Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcoceph...Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcocephalus latifolius fruits aqueous extract against paracetamol-induced liver damage in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg). The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus latifolius fruits extract induced a significant reduction (p < 0.05) of serum enzymes alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (PAL) and total bilirubin (TB). Then, the extract at the dose of 500 mg/kg showed a better protection (p < 0.001) of hepatocytes with a percentage of protection of 43.59% ± 2.03%;59.43% ± 4.12%;73.29% ± 5.72% and 62.55% ± 7.48% for ALAT, ASAT, PAL and TB, respectively. The histology of livers exposed to paracetamol shows an inflammation of the hepatocytes. In addition, there was a significant alteration of the liver parenchyma. The 500 mg/kg extract showed a resorption of the inflammation. Histopathological examination showed that the extract regenerated paracetamol-induced liver damage. Conclusion: Aqueous extract of Sarcocephalus latifolius fruits has hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. But it would be important to evaluate the activity of aqueous extract of Sarcocephalus latifolius fruits on oxidative stress parameters in vivo in rats. .展开更多
The aim of this study was to evaluate in vivo the effect of the aqueous extract of Sarcocephalus latifolius root powder on haemostasis parameters and lipid profile in male and female Wistar rats. The plant material co...The aim of this study was to evaluate in vivo the effect of the aqueous extract of Sarcocephalus latifolius root powder on haemostasis parameters and lipid profile in male and female Wistar rats. The plant material consisted exclusively of Sarcocephalus latifolius roots harvested in Porto-Novo, southern Benin and certified at the Benin National Herbarium under number YH 790/HNB. The animals were divided into four groups of three rats and gavaged for 14 days. The control rats were given distilled water orally, while the test batches were given 100, 200 and 300 mg/Kg of BW extract respectively. Blood samples were taken on days 7 and 14 of treatment and used to explore the intrinsic and extrinsic pathways of haemostasis. These included parameters such as bleeding time, prothrombin time, activated partial thromboplastin time, thrombin time and platelet count. Lipid parameters were also explored. Parameters such as total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were studied. Data on days D0, D7 and D14 for each haemostasis parameter and lipid profile were expressed as the mean plus or minus the standard error for each batch of animals. The data on day D0 were compared with those on days D7 and D14 to check whether there was a significant difference between the data obtained. The difference between D0 and D14 was tested using the parametric paired two-sample test using R Studio software and Graphpad Prism 9.5.1 software (733). A significant dose-dependent decrease in bleeding time, prothrombin time, activated partial thromboplastin and thrombin was recorded, with the exception of the platelet count. As regards lipid parameters, there was a significant dose-dependent reduction in LDL cholesterol and triglycerides, and an increase in HDL cholesterol. The results confirm that the roots of Sarcocephalus latifolius accelerate the arrest of bleeding, thanks to its ability to stimulate the formation of platelet clots and improve the lipid profile of the animals by eliminating bad cholesterol.展开更多
As a good food supply for the local people in various Senegalese regions, the forest fruits are becoming very important. They are using between foods or main condiment for dishes in many part of Africa. These fruits r...As a good food supply for the local people in various Senegalese regions, the forest fruits are becoming very important. They are using between foods or main condiment for dishes in many part of Africa. These fruits represent non negligible sources of vitamins, carbohydrates and minerals. Instead of more commercialized species such as Adansonia digitata L., Detarium senegalensis J.F.Gmel., Saba senegalensis (A.DC.) Pichon, Tamarindus indica L., this article focused on nutritional values of other fruits with little interest or neglected. These species were Ficus gnaphalocarpa, L., Cordyla pinnata (Lepr. ex A.Rich.) Milne-Redh. and Icacina senegalensis, harvested in soudano-sahelian zone;while Sarcocephalus latifolius (Sm.) E.A. Bruce belongs to Sudanese zone. The fruit pulps were isolated and freeze dried before analysis. The results showed that acidity, vitamin C and total minerals were significantly different from one fruit to another. S. latifolius with the highest acidity content (402.43 mg/100 g) and best vitamin C content if 1488 mg/100 g were found. Also as results, S. latifolius provided high protein content nearby the 20%. The caloric contributing (kcal/100 g) were 102.5, 177 and 132 respectively for F. gnaphalocarpa, C. pinnata, and S. latifolius. The ash contents were the same for all species (4.5%), indicating the richness in mineral elements. Furthermore, all species in this study were good sources of iron, copper and zinc. However, small amounts of sodium were noticed in all samples. Analysis of total sugars and their profile showed that I. senegalensis and C. pinnata were more appreciated. These results predicted the useful incomes for forest fruits in human being. Lot of medicinal virtues has been recognized from these fruits. The increase in value and the preservation of the biodiversity are necessary particularly for C. pinnata which presents a serious threat because of the strong income for wood production.展开更多
文摘Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcocephalus latifolius fruits aqueous extract against paracetamol-induced liver damage in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg). The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus latifolius fruits extract induced a significant reduction (p < 0.05) of serum enzymes alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (PAL) and total bilirubin (TB). Then, the extract at the dose of 500 mg/kg showed a better protection (p < 0.001) of hepatocytes with a percentage of protection of 43.59% ± 2.03%;59.43% ± 4.12%;73.29% ± 5.72% and 62.55% ± 7.48% for ALAT, ASAT, PAL and TB, respectively. The histology of livers exposed to paracetamol shows an inflammation of the hepatocytes. In addition, there was a significant alteration of the liver parenchyma. The 500 mg/kg extract showed a resorption of the inflammation. Histopathological examination showed that the extract regenerated paracetamol-induced liver damage. Conclusion: Aqueous extract of Sarcocephalus latifolius fruits has hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. But it would be important to evaluate the activity of aqueous extract of Sarcocephalus latifolius fruits on oxidative stress parameters in vivo in rats. .
文摘The aim of this study was to evaluate in vivo the effect of the aqueous extract of Sarcocephalus latifolius root powder on haemostasis parameters and lipid profile in male and female Wistar rats. The plant material consisted exclusively of Sarcocephalus latifolius roots harvested in Porto-Novo, southern Benin and certified at the Benin National Herbarium under number YH 790/HNB. The animals were divided into four groups of three rats and gavaged for 14 days. The control rats were given distilled water orally, while the test batches were given 100, 200 and 300 mg/Kg of BW extract respectively. Blood samples were taken on days 7 and 14 of treatment and used to explore the intrinsic and extrinsic pathways of haemostasis. These included parameters such as bleeding time, prothrombin time, activated partial thromboplastin time, thrombin time and platelet count. Lipid parameters were also explored. Parameters such as total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were studied. Data on days D0, D7 and D14 for each haemostasis parameter and lipid profile were expressed as the mean plus or minus the standard error for each batch of animals. The data on day D0 were compared with those on days D7 and D14 to check whether there was a significant difference between the data obtained. The difference between D0 and D14 was tested using the parametric paired two-sample test using R Studio software and Graphpad Prism 9.5.1 software (733). A significant dose-dependent decrease in bleeding time, prothrombin time, activated partial thromboplastin and thrombin was recorded, with the exception of the platelet count. As regards lipid parameters, there was a significant dose-dependent reduction in LDL cholesterol and triglycerides, and an increase in HDL cholesterol. The results confirm that the roots of Sarcocephalus latifolius accelerate the arrest of bleeding, thanks to its ability to stimulate the formation of platelet clots and improve the lipid profile of the animals by eliminating bad cholesterol.
文摘As a good food supply for the local people in various Senegalese regions, the forest fruits are becoming very important. They are using between foods or main condiment for dishes in many part of Africa. These fruits represent non negligible sources of vitamins, carbohydrates and minerals. Instead of more commercialized species such as Adansonia digitata L., Detarium senegalensis J.F.Gmel., Saba senegalensis (A.DC.) Pichon, Tamarindus indica L., this article focused on nutritional values of other fruits with little interest or neglected. These species were Ficus gnaphalocarpa, L., Cordyla pinnata (Lepr. ex A.Rich.) Milne-Redh. and Icacina senegalensis, harvested in soudano-sahelian zone;while Sarcocephalus latifolius (Sm.) E.A. Bruce belongs to Sudanese zone. The fruit pulps were isolated and freeze dried before analysis. The results showed that acidity, vitamin C and total minerals were significantly different from one fruit to another. S. latifolius with the highest acidity content (402.43 mg/100 g) and best vitamin C content if 1488 mg/100 g were found. Also as results, S. latifolius provided high protein content nearby the 20%. The caloric contributing (kcal/100 g) were 102.5, 177 and 132 respectively for F. gnaphalocarpa, C. pinnata, and S. latifolius. The ash contents were the same for all species (4.5%), indicating the richness in mineral elements. Furthermore, all species in this study were good sources of iron, copper and zinc. However, small amounts of sodium were noticed in all samples. Analysis of total sugars and their profile showed that I. senegalensis and C. pinnata were more appreciated. These results predicted the useful incomes for forest fruits in human being. Lot of medicinal virtues has been recognized from these fruits. The increase in value and the preservation of the biodiversity are necessary particularly for C. pinnata which presents a serious threat because of the strong income for wood production.
