The crystal structure of the new title compound （E）-ethyl 6-benzyl-2-[（cyclopropylmethylamino）（4-fluorophenylamino）methyleneamino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate ethanol monosolvate （C28H...The crystal structure of the new title compound （E）-ethyl 6-benzyl-2-[（cyclopropylmethylamino）（4-fluorophenylamino）methyleneamino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate ethanol monosolvate （C28H31FN 4O2S·C2H6O, Mr=552.70） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21/c with a=13.806（10）, b=10.850（7）, c=19.938（14）, β=98.842（9）° , V=2951（4）3 , Z=4, Dc=1.244g/cm 3 , F（000）=1176, μ=0.153 mm-1 , MoKα radiation （λ=0.71073）, R=0.0758 and wR=0.2234 for 4262 observed reflections with I 〉 2σ（I）. Intramolecular N-H…S and C-H…N interactions as well as intermolecular N-H…O and O-H…N hydrogen bonds help to stabilize the crystal structure. X-ray diffraction analysis reveals that the asymmetric unit contains one title molecule and one ethanol molecule.展开更多
(3R,5R)-3-((tert-Butyldimethylsily)oxy)-5-((Z)-2-bromovinyl)-tetrahydro-furan-2-one, an intermediate for the synthesis of Fostriecin was achieved by intramolecular asymmetric induction in propene addition of (-)-8-phe...(3R,5R)-3-((tert-Butyldimethylsily)oxy)-5-((Z)-2-bromovinyl)-tetrahydro-furan-2-one, an intermediate for the synthesis of Fostriecin was achieved by intramolecular asymmetric induction in propene addition of (-)-8-phenylmenthyl glyoxylate followed by inversion of C3-hydroxyl group and Sharpless asymmetric dihydroxylation with simultaneous cyclization to give lactone 5. Then protection of C3-hydroxyl group and oxidation of the C6-primary hydroxyl group which reacted with Wittig reagent to yield the target compound 4.展开更多
The reduction of disulfides by samarium diiodide led to sa arium thiolates (ArSSml2).This new thiolate anion species reacted smoothly with α, β -unsaturated esters (nitriles) to give 1,4-addition products β -thioes...The reduction of disulfides by samarium diiodide led to sa arium thiolates (ArSSml2).This new thiolate anion species reacted smoothly with α, β -unsaturated esters (nitriles) to give 1,4-addition products β -thioesters and β -thionitriles in good yields under mild and neutralcondition.展开更多
Les anticorps semblent avoir une influence sur la reponse immunologique in vivo. Si Campbell a signale une stimulation de la synthese d’anticorps anti-albumine bovine (BSA) par l’injection de cet anticorps au cours ...Les anticorps semblent avoir une influence sur la reponse immunologique in vivo. Si Campbell a signale une stimulation de la synthese d’anticorps anti-albumine bovine (BSA) par l’injection de cet anticorps au cours de l’immunisation, Mason et al., Uhr et Baumann, Neiders et al., au contraire, ont montre que l’antitoxine et l’hemolysine elles-memes peuvent inhiber la formation de ces anticorps. Ces resultats contradictoires traduisent la complexite des experiences in vivo, car dans ces conditions, l’antigene co-展开更多
Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various tec...Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization.展开更多
Objective To observe the effect of C-reactive protein (CRP) on platelet endothelial nitric oxide synthase (eNOS) activity. Methods Peripheral venous blood was collected, platelets were isolated with gel-filtration chr...Objective To observe the effect of C-reactive protein (CRP) on platelet endothelial nitric oxide synthase (eNOS) activity. Methods Peripheral venous blood was collected, platelets were isolated with gel-filtration chromatography and incubated with histamine, L-NAME and different concentrations of CRP(5, 10, 25, 50, 100μg) for 30 min, then eNOS activity was measured as formation of 3H-L-citrulline from 3H-L-arginine. Results展开更多
This study explored that the mechanism aboutTCDD-induced cellular proliferation with themonolayer growth of cells,SCC-15G and SCC-25 and synthesis using incorporation of ~3H-TdR into DNA.It is indicated that TCDD-in-d...This study explored that the mechanism aboutTCDD-induced cellular proliferation with themonolayer growth of cells,SCC-15G and SCC-25 and synthesis using incorporation of ~3H-TdR into DNA.It is indicated that TCDD-in-duced increase in cell number and DNA synth-展开更多
Rubescensine A (Rub A; oridonin), one of diterpenoids extracted from Rabdosia rubescens (Hemsl.) Hara, was shown to have inhibitory effect on tumour growth in animals. The clinical study has confirmed its effectivenes...Rubescensine A (Rub A; oridonin), one of diterpenoids extracted from Rabdosia rubescens (Hemsl.) Hara, was shown to have inhibitory effect on tumour growth in animals. The clinical study has confirmed its effectiveness in patients with esophagealcancer. We have recently reported that the CaEs-17 human esophageal cancer展开更多
Ⅰ. INTRODUCTION Following the unusually rapid development of laser and its applications, the research and development work of laser dyes is also pushed on at full speed. Laser dyes being studied and prepared in China...Ⅰ. INTRODUCTION Following the unusually rapid development of laser and its applications, the research and development work of laser dyes is also pushed on at full speed. Laser dyes being studied and prepared in China have been extended to include the entire spectrum, and coumarin derivatives are important laser dyes in the blue-green spectral band. This paper is a report on the ways of preparation and the lasering properties展开更多
Y2002-63059-317 0211378专用宏综合=Application specific macro based synthesis〔会,英〕/Sundararaman,S.& Govindarajan,S.//2001IEEE the 14th International Conference on VLSI De-sign.-317～324(E)
On October 31st, 2005, a 50 000 t/a low-pressure synthetic process methanol unitby Yibin Tianke Coal Chemical Co., Ltd.smoothly produced purified methanolafter 72 hours continuous operation,reaching a high quality of ...On October 31st, 2005, a 50 000 t/a low-pressure synthetic process methanol unitby Yibin Tianke Coal Chemical Co., Ltd.smoothly produced purified methanolafter 72 hours continuous operation,reaching a high quality of National Supe-rior Product level. Established on November 10th, 2003,Yibin Tianke Coal Chemical Co., Ltd. islocated at Qingfu, Gao County, Yibin,Sichuan province, southwest China. Itsregistered capital was RMB70 million.展开更多
基金Supported by the National Natural Science Foundation of China (No.21102084)the Key Project of Hubei Provincial Department of Education (No.D20091301)Doctoral Startup Foundation of China Three Gorges University (No.KJ2009B004)
文摘The crystal structure of the new title compound （E）-ethyl 6-benzyl-2-[（cyclopropylmethylamino）（4-fluorophenylamino）methyleneamino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate ethanol monosolvate （C28H31FN 4O2S·C2H6O, Mr=552.70） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21/c with a=13.806（10）, b=10.850（7）, c=19.938（14）, β=98.842（9）° , V=2951（4）3 , Z=4, Dc=1.244g/cm 3 , F（000）=1176, μ=0.153 mm-1 , MoKα radiation （λ=0.71073）, R=0.0758 and wR=0.2234 for 4262 observed reflections with I 〉 2σ（I）. Intramolecular N-H…S and C-H…N interactions as well as intermolecular N-H…O and O-H…N hydrogen bonds help to stabilize the crystal structure. X-ray diffraction analysis reveals that the asymmetric unit contains one title molecule and one ethanol molecule.
文摘(3R,5R)-3-((tert-Butyldimethylsily)oxy)-5-((Z)-2-bromovinyl)-tetrahydro-furan-2-one, an intermediate for the synthesis of Fostriecin was achieved by intramolecular asymmetric induction in propene addition of (-)-8-phenylmenthyl glyoxylate followed by inversion of C3-hydroxyl group and Sharpless asymmetric dihydroxylation with simultaneous cyclization to give lactone 5. Then protection of C3-hydroxyl group and oxidation of the C6-primary hydroxyl group which reacted with Wittig reagent to yield the target compound 4.
文摘The reduction of disulfides by samarium diiodide led to sa arium thiolates (ArSSml2).This new thiolate anion species reacted smoothly with α, β -unsaturated esters (nitriles) to give 1,4-addition products β -thioesters and β -thionitriles in good yields under mild and neutralcondition.
文摘Les anticorps semblent avoir une influence sur la reponse immunologique in vivo. Si Campbell a signale une stimulation de la synthese d’anticorps anti-albumine bovine (BSA) par l’injection de cet anticorps au cours de l’immunisation, Mason et al., Uhr et Baumann, Neiders et al., au contraire, ont montre que l’antitoxine et l’hemolysine elles-memes peuvent inhiber la formation de ces anticorps. Ces resultats contradictoires traduisent la complexite des experiences in vivo, car dans ces conditions, l’antigene co-
文摘Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization.
文摘Objective To observe the effect of C-reactive protein (CRP) on platelet endothelial nitric oxide synthase (eNOS) activity. Methods Peripheral venous blood was collected, platelets were isolated with gel-filtration chromatography and incubated with histamine, L-NAME and different concentrations of CRP(5, 10, 25, 50, 100μg) for 30 min, then eNOS activity was measured as formation of 3H-L-citrulline from 3H-L-arginine. Results
文摘This study explored that the mechanism aboutTCDD-induced cellular proliferation with themonolayer growth of cells,SCC-15G and SCC-25 and synthesis using incorporation of ~3H-TdR into DNA.It is indicated that TCDD-in-duced increase in cell number and DNA synth-
文摘Rubescensine A (Rub A; oridonin), one of diterpenoids extracted from Rabdosia rubescens (Hemsl.) Hara, was shown to have inhibitory effect on tumour growth in animals. The clinical study has confirmed its effectiveness in patients with esophagealcancer. We have recently reported that the CaEs-17 human esophageal cancer
文摘Ⅰ. INTRODUCTION Following the unusually rapid development of laser and its applications, the research and development work of laser dyes is also pushed on at full speed. Laser dyes being studied and prepared in China have been extended to include the entire spectrum, and coumarin derivatives are important laser dyes in the blue-green spectral band. This paper is a report on the ways of preparation and the lasering properties
文摘Y2002-63059-317 0211378专用宏综合=Application specific macro based synthesis〔会,英〕/Sundararaman,S.& Govindarajan,S.//2001IEEE the 14th International Conference on VLSI De-sign.-317～324(E)
文摘On October 31st, 2005, a 50 000 t/a low-pressure synthetic process methanol unitby Yibin Tianke Coal Chemical Co., Ltd.smoothly produced purified methanolafter 72 hours continuous operation,reaching a high quality of National Supe-rior Product level. Established on November 10th, 2003,Yibin Tianke Coal Chemical Co., Ltd. islocated at Qingfu, Gao County, Yibin,Sichuan province, southwest China. Itsregistered capital was RMB70 million.
