β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene ...β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene substrate range.In this study,we present a pioneering two-component approach utilizing readily accessible sulfenamides as efficient difunctionalization reagents.Key to its success is the careful selection of a suitable photosensitizer,which enables precise modulation of sulfenamides by promoting unprecedented energy transfer rather than traditional single-electron oxidation.This novel strategy leads to the concurrent formation of N-and S-radical species,ensuring high regioselectivity for both electronneutral and electron-deficient alkenes.As a result,a wide range of valuableβ-amino sulfides,including those with congested amine groups,can be readily synthesized.These findings highlight the potential of this method for the efficient synthesis of diverse functionalizedβ-amino sulfides.展开更多
A green and efficient strategy for the synthesis of sulfinamides via the oxidation of sulfenamides using Selectfluor in water has been developed.This mild protocol possesses a good substrate scope,tolerating various f...A green and efficient strategy for the synthesis of sulfinamides via the oxidation of sulfenamides using Selectfluor in water has been developed.This mild protocol possesses a good substrate scope,tolerating various functional groups.Reactions proceed smoothly under additive-free conditions,affording the corresponding sulfinamides in moderate to good yields.A successful scale-up attempt highlights the scalability and practical potential of this method.展开更多
As the aza-isosteres of sulfonyl fluorides,sulfonimidoyl-and sulfondiimidoyl fluorides are versatile and robust SuFEx linkage agents,yet with limited synthetic accessibility.Herein,we report the straightforward,diverg...As the aza-isosteres of sulfonyl fluorides,sulfonimidoyl-and sulfondiimidoyl fluorides are versatile and robust SuFEx linkage agents,yet with limited synthetic accessibility.Herein,we report the straightforward,divergent synthesis of sulfonimidoyl-and sulfondiimidoyl fluorides from bench-stable,readily available sulfenamides and Selectfluor.The obtained sulfonyldiiminyl fluorides readily underwent versatile SuFEx reactions with various nucleophiles to afford various biologically interesting sulfondiimidoyl derivatives.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.22171072,21925103,and22301061)。
文摘β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene substrate range.In this study,we present a pioneering two-component approach utilizing readily accessible sulfenamides as efficient difunctionalization reagents.Key to its success is the careful selection of a suitable photosensitizer,which enables precise modulation of sulfenamides by promoting unprecedented energy transfer rather than traditional single-electron oxidation.This novel strategy leads to the concurrent formation of N-and S-radical species,ensuring high regioselectivity for both electronneutral and electron-deficient alkenes.As a result,a wide range of valuableβ-amino sulfides,including those with congested amine groups,can be readily synthesized.These findings highlight the potential of this method for the efficient synthesis of diverse functionalizedβ-amino sulfides.
文摘A green and efficient strategy for the synthesis of sulfinamides via the oxidation of sulfenamides using Selectfluor in water has been developed.This mild protocol possesses a good substrate scope,tolerating various functional groups.Reactions proceed smoothly under additive-free conditions,affording the corresponding sulfinamides in moderate to good yields.A successful scale-up attempt highlights the scalability and practical potential of this method.
基金Financial support from the National Natural Science Foundation of China(22471038)the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2024z08)is gratefully acknowledged.
文摘As the aza-isosteres of sulfonyl fluorides,sulfonimidoyl-and sulfondiimidoyl fluorides are versatile and robust SuFEx linkage agents,yet with limited synthetic accessibility.Herein,we report the straightforward,divergent synthesis of sulfonimidoyl-and sulfondiimidoyl fluorides from bench-stable,readily available sulfenamides and Selectfluor.The obtained sulfonyldiiminyl fluorides readily underwent versatile SuFEx reactions with various nucleophiles to afford various biologically interesting sulfondiimidoyl derivatives.
