for environmental monitoring and biomedical applications.展开更多
基金the funding support from the Doctoral Start-up Foundation of Guizhou University of Traditional Chinese Medicine(Grant Number[2023]28)and the“Young Sail Plan”Project(Grant Number QNYFZK[2024]17)supported by the Science and Technology Fund of Guizhou Province(Numbers MS[2025]284 and 2024-352),Guizhou Provincial Science and Technology Foundation(KXJZ[2024]029 and CXTD(2025)035)Guizhou Provincial Key Laboratory Platform Project(ZSYS[2025]008).
文摘The precise control of supramolecular assembly to achieve multifunctional integration remains a significant challenge in materials science.In this study,we synthesized a novel,previously unreported AIE-active molecule(BA)through an exceptionally simple procedure.Subsequently,we constructed two cucurbituril-mediated assemblies(Q[8]-BA and Q[10]-BA)using BA as the building block.These assemblies were systematically investigated for their differences in ion recognition,cellular imaging,and cytotoxicity.The Q[8]-BA assembly exhibited enhanced fluorescence intensity,pH sensitivity,and high specificity for Co2+detection(LOD=4.8×10^(-7) M),making it a promising candidate for environmental sensing and cell imaging.In contrast,theQ[10]-BA assembly demonstrated selective cytotoxicity toward melanoma cells while protecting normal cells,highlighting its potential in cancer theranostics.These findings reveal the critical role of cavity size and assembly mode in regulating material properties,providing new insights for designing multifunctional supramolecular systems with tailored functionalities for environmental monitoring and biomedical applications.
