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Coronal plane alignment of the knee phenotypes and ankle joint coronal plane alignment patterns in Egyptian population
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作者 Ahmed A Khalifa Mohamed Moustafa +3 位作者 Shikuria Lemma Mostafa Fayez Ahmed M Abdelaal Amr A Fadle 《World Journal of Orthopedics》 2026年第1期67-80,共14页
BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affectin... BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affecting the alignment,such as ankle joint alignment,should be considered.AIM To determine CPAK distribution in the North African(Egyptian)population with knee osteoarthritis and to assess ankle joint line orientation(AJLO)adaptations across different CPAK types.METHODS A cross-sectional study was conducted on patients with primary knee osteoarthritis and normal ankle joints.Radiographic parameters included the mechanical lateral distal femoral angle,medial proximal tibial angle,and the derived calculations of joint line obliquity(JLO)and arithmetic hip-knee-ankle angle(aHKA).The tibial plafond horizontal angle(TPHA)was used for AJLO assessment,where 0°is neutral(type N),<0°is varus(type A),and>0°is valgus(type B).The nine CPAK types were further divided into 27 subtypes after incorporating the three AJLO types.RESULTS A total of 527 patients(1054 knees)were included for CPAK classification,and 435 patients(870 knees and ankles)for AJLO assessment.The mean age was 57.2±7.8 years,with 79.5%females.Most knees(76.4%)demonstrated varus alignment(mean aHKA was-5.51°±4.84°)and apex distal JLO(55.3%)(mean JLO was 176.43°±4.53°).CPAK types I(44.3%),IV(28.6%),and II(10%)were the most common.Regarding AJLO,70.2%of ankles exhibited varus orientation(mean TPHA was-5.21°±6.45°).The most frequent combined subtypes were CPAK type I-A(33.7%),IV-A(21.5%),and I-N(6.9%).A significant positive correlation was found between the TPHA and aHKA(r=0.40,P<0.001).CONCLUSION In this North African cohort,varus knee alignment with apex distal JLO and varus AJLO predominated.CPAK types I,IV,and II were the most common types,while subtypes I-A,IV-A,and I-N were commonly occurring after incorporating AJLO types;furthermore,the AJLO was significantly correlated to aHKA. 展开更多
关键词 coronal plane alignment of the knee classification coronal alignment Ankle joint alignment Knee arthroplasty Knee replacement North African population
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The Emission Heights of Transition Region Lines in an Equatorial Coronal Hole and the Surrounding Quiet Sun 被引量:1
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作者 Hui Tian Li-Dong Xia +2 位作者 Jian-Sen He Bo Tan Shuo Yao 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2008年第6期732-742,共11页
Using the correlation between the radiance or Doppler velocity and the extrapolated magnetic field, we determined the emission heights of a set of solar transition region lines in an equatorial coronal hole and in the... Using the correlation between the radiance or Doppler velocity and the extrapolated magnetic field, we determined the emission heights of a set of solar transition region lines in an equatorial coronal hole and in the surrounding quiet Sun region. We found that for all of the six lower-transition-region lines, the emission height is about 4-5 Mm in the equatorial coronal hole, and around 2 Mm in the quiet Sun region. This result confirms the previous findings that plasma with different temperature can coexist at the same layer of transition region. In the quiet Sun region, the emission height of the upper-transition-region line Ne VIII is almost the same that of the lower-transition-region line, but in the coronal hole, it is twice as high. This difference reveals that the outflow of Ne VIII is a signature of solar wind in the coronal hole and is just a mass supply to the large loops in the quiet Sun. 展开更多
关键词 sun transition region sun magnetic fields sun solar wind sun UV radiation
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miR-516b-5p靶向NSUN2对乳腺癌细胞增殖和侵袭的影响
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作者 程欣然 范亚楠 +1 位作者 刘俊 皮亚平 《河北医学》 2025年第10期1585-1592,共8页
目的:探讨微小非编码RNA-516b-5p(miR-516b-5p)靶向RNA甲基转移酶家族成员2(NSUN2)对乳腺癌(BC)细胞增殖和侵袭的影响。方法:qRT-PCR实验检测BC癌组织、癌旁组织(n=45)及正常乳腺上皮细胞(MCF-10A)、BC细胞(MCF-7、MDA-MB-231、HCC1937)... 目的:探讨微小非编码RNA-516b-5p(miR-516b-5p)靶向RNA甲基转移酶家族成员2(NSUN2)对乳腺癌(BC)细胞增殖和侵袭的影响。方法:qRT-PCR实验检测BC癌组织、癌旁组织(n=45)及正常乳腺上皮细胞(MCF-10A)、BC细胞(MCF-7、MDA-MB-231、HCC1937)中miR-516b-5p、NSUN2 mRNA表达量。将MCF-7细胞分为NC组、miR-NC组、miR-516b-5p mimic组、sh-NC组、sh-NSUN2组、miR-516b-5p mimic+pcDNA-NC组、miR-516b-5p mimic+pcDNA-NSUN2组,通过克隆形成和Transwell侵袭实验分别检测各组MCF-7细胞增殖和侵袭能力;Western blot实验检测各组细胞中NSUN2、细胞周期蛋白1(CCND1)、细胞周期蛋白依赖性激酶1(CDK1)、基质金属蛋白酶2(MMP2)、基质金属蛋白酶9(MMP9)蛋白表达量;构建裸鼠BC移植瘤模型,并分为Model组、miR-516b-5p mimics组、miR-516b-5p mimic+pcDNA-NSUN2组,测量各组肿瘤质量和体积。结果:与癌旁组织相比,癌组织中miR-516b-5p表达量明显下降,NSUN2 mRNA表达量明显上升(P<0.05)。与MCF-10A细胞相比,MCF-7、MDA-MB-231、HCC1937细胞中miR-516b-5p表达量明显下降,NSUN2 mRNA表达量明显上升(P<0.05),其中MCF-7细胞以上指标变化趋势最为明显。与NC组相比,miR-NC组和sh-NC组细胞各指标无明显变化(P>0.05);与miR-NC组相比,miR-516b-5p mimic组细胞集落形成数量、侵袭细胞数减少,NSUN2 mRNA和NSUN2、CCND1、CDK1、MMP2、MMP9蛋白表达量均明显下降,miR-516b-5p表达量明显上升(P<0.05);与sh-NC组相比,sh-NSUN2组各指标变化趋势与miR-516b-5p mimic组一致(P<0.05);而在miR-516b-5p mimic+pcDNA-NSUN2组中各指标变化趋势与miR-516b-5p mimic组相反(P<0.05)。双荧光素酶实验证实miR-516b-5p与NSUN2存在靶向关系(P<0.05)。裸鼠成瘤实验中,与Model组相比,miR-516b-5p mimics组肿瘤组织质量和体积明显缩小(P<0.05);与miR-516b-5p mimics组相比,miR-516b-5p mimic+pcDNA-NSUN2组肿瘤组织质量和体积明显增大(P<0.05)。结论:miR-516b-5p可通过靶向下调NSUN2表达,抑制BC细胞增殖和侵袭。 展开更多
关键词 微小非编码RNA-516b-5p RNA甲基转移酶家族成员2 乳腺癌 增殖 侵袭
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Investigation of two coronal mass ejections from circular ribbon source region:Origin,Sun-Earth propagation and Geoeffectiveness
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作者 M.Syed Ibrahim Wahab Uddin +2 位作者 Bhuwan Joshi Ramesh Chandra Arun Kumar Awasthi 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第12期531-549,共19页
In this article,we compare the properties of two coronal mass ejections(CMEs)that show similar source region characteristics but different evolutionary behaviors in the later phases.We discuss the two events in terms ... In this article,we compare the properties of two coronal mass ejections(CMEs)that show similar source region characteristics but different evolutionary behaviors in the later phases.We discuss the two events in terms of their near-Sun characteristics,interplanetary evolution and geoeffectiveness.We carefully analyzed the initiation and propagation parameters of these events to establish the precise CMEinterplanetary CME(ICME)connection and their near-Earth consequences.The first event is associated with poor geomagnetic storm disturbance index(Dst≈-20 n T)while the second event is associated with an intense geomagnetic storm of DST≈-119 n T.The configuration of the sunspots in the active regions and their evolution are observed by Helioseismic and Magnetic Imager(HMI).For source region imaging,we rely on data obtained from Atmospheric Imaging Assembly(AIA)on board Solar Dynamics Observatory(SDO)and Hαfiltergrams from the Solar Tower Telescope at Aryabhatta Research Institute of Observational Sciences(ARIES).For both the CMEs,flux rope eruptions from the source region triggered flares of similar intensities(≈M1).At the solar source region of the eruptions,we observed a circular ribbon flare(CRF)for both cases,suggesting fan-spine magnetic configuration in the active region corona.The multi-channel SDO observations confirm that the eruptive flares and subsequent CMEs were intimately related to the filament eruption.Within the Large Angle and Spectrometric Coronograph(LASCO)field of view(FOV)the two CMEs propagated with linear speeds of 671 and 631 km s-1,respectively.These CMEs were tracked up to the Earth by Solar Terrestrial Relations Observatory(STEREO)instruments.We find that the source region evolution of CMEs,guided by the large-scale coronal magnetic field configuration,along with near-Sun propagation characteristics,such as CME-CME interactions,played important roles in deciding the evolution of CMEs in the interplanetary medium and subsequently their geoeffectiveness. 展开更多
关键词 sun:coronal mass ejections(CMEs) sun:flares
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Interpretation of the coronal magnetic field configuration of the Sun 被引量:3
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作者 Bo Li Xing Li Hui Yu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第12期1693-1700,共8页
The origin of the heliospheric magnetic flux on the Sun,and hence the origin of the solar wind,is a topic of hot debate.While the prevailing view is that the solar wind originates from outside the coronal streamer hel... The origin of the heliospheric magnetic flux on the Sun,and hence the origin of the solar wind,is a topic of hot debate.While the prevailing view is that the solar wind originates from outside the coronal streamer helmets,there also exists the suggestion that the open magnetic field spans a far wider region.Without the definitive measurement of the coronal magnetic field,it is difficult to unambiguously resolve the conflict between the two scenarios.We present two 2-dimensional, Alfvénic-turbulence-based models of the solar corona and solar wind,one with and the other without a closed magnetic field region in the inner corona.The purpose of the latter model is to test whether it is possible to realize a picture suggested by polarimetric measurements of the corona using the Fe XⅢ 10747 line,where open magnetic field lines seem to penetrate the streamer base.The boundary conditions at the coronal base are able to account for important observational constraints,especially those on the magnetic flux distribution.Interestingly,the two models provide similar polarized brightness(pB)distributions in the field of view(FOV)of SOHO/LASCO C2 and C3 coronagraphs.In particular,a dome-shaped feature is present in the C2 FOV even for the model without a closed magnetic field.Moreover,both models fit the Ulysses data scaled to 1 AU equally well.We suggest that:1)The pB observations cannot be safely taken as a proxy for the magnetic field topology,as is often implicitly assumed.2)The Ulysses measurements,especially the one showing a nearly uniform distribution with heliocentric latitude of the radial magnetic field,do not rule out the ubiquity of open magnetic fields on the Sun. 展开更多
关键词 sun:corona-sun:magnetic fields-solar wind
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Magnetic cycles of Sun-like stars with different levels of coronal and chromospheric activity——comparison with the Sun
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作者 Elena Shimanovskaya Vasiliy Bruevich Elena Bruevich 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2016年第9期123-136,共14页
The atmospheric activity of the Sun and Sun-like stars is analyzed involving observations from the HK-project at the Mount Wilson Observatory, the California and Carnegie Planet Search Program at the Keck and Lick Obs... The atmospheric activity of the Sun and Sun-like stars is analyzed involving observations from the HK-project at the Mount Wilson Observatory, the California and Carnegie Planet Search Program at the Keck and Lick Observatories and the Magellan Planet Search Program at the Las Campanas Observatory. We show that for stars of E G and K spectral classes, the cyclic activity, similar to the 11-yr solar cycle, is different: it becomes more prominent in K-stars. Comparative study of Sun-like stars with different levels of chromospheric and coronal activity confirms that the Sun belongs to stars with a low level of chromospheric activity and stands apart among these stars by its minimum level of coronal radiation and minimum level of variations in photospheric flux. 展开更多
关键词 sun activity -- sun-like stars ACTIVITY
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NSUN2通过介导ARMC9的m5C修饰促进胃癌细胞的增殖、转移和侵袭
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作者 李越 陈栋 +4 位作者 王瑾 彭怡 张远琦 杨芬 王学军 《中国药科大学学报》 北大核心 2025年第5期583-591,共9页
为研究NOP2/Sun RNA甲基转移酶2(NOP2/Sun RNA methyltransferase 2,NSUN2)对胃癌恶性进展的影响及其潜在机制,使用TCGA数据库分析发现胃癌组织中NSUN2表达水平显著升高;Western blot发现,与胃黏膜上皮细胞相比,NSUN2在胃癌细胞中表达上... 为研究NOP2/Sun RNA甲基转移酶2(NOP2/Sun RNA methyltransferase 2,NSUN2)对胃癌恶性进展的影响及其潜在机制,使用TCGA数据库分析发现胃癌组织中NSUN2表达水平显著升高;Western blot发现,与胃黏膜上皮细胞相比,NSUN2在胃癌细胞中表达上调;集落形成实验显示,NSUN2过表达细胞中集落形成能力增高;Transwell实验也证实NSUN2高表达时,发生迁移和侵袭的细胞数量显著增多。进一步通过数据库分析推测ARMC可能是NSUN2的下游靶分子,接着通过MeRIP-qPCR揭示NSUN2高表达可以提高ARMC9的m5C修饰水平,并且降低ARMC9 mRNA的降解速率,从而提高其蛋白表达水平。此外,过表达ARMC9可以增强细胞的集落形成能力和迁移侵袭能力。上述结果显示,NSUN2可以通过提高ARMC9 mRNA的m5C修饰水平,提高其稳定性,增强其表达,从而促进胃癌进展,因此NSUN2和ARMC9可以作为胃癌进展的潜在治疗靶标。 展开更多
关键词 5-甲基胞嘧啶 甲基转移酶 NOP2/sun RNA甲基转移酶2 犰狳重复序列9 胃癌 肿瘤标志物
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SUN2调控稳定表达绵羊肺腺瘤病毒囊膜蛋白的OAR-L1细胞的恶性转化能力的研究
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作者 鲍安玉 杜晓悦 +3 位作者 陈思旭 段续接 张培 刘淑英 《中国兽医科学》 北大核心 2025年第5期669-677,共9页
为了探究SAD1/UN84结构域蛋白-2(SAD1/UNC84 domain protein-2,SUN2)在绵羊肺腺瘤病(ovine pulmonary adenocarcnoma,OPA)肿瘤细胞恶性转化中的功能,本试验利用实验室保存的JSRV env慢病毒感染绵羊肺成纤维细胞(OAR-L1),建立了OAR-L1-En... 为了探究SAD1/UN84结构域蛋白-2(SAD1/UNC84 domain protein-2,SUN2)在绵羊肺腺瘤病(ovine pulmonary adenocarcnoma,OPA)肿瘤细胞恶性转化中的功能,本试验利用实验室保存的JSRV env慢病毒感染绵羊肺成纤维细胞(OAR-L1),建立了OAR-L1-Env稳转株。通过qPCR和Western-blot检测JSRV Env和SUN2的表达情况,使用CCK-8、划分愈合试验和软琼脂糖集落形成试验检测细胞的恶性转化能力。此外,分别构建SUN2过表达和干扰质粒,并转染OAR-L1-Env稳转株,利用qPCR和Western-blot检测其SUN2的表达情况,通过CCK-8和划分愈合试验检测细胞的增殖和迁移能力。结果显示,OAR-L1-Env稳转株成功建立,且SUN2表达量显著下调(P<0.05),CCK-8、划分愈合试验和软琼脂糖集落形成试验表明OAR-L1-Env稳转株发生恶性转化。OAR-L1-Env稳转株中过表达SUN2可抑制细胞的增殖和迁移能力(P<0.05),而干扰SUN2则促进细胞的增殖和迁移能力(P<0.05)。综上所述,本研究表明SUN2参与调控JSRV Env诱导的细胞恶性转化,提示其可能对OPA肿瘤生成有抑制作用。本研究为进一步探究SUN2在OPA中的细胞增殖等生物学作用的研究提供了一定的参考资料。 展开更多
关键词 稳转株 囊膜蛋白 sun2 增殖 迁移
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宫颈癌组织NSUN6、SULF1表达与临床病理特征关系及预后价值 被引量:1
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作者 张毅 伍紫蕊 +1 位作者 李玉佳 黄官友 《疑难病杂志》 2025年第7期843-847,854,共6页
目的 研究宫颈癌组织NOP2/Sun RNA甲基转移酶家族成员6(NSUN6)、硫酸酯酶1(SULF1)的表达及其与临床病理特征和预后的关系。方法 选取2019年6月—2021年6月贵州医科大学附属医院妇产科收治的宫颈癌患者92例的临床资料。利用实时荧光定量... 目的 研究宫颈癌组织NOP2/Sun RNA甲基转移酶家族成员6(NSUN6)、硫酸酯酶1(SULF1)的表达及其与临床病理特征和预后的关系。方法 选取2019年6月—2021年6月贵州医科大学附属医院妇产科收治的宫颈癌患者92例的临床资料。利用实时荧光定量PCR和免疫组织化学检测癌组织NSUN6、SULF1 mRNA和蛋白表达;应用R语言分析人类基因组图谱(TCGA)数据库中宫颈癌组织和正常宫颈组织中NSUN6、SULF1表达差异;K-M曲线分析NSUN6、SULF1蛋白表达对宫颈癌患者预后的影响;Cox回归模型筛选宫颈癌预后的影响因素。结果 TCGA数据库分析结果显示,宫颈癌组织中NSUN6、SULF1 mRNA表达高于正常宫颈组织(t/P=22.281/<0.001、53.721/<0.001);宫颈癌患者癌组织NSUN6、SULF1 mRNA表达均高于癌旁组织(t/P=37.619/<0.001、36.442/<0.001),宫颈癌组织NSUN6、SULF1蛋白阳性率均高于癌旁组织(χ^(2)/P=85.546/<0.001、86.891/<0.001);宫颈癌组织NSUN6、SULF1蛋白阳性率在FIGO分期ⅠB2~ⅡB期、淋巴结转移均高于ⅠA~ⅠB1期、无淋巴结转移(t/P=7.934/0.005、5.327/0.021、13.512/<0.001、4.564/0.033);NSUN6阳性与阴性、SULF1阳性与阴性3年总生存(OS)率之间比较,差异均无统计学意义(P>0.05),NSUN6阳性、SULF1阳性患者3年无进展生存(PFS)率均低于阴性患者(χ^(2)/P=8.120/0.004、36.442/<0.001);FIGO分期ⅠB2~ⅡB期、淋巴结转移、NSUN6阳性、SULF1阳性是宫颈癌患者预后不良的危险因素[HR(95%CI)=1.402(1.115~1.764)、1.339(1.094~1.639)、1.374(1.082~1.746)、1.278(1.054~1.548)]。结论 宫颈癌组织中NSUN6、SULF1 mRNA和蛋白表达均升高,两者均与不良临床病理特征相关,是评估宫颈癌预后的标志物。 展开更多
关键词 宫颈癌 NOP2/sun RNA甲基转移酶家族成员6 硫酸酯酶1 预后
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视网膜母细胞瘤组织中NSUN2 mRNA,PRMT5 mRNA表达水平与临床病理学特征及预后的相关性研究
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作者 万宇 邹云春 +3 位作者 王岚 李娜 何艺岚 王淑 《现代检验医学杂志》 2025年第4期61-66,共6页
目的探讨视网膜母细胞瘤(Rb)组织中NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)、蛋白精氨酸甲基转移酶5(PRMT5)表达水平及与Rb患者生存预后的相关性。方法选取2019年2月~2021年2月首都医科大学附属北京安贞医院南充医院诊治的84例Rb患者(R... 目的探讨视网膜母细胞瘤(Rb)组织中NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)、蛋白精氨酸甲基转移酶5(PRMT5)表达水平及与Rb患者生存预后的相关性。方法选取2019年2月~2021年2月首都医科大学附属北京安贞医院南充医院诊治的84例Rb患者(Rb组),以50例正常视网膜组织为对照组。采用实时荧光定量PCR(qRT-PCR)检测视网膜组织中NSUN2 mRNA,PRMT5 mRNA表达水平。Kaplan-Meier曲线分析NSUN2 mRNA,PRMT5 mRNA对Rb患者预后的影响。COX回归分析影响Rb预后的因素。结果Rb癌组织NSUN2 mRNA(3.11±0.42),PRMT5 mRNA(2.84±0.39)表达高于对照组(0.80±0.23,0.76±0.20),差异具有统计学意义(t=35.935,35.033,均P<0.001)。肿瘤直径≥20mm,未分化型及IIRC分期D~E期Rb癌组织NSUN2 mRNA,PRMT5 mRNA表达高于肿瘤直径<20mm,分化型组织及IIRC分期A~C期,差异具有统计学意义(t=18.297,141.770,16.693;18.663,139.144,39.947,均P<0.001)。NSUN2 mRNA高表达组三年无进展生存率低于低表达组(60.00%vs 88.64%),PRMT5 mRNA高表达组三年无进展生存率低于低表达组(56.10%vs 93.02%),差异具有统计学意义(Log rankχ^(2)=13.440,19.501,均P<0.001)。未分化型、IIRC分期D~E期、NSUN2 mRNA高表达、PRMT5 mRNA高表达是影响Rb患者预后的危险因素(Waldχ^(2)=5.923~7.161,均P<0.001)。结论Rb组织中NSUN2 mRNA,PRMT5 mRNA表达升高,与肿瘤最大径、病理分型及IIRC分期有关,可作为评估Rb生存预后的肿瘤标志物。 展开更多
关键词 视网膜母细胞瘤 NOP2/sun RNA甲基转移酶家族成员2 蛋白精氨酸甲基转移酶5
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RNA甲基转移酶NSUN2通过介导TEAD1 m5C甲基化修饰促进胃癌细胞的糖酵解作用
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作者 王春云 阳乐斌 唐芬芬 《华中科技大学学报(医学版)》 北大核心 2025年第6期812-820,883,共10页
目的 探讨NOP2/Sun RNA甲基转移酶2(NSUN2)通过介导TEA结构域转录因子1(TEAD1)5-甲基胞嘧啶(m5C)甲基化修饰对胃癌(gastric cancer, GC)细胞糖酵解的影响及其机制。方法 实时荧光定量PCR(qRT-PCR)检测人胃癌(GC)组织中NSUN2和TEAD1 mRN... 目的 探讨NOP2/Sun RNA甲基转移酶2(NSUN2)通过介导TEA结构域转录因子1(TEAD1)5-甲基胞嘧啶(m5C)甲基化修饰对胃癌(gastric cancer, GC)细胞糖酵解的影响及其机制。方法 实时荧光定量PCR(qRT-PCR)检测人胃癌(GC)组织中NSUN2和TEAD1 mRNA表达水平,Pearson相关分析两者相关性。qRT-PCR和蛋白质印迹法(Western blot)检测人正常胃黏膜上皮细胞GES-1及胃癌AGS、HGC-27、SNU-1和MKN-45等细胞系中NSUN2表达水平。将NSUN2干扰慢病毒(sh-NSUN2)及其阴性对照sh-NC、TEAD1过表达质粒(oe-TEAD1)及其阴性对照(Vector)分别或同时转染至HGC-27细胞中,CCK-8检测细胞增殖活性。葡萄糖摄取、乳酸含量以及三磷酸腺苷(ATP)检测试剂盒评估细胞糖酵解。Western blot检测细胞中糖酵解途径相关蛋白(HK2、LDHA、GLUT1)表达水平。qRT-PCR和Western blot检测细胞中TEAD1 mRNA和蛋白表达水平。RNA测序(RNA-seq)和RNA甲基化免疫共沉淀实验筛选NSUN2的5-甲基胞嘧啶(m5C)修饰靶点,同时采用斑点杂交和双荧光素酶报告基因实验验证其调控功能。结果 与癌旁组织比较,GC组织中NSUN2和TEAD1 mRNA表达水平均显著升高(均P<0.05),且两者呈正相关(r=0.3266,P<0.05)。与GES-1细胞系比较,胃癌细胞系(AGS、HGC-27、SNU-1和MKN-45)中NSUN2 mRNA和蛋白表达水平显著升高,其中在HGC-27细胞系中表达最高(均P<0.05)。沉默NSUN2可显著降低HGC-27细胞增殖活性和糖酵解,下调HK2、LDHA和GLUT1蛋白表达水平,同时细胞中TEAD1 mRNA和蛋白表达水平显著降低(均P<0.05)。TEAD1是NSUN2调控的潜在靶点,沉默NSUN2通过m5C修饰的方式降低TEAD1的表达(P<0.05)。然而,过表达TEAD1可明显逆转沉默NSUN2对HGC-27细胞增殖活性和糖酵解的抑制作用。结论 NSUN2通过m5C依赖性的方式增强TEAD1的表达进而促进GC细胞的糖酵解。 展开更多
关键词 NOP2/sun RNA甲基转移酶2 TEA结构域转录因子1 5-甲基胞嘧啶 甲基化 胃癌 糖酵解
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Observations of Wave Amplitude Modulation in and Around Sunspots by SDO
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作者 A.Abedini 《Research in Astronomy and Astrophysics》 2025年第12期20-33,共14页
This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magn... This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magnetic Imager(HMI)on board the Solar Dynamics Observatory(SDO).Intensity time series were extracted and analyzed from consecutive macropixels along thin coronal loop paths originating in a quiet sunspot.Fourier and wavelet analyses of corrected intensity time series reveal dominant 3 and 5 minute oscillations.Signals were filtered using the Fourier and inverse transforms to isolate narrow bands around the dominant oscillation periods.Diagrams and time-distance maps of intensity time series were plotted for Fourierfiltered AIA 131A,171A,193A,and 211A channels,along with SDO/HMI magnetograms and dopplergrams at 6173A.The plots clearly show propagating oscillations with amplitude modulation(AM)across all macropixels along selected coronal paths in nearly all AIA and HMI channels.The phase speeds of the filtered oscillations,measured via slope calculations in time-distance maps,indicate that the intensity disturbances are slow magneto-acoustic waves.These results suggest that AM likely arises from the superposition of counterpropagating waves with slightly different frequencies(beta-like phenomena)due to Doppler shifts from background plasma flow along loop paths.Validating this hypothesis could establish AM's significance in solar coronal seismology for determining background plasma flow speed,the source of long-period oscillations,and coronal plasma heating mechanisms. 展开更多
关键词 The sun sun:corona (sun:)sunspots sun:oscillations
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The Sun in Winter
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作者 张红莲 张超 《中学生英语》 2025年第19期6-6,共1页
In winter,the weather is usually cold and everything seems a bit dull.Butthe sun in winter is special.When the sun shines brightly in the clear blue sky,it brings warm(1)to thecold world.The golden sunlight spreads he... In winter,the weather is usually cold and everything seems a bit dull.Butthe sun in winter is special.When the sun shines brightly in the clear blue sky,it brings warm(1)to thecold world.The golden sunlight spreads here and there and it makes the whitesnow shine like diamonds.Although the trees are usually bare in winter,but(2)they look beautiful with the sunlight falling on them. 展开更多
关键词 SKY weather WINTER trees SNOW sunLIGHT sun WARMTH
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子宫内膜癌中NLRC5、NSUN2表达及临床预后价值分析
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作者 郭阳 张凤格 +1 位作者 朱丹 倪琴 《疑难病杂志》 2025年第6期693-698,共6页
目的研究子宫内膜癌(EC)中核苷酸结合寡聚化结构域样受体5(NLRC5)、NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)表达及其与临床病理因素的关系及预后意义。方法选取2016年2月—2019年2月北京市顺义妇幼保健院妇科诊治的EC患者136例的癌组... 目的研究子宫内膜癌(EC)中核苷酸结合寡聚化结构域样受体5(NLRC5)、NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)表达及其与临床病理因素的关系及预后意义。方法选取2016年2月—2019年2月北京市顺义妇幼保健院妇科诊治的EC患者136例的癌组织及癌旁组织。分别采用免疫组织化学、qPCR检测EC癌组织和癌旁组织中NLRC5、NSUN2蛋白和mRNA表达;比较不同临床病理参数EC患者NLRC5、NSUN2 mRNA表达差异;受试者工作特征(ROC)曲线分析NLRC5、NSUN2 mRNA表达对EC患者预后的评估价值;Kaplan-Meier曲线和Cox回归分析影响EC患者预后的因素。结果与癌旁组织比较,癌组织中NLRC5 mRNA和蛋白阳性率降低,NSUN2 mRNA和蛋白阳性率升高(NLRC5:t=14.428、χ^(2)=159.835,P均<0.001;NSUN2:t=31.642、χ^(2)=143.753,P均<0.001);在FIGO分期Ⅲ期、淋巴结转移EC患者癌组织NLRC5 mRNA表达较低,NSUN2 mRNA表达较高(NLRC5:t/P=51.911/<0.001、6.777/<0.001;NSUN2:t/P=47.251/<0.001、16.033/<0.001);EC癌组织中NLRC5、NSUN2 mRNA表达对预后评估的最佳截断值分别为2.52、3.83。NLRC5 mRNA高表达组与低表达组5年总生存率分别为91.67%(22/24)、73.21%(82/112),差异有统计学意义(Log-Rankχ^(2)=3.402,P=0.012)。NSUN2 mRNA高表达组与低表达组5年总生存率分别为42.31%(11/26)、84.55%(93/110),差异有统计学意义(Log-Rankχ^(2)=18.910,P<0.001)。FIGO分期Ⅲ期、淋巴结转移、NSUN2 mRNA高是影响EC患者预后的危险因素[HR(95%CI)=1.449(1.148~1.830),1.442(1.124~1.850),1.570(1.145~2.152)],NLRC5 mRNA高是保护因素[HR(95%CI)=0.611(0.462~0.807)]。结论EC中NLRC5表达降低,NSUN2表达升高,与FIGO分期、淋巴结转移相关,是评估EC预后的可能标志物。 展开更多
关键词 子宫内膜癌 核苷酸结合寡聚化结构域样受体5 NOP2/sun RNA甲基转移酶家族成员2 预后
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Enhancing back pain and sciatica diagnosis:Coronal short tau inversion recovery’s role in routine lumbar magnetic resonance imaging protocols
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作者 Somaya Al Kiswani Maysoon Nasser +1 位作者 Abdulla Alzibdeh Elias EQ Lahham 《World Journal of Radiology》 2025年第6期158-165,共8页
BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axia... BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axial T1 and T2 sequences;however,these may miss certain pathologies.The addition of coronal short tau inversion recovery(STIR)sequences offers the potential to enhance the detection of both spinal and extra-spinal abnormalities,thereby improving clinical decisionmaking and patient outcomes.AIM To evaluate the impact of adding coronal STIR sequences to routine lumbar MRI in diagnosing back pain and sciatica.METHODS We prospectively analyzed data from patients aged 6 and older presenting with back pain or sciatica who underwent lumbar spine MRI at our institution.The standardized MRI protocol utilized included sagittal and axial T1 and T2 sequences,complemented by a coronal STIR sequence.Data on structural abnormalities were collected,reviewed,and analyzed using counts,percentages,and Fisher's exact test for categorical variables.RESULTS Our cohort comprised 274 patients(115 males,159 females;mean age 44.91 years).Notably,39 patients exhibited abnormalities across all sequences,while 72.63%showed normal findings on the coronal STIR sequence.Importantly,30.29%of cases were diagnosed as normal without the coronal STIR,and 36 patients with normal T1 and T2 sequences presented abnormalities on the coronal STIR.The coronal STIR sequence successfully identified 26 spinal and 10 non-spinal pathologies,including 17 cases of sacroiliitis,with a significant association(P<0.0001)between sacroiliitis diagnosis and abnormalities visible solely on this sequence.CONCLUSION Integrating coronal STIR into routine lumbar MRI enhances detection of hidden spinal and extra-spinal pathologies,improves patient management,and offers a cost-effective,practical upgrade with significant diagnostic and clinical value. 展开更多
关键词 Low back pain Magnetic resonance imaging coronal short tau inversion recovery SACROILIITIS Diagnostic accuracy
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Measurements of the Solar Coronal Magnetic Field Based on Coronal Seismology with Propagating Alfvénic Waves:Forward Modeling
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作者 Yuhang Gao Hui Tian +3 位作者 Tom Van Doorsselaere Zihao Yang Mingzhe Guo Konstantinos Karampelas 《Research in Astronomy and Astrophysics》 2025年第1期238-246,共9页
Recent observations have demonstrated the capability of mapping the solar coronal magnetic field using the technique of coronal seismology based on the ubiquitous propagating Alfvénic/kink waves through imaging s... Recent observations have demonstrated the capability of mapping the solar coronal magnetic field using the technique of coronal seismology based on the ubiquitous propagating Alfvénic/kink waves through imaging spectroscopy.We established a magnetohydrodynamic model of a gravitationally stratified open magnetic flux tube,exciting kink waves propagating upwards along the tube.Forward modeling was performed to synthesize the Fe XIII 1074.7 and 1079.8 nm spectral line profiles,which were then used to determine the wave phase speed,plasma density,and magnetic field with seismology method.A comparison between the seismologically inferred results and the corresponding input values verifies the reliability of the seismology method.In addition,we also identified some factors that could lead to errors during magnetic field measurements.Our results may serve as a valuable reference for current and future coronal magnetic field measurements based on observations of propagating kink waves. 展开更多
关键词 sun corona-sun magnetic fields-magnetohydrodynamics(MHD)
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上海轻良为印尼Sun Paper提供的PM18成功开机
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作者 《生活用纸》 2025年第3期25-25,共1页
(本刊讯)2025年1月24日,上海轻良实业供给印度尼西亚Sun Paper纸厂的PM18新月型卫生纸机成功开机。Sun Paper纸厂一次性订购3台同型号的新月型卫生纸机,该机型具有先进的成形技术,使纸张在成形过程中纤维分布均匀,成纸柔软细腻,同时极... (本刊讯)2025年1月24日,上海轻良实业供给印度尼西亚Sun Paper纸厂的PM18新月型卫生纸机成功开机。Sun Paper纸厂一次性订购3台同型号的新月型卫生纸机,该机型具有先进的成形技术,使纸张在成形过程中纤维分布均匀,成纸柔软细腻,同时极大地提升了纸张的强度和韧性。该纸机幅宽2,850mm,运行速度可达1,800m/min,单机产能突破2万t。 展开更多
关键词 柔软细腻 运行速度 sun 印度尼西亚 成形过程 开机
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Thermal Control Design for Enhancing Tolerance of Large-Aperture Reflective Camera“Sun Transit”on Geostationary Earth Orbit
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作者 LIAN Xinhao XIA Chenhui GAO Chao 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第4期452-463,共12页
The large-aperture reflective cameras on the geostationary orbit are susceptible to significant temperature fluctuations due to the“Sun transit”effect.To address the shortcomings of existing thermal control measures... The large-aperture reflective cameras on the geostationary orbit are susceptible to significant temperature fluctuations due to the“Sun transit”effect.To address the shortcomings of existing thermal control measures using camera sunshades to suppress the“Sun transit”and the issue of excessively large solar avoidance angles determined solely by geometric relationships,a thermal control design method is proposed that involves adding multi-layer thermal protection at the secondary mirror position of the camera.The goal is to optimize the avoidance angle and enhance the camera’s tolerance to“Sun transit”.A heat balance and motion relationship between the avoidance angle and duration is established.Then,the minimum solar avoidance angle after adopting the multi-layer thermal protection design is calculated.This angle is compared with the one determined by geometric relationships,leading to the conclusion that this method can effectively enhance the camera’s tolerance to“Sun transit”.A heat dissipation scheme is proposed that involves a coupled north-south heat spreader design with low-temperature compensation for the internal heat source.The calculation results of the two avoidance angles are applied to the calculation of the heat dissipation area and low-temperature compensation power,achieving a closed-loop heat dissipation scheme.Puls,the superiority of the multi-layer thermal protection design method is demonstrated from the perspectives of heat dissipation area and low-temperature compensation power requirements.A comparative analysis of simulation analysis,thermal balance tests,and in-orbit temperature data further validates the effectiveness of this method. 展开更多
关键词 geostationary earth orbit sun transit solar avoidance thermal control design thermal protection
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Sun Chemical颜料油墨价格上涨
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作者 枫林 《广东印刷》 2025年第1期3-3,共1页
Sun Chemical将提高其在欧洲、中东和非洲(EMEA)的多种油墨产品组合的价格,立即生效。近几个月来,彩色和白色颜料的供应链受到各种挑战的严重影响,包括中断、短缺、破产、反倾销进口税以及来自亚洲的海运费进一步上涨。这些因素一直推... Sun Chemical将提高其在欧洲、中东和非洲(EMEA)的多种油墨产品组合的价格,立即生效。近几个月来,彩色和白色颜料的供应链受到各种挑战的严重影响,包括中断、短缺、破产、反倾销进口税以及来自亚洲的海运费进一步上涨。这些因素一直推高了太阳化学油墨产品的成本,包括彩色和白色油墨。 展开更多
关键词 反倾销 白色颜料 供应链 油墨产品 海运费 sun 价格上涨 进口税
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面向微电网群协调控制的多跳Wi-SUN设计与部署
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作者 史册 《通信电源技术》 2025年第24期182-184,共3页
为提升微电网群协调控制的通信效率与可靠性,以微电网群协调控制为研究目标,分析现有通信技术的局限性,探讨多跳智能无线网络(Wireless Utility Network,Wi-SUN)的设计与部署方案,提出分层网状拓扑结构及安全、抗干扰技术措施。研究结... 为提升微电网群协调控制的通信效率与可靠性,以微电网群协调控制为研究目标,分析现有通信技术的局限性,探讨多跳智能无线网络(Wireless Utility Network,Wi-SUN)的设计与部署方案,提出分层网状拓扑结构及安全、抗干扰技术措施。研究结果表明,所构建的网络解决了传统网络存在的不足,为微电网群的实时控制提供了稳定支撑。 展开更多
关键词 微电网群 协调控制 智能无线网络(Wi-sun)
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