Background:Sapindus mukurossi extract(SME)is a kind of natural surface active ingredient with potential applications in cleansing products.However,the polyphenols and pigments contained in the extract may cause color ...Background:Sapindus mukurossi extract(SME)is a kind of natural surface active ingredient with potential applications in cleansing products.However,the polyphenols and pigments contained in the extract may cause color browning of the products during storage especially at elevated temperatures,affecting its high level addition in the products.Objective:To explore a decolorization process suitable for industrialization realize the high level addition of SME and explore the potential of SME in the field of controlling sebum esters.Materials and Methods:SME was prepared by adsorbing polyphenols on the D301 resin and oxidation decoloring oxidation.Investigated its sebum-control efficacy by SZ95 model and clinical study.Results:The results demonstrate that the D301 resin displays the best adsorption selectivity for polyphenols in SME,and the polyphenol adsorption ratio of D301 resin(5 wt%)can reach 83.6%;The optimal decolorization conditions are pH=7.8,temperature 73℃and decolorization time 5.7 h when H2O2 content is 6%,The prepared SME shows no obvious changes in color and retain stable during the high temperature(50℃)test period of 28 days.4μg/mL of SME decreases the lipid synthesis of SZ95 cells by 24.8%.The clinic efficacy of the shampoo containing 10%SME(by dry extract weigh)is further evaluated.No significant changes in the skin moisture content and transepidermal water loss(TEWL)are observed within four weeks after using the product,while the scalp sebum level is significantly reduced.Conclusion:In this study,we prepared a light-colored,highly stable SME,enabled its high-level addition in cleansing and care products and found its sebum-control efficacy.展开更多
Oily skin,a facial skin condition,appears shiny and greasy and is a source of common skin disorders such as acne vulgaris and seborrheic dermatitis.Moreover,oily skin can lead to depression,distress,and so on,which ca...Oily skin,a facial skin condition,appears shiny and greasy and is a source of common skin disorders such as acne vulgaris and seborrheic dermatitis.Moreover,oily skin can lead to depression,distress,and so on,which can be detrimental to social interactions.In this study,the effect of Norway spruce leaf extract(NSLE)on the management of oily skin was investigated both in vitro and in vivo,focusing on its sebum-controlling and anti-inflammatory properties.The in vitro results showed that the NSLE significantly reduced neutral lipids in linoleic acid(LA)-induced human SZ95 sebocytes in a dose-dependent manner(P<0.05).Additionally,the 2.5%NSLE was able to reduce the lipopolysaccharide(LPS)-induced elevation of nitric oxide(NO)levels in RAW264.7 cells(P<0.05).The human efficacy evaluation showed that the emulsion containing 2.5%NSLE had a significant sebum-controlling effect,the skin sebum content decreased by 29.3%after 7 days.Furthermore,the results also indicated a notable improvement in skin glossiness and lightness(P<0.05)after two weeks of application,compared to baseline.In conclusion,NSLE effectively enhances the skin health of oily skin by reducing sebum production and inhibiting inflammation.This study provided evidence for NSLE as a natural and effective ingredient in skincare products for individuals with oily skin.展开更多
文摘Background:Sapindus mukurossi extract(SME)is a kind of natural surface active ingredient with potential applications in cleansing products.However,the polyphenols and pigments contained in the extract may cause color browning of the products during storage especially at elevated temperatures,affecting its high level addition in the products.Objective:To explore a decolorization process suitable for industrialization realize the high level addition of SME and explore the potential of SME in the field of controlling sebum esters.Materials and Methods:SME was prepared by adsorbing polyphenols on the D301 resin and oxidation decoloring oxidation.Investigated its sebum-control efficacy by SZ95 model and clinical study.Results:The results demonstrate that the D301 resin displays the best adsorption selectivity for polyphenols in SME,and the polyphenol adsorption ratio of D301 resin(5 wt%)can reach 83.6%;The optimal decolorization conditions are pH=7.8,temperature 73℃and decolorization time 5.7 h when H2O2 content is 6%,The prepared SME shows no obvious changes in color and retain stable during the high temperature(50℃)test period of 28 days.4μg/mL of SME decreases the lipid synthesis of SZ95 cells by 24.8%.The clinic efficacy of the shampoo containing 10%SME(by dry extract weigh)is further evaluated.No significant changes in the skin moisture content and transepidermal water loss(TEWL)are observed within four weeks after using the product,while the scalp sebum level is significantly reduced.Conclusion:In this study,we prepared a light-colored,highly stable SME,enabled its high-level addition in cleansing and care products and found its sebum-control efficacy.
文摘Oily skin,a facial skin condition,appears shiny and greasy and is a source of common skin disorders such as acne vulgaris and seborrheic dermatitis.Moreover,oily skin can lead to depression,distress,and so on,which can be detrimental to social interactions.In this study,the effect of Norway spruce leaf extract(NSLE)on the management of oily skin was investigated both in vitro and in vivo,focusing on its sebum-controlling and anti-inflammatory properties.The in vitro results showed that the NSLE significantly reduced neutral lipids in linoleic acid(LA)-induced human SZ95 sebocytes in a dose-dependent manner(P<0.05).Additionally,the 2.5%NSLE was able to reduce the lipopolysaccharide(LPS)-induced elevation of nitric oxide(NO)levels in RAW264.7 cells(P<0.05).The human efficacy evaluation showed that the emulsion containing 2.5%NSLE had a significant sebum-controlling effect,the skin sebum content decreased by 29.3%after 7 days.Furthermore,the results also indicated a notable improvement in skin glossiness and lightness(P<0.05)after two weeks of application,compared to baseline.In conclusion,NSLE effectively enhances the skin health of oily skin by reducing sebum production and inhibiting inflammation.This study provided evidence for NSLE as a natural and effective ingredient in skincare products for individuals with oily skin.
