Two new isomeric compounds of rare acyclic C13-norisoprenoids, along with two known lignans sauchinone and licarin A, were isolated from the herb of Saururus chinensis （Lour.） Baill. Their structures were elucidated...Two new isomeric compounds of rare acyclic C13-norisoprenoids, along with two known lignans sauchinone and licarin A, were isolated from the herb of Saururus chinensis （Lour.） Baill. Their structures were elucidated on the basis of spectral analysis.展开更多
In this study,the improvement effects of oral administration of polysaccharides isolated from Saururus chinensis on a DSS-induced ulcerative colitis mouse model were evaluated.To achieve this,S.chinensis-derived crude...In this study,the improvement effects of oral administration of polysaccharides isolated from Saururus chinensis on a DSS-induced ulcerative colitis mouse model were evaluated.To achieve this,S.chinensis-derived crude polysaccharides(SCP)were extracted using hot water extraction and ethanol precipitation.SCP is composed primarily of eight monosaccharides,including galacturonic acid(46.6%),galactose(10.4%),arabinose(5.6%),and rhamnose(3.8%),that are typical sugar components of pectic polysaccharides.Oral administration of SCP recovered body weight loss and significantly alleviated various ulcerative colitis symptoms such as stool consistency,blood in stool,and blood in the anus.Additionally,the DSS-treated group that exhibited a decrease in colon length,and SCP treatment significantly reduced colon length shortening in a dose-dependent manner.Levels of inflammatory factors such as interleukin-6,tumor necrosis factor-α,and myeloperoxidase were lower in the SCP-treated groups than they were in the DSS-treated group.In contrast,Alcian blue-periodic acid Schiff staining revealed that SCP treatment effectively maintained the amount of mucus and goblet cells in the intestinal lumen compared to that in the DSS-treated group.The short-chain fatty acid content decreased by DSS administration was recovered through oral administration of SCP,and the amount of butyric acid was significantly improved.Consequently,the aforementioned results suggest that SCP isolated from S.chinensis is a potent candidate for use as a new health functional food and pharmaceutical ingredient for colitis treatment.展开更多
OBJECTIVE: The aim of this study was to investigate the effects and safety of modified fasting therapy using fermented medicinal herbs and exercise on body weight, fat and muscle mass, and blood chemistry in obese sub...OBJECTIVE: The aim of this study was to investigate the effects and safety of modified fasting therapy using fermented medicinal herbs and exercise on body weight, fat and muscle mass, and blood chemistry in obese subjects.METHODS: Twenty-six patients participated in a14-day fast, during which they ingested a supplement made from fermented medicinal herbs and carbohydrates(intake: 400-600 kcal/d). The schedule included 7 prefasting relief days and 14 days of stepwise reintroduction of food. The patients also took part in an exercise program that incorporated Qigong, weight training, and walking exercises. The efficacy of treatments was observed by assessing body fat mass and muscle mass, and alanine aminotransferase(ALT), aspartate aminotransferase(AST),cholesterol, and triglycerides in each study period.Specific symptoms or side effects were reported.RESULTS: Body weight and body fat mass both decreased significantly by(5.16 ± 0.95) and(3.89 ±0.79) kg(both P < 0.05), while muscle mass decreased by an average of(0.26 ± 0.22) kg, without statistical significance. ALT levels were significantly decreased(P < 0.05), while AST levels decreased without statistical significance(P = 0.052). The levels of total cholesterol and triglycerides were also significantly decreased(both P < 0.05). There were few adverse events except for mild dizziness, which did not affect everyday living.CONCLUSION: These results suggest that modified fasting therapy using fermented medicinal herbs and exercise could be effective and safe on obese patients.展开更多
文摘Two new isomeric compounds of rare acyclic C13-norisoprenoids, along with two known lignans sauchinone and licarin A, were isolated from the herb of Saururus chinensis （Lour.） Baill. Their structures were elucidated on the basis of spectral analysis.
基金supported by the PharmacoBio Assistantship 2019supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2020R1F1A1070996).
文摘In this study,the improvement effects of oral administration of polysaccharides isolated from Saururus chinensis on a DSS-induced ulcerative colitis mouse model were evaluated.To achieve this,S.chinensis-derived crude polysaccharides(SCP)were extracted using hot water extraction and ethanol precipitation.SCP is composed primarily of eight monosaccharides,including galacturonic acid(46.6%),galactose(10.4%),arabinose(5.6%),and rhamnose(3.8%),that are typical sugar components of pectic polysaccharides.Oral administration of SCP recovered body weight loss and significantly alleviated various ulcerative colitis symptoms such as stool consistency,blood in stool,and blood in the anus.Additionally,the DSS-treated group that exhibited a decrease in colon length,and SCP treatment significantly reduced colon length shortening in a dose-dependent manner.Levels of inflammatory factors such as interleukin-6,tumor necrosis factor-α,and myeloperoxidase were lower in the SCP-treated groups than they were in the DSS-treated group.In contrast,Alcian blue-periodic acid Schiff staining revealed that SCP treatment effectively maintained the amount of mucus and goblet cells in the intestinal lumen compared to that in the DSS-treated group.The short-chain fatty acid content decreased by DSS administration was recovered through oral administration of SCP,and the amount of butyric acid was significantly improved.Consequently,the aforementioned results suggest that SCP isolated from S.chinensis is a potent candidate for use as a new health functional food and pharmaceutical ingredient for colitis treatment.
文摘OBJECTIVE: The aim of this study was to investigate the effects and safety of modified fasting therapy using fermented medicinal herbs and exercise on body weight, fat and muscle mass, and blood chemistry in obese subjects.METHODS: Twenty-six patients participated in a14-day fast, during which they ingested a supplement made from fermented medicinal herbs and carbohydrates(intake: 400-600 kcal/d). The schedule included 7 prefasting relief days and 14 days of stepwise reintroduction of food. The patients also took part in an exercise program that incorporated Qigong, weight training, and walking exercises. The efficacy of treatments was observed by assessing body fat mass and muscle mass, and alanine aminotransferase(ALT), aspartate aminotransferase(AST),cholesterol, and triglycerides in each study period.Specific symptoms or side effects were reported.RESULTS: Body weight and body fat mass both decreased significantly by(5.16 ± 0.95) and(3.89 ±0.79) kg(both P < 0.05), while muscle mass decreased by an average of(0.26 ± 0.22) kg, without statistical significance. ALT levels were significantly decreased(P < 0.05), while AST levels decreased without statistical significance(P = 0.052). The levels of total cholesterol and triglycerides were also significantly decreased(both P < 0.05). There were few adverse events except for mild dizziness, which did not affect everyday living.CONCLUSION: These results suggest that modified fasting therapy using fermented medicinal herbs and exercise could be effective and safe on obese patients.
