Objective:To investigate the ability of an aqueous extract of the leaves of Sansevieria liberica (S.liberica) to alter the hematology,plasma biochemistry and ocular indices of oxidative stress in alloxan-induced diabe...Objective:To investigate the ability of an aqueous extract of the leaves of Sansevieria liberica (S.liberica) to alter the hematology,plasma biochemistry and ocular indices of oxidative stress in alloxan-induced diabetic rats.Method:Diabetes meUitus was induced by injection of alloxan (80 mg/kg body weight),via the tail vein.The extract was administered orally at 100,200 and 300 mg/kg body weight(both to normal and diabetic rats),and metformin at SO mg/kg body weight. Results:Compared to test control,the treatment dose dependently,significantly lowered(P【0.05) ocular malondialdehyde content,atherogenic indices,red cell,total white cell and lymphocyte counts,mean cell hemoglobin concentration;and plasma levels of glucose,triglyceride,total-, very low density lipoprotein-,low density lipoprotein- and non-high density lipoprotein cholesterols,total,conjugated and unconjugated bilirubin,sodium,urea,blood urea nitrogen,as well as plasma activities of alkaline phosphatase,alanine and aspartate transaminases.However, the treatment significantly increased(P【0.05) hematocrit,hemoglobin concentration,mean cell hemoglobin,and mean cell volume,neutrophil and monocyte counts,and plasma levels of high density lipoprotein cholesterol,potassium,chloride,calcium,bicarbonate and total protein, ocular ascorbic acid content and ocular activities of catalase and superoxide dismutase.This study showed the hypoglycemic,hypolipidemic,immune-modulating,ocular-,hepato-renal and cardio-protective potentials of the extract.Conclusions:All these,support the use of the leaves of S.liberica in African traditional health care practices for the management of diabetes mellitus.展开更多
Objective:To evaluate the anti-inflammatory property of leaves of Sansevieria liberica Ger. and Labr.and to ascertain the toxicity and phytochemical profiles of the extract of the leaves. Methods:The juice from the fr...Objective:To evaluate the anti-inflammatory property of leaves of Sansevieria liberica Ger. and Labr.and to ascertain the toxicity and phytochemical profiles of the extract of the leaves. Methods:The juice from the fresh leaves was expressed manually and lyophilized.The crude extract（CE） was then fractionated into n-hexane fraction（HF）,chloroform fraction（CF）, ethylacetate fraction（EF） and methanol fraction（MF）.The crude extract（CF） and the fractions were screened for anti-inflammatory activity using egg albumen-induced paw（systemic） edema in rats as a measure of acute inflammation.The toxicity test and phytochemical screening were done using standard procedures.Results:The CE and the fractions significantly（P【0.05） inhibited the development of paw edema induced by egg albumen in rats.The potency/activity of the CE and the fractions increased in the order HF】CE】MF】CF】EF,with the CE and HF at 400 mg/kg exhibiting inhibition comparable to that obtained with 5 mg/kg diclofenac sodium. Acute toxicity test on CE established an oral and intraperitoneal LD<sub>50</sub> of 】 5 000 mg/kg in mice. Phytochemical screening of the CE and the fractions showed the presence of various bioactive substances such as alkaloids,saponins,flavonoids,terpenoids,steroids,glycosides,reducing sugars,tannins,resins,carbohydrates,proteins,acidic compounds,fats and oils.Conclusions: The results of the study showed that the leaves of Sansevieria liberica Ger and Labr.possess antiinflammatory effects which may be due to its bioactive constituents.Further purification on these bioactive constituents may result in the development of potent anti-inflammatory agent with low toxicity and better therapeutic index.展开更多
Phytoremediation techniques to clean heavy metal pollution soil depend on identifying plant species that can act as phytoremediators.One important approach to screening potential phytoremediators is to evaluate charac...Phytoremediation techniques to clean heavy metal pollution soil depend on identifying plant species that can act as phytoremediators.One important approach to screening potential phytoremediators is to evaluate characteristics of heavy metal accumulation.In this study,we performed firsthand analysis of Cd tolerance and accumulation characteristics of three Sansevieria trifasciata cultivars by pot experiment.Plant growth results showed that all three S.trifasciata cultivars can tolerate 50 mg kg^-1 soil Cd concentration.After growth under 50 mg kg^-1 soil Cd concentration for 4 months,the Cd bioconcentration factors in the shoots of S.‘Trifasciata’,S.trifasciata‘Laurentii’,and S.trifasciata‘Silver Hahnii’were 1.26,1.30,and 1.19,while those in the roots were 12.53,11.43,and 5.45,respectively.This result reveals the considerably low translocation factors of 0.10,0.12,and 0.22 for S.‘Trifasciata’,S.trifasciata‘Laurentii’,and S.trifasciata‘Silver Hahnii’,respectively.These results suggest that all three S.trifasciata cultivars had high Cd absorption capacities but low Cd translocation capacities.In combination with total Cd accumulation distribution and plant growth characteristics,S.trifasciata can be designed as a phytostabilizer in Cd-contaminated soils in its cultivation regions.Meanwhile,the mechanism of high Cd tolerance and accumulation characteristics in the roots of S.trifasciata should be explored.This study provides new resources for dealing with Cd-contaminated soils and exploring Cd tolerance and accumulation mechanisms in plants.展开更多
文摘Objective:To investigate the ability of an aqueous extract of the leaves of Sansevieria liberica (S.liberica) to alter the hematology,plasma biochemistry and ocular indices of oxidative stress in alloxan-induced diabetic rats.Method:Diabetes meUitus was induced by injection of alloxan (80 mg/kg body weight),via the tail vein.The extract was administered orally at 100,200 and 300 mg/kg body weight(both to normal and diabetic rats),and metformin at SO mg/kg body weight. Results:Compared to test control,the treatment dose dependently,significantly lowered(P【0.05) ocular malondialdehyde content,atherogenic indices,red cell,total white cell and lymphocyte counts,mean cell hemoglobin concentration;and plasma levels of glucose,triglyceride,total-, very low density lipoprotein-,low density lipoprotein- and non-high density lipoprotein cholesterols,total,conjugated and unconjugated bilirubin,sodium,urea,blood urea nitrogen,as well as plasma activities of alkaline phosphatase,alanine and aspartate transaminases.However, the treatment significantly increased(P【0.05) hematocrit,hemoglobin concentration,mean cell hemoglobin,and mean cell volume,neutrophil and monocyte counts,and plasma levels of high density lipoprotein cholesterol,potassium,chloride,calcium,bicarbonate and total protein, ocular ascorbic acid content and ocular activities of catalase and superoxide dismutase.This study showed the hypoglycemic,hypolipidemic,immune-modulating,ocular-,hepato-renal and cardio-protective potentials of the extract.Conclusions:All these,support the use of the leaves of S.liberica in African traditional health care practices for the management of diabetes mellitus.
文摘Objective:To evaluate the anti-inflammatory property of leaves of Sansevieria liberica Ger. and Labr.and to ascertain the toxicity and phytochemical profiles of the extract of the leaves. Methods:The juice from the fresh leaves was expressed manually and lyophilized.The crude extract（CE） was then fractionated into n-hexane fraction（HF）,chloroform fraction（CF）, ethylacetate fraction（EF） and methanol fraction（MF）.The crude extract（CF） and the fractions were screened for anti-inflammatory activity using egg albumen-induced paw（systemic） edema in rats as a measure of acute inflammation.The toxicity test and phytochemical screening were done using standard procedures.Results:The CE and the fractions significantly（P【0.05） inhibited the development of paw edema induced by egg albumen in rats.The potency/activity of the CE and the fractions increased in the order HF】CE】MF】CF】EF,with the CE and HF at 400 mg/kg exhibiting inhibition comparable to that obtained with 5 mg/kg diclofenac sodium. Acute toxicity test on CE established an oral and intraperitoneal LD<sub>50</sub> of 】 5 000 mg/kg in mice. Phytochemical screening of the CE and the fractions showed the presence of various bioactive substances such as alkaloids,saponins,flavonoids,terpenoids,steroids,glycosides,reducing sugars,tannins,resins,carbohydrates,proteins,acidic compounds,fats and oils.Conclusions: The results of the study showed that the leaves of Sansevieria liberica Ger and Labr.possess antiinflammatory effects which may be due to its bioactive constituents.Further purification on these bioactive constituents may result in the development of potent anti-inflammatory agent with low toxicity and better therapeutic index.
基金This work was financially supported by the Youth Innovation Promotion Association CAS(2020387).
文摘Phytoremediation techniques to clean heavy metal pollution soil depend on identifying plant species that can act as phytoremediators.One important approach to screening potential phytoremediators is to evaluate characteristics of heavy metal accumulation.In this study,we performed firsthand analysis of Cd tolerance and accumulation characteristics of three Sansevieria trifasciata cultivars by pot experiment.Plant growth results showed that all three S.trifasciata cultivars can tolerate 50 mg kg^-1 soil Cd concentration.After growth under 50 mg kg^-1 soil Cd concentration for 4 months,the Cd bioconcentration factors in the shoots of S.‘Trifasciata’,S.trifasciata‘Laurentii’,and S.trifasciata‘Silver Hahnii’were 1.26,1.30,and 1.19,while those in the roots were 12.53,11.43,and 5.45,respectively.This result reveals the considerably low translocation factors of 0.10,0.12,and 0.22 for S.‘Trifasciata’,S.trifasciata‘Laurentii’,and S.trifasciata‘Silver Hahnii’,respectively.These results suggest that all three S.trifasciata cultivars had high Cd absorption capacities but low Cd translocation capacities.In combination with total Cd accumulation distribution and plant growth characteristics,S.trifasciata can be designed as a phytostabilizer in Cd-contaminated soils in its cultivation regions.Meanwhile,the mechanism of high Cd tolerance and accumulation characteristics in the roots of S.trifasciata should be explored.This study provides new resources for dealing with Cd-contaminated soils and exploring Cd tolerance and accumulation mechanisms in plants.
