BACKGROUND The 5-year survival rate of patients with advanced gastric cancer remains extremely low(<15%),whereas the 5-year survival rate of patients with early gastric cancer(EGC)is>90%.Consequently,strengtheni...BACKGROUND The 5-year survival rate of patients with advanced gastric cancer remains extremely low(<15%),whereas the 5-year survival rate of patients with early gastric cancer(EGC)is>90%.Consequently,strengthening the screening of patients with EGC and precancerous lesions(PCLs)is essential.AIM To identify the value of serum pepsinogen ratio(PGR)screening for EGC and PCLs in the Shengli Oilfield Central Hospital.METHODS We first selected 385 patients with gastric lesions in the Youcheng area,deter-mining benign lesions,PCLs,and EGC in 135,123,and 127 cases,respec-tively,based on endoscopy and case diagnosis.The positive rates of pepsinogen I,pep-sinogen II and Helicobacter pylori(H.pylori)in the three groups were detected,and the PGR was calculated.Subsequently,we plotted receiver operating charac-teristic curves to analyze the screening value of PGR and H.pylori-positive rates for PCLs and EGC.RESULTS PGR expression demonstrated a decreasing trend in patients with benign lesions,PCLs,and EGC successively according to the detection results,whereas the H.pylori-positive rate was notably increased in patients with PCLs and EGC compared to those with benign lesions.The area under the curves(AUCs)of PGR,H.pylori,and their combination in differentiating patients with benign lesions from those with PCLs were 0.611,0.582,and 0.689,respectively;PGR,H.pylori,and their combination had an AUC of 0.618,0.502,and 0.618 in distinguishing PCL patients from EGC patients,respectively;the AUCs of PGR,H.pylori,and their combination in discriminating patients with benign lesions from those with EGC were 0.708,0.581,and 0.750,respectively.CONCLUSION PGR has great screening potential for patients with EGC and PCLs in the Youcheng area,and the screening efficiency is further improved by combining the H.pylori-positive rate.展开更多
Objective: to analyze the application value of mean erythrocyte volume in the screening of thalassemia in pregnant women. Methods: from January 2020 to March 2021, 123 pregnant women who received prenatal examination ...Objective: to analyze the application value of mean erythrocyte volume in the screening of thalassemia in pregnant women. Methods: from January 2020 to March 2021, 123 pregnant women who received prenatal examination in our hospital and were diagnosed with thalassemia by genetic examination were selected as the research objects, and they were taken as the observation group, and 100 pregnant women who received pregnancy examination during the same period but the results were normal were taken as the control group. The results of routine blood tests of the two were retrospectively analyzed. The sensitivity, specificity and total accuracy of average erythrocyte volume in the diagnosis of different types of thalassemia were calculated. Results: among 123 pregnant women with thalassemia confirmed by gene testing, 65 cases were α thalassemia, 50 cases were β thalassemia and 8 cases were α and β combined thalassemia. MCV test values of pregnant women in the two groups were compared, indicating that pregnant women with different types of thalassemia were significantly lower than normal pregnant women, with statistical difference (P < 0.05). The sensitivity and specificity of α thalassemia, β thalassemia, α and β compound thalassemia were 90.77%, 92.00% and 100.00%, respectively, using genetic test results as the diagnostic gold standard. The overall accuracy was 78.03%. Conclusion: mean erythrocyte volume is of great value in the screening of thalassemia in pregnant women.展开更多
文摘BACKGROUND The 5-year survival rate of patients with advanced gastric cancer remains extremely low(<15%),whereas the 5-year survival rate of patients with early gastric cancer(EGC)is>90%.Consequently,strengthening the screening of patients with EGC and precancerous lesions(PCLs)is essential.AIM To identify the value of serum pepsinogen ratio(PGR)screening for EGC and PCLs in the Shengli Oilfield Central Hospital.METHODS We first selected 385 patients with gastric lesions in the Youcheng area,deter-mining benign lesions,PCLs,and EGC in 135,123,and 127 cases,respec-tively,based on endoscopy and case diagnosis.The positive rates of pepsinogen I,pep-sinogen II and Helicobacter pylori(H.pylori)in the three groups were detected,and the PGR was calculated.Subsequently,we plotted receiver operating charac-teristic curves to analyze the screening value of PGR and H.pylori-positive rates for PCLs and EGC.RESULTS PGR expression demonstrated a decreasing trend in patients with benign lesions,PCLs,and EGC successively according to the detection results,whereas the H.pylori-positive rate was notably increased in patients with PCLs and EGC compared to those with benign lesions.The area under the curves(AUCs)of PGR,H.pylori,and their combination in differentiating patients with benign lesions from those with PCLs were 0.611,0.582,and 0.689,respectively;PGR,H.pylori,and their combination had an AUC of 0.618,0.502,and 0.618 in distinguishing PCL patients from EGC patients,respectively;the AUCs of PGR,H.pylori,and their combination in discriminating patients with benign lesions from those with EGC were 0.708,0.581,and 0.750,respectively.CONCLUSION PGR has great screening potential for patients with EGC and PCLs in the Youcheng area,and the screening efficiency is further improved by combining the H.pylori-positive rate.
文摘Objective: to analyze the application value of mean erythrocyte volume in the screening of thalassemia in pregnant women. Methods: from January 2020 to March 2021, 123 pregnant women who received prenatal examination in our hospital and were diagnosed with thalassemia by genetic examination were selected as the research objects, and they were taken as the observation group, and 100 pregnant women who received pregnancy examination during the same period but the results were normal were taken as the control group. The results of routine blood tests of the two were retrospectively analyzed. The sensitivity, specificity and total accuracy of average erythrocyte volume in the diagnosis of different types of thalassemia were calculated. Results: among 123 pregnant women with thalassemia confirmed by gene testing, 65 cases were α thalassemia, 50 cases were β thalassemia and 8 cases were α and β combined thalassemia. MCV test values of pregnant women in the two groups were compared, indicating that pregnant women with different types of thalassemia were significantly lower than normal pregnant women, with statistical difference (P < 0.05). The sensitivity and specificity of α thalassemia, β thalassemia, α and β compound thalassemia were 90.77%, 92.00% and 100.00%, respectively, using genetic test results as the diagnostic gold standard. The overall accuracy was 78.03%. Conclusion: mean erythrocyte volume is of great value in the screening of thalassemia in pregnant women.
