Using highly dilute method and 5-fold excess of diamine a new acyclic diamine containing pyridine moiety,N,N'-bis(2-aminoethyl)-2,6-pyridinedicarbamide(1a)was synthesized.Six novel linear polydentate Schiff baseli...Using highly dilute method and 5-fold excess of diamine a new acyclic diamine containing pyridine moiety,N,N'-bis(2-aminoethyl)-2,6-pyridinedicarbamide(1a)was synthesized.Six novel linear polydentate Schiff baseligands containing pyridine and amide moieties,N,N'-bis[ß-(R-substitutedbenzalimino)ethyl]-2,6-pyridinedicar-bamide(2a--2e),where R=H,o-OH,p-OH,m-NO2,p-N(CHg)2,and N,N'-bis(y-salicylideneaminopropyl)-2,6-pyridinedicarbamide(2f)have been synthesized and characterized by elemental analysis,IR,UV-Vis,MS and IHNMR methods.The single-crystal analysis of 2e showed that it belongs to triclinic system with P-1 space group andthe unit cell parameters:a=11.010(2)nm,b=13.865(3)nm,c=9.6537(19)nm,a=102.77(2)°,B=92.07(3)°,y=87.98(3)°,V=1435.7(5)nm3,Z=2,D=1.230 mg·cm=3,M,=531.66.In addition,microcalorimetric test of theinhibitory capacities of these compounds for E.coli has shown that they have antibacterial activity to differentextent and that of salicylidene Schiff base is the best.The structure-activity relationship has been primarilydiscussed.展开更多
基金supported by the NationalNatural Science Foundation of China(No.20072029)
文摘Using highly dilute method and 5-fold excess of diamine a new acyclic diamine containing pyridine moiety,N,N'-bis(2-aminoethyl)-2,6-pyridinedicarbamide(1a)was synthesized.Six novel linear polydentate Schiff baseligands containing pyridine and amide moieties,N,N'-bis[ß-(R-substitutedbenzalimino)ethyl]-2,6-pyridinedicar-bamide(2a--2e),where R=H,o-OH,p-OH,m-NO2,p-N(CHg)2,and N,N'-bis(y-salicylideneaminopropyl)-2,6-pyridinedicarbamide(2f)have been synthesized and characterized by elemental analysis,IR,UV-Vis,MS and IHNMR methods.The single-crystal analysis of 2e showed that it belongs to triclinic system with P-1 space group andthe unit cell parameters:a=11.010(2)nm,b=13.865(3)nm,c=9.6537(19)nm,a=102.77(2)°,B=92.07(3)°,y=87.98(3)°,V=1435.7(5)nm3,Z=2,D=1.230 mg·cm=3,M,=531.66.In addition,microcalorimetric test of theinhibitory capacities of these compounds for E.coli has shown that they have antibacterial activity to differentextent and that of salicylidene Schiff base is the best.The structure-activity relationship has been primarilydiscussed.
