Paeonol is a natural phenolic compound found in plants of the Ranunculaceae family,such as Mudanpi(Moutan Cortex)and Shaoyao(Paeoniae Radix).It possesses a wide range of pharmacological activities.Modern research conf...Paeonol is a natural phenolic compound found in plants of the Ranunculaceae family,such as Mudanpi(Moutan Cortex)and Shaoyao(Paeoniae Radix).It possesses a wide range of pharmacological activities.Modern research confirms that paeonol exhibits various pharmacological effects,including anti-inflammatory,antioxidant,antitumor,and immunomodulatory activities,demonstrating unique application value in the treatment of respiratory diseases.With the recent development of nanodelivery systems and derivatives,issues such as low oral bioavailability,poor stability,and short half-life of paeonol have been significantly improved.This article systematically reviews the role and mechanisms of paeonol in treating respiratory diseases such as asthma,pulmonary fibrosis,chronic obstructive pulmonary disease(COPD),lung cancer,allergic rhinitis,and pneumonia,analyzing existing application problems and potential solutions,aiming to provide a theoretical basis for its clinical application and further research and development.展开更多
To the Editor:Abeleda et al.[1]recently argued in a perspective article that the Philippines should do better in order to achieve its goal of reducing schistosomiasis incidence to zero in humans,animals,and snails by ...To the Editor:Abeleda et al.[1]recently argued in a perspective article that the Philippines should do better in order to achieve its goal of reducing schistosomiasis incidence to zero in humans,animals,and snails by 2025[2,3].The authors appropriately ascribed the need to ramp up surveillance,WASH(water,sanitation,and hygiene),and veterinary efforts.In this letter,I would like to add to the discussion that the key to achieving schistosomiasis elimination may be strengthening the veterinary public health sector and framing mitigation efforts within the One Health lens.Schistosoma(S.)japonicum infection is a zoonotic disease and it affects more than 40 species of animals,including livestock animals like cattle,pigs,and water buffaloes,and pets like dogs[4].In the Philippines,the prevalence of infection in animal reservoirs remains largely unknown in most endemic areas due to the lack of concerted epidemiological efforts unlike what is being done in human hosts.In areas where studies have been done,infection rates are from less than 10%to 97%in water buffaloes tested[5-7].Indeed,as Abeleda et al.[1]argued,there is a need to do better on this front.展开更多
基金National Natural Science Foundation of China(82104662)Natural Science Foundation of Henan Province(252300420126)+1 种基金International Science and Technology Cooperation Project of Henan Province(252102521022)Science and Technology Tackling Project of Henan Province(242102311251).
文摘Paeonol is a natural phenolic compound found in plants of the Ranunculaceae family,such as Mudanpi(Moutan Cortex)and Shaoyao(Paeoniae Radix).It possesses a wide range of pharmacological activities.Modern research confirms that paeonol exhibits various pharmacological effects,including anti-inflammatory,antioxidant,antitumor,and immunomodulatory activities,demonstrating unique application value in the treatment of respiratory diseases.With the recent development of nanodelivery systems and derivatives,issues such as low oral bioavailability,poor stability,and short half-life of paeonol have been significantly improved.This article systematically reviews the role and mechanisms of paeonol in treating respiratory diseases such as asthma,pulmonary fibrosis,chronic obstructive pulmonary disease(COPD),lung cancer,allergic rhinitis,and pneumonia,analyzing existing application problems and potential solutions,aiming to provide a theoretical basis for its clinical application and further research and development.
文摘To the Editor:Abeleda et al.[1]recently argued in a perspective article that the Philippines should do better in order to achieve its goal of reducing schistosomiasis incidence to zero in humans,animals,and snails by 2025[2,3].The authors appropriately ascribed the need to ramp up surveillance,WASH(water,sanitation,and hygiene),and veterinary efforts.In this letter,I would like to add to the discussion that the key to achieving schistosomiasis elimination may be strengthening the veterinary public health sector and framing mitigation efforts within the One Health lens.Schistosoma(S.)japonicum infection is a zoonotic disease and it affects more than 40 species of animals,including livestock animals like cattle,pigs,and water buffaloes,and pets like dogs[4].In the Philippines,the prevalence of infection in animal reservoirs remains largely unknown in most endemic areas due to the lack of concerted epidemiological efforts unlike what is being done in human hosts.In areas where studies have been done,infection rates are from less than 10%to 97%in water buffaloes tested[5-7].Indeed,as Abeleda et al.[1]argued,there is a need to do better on this front.
