The novel reversible anticholinesterase (anti-ChE) agent suberogorgin (S) has potent anti-ChE activity and lower toxicity and is possible to become the new drug for the treatment of senile dementia and amnesia. It has...The novel reversible anticholinesterase (anti-ChE) agent suberogorgin (S) has potent anti-ChE activity and lower toxicity and is possible to become the new drug for the treatment of senile dementia and amnesia. It has been found that the carboxyl, carbonyl groups and double bond of S are the main groups to produce the biological activity in our previous studies on its structure-activity relationships (SAR). In order to explore the relationship between the conformers and biological activity, we have studied the conformational characteris-展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘The novel reversible anticholinesterase (anti-ChE) agent suberogorgin (S) has potent anti-ChE activity and lower toxicity and is possible to become the new drug for the treatment of senile dementia and amnesia. It has been found that the carboxyl, carbonyl groups and double bond of S are the main groups to produce the biological activity in our previous studies on its structure-activity relationships (SAR). In order to explore the relationship between the conformers and biological activity, we have studied the conformational characteris-
