Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance(^(31)P NMR)spectroscopy and thin-layer chromatography(TLC) scanning combined with the corrective method of absorbance pr...Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance(^(31)P NMR)spectroscopy and thin-layer chromatography(TLC) scanning combined with the corrective method of absorbance proportional coefficient. The NMR spectrometer used this investigation was a Bruker AM-500 spectrometer operating at 202.4 MHz for ^(31)P chemical shifts are relative to 85% phosphoric acid. TIC was carried out by silica gel H plate developed in chloroform-methanol-glacial acetic acid-ethanol-water(25:4:6:2:0.5),with Vaskovsky reagent as colour -developing agent of phospholipids.展开更多
In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiat...In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic effect.Specifically,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal design.In the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation terminals.In order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam line.However,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation uniformity.To mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at SESRI.In the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS waveforms.In this paper,the method and experimental results were introduced.展开更多
Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between...Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between the severity of knee joint osteoarthritis and the alignment of patellofemoral and patellar height on radiographs.Methods:This multi-center,retrospective study analyzed the magnetic resonance imaging(MRI)scans and anteroposterior radiographs of 534 adult outpatients with KOA.To evaluate the radiographic severity of KOA,anteroposterior radiographs of the knee and the Kellgren-Lawrence(K-L)grade were used.Knee MRI scans were used to measure the patellar length ratio(PLR),sulcus angle(SA),lateral patellar tilt angle(LPTA),and the distance between tibial tuberosity and trochlear groove(TT-TG).We examined the association between the configuration of the PFJ,arrangement,and harshness of the KOA.Information on participants’demographics,such as age,sex,side,height,and weight,was collected.A chi-squared test was used for the correlation of radiographic severity of KOA with sex and the affected side.Spearman correlation was used for patellofemoral alignment or morphology and the radiographic severity of lateral KOA.Multiple linear regression models were used for the association between LPTA,SA,TT-TG,and severity of KOA after accounting for demographic variables.Results:The study comprised of 534 patients;of these,339(63%)were female.A total of 586 knees were evaluated in this study.Age showed a strong positive correlation with KOA severity(r=0.516,P<0.01),whereas LPTA showed a strong negative correlation(r=–0.662,P<0.01).Additionally,SA(r=0.616,P<0.05),and TT-TG showed a strong positive correlation(r=0.770,P<0.01)with tibiofemoral osteoarthritis(TFOA)severity.Multiple linear regression analysis indicated that knee osteoarthritis severity(β=–2.946,P<0.001)and side(β=–0.839,P=0.001)was associated with LPTA;knee osteoarthritis severity(β=5.032,P<0.001)and age(β=–0.095,P<0.001)was associated with SA;knee osteoarthritis severity(β=2.445,P<0.001),sex(β=–0.326,P=0.041),body mass index(β=–0.061,P=0.017)and age(β=–0.025,P<0.001)was associated with TT-TG.Conclusion:Radiographic severity of KOA was positively associated with age,SA,and TT-TG but negatively associated with LPTA.展开更多
文摘Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance(^(31)P NMR)spectroscopy and thin-layer chromatography(TLC) scanning combined with the corrective method of absorbance proportional coefficient. The NMR spectrometer used this investigation was a Bruker AM-500 spectrometer operating at 202.4 MHz for ^(31)P chemical shifts are relative to 85% phosphoric acid. TIC was carried out by silica gel H plate developed in chloroform-methanol-glacial acetic acid-ethanol-water(25:4:6:2:0.5),with Vaskovsky reagent as colour -developing agent of phospholipids.
基金Supported by National Key R&D Program of China(2019YFA0405400)。
文摘In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic effect.Specifically,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal design.In the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation terminals.In order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam line.However,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation uniformity.To mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at SESRI.In the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS waveforms.In this paper,the method and experimental results were introduced.
基金supported by Shandong Province Medical and Health Science Technology Development Program(No.202104070134)the Guangxi Key Research and Development Plan(No.AB22035014)the Special Fund of Characteristic Innovation Team of the First Affiliated Hospital of Guangxi MedicalUniversity(No.YYZS2022003)
文摘Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between the severity of knee joint osteoarthritis and the alignment of patellofemoral and patellar height on radiographs.Methods:This multi-center,retrospective study analyzed the magnetic resonance imaging(MRI)scans and anteroposterior radiographs of 534 adult outpatients with KOA.To evaluate the radiographic severity of KOA,anteroposterior radiographs of the knee and the Kellgren-Lawrence(K-L)grade were used.Knee MRI scans were used to measure the patellar length ratio(PLR),sulcus angle(SA),lateral patellar tilt angle(LPTA),and the distance between tibial tuberosity and trochlear groove(TT-TG).We examined the association between the configuration of the PFJ,arrangement,and harshness of the KOA.Information on participants’demographics,such as age,sex,side,height,and weight,was collected.A chi-squared test was used for the correlation of radiographic severity of KOA with sex and the affected side.Spearman correlation was used for patellofemoral alignment or morphology and the radiographic severity of lateral KOA.Multiple linear regression models were used for the association between LPTA,SA,TT-TG,and severity of KOA after accounting for demographic variables.Results:The study comprised of 534 patients;of these,339(63%)were female.A total of 586 knees were evaluated in this study.Age showed a strong positive correlation with KOA severity(r=0.516,P<0.01),whereas LPTA showed a strong negative correlation(r=–0.662,P<0.01).Additionally,SA(r=0.616,P<0.05),and TT-TG showed a strong positive correlation(r=0.770,P<0.01)with tibiofemoral osteoarthritis(TFOA)severity.Multiple linear regression analysis indicated that knee osteoarthritis severity(β=–2.946,P<0.001)and side(β=–0.839,P=0.001)was associated with LPTA;knee osteoarthritis severity(β=5.032,P<0.001)and age(β=–0.095,P<0.001)was associated with SA;knee osteoarthritis severity(β=2.445,P<0.001),sex(β=–0.326,P=0.041),body mass index(β=–0.061,P=0.017)and age(β=–0.025,P<0.001)was associated with TT-TG.Conclusion:Radiographic severity of KOA was positively associated with age,SA,and TT-TG but negatively associated with LPTA.
