Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and o...Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and operation of NSUN2 in cardiac hypertrophy and HF remain unclear.Here,we observed a significant increase in the levels of NSUN2 expression in both human hearts with HF and in mouse hearts with hypertrophy induced by transverse aortic constriction(TAC)and angiotensin II(Ang II)treatment.Cardiomyocyte-specific knockout of NSUN2 attenuated the reduced cardiac ejection fraction(EF)and fractional shortening(FS)and the increased heart weight to tibial length(HW/TL)upon either TAC or Ang II infusion.Conversely,cardiac-specific overexpression of NSUN2 resulted in cardiac remodeling as indicated by a prominent increase in hypertrophic growth and cardiac fibrosis and a robust decline in cardiac EF and FS.Mechanistically,NSUN2 induces 5-methylcytosine(m5C)modification of La-related protein 1(LARP1)to enhance its messenger RNA(mRNA)stability,which is mediated by Y-box binding protein 1(YBX1).Increased LARP1 further interacts with GATA binding protein 4(GATA4)mRNA and prevents its degradation.LARP1 silencing partially attenuates TAC and NSUN2 induced cardiac hypertrophy and HF.Collectively,this study provides a new insight into the central role of NSUN2 in cardiac hypertrophy,indicating that NSUN2 may serve as a novel therapeutic target for HF.展开更多
The paper investigates a few of the major areas of the next generation technological advancement,“smart city planning concept”.The areas that the paper focuses are vehicle to grid(V2G),sun to vehicle(S2V),and vehicl...The paper investigates a few of the major areas of the next generation technological advancement,“smart city planning concept”.The areas that the paper focuses are vehicle to grid(V2G),sun to vehicle(S2V),and vehicle to infrastructure(V2I).For the bi-directional crowd energy single entity concept,V2G and building to grid(B2G)are the primary parts of distributed renewable generation(DRG)under smart living.This research includes an in-depth overview of this three major areas.Next,the research conducts a case analysis of V2G,S2V,and V2I along with their possible limitations in order to find out the novel solutions for future development both for academia and industry levels.Lastly,few possible solutions have been proposed to minimize the limitations and to develop the existing system for future expansion.展开更多
The graft polymerization of acrylic acid(A) and acrylamide(B) was carried out onto bi-oriented polyester BOPET corona film.The influence of monomer concentration,reducer concentration and reaction time on the graft po...The graft polymerization of acrylic acid(A) and acrylamide(B) was carried out onto bi-oriented polyester BOPET corona film.The influence of monomer concentration,reducer concentration and reaction time on the graft polymerization was investigated.The surface tension of the films increased with an increase of monomer concentration,till the concentration of monomer A reached 1.5×10^(-2)g/mL and the concentration of monomer B reached 4.0×10^(-2)g/mL.The surface tension of the films reached a maximum value at 7×10^(-4)M of reducer concentration and subsequently decreased with further increase in reducer concentration.The surface tension of the films increased with the increase of the reaction time apparently within 50min.The grafted corona BOPET films were characterized with IR and XPS.The presence of graft on the film surface was confirmed.The attenuation experiments on grafted corona BOPET films in air at 50℃ and in water were carried out to investigate the persistence of graft polymerization of acrylic acid and arylamide onto BOPET corona films.展开更多
Subject Code:A04With the support by the National Natural Science Foundation of China and the State Key Program for Basic Research of China,the research team led by Prof.Zhu Jia(朱嘉)at the National Laboratory of Solid...Subject Code:A04With the support by the National Natural Science Foundation of China and the State Key Program for Basic Research of China,the research team led by Prof.Zhu Jia(朱嘉)at the National Laboratory of Solid State Microstructures,College of Engineering and Applied Sciences,Nanjing University,improved the efficiency of solar desalination using graphene oxide film through suppressing the conduction loss。展开更多
基金supported by grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2024ZD0537909)the National Natural Science Foundation of China(82273928,82473919,82330011,82161148007)+2 种基金the Distinguished Young Scholars of Natural Science Foundation of Heilongjiang Province(JQ2024H002)the Chunyan Programme of Heilongjiang Province(CYQN2403)the CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003).
文摘Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and operation of NSUN2 in cardiac hypertrophy and HF remain unclear.Here,we observed a significant increase in the levels of NSUN2 expression in both human hearts with HF and in mouse hearts with hypertrophy induced by transverse aortic constriction(TAC)and angiotensin II(Ang II)treatment.Cardiomyocyte-specific knockout of NSUN2 attenuated the reduced cardiac ejection fraction(EF)and fractional shortening(FS)and the increased heart weight to tibial length(HW/TL)upon either TAC or Ang II infusion.Conversely,cardiac-specific overexpression of NSUN2 resulted in cardiac remodeling as indicated by a prominent increase in hypertrophic growth and cardiac fibrosis and a robust decline in cardiac EF and FS.Mechanistically,NSUN2 induces 5-methylcytosine(m5C)modification of La-related protein 1(LARP1)to enhance its messenger RNA(mRNA)stability,which is mediated by Y-box binding protein 1(YBX1).Increased LARP1 further interacts with GATA binding protein 4(GATA4)mRNA and prevents its degradation.LARP1 silencing partially attenuates TAC and NSUN2 induced cardiac hypertrophy and HF.Collectively,this study provides a new insight into the central role of NSUN2 in cardiac hypertrophy,indicating that NSUN2 may serve as a novel therapeutic target for HF.
文摘The paper investigates a few of the major areas of the next generation technological advancement,“smart city planning concept”.The areas that the paper focuses are vehicle to grid(V2G),sun to vehicle(S2V),and vehicle to infrastructure(V2I).For the bi-directional crowd energy single entity concept,V2G and building to grid(B2G)are the primary parts of distributed renewable generation(DRG)under smart living.This research includes an in-depth overview of this three major areas.Next,the research conducts a case analysis of V2G,S2V,and V2I along with their possible limitations in order to find out the novel solutions for future development both for academia and industry levels.Lastly,few possible solutions have been proposed to minimize the limitations and to develop the existing system for future expansion.
文摘The graft polymerization of acrylic acid(A) and acrylamide(B) was carried out onto bi-oriented polyester BOPET corona film.The influence of monomer concentration,reducer concentration and reaction time on the graft polymerization was investigated.The surface tension of the films increased with an increase of monomer concentration,till the concentration of monomer A reached 1.5×10^(-2)g/mL and the concentration of monomer B reached 4.0×10^(-2)g/mL.The surface tension of the films reached a maximum value at 7×10^(-4)M of reducer concentration and subsequently decreased with further increase in reducer concentration.The surface tension of the films increased with the increase of the reaction time apparently within 50min.The grafted corona BOPET films were characterized with IR and XPS.The presence of graft on the film surface was confirmed.The attenuation experiments on grafted corona BOPET films in air at 50℃ and in water were carried out to investigate the persistence of graft polymerization of acrylic acid and arylamide onto BOPET corona films.
文摘Subject Code:A04With the support by the National Natural Science Foundation of China and the State Key Program for Basic Research of China,the research team led by Prof.Zhu Jia(朱嘉)at the National Laboratory of Solid State Microstructures,College of Engineering and Applied Sciences,Nanjing University,improved the efficiency of solar desalination using graphene oxide film through suppressing the conduction loss。
