[Objectives] To explore whether there are natural substances that inhibit human aldose reductase in different extracts of Salvia deserta Schang.[Methods] The inhibitory activities of human aldose reductase from 28 ext...[Objectives] To explore whether there are natural substances that inhibit human aldose reductase in different extracts of Salvia deserta Schang.[Methods] The inhibitory activities of human aldose reductase from 28 extracts were screened.[Results] The methanol extract of roots of Salvia deserta Schang had the strongest inhibitory effect on human aldose reductase.[Conclusions] It was confirmed that Salvia deserta Schang has inhibitory effect on human aldose reductase.展开更多
[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid wer...[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.展开更多
基金Supported by Scientific Research Program of Universities in Xinjiang Uygur Autonomous Region(XJEDU2018Y025)
文摘[Objectives] To explore whether there are natural substances that inhibit human aldose reductase in different extracts of Salvia deserta Schang.[Methods] The inhibitory activities of human aldose reductase from 28 extracts were screened.[Results] The methanol extract of roots of Salvia deserta Schang had the strongest inhibitory effect on human aldose reductase.[Conclusions] It was confirmed that Salvia deserta Schang has inhibitory effect on human aldose reductase.
基金Supported by Scientific Research Plan for Colleges and Universities in Xinjiang Uygur Autonomous Region(XJEDU2018Y025)
文摘[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.
