Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were i...Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were included in the study. The operation time was from January 2015 to August 2022. Randomized grouping was carried out by means of computer number drawing, which was divided into control group (n75) and observation group (n75). The control group was anesthetized with a conventional protocol (midazolam+rocuronium), while the observation group was anesthetized with propofol during the induction period. The sedation effect, the incidence of adverse anesthetic reactions, the correlation of operation methods (duration of anesthesia induction, duration of respiratory recovery, duration of consciousness, concentration of propofol effect room, bispectral index of anesthesia EEG) and the hemodynamic index data at different time points were compared between the two groups. Results: the effective rate of sedation in the observation group was 98.67%, which was higher than that in the control group. The difference was significant after statistical software analysis (P<0.05). The incidence of adverse reaction of anesthesia in the observation group was 10.67%, which was insignificant compared with the control group after statistical software analysis (P>0.05). In the observation group, the duration of anesthesia induction was (4.05 ± 0.48) min, the duration of respiratory recovery was (5.35 ± 1.25) min, the duration of conscious awakening was (9.75 ± 3.55) min, the concentration of propofol in the response room was (1.18 ± 0.29) ug/mL, and the bispectral index of anesthesia EEG was (79.65 ± 6.84). Compared with the control group, the differences were significant after statistical software analysis (P<0.05). At 5 minutes after operation, the heart rate (91.58 ± 5.82) times/min, blood oxygen saturation (93.28 ± 6.34)%, and mean arterial pressure (80.35 ± 5.85) mmHg were observed in the observation group. Compared with the control group, the mean arterial pressure in the observation group was statistically significant (P<0.05). Conclusion: propofol can improve the sedative effect, reduce the influence of anesthesia, surgery and other operations on the hemodynamics of children during the induction period of pediatric anesthesia, and has high drug safety, which is worthy of promotion.展开更多
Objective:To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia(PT)on treating aged insomnia rats.Methods:Sixty Sprague-Dawley male rats were divided into 6 groups by a random num...Objective:To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia(PT)on treating aged insomnia rats.Methods:Sixty Sprague-Dawley male rats were divided into 6 groups by a random number table,including control group,model group,diazepam group(0.92 mg/kg),as well as PT low-,medium-and high-dose groups(0.0875,0.175,0.35 g/kg,respectively),10 rats in each group.Aged insomnia rat model was established with subcutaneous injection of D-galactose for 42 days and then intraperitoneal injection of para-chlorophenylalanine for 3 days.PT and diazepam were respectively given to aged insomnia rats by intragastric administration for 7 days after model establishment.Then the rats were investigated by body weight,Morris water maze test,pentobarbital test,enzyme-linked immunosorbent assay,and transcriptome sequencing.Results:Compared with the model group,PT increased the body weight,improved memory ability,and prolonged pentobarbital-induced sleep time of aged insomnia rats(P<0.01 or P<0.05).The medium dose of PT also increased the neurotransmitter levels of 5-hydroxytryptamine(5-HT)and gamma-aminobutyric acid(GABA),and decreased the level of Glu in the hippocampus of aged insomnia rats(P<0.05 or P<0.01).Twenty-four differentially expressed genes(DEGs)were overlapped among model group,medium-dose PT group,and diazepam group in transcriptome analysis.Fuom and Pcp2 were down-regulated by the treatment of medium-dose PT(P<0.01 or P<0.05).The metabolic pathways of PT were relatively less than diazepam(91 vs.104).Conclusions:The sedative and hypnotic effects of PT in aged insomnia rats might be related to neuro,metabolism pathways,especially through GABAergic signaling pathway.It provided more effective herb choice for the treatment of senile insomnia.展开更多
Objective: to explore the application effect of programmed sedation nursing in ICU patients with mechanical ventilation. Methods: 128 mechanical ventilation patients in ICU of our hospital from May 2018 to May 2020 we...Objective: to explore the application effect of programmed sedation nursing in ICU patients with mechanical ventilation. Methods: 128 mechanical ventilation patients in ICU of our hospital from May 2018 to May 2020 were randomly divided into control group (routine sedation nursing) and program group (programmed sedation nursing). The sedation effect and sedation adverse reactions of the two groups were observed. Results: after the programmed sedation nursing, the sedative dosage of the program group was significantly less than that of the control group, and the mechanical ventilation time and ICU treatment time of the program group were significantly shorter than those of the control group, P < 0.05. The incidence of sedation adverse reactions in the program group was significantly lower than that in the control group, P < 0.05. Conclusion: programmed sedation nursing for ICU patients with mechanical ventilation can effectively improve the sedation effect and reduce the occurrence of sedation adverse reactions, which is worthy of promotion.展开更多
Objective To study the hypnotic and anticonvulsant activities of the leaves of Eucommia ulmoides（LEU）,the total alkaloids were extracted from LEU using water-acid method.Methods Mice were divided into five groups,in...Objective To study the hypnotic and anticonvulsant activities of the leaves of Eucommia ulmoides（LEU）,the total alkaloids were extracted from LEU using water-acid method.Methods Mice were divided into five groups,including groups contained total alkaloids in three different doses,negative and positive control groups.Direct hypnotic experiment in mice,pentobarbital sodium synergistic experiment,and anticonvulsant experiment were used.The numbers of spontaneous activities,sleep rate,sleep latency,sleep time,convulsion rate,and convulsion latency of the mice were recorded and analyzed.Results The total alkaloids from LEU could increase the sleep rate,significantly lengthen the sleep time,and shorten the sleep latency of mice.Even the low dose of total alkaloids（0.33 g/kg）showed significantly different activities with negative control group（physiological saline）with the synergistic effect of the superthreshold dose of pentobarbital sodium.Furthermore,the total alkaloids efficiently inhibited the convulsion caused by nikethamide.Conclusion The total alkaloids from LEU have the excellent sedative,hypnotic,and anticonvulsant activities in mice,with high safety and little drug side effects.Therefore,they have the protential development prospects in sedative-hypnotic drugs.展开更多
文摘Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were included in the study. The operation time was from January 2015 to August 2022. Randomized grouping was carried out by means of computer number drawing, which was divided into control group (n75) and observation group (n75). The control group was anesthetized with a conventional protocol (midazolam+rocuronium), while the observation group was anesthetized with propofol during the induction period. The sedation effect, the incidence of adverse anesthetic reactions, the correlation of operation methods (duration of anesthesia induction, duration of respiratory recovery, duration of consciousness, concentration of propofol effect room, bispectral index of anesthesia EEG) and the hemodynamic index data at different time points were compared between the two groups. Results: the effective rate of sedation in the observation group was 98.67%, which was higher than that in the control group. The difference was significant after statistical software analysis (P<0.05). The incidence of adverse reaction of anesthesia in the observation group was 10.67%, which was insignificant compared with the control group after statistical software analysis (P>0.05). In the observation group, the duration of anesthesia induction was (4.05 ± 0.48) min, the duration of respiratory recovery was (5.35 ± 1.25) min, the duration of conscious awakening was (9.75 ± 3.55) min, the concentration of propofol in the response room was (1.18 ± 0.29) ug/mL, and the bispectral index of anesthesia EEG was (79.65 ± 6.84). Compared with the control group, the differences were significant after statistical software analysis (P<0.05). At 5 minutes after operation, the heart rate (91.58 ± 5.82) times/min, blood oxygen saturation (93.28 ± 6.34)%, and mean arterial pressure (80.35 ± 5.85) mmHg were observed in the observation group. Compared with the control group, the mean arterial pressure in the observation group was statistically significant (P<0.05). Conclusion: propofol can improve the sedative effect, reduce the influence of anesthesia, surgery and other operations on the hemodynamics of children during the induction period of pediatric anesthesia, and has high drug safety, which is worthy of promotion.
基金Supported by the National Natural Science Foundation of China(No.81960837 and 81560762)Xinjiang Uygur Autonomous Region Healthy Young Medical Science and Technology Talents Special Research Project(No.WJWY-201919)the 13th Five-Year Plan of Traditional Chinese M edicine Strategic Emerging Key Profession of Xinjiang。
文摘Objective:To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia(PT)on treating aged insomnia rats.Methods:Sixty Sprague-Dawley male rats were divided into 6 groups by a random number table,including control group,model group,diazepam group(0.92 mg/kg),as well as PT low-,medium-and high-dose groups(0.0875,0.175,0.35 g/kg,respectively),10 rats in each group.Aged insomnia rat model was established with subcutaneous injection of D-galactose for 42 days and then intraperitoneal injection of para-chlorophenylalanine for 3 days.PT and diazepam were respectively given to aged insomnia rats by intragastric administration for 7 days after model establishment.Then the rats were investigated by body weight,Morris water maze test,pentobarbital test,enzyme-linked immunosorbent assay,and transcriptome sequencing.Results:Compared with the model group,PT increased the body weight,improved memory ability,and prolonged pentobarbital-induced sleep time of aged insomnia rats(P<0.01 or P<0.05).The medium dose of PT also increased the neurotransmitter levels of 5-hydroxytryptamine(5-HT)and gamma-aminobutyric acid(GABA),and decreased the level of Glu in the hippocampus of aged insomnia rats(P<0.05 or P<0.01).Twenty-four differentially expressed genes(DEGs)were overlapped among model group,medium-dose PT group,and diazepam group in transcriptome analysis.Fuom and Pcp2 were down-regulated by the treatment of medium-dose PT(P<0.01 or P<0.05).The metabolic pathways of PT were relatively less than diazepam(91 vs.104).Conclusions:The sedative and hypnotic effects of PT in aged insomnia rats might be related to neuro,metabolism pathways,especially through GABAergic signaling pathway.It provided more effective herb choice for the treatment of senile insomnia.
文摘Objective: to explore the application effect of programmed sedation nursing in ICU patients with mechanical ventilation. Methods: 128 mechanical ventilation patients in ICU of our hospital from May 2018 to May 2020 were randomly divided into control group (routine sedation nursing) and program group (programmed sedation nursing). The sedation effect and sedation adverse reactions of the two groups were observed. Results: after the programmed sedation nursing, the sedative dosage of the program group was significantly less than that of the control group, and the mechanical ventilation time and ICU treatment time of the program group were significantly shorter than those of the control group, P < 0.05. The incidence of sedation adverse reactions in the program group was significantly lower than that in the control group, P < 0.05. Conclusion: programmed sedation nursing for ICU patients with mechanical ventilation can effectively improve the sedation effect and reduce the occurrence of sedation adverse reactions, which is worthy of promotion.
基金National Natural Science Foundation of China(31000017)
文摘Objective To study the hypnotic and anticonvulsant activities of the leaves of Eucommia ulmoides（LEU）,the total alkaloids were extracted from LEU using water-acid method.Methods Mice were divided into five groups,including groups contained total alkaloids in three different doses,negative and positive control groups.Direct hypnotic experiment in mice,pentobarbital sodium synergistic experiment,and anticonvulsant experiment were used.The numbers of spontaneous activities,sleep rate,sleep latency,sleep time,convulsion rate,and convulsion latency of the mice were recorded and analyzed.Results The total alkaloids from LEU could increase the sleep rate,significantly lengthen the sleep time,and shorten the sleep latency of mice.Even the low dose of total alkaloids（0.33 g/kg）showed significantly different activities with negative control group（physiological saline）with the synergistic effect of the superthreshold dose of pentobarbital sodium.Furthermore,the total alkaloids efficiently inhibited the convulsion caused by nikethamide.Conclusion The total alkaloids from LEU have the excellent sedative,hypnotic,and anticonvulsant activities in mice,with high safety and little drug side effects.Therefore,they have the protential development prospects in sedative-hypnotic drugs.
