Mycothiol （MSH） is the major low molecular weight thiol in most actinomycetes. Chemical synthesis of MSH is of value for enzymology and inhibitor screening assays, but is hampered by difficulties in large scale sysn...Mycothiol （MSH） is the major low molecular weight thiol in most actinomycetes. Chemical synthesis of MSH is of value for enzymology and inhibitor screening assays, but is hampered by difficulties in large scale sysnthesis. We achieved the total synthesis of MSH by linking 2-camphanoyl-3,4,5,6-tetra-O-benzyl-D-rnyo-inositol （D-1） and 2-deoxy-2-azido-3,4,6-tri-O-benzyl- 1-p-toluene-thio-o-glucoside （2） first, followed by coupling with N-Boc-S-acetyl-L-cysteine （3）. This route of synthesis allowed the efficient and convenient synthesis of mycothiol on a large scale.展开更多
Large scale synthesis of oligoribonucleotides has been successfully performed on PEG support by the phosphoramidite approach using t-butyldimethylsilyl to protect the 2'-hydroxyl group of ribonucleoside. By means ...Large scale synthesis of oligoribonucleotides has been successfully performed on PEG support by the phosphoramidite approach using t-butyldimethylsilyl to protect the 2'-hydroxyl group of ribonucleoside. By means of this procedure, the dodecamer r(AGUGGUCUUUGU) was synthesized in 98.1% average coupling yield, and 55 mg pure product was obtained from one gram of functionalized PEG.展开更多
A series of MCM 41 molecular sieves have been prepared on an industrial scale, and the effect of preparation factors such as aging temperature, pH values on the structure and pore distribution of the MCM 41 product ...A series of MCM 41 molecular sieves have been prepared on an industrial scale, and the effect of preparation factors such as aging temperature, pH values on the structure and pore distribution of the MCM 41 product have been studied by using X ray diffraction(XRD), thermogravimetric(TG) and electron microscopy(TEM). It is shown that the pH values have a significant effect on the crystallinity of the synthesized product. Under proper conditions, the MCM 41 prepared on an industrial scale has the same performance as the samples prepared on an Lab scale. The prepared MCM 41 was used as a modifier of zeolite Y for fluid catalytic cracking(FCC) of residual oil. It is shown that the addition of the MCM 41 in the zeolite Y catalyst increases the pore size, and surface area of the catalysts, which helps to increase the yield of gasoline and diesel and decrease the production of gaseous product and carbon deposition in the catalyst. The better performance of the MCM 41 modified zeolite Y catalyst is believed to be due to its adjustment on the acidity and increase of the pore size.展开更多
Aiming at scheduling problems of networked control system （NCS） used to fulfill motion synthesis and cooperation control of the distributed multi-mechatronic systems, the differences of network scheduling and task s...Aiming at scheduling problems of networked control system （NCS） used to fulfill motion synthesis and cooperation control of the distributed multi-mechatronic systems, the differences of network scheduling and task scheduling are compared, and the mathematic description of task scheduling is presented. A performance index function of task scheduling of NCS according to task balance and traffic load matching principles is defined. According to this index, a static scheduling method is designed and implemented to controlling task set simulation of the DCY100 transportation vehicle. The simulation results are applied successfully to practical engineering in this case so as to validate the effectiveness of the proposed performance index and scheduling algorithm.展开更多
Dimethyl sulfide-mediated electrochemical synthetic strategy for esterification of amino acids has been reported.A series of amino acids could react smoothly with alcohols,affording the desired esterification products...Dimethyl sulfide-mediated electrochemical synthetic strategy for esterification of amino acids has been reported.A series of amino acids could react smoothly with alcohols,affording the desired esterification products with good efficiency.Importantly,the tolerance of peptides and gram-scale synthesis shed light on the utility of this protocol.Mechanistically,the dimethyl sulfide as a mediator plays an essential role in the transformation of amino acids.展开更多
基金National Natural Science Foundation of China(NSFC,Grant No.91213303)
文摘Mycothiol （MSH） is the major low molecular weight thiol in most actinomycetes. Chemical synthesis of MSH is of value for enzymology and inhibitor screening assays, but is hampered by difficulties in large scale sysnthesis. We achieved the total synthesis of MSH by linking 2-camphanoyl-3,4,5,6-tetra-O-benzyl-D-rnyo-inositol （D-1） and 2-deoxy-2-azido-3,4,6-tri-O-benzyl- 1-p-toluene-thio-o-glucoside （2） first, followed by coupling with N-Boc-S-acetyl-L-cysteine （3）. This route of synthesis allowed the efficient and convenient synthesis of mycothiol on a large scale.
文摘Large scale synthesis of oligoribonucleotides has been successfully performed on PEG support by the phosphoramidite approach using t-butyldimethylsilyl to protect the 2'-hydroxyl group of ribonucleoside. By means of this procedure, the dodecamer r(AGUGGUCUUUGU) was synthesized in 98.1% average coupling yield, and 55 mg pure product was obtained from one gram of functionalized PEG.
文摘A series of MCM 41 molecular sieves have been prepared on an industrial scale, and the effect of preparation factors such as aging temperature, pH values on the structure and pore distribution of the MCM 41 product have been studied by using X ray diffraction(XRD), thermogravimetric(TG) and electron microscopy(TEM). It is shown that the pH values have a significant effect on the crystallinity of the synthesized product. Under proper conditions, the MCM 41 prepared on an industrial scale has the same performance as the samples prepared on an Lab scale. The prepared MCM 41 was used as a modifier of zeolite Y for fluid catalytic cracking(FCC) of residual oil. It is shown that the addition of the MCM 41 in the zeolite Y catalyst increases the pore size, and surface area of the catalysts, which helps to increase the yield of gasoline and diesel and decrease the production of gaseous product and carbon deposition in the catalyst. The better performance of the MCM 41 modified zeolite Y catalyst is believed to be due to its adjustment on the acidity and increase of the pore size.
基金This project is supported by National Natural Science Foundation of China (No. 50575013)
文摘Aiming at scheduling problems of networked control system （NCS） used to fulfill motion synthesis and cooperation control of the distributed multi-mechatronic systems, the differences of network scheduling and task scheduling are compared, and the mathematic description of task scheduling is presented. A performance index function of task scheduling of NCS according to task balance and traffic load matching principles is defined. According to this index, a static scheduling method is designed and implemented to controlling task set simulation of the DCY100 transportation vehicle. The simulation results are applied successfully to practical engineering in this case so as to validate the effectiveness of the proposed performance index and scheduling algorithm.
基金This work was supported by the National Natural Science Foundation of China(No.22031008)and the Science Foundation of Wuhan(No.2020010601012192)The Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciatedThis work was dedicated to Professor Christian Bru-neau for his outstanding contribution to catalysis.
文摘Dimethyl sulfide-mediated electrochemical synthetic strategy for esterification of amino acids has been reported.A series of amino acids could react smoothly with alcohols,affording the desired esterification products with good efficiency.Importantly,the tolerance of peptides and gram-scale synthesis shed light on the utility of this protocol.Mechanistically,the dimethyl sulfide as a mediator plays an essential role in the transformation of amino acids.
