Human saccade is a dynamic process of information pursuit. There are many methods using either global context or local context cues to model human saccadic scan-paths. In contrast to them, this paper introduces a mode...Human saccade is a dynamic process of information pursuit. There are many methods using either global context or local context cues to model human saccadic scan-paths. In contrast to them, this paper introduces a model for gaze movement control using both global and local cues. To test the performance of this model, an experiment is done to collect human eye movement data by using an SMI iVIEW X Hi-Speed eye tracker with a sampling rate of 1250 Hz. The experiment used a two-by-four mixed design with the location of the targets and the four initial positions. We compare the saccadic scan-paths generated by the proposed model against human eye movement data on a face benchmark dataset. Experimental results demonstrate that the simulated scan-paths by the proposed model are similar to human saccades in term of the fixation order, Hausdorff distance, and prediction accuracy for both static fixation locations and dynamic scan-paths.展开更多
While multiple step saccades(MSS)are occasionally reported in the healthy population,they are more evident in patients with Parkinson’s disease(PD).Therefore,MSS has been suggested as a biological marker for the diag...While multiple step saccades(MSS)are occasionally reported in the healthy population,they are more evident in patients with Parkinson’s disease(PD).Therefore,MSS has been suggested as a biological marker for the diagnosis of PD.However,the lack of clarity on the neural mechanism underlying the generation of MSS largely impedes their application in the clinic.We have proposed recently that MSS are triggered by the discrepancy between desired and executed saccades.Accordingly,brain regions involved in saccadic planning and execution might play a role in the generation of MSS.To test this hypothesis,we explored the role of the prefrontal(PFC)and posterior parietal cortex(PPC)in generating MSS by conducting two experiments:electroencephalographic recording and single-pulse transcranial magnetic stimulation in the PFC or PPC of humans while participants were performing a gap saccade task.We found that the PFC and PPC are involved in the generation of MSS.展开更多
Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can...Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can respond immediately to the threat.Therefore,when an animal detects a threat through its visual system,it must quickly direct its gaze and attention toward the source of danger,assess the threat level,and take appropriate action.展开更多
There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granular...There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granularity, of the time perception at the time of the saccade. This model uses functional pathway knowledge and is inspired by, and integrates, recent findings in both psychophysics and neurophysiology. Perceived time delays in the perisaccadic window are shown numerically consistent with recent experimental measures. Our model provides explanation for several experimental outcomes on saccades, estimates popu-lation variance of the error in time perception and represent a meaningful example for bridging psychophysics and neurophysiology. Finally we found that the insights into information processing during saccadic events lead to considerations on engineering exploitation of the underlying phenomena.展开更多
The space-time distortion perceived subjectively during saccadic eye movements is an associative phenomenon of a transient shift of observer’s visual frame of reference from one position to another. Here we report th...The space-time distortion perceived subjectively during saccadic eye movements is an associative phenomenon of a transient shift of observer’s visual frame of reference from one position to another. Here we report that the lines of subjective simultaneity defined as two spatially separated flashes perceived during saccades were nearly uniformly tilted along the physical time-course. The causality of the resulting space-time compression may be explained by the Minkowski space-time diagram in physics.展开更多
Objective:This study aimed to develop and evaluate a novel software tool for robust analysis of the Visually Enhanced Vestibular-Ocular Reflex(VVOR)and video head impulse test(vHIT)saccades.Methods:A retrospective stu...Objective:This study aimed to develop and evaluate a novel software tool for robust analysis of the Visually Enhanced Vestibular-Ocular Reflex(VVOR)and video head impulse test(vHIT)saccades.Methods:A retrospective study was conducted on 94 patients with Meniere’s Disease(MD),unilateral vestibular hypofunction(UVH),and vestibular migraine(VM).The MATLAB-based VVOR Analysis System and Saccades All in One software were utilized for data processing.New techniques,VVOR_diff and VVOR_cycle,were deployed for saccade parameter extraction.Results:Saccade incidence rates,examined through vHIT,VVOR_diff,and VVOR_cycle,exhibited distinct patterns in MD,UVH,and VM patients.Frequent instances of multiple saccades within a single cycle were noted on the affected side in MD and UVH patients.Statistically significant differences in saccade gain and incidence rates between the affected and unaffected sides were evident in MD and UVH patients.Notably,high inter-method and intra-method correlations suggested consistency across different methods and potential interactions within one.Conclusion:The software proved effective in extracting saccades and reducing noise in VVOR data,thereby enhancing the evaluation of vestibular function and potentially improving diagnostic accuracy for vestibular disorders.展开更多
Purpose. To investigate the peak latency of the orbital presaccadic spike potential (SP) with horizontal eye movement in normals.Methods. Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes...Purpose. To investigate the peak latency of the orbital presaccadic spike potential (SP) with horizontal eye movement in normals.Methods. Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes with Pz as the reference while performing 5°, 10°, 20°, 30° and 40°horizontal saccades to visual targets. SP peak latency was measured from SP onset to SP peak on averaged data aligned on SP peak.Results. Significant main effects on SP peak latency are found for saccade size (<0. 01), saccade direction (P<0. 01) and electrode site (P<0. 05). No significant main effect on SP peak latency is found for eye (P>0. 05). SP peak latency increases with increasing saccade size from 5°to 40°. SP peak latency is longer with saccades back to center than away from center, and with abducting saccades than with adducting saccades. SP peak latency differs at the electrode sites with an order from shorter to longer as follows: inner canthus (IC); inferior orbit (IO): outer canthus (OC); superior orbit (SO).Conclusicos. The effects on the peak latency of orbital SP can be explained by the saccade dynamic property, volume conduction as well as physiologic and anatomic factors of the eyes and orbits. The peak latency of orbital SP can be used to reflect the temporal characteristics of ocular motor units controlling saccadic eye movement.展开更多
Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neuron...Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently.We discovered that the animal’s choice was dictated by the reward amount while the luminance had a marginal effect.In the LIP,neuronal activity corresponded well with the animal’s choice pattern,in that a majority of reward-modulated neurons encoded the reward amount in the neuron’s preferred hemifield with a positive slope.In contrast,compared to their responses to low luminance,an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity,leading to a much weaker population-level response.Meanwhile,in the non-preferred hemifield,the strength of encoding for reward amount and luminance was positively correlated,suggesting the integration of these two factors in the LIP.Moreover,neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP.Overall,our study provides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions.展开更多
Background:Cognitive control is defined as the ability to act flexibly in the environment by either behaving automatically or inhibiting said automatic behaviour and it can be measured using an interleaved pro/anti-sa...Background:Cognitive control is defined as the ability to act flexibly in the environment by either behaving automatically or inhibiting said automatic behaviour and it can be measured using an interleaved pro/anti-saccade task.Decline in cognitive control has been attributed to normal aging and neurological illnesses such as Parkinson’s disease(PD)as well as decline in other cognitive abilities.This parallel might highlight the role played by cognitive control in information processing and working memory.However,little is known about the relationship between cognitive control and other cognitive processes such as visual memory,decision making,and visual search.We thus propose to correlate the incidence of impaired cognitive control with deficits in visual memory,decision making and visual search in three groups:younger adults,older adults and patients with idiopathic PD.Methods:Seventy-one participants,namely 34 adults(M=22.75,SD=3.8),22 older adults(M=67.4,SD=8.3),and 20 PD patients(M=65.59,SD=8.2)performed four tasks:interleaved pro/anti-saccade,visual memory,decision making,and serial and pop-out visual search.Results:Results show that within each group,anti-saccade error rate(ER)were significantly and negatively correlated with visual memory ER(ryounger=−0.378,P=0.036;rolder=−0.440,Polder=0.046;rPD=−0.609,P=0.016).On the other hand,correct decision-making reaction times(RT)were significantly correlated with anti-saccade ER,and RTs only in older adults(rER=0.529,P=0.014;rRT=0.512,P=0.018)and PD patients(rER=0.727,P=0.012;rRT=0.769,P=0.001).For visual search,PD patients showed a significant relationship between RTs for correct pro-saccades and pop-out(r=0.665,P=0.007),and serial(r=0.641,P=0.010)search RTs.Furthermore,there was a significant correlation between MoCA scores and anti-saccade RTs(r=−0.559,P=0.030)and ER(r=−0.562,P=0.029)in PD patients.Taken together,these results support the hypothesis of PD patients’reliance on bottom-up processes as top-down processes decline.For younger adults,there was a significant correlation between serial search performance and both anti-saccade ER(r=0.488,P=0.005),and correct pro-saccade ER(r=0.413,P=0.021).In older adults,this relationship was absent,but anti-saccade ER significantly correlated with pop-out search times(r=0.473,P=0.030).Conclusions:We found significant relationships between cognitive tasks and cognitive control as measured through the interleaved pro/anti-saccade task across and within participant groups,providing evidence of the appropriateness of the use of the interleaved pro/anti-saccade task as a measure of overall cognitive control.展开更多
Background:Many studies have shown that attention is shifted toward the goal of the upcoming saccade.It has been suggested that the purpose of this attentional shift is to aid in trans-saccadic integration by acting a...Background:Many studies have shown that attention is shifted toward the goal of the upcoming saccade.It has been suggested that the purpose of this attentional shift is to aid in trans-saccadic integration by acting as a‘pointer’(Cavanagh,Hunt,Afraz&Rolfs,2010)for remembering,processing and updating objects across saccadic eye movements(Rolfs,Jonikaitis,Deubel&Cavanagh,2011).We tested this hypothesis that pre-saccadic attentional facilitation acts as a pointer for trans-saccadic integration by investigating how irrelevant post-saccadic changes influenced pre-saccadic attentional discrimination.On one hand,if pre-saccadic attentional facilitation is an independent process involved only in enhancing peripheral information before the saccade,then manipulating visual information(absence or shift)after the saccade should have no influence on discrimination.On the other hand,if pre-saccadic attentional facilitation is involved in trans-saccadic integration,changes in visual information should influence discrimination of the pre-saccadic information.Methods:We tested different conditions involving different post-saccadic changes.In the baseline condition,participants made a saccade at the appearance of an arrow and discriminated a symbol(DS)that was presented briefly before the saccade at one of six peripheral locations.The symbol was masked thereafter with a figure 8,which remained till the end of the trial.Importantly,the DS was always presented while participants were fixating at center,and only the figure 8 was present at the end of the saccade.Participants were instructed to make the saccade then report the identity of the DS(4AFC).We then tested how blanking post-saccadic information[blanking of the saccade goal(SG)location,DSOff condition;of the entire visual scene including or excluding the SG location,AllOff and DSOnly conditions]and how displacement of the figure 8s after the saccade would affect performance.Results:We observed that discrimination performance was significantly lower when the SG location disappeared during the saccade and was no longer present when the saccade was completed(DSOff,-6.9%).This decrease in performance cannot be attributed to changes in the visual scene that may have drawn attention,as this was the case for all conditions;performance was not different when the entire visual scene was blanked(AllOff,-0.0%)or when only the DS remained(DSOnly,-1.6%).We also found that the performance decreased as a function of the displacement of the figure 8 from the SG location,particularly if it was displaced outside of the saccade landing zone.Conclusions:Based on these pattern of results,we suggest that pre-saccadic attentional facilitation is indeed involved in trans-saccadic integration by acting as a location marker or pointer.The lack of a visual target at the saccade goal,even if it is irrelevant to the pre-saccadic discrimination task,disrupted performance.展开更多
Objective: The present study aimed to investigate and to compare the electrophysiological changes in bipolar patients and healthy subjects during the execution of a saccade task. Materials and Methods: The subjects ha...Objective: The present study aimed to investigate and to compare the electrophysiological changes in bipolar patients and healthy subjects during the execution of a saccade task. Materials and Methods: The subjects had to respond to a fixed visual stimulus presented by a LEDs bar. We executed an ANOVA (one-way) and post hoc Scheffé test to examine the difference of absolute alpha power and reaction time among four groups: control, depression, manic and euthymic. We observed the frontal, parietal and occipital regions. The paired t test was realized on each electrode and group to compare the pre and post moment in the task. Results: We observed a statistical difference among the groups for the behavioral variable—saccade reaction time. For the electrophysiological variable—absolute alpha power, we did not find significant difference between the moments (pre and post stimulus presentation) for none of the electrodes of each bipolar group. However, the results pointed out to a difference between the moments for F3, P3, O1 and O2 electrodes for control group. Conclusion: We cannot affirm that the task influences the cortical activity of the patients. It is possible that the method used to analyze the data is not the adequate. The time-frequency analysis could be better to analyze the present data. We also observed that the absolute alpha power could be considered a marker of bipolar disorder, but not of the different states (i.e., mania, depression, euthymia).展开更多
Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their uti...Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their utility in diagnosing VM.To better understand clinical features of VM,it is necessary to understand raw saccades data.Methods:Fourteen patients with confirmed VM,45 patients with probable VM(p-VM)and 14 agematched healthy volunteers were included in this study.Clinical findings related to spontaneous nystagmus(SN),positional nystagmus(PN),head-shaking nystagmus(HSN),caloric test and vHIT were recorded.Raw saccades data were exported and numbered by their sequences,and their features analyzed.Results:VM patients showed no SN,PN or HSN,and less than half of them showed unilateral weakness(UW)on caloric test.The first saccades from lateral semicircular canal stimulation were the most predominant for both left and right sides.Neither velocity nor time parameters were significantly different when compared between the two sides.Most VM patients(86%)exhibited small saccades,around 35%of the head peak velocity,with a latency of 200e400 ms.Characteristics of saccades were similar in patients with p-VM.Only four normal subjects showed saccades,all unilateral and seemingly random.Conclusions:Small saccades involving bilateral semicircular canals with a scattered distribution pattern are common in patients with VM and p-VM.展开更多
Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This stud...Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.展开更多
文摘Human saccade is a dynamic process of information pursuit. There are many methods using either global context or local context cues to model human saccadic scan-paths. In contrast to them, this paper introduces a model for gaze movement control using both global and local cues. To test the performance of this model, an experiment is done to collect human eye movement data by using an SMI iVIEW X Hi-Speed eye tracker with a sampling rate of 1250 Hz. The experiment used a two-by-four mixed design with the location of the targets and the four initial positions. We compare the saccadic scan-paths generated by the proposed model against human eye movement data on a face benchmark dataset. Experimental results demonstrate that the simulated scan-paths by the proposed model are similar to human saccades in term of the fixation order, Hausdorff distance, and prediction accuracy for both static fixation locations and dynamic scan-paths.
基金supported by North Sichuan Medical College(CBY23-QDA14)the National Natural Science Foundation of China(32030045 and 82071454)+4 种基金Nanchong Federation of Social Science Associations(NC24C145)the Sichuan Science and Technology Program(2024NSFSC2017,2024ZYD0086)the Sichuan Students'Platform for Innovation Training Program(S202410634035)the Health Commission of Sichuan Province(24WSXT044)funded by the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB2403).
文摘While multiple step saccades(MSS)are occasionally reported in the healthy population,they are more evident in patients with Parkinson’s disease(PD).Therefore,MSS has been suggested as a biological marker for the diagnosis of PD.However,the lack of clarity on the neural mechanism underlying the generation of MSS largely impedes their application in the clinic.We have proposed recently that MSS are triggered by the discrepancy between desired and executed saccades.Accordingly,brain regions involved in saccadic planning and execution might play a role in the generation of MSS.To test this hypothesis,we explored the role of the prefrontal(PFC)and posterior parietal cortex(PPC)in generating MSS by conducting two experiments:electroencephalographic recording and single-pulse transcranial magnetic stimulation in the PFC or PPC of humans while participants were performing a gap saccade task.We found that the PFC and PPC are involved in the generation of MSS.
基金supported by the National Natural Science Foundation of China(32471055 and 82171090)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJLab,Shanghai Center for Brain Science and Brain-Inspired Technology,the Lingang Laboratory(LG-QS-202203-12).
文摘Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can respond immediately to the threat.Therefore,when an animal detects a threat through its visual system,it must quickly direct its gaze and attention toward the source of danger,assess the threat level,and take appropriate action.
文摘There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granularity, of the time perception at the time of the saccade. This model uses functional pathway knowledge and is inspired by, and integrates, recent findings in both psychophysics and neurophysiology. Perceived time delays in the perisaccadic window are shown numerically consistent with recent experimental measures. Our model provides explanation for several experimental outcomes on saccades, estimates popu-lation variance of the error in time perception and represent a meaningful example for bridging psychophysics and neurophysiology. Finally we found that the insights into information processing during saccadic events lead to considerations on engineering exploitation of the underlying phenomena.
文摘The space-time distortion perceived subjectively during saccadic eye movements is an associative phenomenon of a transient shift of observer’s visual frame of reference from one position to another. Here we report that the lines of subjective simultaneity defined as two spatially separated flashes perceived during saccades were nearly uniformly tilted along the physical time-course. The causality of the resulting space-time compression may be explained by the Minkowski space-time diagram in physics.
基金supported by grants from National Science and Technology Ministry Key Research and Development Program–Project(2022YFC2402703).
文摘Objective:This study aimed to develop and evaluate a novel software tool for robust analysis of the Visually Enhanced Vestibular-Ocular Reflex(VVOR)and video head impulse test(vHIT)saccades.Methods:A retrospective study was conducted on 94 patients with Meniere’s Disease(MD),unilateral vestibular hypofunction(UVH),and vestibular migraine(VM).The MATLAB-based VVOR Analysis System and Saccades All in One software were utilized for data processing.New techniques,VVOR_diff and VVOR_cycle,were deployed for saccade parameter extraction.Results:Saccade incidence rates,examined through vHIT,VVOR_diff,and VVOR_cycle,exhibited distinct patterns in MD,UVH,and VM patients.Frequent instances of multiple saccades within a single cycle were noted on the affected side in MD and UVH patients.Statistically significant differences in saccade gain and incidence rates between the affected and unaffected sides were evident in MD and UVH patients.Notably,high inter-method and intra-method correlations suggested consistency across different methods and potential interactions within one.Conclusion:The software proved effective in extracting saccades and reducing noise in VVOR data,thereby enhancing the evaluation of vestibular function and potentially improving diagnostic accuracy for vestibular disorders.
文摘Purpose. To investigate the peak latency of the orbital presaccadic spike potential (SP) with horizontal eye movement in normals.Methods. Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes with Pz as the reference while performing 5°, 10°, 20°, 30° and 40°horizontal saccades to visual targets. SP peak latency was measured from SP onset to SP peak on averaged data aligned on SP peak.Results. Significant main effects on SP peak latency are found for saccade size (<0. 01), saccade direction (P<0. 01) and electrode site (P<0. 05). No significant main effect on SP peak latency is found for eye (P>0. 05). SP peak latency increases with increasing saccade size from 5°to 40°. SP peak latency is longer with saccades back to center than away from center, and with abducting saccades than with adducting saccades. SP peak latency differs at the electrode sites with an order from shorter to longer as follows: inner canthus (IC); inferior orbit (IO): outer canthus (OC); superior orbit (SO).Conclusicos. The effects on the peak latency of orbital SP can be explained by the saccade dynamic property, volume conduction as well as physiologic and anatomic factors of the eyes and orbits. The peak latency of orbital SP can be used to reflect the temporal characteristics of ocular motor units controlling saccadic eye movement.
基金supported by the National Science and Technology Innovation 2030 Major Program(2021ZD0203700/2021ZD0203702)the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)+1 种基金the Program of Introducing Talents of Discipline to Universities(Ministry of Education of China,Base B16018)NYU Shanghai Boost Fund.
文摘Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently.We discovered that the animal’s choice was dictated by the reward amount while the luminance had a marginal effect.In the LIP,neuronal activity corresponded well with the animal’s choice pattern,in that a majority of reward-modulated neurons encoded the reward amount in the neuron’s preferred hemifield with a positive slope.In contrast,compared to their responses to low luminance,an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity,leading to a much weaker population-level response.Meanwhile,in the non-preferred hemifield,the strength of encoding for reward amount and luminance was positively correlated,suggesting the integration of these two factors in the LIP.Moreover,neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP.Overall,our study provides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions.
文摘Background:Cognitive control is defined as the ability to act flexibly in the environment by either behaving automatically or inhibiting said automatic behaviour and it can be measured using an interleaved pro/anti-saccade task.Decline in cognitive control has been attributed to normal aging and neurological illnesses such as Parkinson’s disease(PD)as well as decline in other cognitive abilities.This parallel might highlight the role played by cognitive control in information processing and working memory.However,little is known about the relationship between cognitive control and other cognitive processes such as visual memory,decision making,and visual search.We thus propose to correlate the incidence of impaired cognitive control with deficits in visual memory,decision making and visual search in three groups:younger adults,older adults and patients with idiopathic PD.Methods:Seventy-one participants,namely 34 adults(M=22.75,SD=3.8),22 older adults(M=67.4,SD=8.3),and 20 PD patients(M=65.59,SD=8.2)performed four tasks:interleaved pro/anti-saccade,visual memory,decision making,and serial and pop-out visual search.Results:Results show that within each group,anti-saccade error rate(ER)were significantly and negatively correlated with visual memory ER(ryounger=−0.378,P=0.036;rolder=−0.440,Polder=0.046;rPD=−0.609,P=0.016).On the other hand,correct decision-making reaction times(RT)were significantly correlated with anti-saccade ER,and RTs only in older adults(rER=0.529,P=0.014;rRT=0.512,P=0.018)and PD patients(rER=0.727,P=0.012;rRT=0.769,P=0.001).For visual search,PD patients showed a significant relationship between RTs for correct pro-saccades and pop-out(r=0.665,P=0.007),and serial(r=0.641,P=0.010)search RTs.Furthermore,there was a significant correlation between MoCA scores and anti-saccade RTs(r=−0.559,P=0.030)and ER(r=−0.562,P=0.029)in PD patients.Taken together,these results support the hypothesis of PD patients’reliance on bottom-up processes as top-down processes decline.For younger adults,there was a significant correlation between serial search performance and both anti-saccade ER(r=0.488,P=0.005),and correct pro-saccade ER(r=0.413,P=0.021).In older adults,this relationship was absent,but anti-saccade ER significantly correlated with pop-out search times(r=0.473,P=0.030).Conclusions:We found significant relationships between cognitive tasks and cognitive control as measured through the interleaved pro/anti-saccade task across and within participant groups,providing evidence of the appropriateness of the use of the interleaved pro/anti-saccade task as a measure of overall cognitive control.
文摘Background:Many studies have shown that attention is shifted toward the goal of the upcoming saccade.It has been suggested that the purpose of this attentional shift is to aid in trans-saccadic integration by acting as a‘pointer’(Cavanagh,Hunt,Afraz&Rolfs,2010)for remembering,processing and updating objects across saccadic eye movements(Rolfs,Jonikaitis,Deubel&Cavanagh,2011).We tested this hypothesis that pre-saccadic attentional facilitation acts as a pointer for trans-saccadic integration by investigating how irrelevant post-saccadic changes influenced pre-saccadic attentional discrimination.On one hand,if pre-saccadic attentional facilitation is an independent process involved only in enhancing peripheral information before the saccade,then manipulating visual information(absence or shift)after the saccade should have no influence on discrimination.On the other hand,if pre-saccadic attentional facilitation is involved in trans-saccadic integration,changes in visual information should influence discrimination of the pre-saccadic information.Methods:We tested different conditions involving different post-saccadic changes.In the baseline condition,participants made a saccade at the appearance of an arrow and discriminated a symbol(DS)that was presented briefly before the saccade at one of six peripheral locations.The symbol was masked thereafter with a figure 8,which remained till the end of the trial.Importantly,the DS was always presented while participants were fixating at center,and only the figure 8 was present at the end of the saccade.Participants were instructed to make the saccade then report the identity of the DS(4AFC).We then tested how blanking post-saccadic information[blanking of the saccade goal(SG)location,DSOff condition;of the entire visual scene including or excluding the SG location,AllOff and DSOnly conditions]and how displacement of the figure 8s after the saccade would affect performance.Results:We observed that discrimination performance was significantly lower when the SG location disappeared during the saccade and was no longer present when the saccade was completed(DSOff,-6.9%).This decrease in performance cannot be attributed to changes in the visual scene that may have drawn attention,as this was the case for all conditions;performance was not different when the entire visual scene was blanked(AllOff,-0.0%)or when only the DS remained(DSOnly,-1.6%).We also found that the performance decreased as a function of the displacement of the figure 8 from the SG location,particularly if it was displaced outside of the saccade landing zone.Conclusions:Based on these pattern of results,we suggest that pre-saccadic attentional facilitation is indeed involved in trans-saccadic integration by acting as a location marker or pointer.The lack of a visual target at the saccade goal,even if it is irrelevant to the pre-saccadic discrimination task,disrupted performance.
文摘Objective: The present study aimed to investigate and to compare the electrophysiological changes in bipolar patients and healthy subjects during the execution of a saccade task. Materials and Methods: The subjects had to respond to a fixed visual stimulus presented by a LEDs bar. We executed an ANOVA (one-way) and post hoc Scheffé test to examine the difference of absolute alpha power and reaction time among four groups: control, depression, manic and euthymic. We observed the frontal, parietal and occipital regions. The paired t test was realized on each electrode and group to compare the pre and post moment in the task. Results: We observed a statistical difference among the groups for the behavioral variable—saccade reaction time. For the electrophysiological variable—absolute alpha power, we did not find significant difference between the moments (pre and post stimulus presentation) for none of the electrodes of each bipolar group. However, the results pointed out to a difference between the moments for F3, P3, O1 and O2 electrodes for control group. Conclusion: We cannot affirm that the task influences the cortical activity of the patients. It is possible that the method used to analyze the data is not the adequate. The time-frequency analysis could be better to analyze the present data. We also observed that the absolute alpha power could be considered a marker of bipolar disorder, but not of the different states (i.e., mania, depression, euthymia).
文摘Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their utility in diagnosing VM.To better understand clinical features of VM,it is necessary to understand raw saccades data.Methods:Fourteen patients with confirmed VM,45 patients with probable VM(p-VM)and 14 agematched healthy volunteers were included in this study.Clinical findings related to spontaneous nystagmus(SN),positional nystagmus(PN),head-shaking nystagmus(HSN),caloric test and vHIT were recorded.Raw saccades data were exported and numbered by their sequences,and their features analyzed.Results:VM patients showed no SN,PN or HSN,and less than half of them showed unilateral weakness(UW)on caloric test.The first saccades from lateral semicircular canal stimulation were the most predominant for both left and right sides.Neither velocity nor time parameters were significantly different when compared between the two sides.Most VM patients(86%)exhibited small saccades,around 35%of the head peak velocity,with a latency of 200e400 ms.Characteristics of saccades were similar in patients with p-VM.Only four normal subjects showed saccades,all unilateral and seemingly random.Conclusions:Small saccades involving bilateral semicircular canals with a scattered distribution pattern are common in patients with VM and p-VM.
基金supported by grants from National Key Research and Development Program of China-part3(2020YFC2005203)Capital's Funds for Health Improvement and Research(No.2022-1-2023).
文摘Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.
