Sorbus pohuashanensis(Hance) Hedl. is a potential horticulture and medicinal plant, but its genomic and genetic backgrounds remain unknown. Here, we sequence and assemble the S. pohuashanensis reference genome using P...Sorbus pohuashanensis(Hance) Hedl. is a potential horticulture and medicinal plant, but its genomic and genetic backgrounds remain unknown. Here, we sequence and assemble the S. pohuashanensis reference genome using Pac Bio long reads. Based on the new reference genome, we resequence a core collection of22 Sorbus spp. samples, which are divided into 2 groups(G1 and G2) based on phylogenetic and PCA analyses. These phylogenetic clusters are highly consistent with their classification based on leaf shape.Natural hybridization between the G1 and G2 groups is evidenced by a sample(R21) with a highly heterozygous genotype. Nucleotide diversity(π) analysis shows that G1 has a higher diversity than G2 and that G2 originated from G1. During the evolution process, the gene families involved in photosynthesis pathways expanded and the gene families involved in energy consumption contracted. RNA-seq data suggests that flavonoid biosynthesis and heat-shock protein(HSP)-heat-shock factor(HSF) pathways play important roles in protection against sunburn. This study provides new insights into the evolution of Sorbus spp.genomes. In addition, the genomic resources, and the identified genetic variations, especially those related to stress resistance, will help future efforts to produce and breed Sorbus spp.展开更多
BACKGROUND While sunburns are very common,especially in pediatrics,curling ulcers secondary to sunburns are a very rare entity that has not been noted in the literature in over fifty years.This case is the first addit...BACKGROUND While sunburns are very common,especially in pediatrics,curling ulcers secondary to sunburns are a very rare entity that has not been noted in the literature in over fifty years.This case is the first addition to the literature since the originally documented case.CASE SUMMARY A previously healthy 17 year old male presents to the emergency room with lethargy,shortness of breath on exertion,dark stools and nausea.His fatigue started to become significantly worse four days prior to admission.Approximately two weeks prior to admission,the patient was on a beach vacation with his family at which time he suffered severe sunburns.He had developed crampy epigastric abdominal pain,which was followed by dark,loose stools.On exam,he is non-toxic appearing,but with pallor and peeling skin on his face and chest with epigastric tenderness.Infectious stool studies were all negative including Helicobacter pylori.He denies use of any non-steroidal anti-inflammatory drugs and also denies alcohol or recreational drug use.While admitted he is found to be significantly anemic with his hemoglobin as low as 6.3 requiring two units of packed red blood cells.Endoscopy revealed several severe and deep ulcerations in the antrum and body of the stomach indicative of stress or curling ulcers.CONCLUSION While the incidence of stress ulcers is not known,it is most common with severe acute illness,most commonly presenting as upper gastrointestinal(GI)bleeding.It is essential to be aware of the risk of curling ulcers secondary to severe sunburns as patients with stress ulcer GI bleeding have increased morbidity and mortality compared to those who do not have GI bleed.展开更多
Heat and light stress causes sunburn to the maturing apple fruits and results in crop production and quality losses.Typically,when the fruit surface temperature(FST)rises above critical limits for a prolonged duration...Heat and light stress causes sunburn to the maturing apple fruits and results in crop production and quality losses.Typically,when the fruit surface temperature(FST)rises above critical limits for a prolonged duration,the fruit may suffer several physiological disorders including sunburn.To manage apple sunburn,monitoring FST is critical and our group at Washington State University is developing a noncontact smart sensing system that integrates thermal infrared and visible imaging sensors for real time FST monitoring.Pertinent system needs to perform in-field imagery data analysis onboard a single board computer with processing unit that has limited computational resources.Therefore,key objective of this study was to develop a novel image processing algorithm optimized to use available resources of a single board computer.Algorithm logic flow includes color space transformation,k-means++classification and morphological operators prior to fruit segmentation and FST estimation.The developed algorithm demonstrated the segmentation accuracy of 57.78%(missing error=12.09%and segmentation error=0.13%).This aided successful apple FST estimation that was 10–18C warmer than ambient air temperature.Moreover,algorithm reduced the imagery data processing time cost of the smart sensing systemfrom 87 s to 44 s using image compression approach.展开更多
To the Editor： I read with great interest the recent article by Song et al1 who showed that green tea may play a protective role from ultraviolet B （UVB）-induced skin damage and thus may be a therapeutically effect...To the Editor： I read with great interest the recent article by Song et al1 who showed that green tea may play a protective role from ultraviolet B （UVB）-induced skin damage and thus may be a therapeutically effective agent against sunburn. Since excessive exposure to the sun and frequent sunburns predispose to melanoma, one wonders if green tea can also protect against melanoma.展开更多
目的:运用CiteSpace梳理中药黄芩治疗日光性皮炎的国内外研究现状、热点及发展趋势,以期为临床治疗日光性皮炎提供新的思路与方向。方法:通过检索中国知网(CNKI)、Web of Science (WoS)核心数据库中近30年黄芩治疗日光性皮炎的相关文献...目的:运用CiteSpace梳理中药黄芩治疗日光性皮炎的国内外研究现状、热点及发展趋势,以期为临床治疗日光性皮炎提供新的思路与方向。方法:通过检索中国知网(CNKI)、Web of Science (WoS)核心数据库中近30年黄芩治疗日光性皮炎的相关文献,导出格式为Refworks,采用CiteSpace6.1.6软件对相关文献的作者、研究机构和关键词进行可视化分析。结果:中英文文献共纳入262篇,作者共现分析显示发文量最多的作者分别为骆丹(19篇)、Luo, Dan(11篇);机构共现分析显示发文量最多的机构分别是南京医科大学第一附属医院皮肤科(10篇)与Nanjing Med Univ(12篇);年发文量统计分析显示中文文献发表量呈逐渐上升趋势,近三年发文量有所下降,国外年发文量波动不大,此领域研究数据较少;中英文文献关键词共现分析显示,研究主题多集中在黄芩及其提取物治疗日光性皮炎的作用机制方面以及黄芩复方制剂在临床治疗光敏性皮肤病的疗效等。结论:黄芩治疗日光性皮炎的研究主要集中在国内,国外研究较少,尤其是临床与基础实验方面;各研究团体及机构未形成紧密联系,缺乏学术交流与学科交叉。因此,为了促进中医药治疗日光性皮炎的发展,需要加强跨机构合作,多学科融合发展,增强发病机制与疾病防治的研究。展开更多
基金supported by the Fund of the National Natural Science Foundation of China (grant number 31770369) to J. Z。
文摘Sorbus pohuashanensis(Hance) Hedl. is a potential horticulture and medicinal plant, but its genomic and genetic backgrounds remain unknown. Here, we sequence and assemble the S. pohuashanensis reference genome using Pac Bio long reads. Based on the new reference genome, we resequence a core collection of22 Sorbus spp. samples, which are divided into 2 groups(G1 and G2) based on phylogenetic and PCA analyses. These phylogenetic clusters are highly consistent with their classification based on leaf shape.Natural hybridization between the G1 and G2 groups is evidenced by a sample(R21) with a highly heterozygous genotype. Nucleotide diversity(π) analysis shows that G1 has a higher diversity than G2 and that G2 originated from G1. During the evolution process, the gene families involved in photosynthesis pathways expanded and the gene families involved in energy consumption contracted. RNA-seq data suggests that flavonoid biosynthesis and heat-shock protein(HSP)-heat-shock factor(HSF) pathways play important roles in protection against sunburn. This study provides new insights into the evolution of Sorbus spp.genomes. In addition, the genomic resources, and the identified genetic variations, especially those related to stress resistance, will help future efforts to produce and breed Sorbus spp.
文摘BACKGROUND While sunburns are very common,especially in pediatrics,curling ulcers secondary to sunburns are a very rare entity that has not been noted in the literature in over fifty years.This case is the first addition to the literature since the originally documented case.CASE SUMMARY A previously healthy 17 year old male presents to the emergency room with lethargy,shortness of breath on exertion,dark stools and nausea.His fatigue started to become significantly worse four days prior to admission.Approximately two weeks prior to admission,the patient was on a beach vacation with his family at which time he suffered severe sunburns.He had developed crampy epigastric abdominal pain,which was followed by dark,loose stools.On exam,he is non-toxic appearing,but with pallor and peeling skin on his face and chest with epigastric tenderness.Infectious stool studies were all negative including Helicobacter pylori.He denies use of any non-steroidal anti-inflammatory drugs and also denies alcohol or recreational drug use.While admitted he is found to be significantly anemic with his hemoglobin as low as 6.3 requiring two units of packed red blood cells.Endoscopy revealed several severe and deep ulcerations in the antrum and body of the stomach indicative of stress or curling ulcers.CONCLUSION While the incidence of stress ulcers is not known,it is most common with severe acute illness,most commonly presenting as upper gastrointestinal(GI)bleeding.It is essential to be aware of the risk of curling ulcers secondary to severe sunburns as patients with stress ulcer GI bleeding have increased morbidity and mortality compared to those who do not have GI bleed.
基金This project was funded in part by NSF/USDA-NIFA Cyber Physical Systems and USDA-NIFA WNP0745 projects.The author extends their gratitude to Dr.Sindhuja Sankaran and Mr.Chongyuan Zhang of Washington State University for their assistance in completion of this study.
文摘Heat and light stress causes sunburn to the maturing apple fruits and results in crop production and quality losses.Typically,when the fruit surface temperature(FST)rises above critical limits for a prolonged duration,the fruit may suffer several physiological disorders including sunburn.To manage apple sunburn,monitoring FST is critical and our group at Washington State University is developing a noncontact smart sensing system that integrates thermal infrared and visible imaging sensors for real time FST monitoring.Pertinent system needs to perform in-field imagery data analysis onboard a single board computer with processing unit that has limited computational resources.Therefore,key objective of this study was to develop a novel image processing algorithm optimized to use available resources of a single board computer.Algorithm logic flow includes color space transformation,k-means++classification and morphological operators prior to fruit segmentation and FST estimation.The developed algorithm demonstrated the segmentation accuracy of 57.78%(missing error=12.09%and segmentation error=0.13%).This aided successful apple FST estimation that was 10–18C warmer than ambient air temperature.Moreover,algorithm reduced the imagery data processing time cost of the smart sensing systemfrom 87 s to 44 s using image compression approach.
文摘To the Editor： I read with great interest the recent article by Song et al1 who showed that green tea may play a protective role from ultraviolet B （UVB）-induced skin damage and thus may be a therapeutically effective agent against sunburn. Since excessive exposure to the sun and frequent sunburns predispose to melanoma, one wonders if green tea can also protect against melanoma.
文摘目的:运用CiteSpace梳理中药黄芩治疗日光性皮炎的国内外研究现状、热点及发展趋势,以期为临床治疗日光性皮炎提供新的思路与方向。方法:通过检索中国知网(CNKI)、Web of Science (WoS)核心数据库中近30年黄芩治疗日光性皮炎的相关文献,导出格式为Refworks,采用CiteSpace6.1.6软件对相关文献的作者、研究机构和关键词进行可视化分析。结果:中英文文献共纳入262篇,作者共现分析显示发文量最多的作者分别为骆丹(19篇)、Luo, Dan(11篇);机构共现分析显示发文量最多的机构分别是南京医科大学第一附属医院皮肤科(10篇)与Nanjing Med Univ(12篇);年发文量统计分析显示中文文献发表量呈逐渐上升趋势,近三年发文量有所下降,国外年发文量波动不大,此领域研究数据较少;中英文文献关键词共现分析显示,研究主题多集中在黄芩及其提取物治疗日光性皮炎的作用机制方面以及黄芩复方制剂在临床治疗光敏性皮肤病的疗效等。结论:黄芩治疗日光性皮炎的研究主要集中在国内,国外研究较少,尤其是临床与基础实验方面;各研究团体及机构未形成紧密联系,缺乏学术交流与学科交叉。因此,为了促进中医药治疗日光性皮炎的发展,需要加强跨机构合作,多学科融合发展,增强发病机制与疾病防治的研究。
