In the relentless quest for digital sovereignty, organizations face an unprecedented challenge in safeguarding sensitive information, protecting against cyber threats, and maintaining regulatory compliance. This manus...In the relentless quest for digital sovereignty, organizations face an unprecedented challenge in safeguarding sensitive information, protecting against cyber threats, and maintaining regulatory compliance. This manuscript unveils a revolutionary blueprint for cyber resilience, empowering organizations to transcend the limitations of traditional cybersecurity paradigms and forge ahead into uncharted territories of data security excellence and frictionless secrets management experience. Enter a new era of cybersecurity innovation and continued excellence. By seamlessly integrating secrets based on logical environments and applications (assets), dynamic secrets management orchestrates and automates the secrets lifecycle management with other platform cohesive integrations. Enterprises can enhance security, streamline operations, fasten development practices, avoid secrets sprawl, and improve overall compliance and DevSecOps practice. This enables the enterprises to enhance security, streamline operations, fasten development & deployment practices, avoid secrets spawls, and improve overall volume in shipping software with paved-road DevSecOps Practices, and improve developers’ productivity. By seamlessly integrating secrets based on logical environments and applications (assets), dynamic secrets management orchestrates and automates the application secrets lifecycle with other platform cohesive integrations. Organizations can enhance security, streamline operations, fasten development & deployment practices, avoid secrets sprawl, and improve overall volume in shipping software with paved-road DevSecOps practices. Most importantly, increases developer productivity.展开更多
Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to...Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to the characteristics of the human vision system. Considering the issue of sharing the secret image at multiple image resolutions with the meaningful shadows, in this paper, we present a friendly progressive visual secret sharing scheme without expanding the image size in the shadows and the reconstructed secret image based on applying a 2x2-sized block-wise operation to generate the shadows block by block. The proposed method can achieve these benefits： 1） the generated shadows are meaningful, and their sizes are not expanded, and 2） the secret image can be recovered at different resolutions by stacking different quantities of shadows together. The experimental results also show that the proposed method is superior to other compared schemes.展开更多
IT is a common notion that Cantonese seldom make noodles because the climate of southern China’s Guangdong Province is unsuitable for growing highquality wheat.But along with the exchanges and integration between nor...IT is a common notion that Cantonese seldom make noodles because the climate of southern China’s Guangdong Province is unsuitable for growing highquality wheat.But along with the exchanges and integration between northern and southern food in China,Cantonese have mastered their own way of making jook-sing noodles,or bamboo pressed noodles,ingredients for a variety of local specialties like wonton noodles,shrimp noodles,longevity noodles and Teochew-style sweet and sour fried noodles.展开更多
Alice Munro,the first short story writer in Canada to receive the Nobel Prize laureate in 2013,applies the unconscious to the portrayal of characters and the construction of engrossing stories.Based on the unconscious...Alice Munro,the first short story writer in Canada to receive the Nobel Prize laureate in 2013,applies the unconscious to the portrayal of characters and the construction of engrossing stories.Based on the unconscious theory of Sigmund Freud’s psychoanalysis,this article focuses on one of Alice Munro’s short stories,Open Secrets,by analyzing the unconscious of representative characters,to explore their power conversion through the conflicts triggered by their unconscious mind.Via uncovering their unique personalities and values,as well as displaying their power against each other through conflict,this article reveals that the relationship between characters is sophisticated and changeable,and their power against each other has been a state of change in continuous conflicts.Behind the unconscious displays a thoroughly different comparison of forces:the strong who behaves violently and arrogantly actually shows weakness;in turn,the obedience and endurance of the weak strongly manifest a tenacious resistance.展开更多
Living to a ripe old age in China is on the increase - and a healthy lifestyle emerges as the key by Tang Yuankai SHE moves about with ease and sees and hears without any trouble.And on most days she climbs a mountain...Living to a ripe old age in China is on the increase - and a healthy lifestyle emerges as the key by Tang Yuankai SHE moves about with ease and sees and hears without any trouble.And on most days she climbs a mountain to work on展开更多
History shows that once a nation declines, chances of revival are slim, especially for very small nations. They are either assimilated by other strong nations or shut up deep in the mountains, living a slash and burn ...History shows that once a nation declines, chances of revival are slim, especially for very small nations. They are either assimilated by other strong nations or shut up deep in the mountains, living a slash and burn way of living. Even if there are some ancient nations that have survived and made some progress, they did so with great difficulty. Mesopotamia, Egypt, India, Greece and Persia all are proud of their glorious past and are ambitious for national revival. But the path is not smooth. The Jewish nation, however, is an exception. What is the secret of its survival and seemingly sudden revival？展开更多
一年一度的莱卡风尚大典,每次都是明星的聚会,时尚的 SHOW 场。从星光大道的红地毯到华丽大气的颁奖现场再到与记者面对面的采访大厅,他们时时刻刻都在展示着自己的绰约丰姿。当天的盛况你可能已经从其他媒体领略了一二,但你一定没有看...一年一度的莱卡风尚大典,每次都是明星的聚会,时尚的 SHOW 场。从星光大道的红地毯到华丽大气的颁奖现场再到与记者面对面的采访大厅,他们时时刻刻都在展示着自己的绰约丰姿。当天的盛况你可能已经从其他媒体领略了一二,但你一定没有看过 Easy 要Show 你的聚光灯背后的点点滴滴。不信?Let's Go.展开更多
We consider the reconstruction of shared secrets in communication networks, which are modelled by graphs whose components are subject to possible failure. The reconstruction probability can be approximated using minim...We consider the reconstruction of shared secrets in communication networks, which are modelled by graphs whose components are subject to possible failure. The reconstruction probability can be approximated using minimal cuts, if the failure probabilities of vertices and edges are close to zero. As the main contribution of this paper, node separators are used to design a heuristic for the near-optimal placement of secrets sets on the vertices of the graph.展开更多
The exhibition Echoes of King Kaolie Archaeological Discoveries From the Wuwangdun Tomb No.1 opened at the National Museum of China in Beijing on December 26,2025.Wuwangdun Tomb No.1 is the mausoleum of King Kaolie,wh...The exhibition Echoes of King Kaolie Archaeological Discoveries From the Wuwangdun Tomb No.1 opened at the National Museum of China in Beijing on December 26,2025.Wuwangdun Tomb No.1 is the mausoleum of King Kaolie,who ruled the State of Chu during the Warring States Period(475-221 B.C.).展开更多
Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unco...Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unconventional secretion pathways,focusing on secretory autophagy and its role in secreting protein aggregates associated with neurodegenerative disorders.We also explore additional neuronal functions of secretory autophagy beyond the release of protein aggregates.We propose autophagosomes as transport organelles that deliver cargo material directly from the endoplasmatic reticulum(ER)to the plasma membrane rather than solely to lysosomes.展开更多
Progranulin(PGRN),encoded by the GRN gene,is a secreted glycoprotein that undergoes proteolytic cleavage to generate individual granulin peptides(granulin A-G)capable of exerting distinct biological functions.PGRN is ...Progranulin(PGRN),encoded by the GRN gene,is a secreted glycoprotein that undergoes proteolytic cleavage to generate individual granulin peptides(granulin A-G)capable of exerting distinct biological functions.PGRN is widely expressed in multiple tissues,including the central nervous and immune systems.Within the central nervous system,PGRN is highly expressed in the hippocampus,cerebral cortex,and hypothalamus,and has been detected in various neuronal subtypes,including Purkinje cells and motor neurons,where it plays a crucial role in neuronal functions,such as neurite outgrowth and synaptic plasticity.In addition to neurons,PGRN is expressed in glial cells,particularly in microglia,where it regulates phagocytosis.Furthermore,PGRN is presented in peripheral immune cells,including macrophages,and contributes to the regulation of inflammatory responses.PGRN exerts its diverse functions via binding partners,including receptors such as sortilin,EphA2,Notch,death receptor 3,and toll-like receptor 9(Chitramuthu et al.,2017).展开更多
In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaq...In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaqi Han,Bowen Xu,Yang Zhou,Jing Wu,Xiaowen Pu,and Wenhong Zhang;Biomed Environ Sci,2026;39(2):215-222).展开更多
From watch repairman to cable magnate, Jiang Xipei takes success in his stride Jiang Xipei, Chairman of Far East Group, has worked his way up from being an ordinary watch repairman to being China’s 'King of Cable...From watch repairman to cable magnate, Jiang Xipei takes success in his stride Jiang Xipei, Chairman of Far East Group, has worked his way up from being an ordinary watch repairman to being China’s 'King of Cable'-leading his company to a ranking of展开更多
Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms.We showed previously that astrocytes cultured from mice transgenic for human P30...Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms.We showed previously that astrocytes cultured from mice transgenic for human P301S-tau(P301S-mice)recapitulate the deficit in production and secretion of thrombospondin1 found in symptomatic P301S mouse brains,causing both reduced synapse formation and survival of cultured neurons.To further characterize how P301S-derived astrocytes differ from controls,we have compared the astrocyte-conditioned media of cultured astrocytes from postnatal day 7/8 P301S mice(P301S-astrocyte-conditioned media)versus controls(C57-astrocyte-conditioned media)using label-free liquid chromatography-mass spectrometry.We verified that thrombospondin1 secretion was significantly reduced in the P301S-astrocyte-conditioned media versus C57-astrocyte-conditioned media,demonstrating the robustness of the analysis.The most notable distinction was that~57%of the P301S-astrocyte-conditioned media-enriched proteins were cytoplasmic proteins linked to cellular metabolism that are not predicted to be secreted via classical or non-classical secretion pathways,whereas~88%of C57-astrocyte-conditioned media-enriched proteins comprised classically secreted proteins enriched in extracellular matrix components.These differences are associated with the finding that P301S-derived cultured astrocytes were smaller and in vivo appeared less mature in the cortex of P301S mice.The unconventional secretion pathway that P301S-astrocyte-conditioned media display shares similarities with several amyloid-β-exposed astrocyte-conditioned media,indicating that stimuli induced by tau and amyloid-βmay induce a common adverse response pathway.Altogether,members of this adverse pathway may serve as a potential set of biomarkers to aid the clinical diagnosis of Alzheimer’s disease and other tauopathies,while the list of reduced neurosupportive factors could indicate new approaches to enhance neuronal survival by factor supplementation in tauopathies.展开更多
文摘In the relentless quest for digital sovereignty, organizations face an unprecedented challenge in safeguarding sensitive information, protecting against cyber threats, and maintaining regulatory compliance. This manuscript unveils a revolutionary blueprint for cyber resilience, empowering organizations to transcend the limitations of traditional cybersecurity paradigms and forge ahead into uncharted territories of data security excellence and frictionless secrets management experience. Enter a new era of cybersecurity innovation and continued excellence. By seamlessly integrating secrets based on logical environments and applications (assets), dynamic secrets management orchestrates and automates the secrets lifecycle management with other platform cohesive integrations. Enterprises can enhance security, streamline operations, fasten development practices, avoid secrets sprawl, and improve overall compliance and DevSecOps practice. This enables the enterprises to enhance security, streamline operations, fasten development & deployment practices, avoid secrets spawls, and improve overall volume in shipping software with paved-road DevSecOps Practices, and improve developers’ productivity. By seamlessly integrating secrets based on logical environments and applications (assets), dynamic secrets management orchestrates and automates the application secrets lifecycle with other platform cohesive integrations. Organizations can enhance security, streamline operations, fasten development & deployment practices, avoid secrets sprawl, and improve overall volume in shipping software with paved-road DevSecOps practices. Most importantly, increases developer productivity.
文摘Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to the characteristics of the human vision system. Considering the issue of sharing the secret image at multiple image resolutions with the meaningful shadows, in this paper, we present a friendly progressive visual secret sharing scheme without expanding the image size in the shadows and the reconstructed secret image based on applying a 2x2-sized block-wise operation to generate the shadows block by block. The proposed method can achieve these benefits： 1） the generated shadows are meaningful, and their sizes are not expanded, and 2） the secret image can be recovered at different resolutions by stacking different quantities of shadows together. The experimental results also show that the proposed method is superior to other compared schemes.
文摘IT is a common notion that Cantonese seldom make noodles because the climate of southern China’s Guangdong Province is unsuitable for growing highquality wheat.But along with the exchanges and integration between northern and southern food in China,Cantonese have mastered their own way of making jook-sing noodles,or bamboo pressed noodles,ingredients for a variety of local specialties like wonton noodles,shrimp noodles,longevity noodles and Teochew-style sweet and sour fried noodles.
文摘Alice Munro,the first short story writer in Canada to receive the Nobel Prize laureate in 2013,applies the unconscious to the portrayal of characters and the construction of engrossing stories.Based on the unconscious theory of Sigmund Freud’s psychoanalysis,this article focuses on one of Alice Munro’s short stories,Open Secrets,by analyzing the unconscious of representative characters,to explore their power conversion through the conflicts triggered by their unconscious mind.Via uncovering their unique personalities and values,as well as displaying their power against each other through conflict,this article reveals that the relationship between characters is sophisticated and changeable,and their power against each other has been a state of change in continuous conflicts.Behind the unconscious displays a thoroughly different comparison of forces:the strong who behaves violently and arrogantly actually shows weakness;in turn,the obedience and endurance of the weak strongly manifest a tenacious resistance.
文摘Living to a ripe old age in China is on the increase - and a healthy lifestyle emerges as the key by Tang Yuankai SHE moves about with ease and sees and hears without any trouble.And on most days she climbs a mountain to work on
文摘History shows that once a nation declines, chances of revival are slim, especially for very small nations. They are either assimilated by other strong nations or shut up deep in the mountains, living a slash and burn way of living. Even if there are some ancient nations that have survived and made some progress, they did so with great difficulty. Mesopotamia, Egypt, India, Greece and Persia all are proud of their glorious past and are ambitious for national revival. But the path is not smooth. The Jewish nation, however, is an exception. What is the secret of its survival and seemingly sudden revival？
文摘We consider the reconstruction of shared secrets in communication networks, which are modelled by graphs whose components are subject to possible failure. The reconstruction probability can be approximated using minimal cuts, if the failure probabilities of vertices and edges are close to zero. As the main contribution of this paper, node separators are used to design a heuristic for the near-optimal placement of secrets sets on the vertices of the graph.
文摘The exhibition Echoes of King Kaolie Archaeological Discoveries From the Wuwangdun Tomb No.1 opened at the National Museum of China in Beijing on December 26,2025.Wuwangdun Tomb No.1 is the mausoleum of King Kaolie,who ruled the State of Chu during the Warring States Period(475-221 B.C.).
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)grant LU 2347/3-1(to PL).
文摘Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unconventional secretion pathways,focusing on secretory autophagy and its role in secreting protein aggregates associated with neurodegenerative disorders.We also explore additional neuronal functions of secretory autophagy beyond the release of protein aggregates.We propose autophagosomes as transport organelles that deliver cargo material directly from the endoplasmatic reticulum(ER)to the plasma membrane rather than solely to lysosomes.
基金SENSHIN Medical Research Foundation,Takeda Science Foundation,Taiju Life Social Welfare Foundation,Mitsui Sumitomo Insurance Welfare Foundation,Research Foundation for Pharmaceutical Sciences,Tokyo Medical University Research Grant,JSPS KAKENHI(23K06369)to SKJSPS KAKENHI(24K02187)to KK.
文摘Progranulin(PGRN),encoded by the GRN gene,is a secreted glycoprotein that undergoes proteolytic cleavage to generate individual granulin peptides(granulin A-G)capable of exerting distinct biological functions.PGRN is widely expressed in multiple tissues,including the central nervous and immune systems.Within the central nervous system,PGRN is highly expressed in the hippocampus,cerebral cortex,and hypothalamus,and has been detected in various neuronal subtypes,including Purkinje cells and motor neurons,where it plays a crucial role in neuronal functions,such as neurite outgrowth and synaptic plasticity.In addition to neurons,PGRN is expressed in glial cells,particularly in microglia,where it regulates phagocytosis.Furthermore,PGRN is presented in peripheral immune cells,including macrophages,and contributes to the regulation of inflammatory responses.PGRN exerts its diverse functions via binding partners,including receptors such as sortilin,EphA2,Notch,death receptor 3,and toll-like receptor 9(Chitramuthu et al.,2017).
文摘In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaqi Han,Bowen Xu,Yang Zhou,Jing Wu,Xiaowen Pu,and Wenhong Zhang;Biomed Environ Sci,2026;39(2):215-222).
文摘From watch repairman to cable magnate, Jiang Xipei takes success in his stride Jiang Xipei, Chairman of Far East Group, has worked his way up from being an ordinary watch repairman to being China’s 'King of Cable'-leading his company to a ranking of
基金MGS from the Alzheimer Society(#384,AS-PG-17-026),Alzheimer’s Research UK(ART-PG2011-20 and ARUK-EXT2015B-2)the BBSRC(BB/T509085/1)+1 种基金The Fondation Recherche Alzheimer(G112606)the Scholl Foundation,and to MGS and AMT from the National Center for the Replacement,Refinement,&Reduction of Animals in Research(NC3R)(#NC/L000741/1).
文摘Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms.We showed previously that astrocytes cultured from mice transgenic for human P301S-tau(P301S-mice)recapitulate the deficit in production and secretion of thrombospondin1 found in symptomatic P301S mouse brains,causing both reduced synapse formation and survival of cultured neurons.To further characterize how P301S-derived astrocytes differ from controls,we have compared the astrocyte-conditioned media of cultured astrocytes from postnatal day 7/8 P301S mice(P301S-astrocyte-conditioned media)versus controls(C57-astrocyte-conditioned media)using label-free liquid chromatography-mass spectrometry.We verified that thrombospondin1 secretion was significantly reduced in the P301S-astrocyte-conditioned media versus C57-astrocyte-conditioned media,demonstrating the robustness of the analysis.The most notable distinction was that~57%of the P301S-astrocyte-conditioned media-enriched proteins were cytoplasmic proteins linked to cellular metabolism that are not predicted to be secreted via classical or non-classical secretion pathways,whereas~88%of C57-astrocyte-conditioned media-enriched proteins comprised classically secreted proteins enriched in extracellular matrix components.These differences are associated with the finding that P301S-derived cultured astrocytes were smaller and in vivo appeared less mature in the cortex of P301S mice.The unconventional secretion pathway that P301S-astrocyte-conditioned media display shares similarities with several amyloid-β-exposed astrocyte-conditioned media,indicating that stimuli induced by tau and amyloid-βmay induce a common adverse response pathway.Altogether,members of this adverse pathway may serve as a potential set of biomarkers to aid the clinical diagnosis of Alzheimer’s disease and other tauopathies,while the list of reduced neurosupportive factors could indicate new approaches to enhance neuronal survival by factor supplementation in tauopathies.
