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The Optimized Design of The Fuzzy Controller(Ⅱ)——the disquisition of optimized triangle subjection function
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作者 ZHANG Jian guo,YIN Hai dong,XIN Ming ying (The Computer Department of Harbin Institute of Technology,Harbin,Heilongjiang,150090,PRC) 《Journal of Northeast Agricultural University(English Edition)》 CAS 2002年第2期158-161,共4页
The subjection function of the fuzzy quantity is bell like,which is on the base of the theory;but during the course of the control,each fuzzy grade should be predigested into a triangle of W=4.
关键词 the subjection function the fuzzy consequence the rules of the fuzzy control optimize TRIANGLE
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Defamiliarizing Reality for Mental and Physical Subjection:Rereading Harold Pinter's The Room and The Dumb Waiter as Political Comedies 被引量:1
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作者 Ahmed Abdulkhair Abulmagd Khaled 《Fudan Journal of the Humanities and Social Sciences》 2024年第1期159-191,共33页
While Pinter's earliest plays have been recognized in the modernist history of theatre as comedies of menace and his later plays as political comedies,this article argues that his earliest plays are equally very l... While Pinter's earliest plays have been recognized in the modernist history of theatre as comedies of menace and his later plays as political comedies,this article argues that his earliest plays are equally very liable to be interpreted as political comedies.Regardless of their absurdist dramatization of people's helpless exposure to external,unidentifiable threats,a common post-WWII characteristic feature of human experience,I claim that The Room and The Dumb Waiter(both written 1957,staged 1960),two model examples of Pinter's earliest oeuvres,do not simply follow the aesthetic of absurdist theatre to express human futility.The audience's experience of viewing the theatrical performances of both plays in terms of discursive cyclicality or character normality is subverted into one of changeability,strangeness,and contradiction.To foreground the political implications of such revolutionary theatrical experience,Pinter's plays are examined in the light of his unique use of defamiliarization,relying not on Brecht's traditional techniques of singing,dancing,image-projecting,or captioning,but on a simple,dual technique of image destruction and creation.It consists of divesting characters of their normality and portraying them instead as individuals who identify only with unusual images of place,time,body,and consciousness.Using this special technique of defamiliarization,both plays are examined to reveal Pinter's central political theme of undermining reality for purposes of mental and physical subjections. 展开更多
关键词 DEFAMILIARIZATION Comedy of menace Political comedy subjection Harold Pinter
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The Relationship among Chinese Teachers’Organizational Support,Career Adaptability and Job Satisfaction:The Mediating Effect of DecentWork
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作者 Huaruo Chen Gefan Wang +4 位作者 Hancai Qiu Hui Ma Zhentao Peng Ruihan Liu Feng Xu 《International Journal of Mental Health Promotion》 2026年第1期72-91,共20页
Background:As an important indicator of subjective well-being(SWB),decent work is a key guarantee for the sustainable development of teachers and their psychological health and work quality.Faced with the rapid develo... Background:As an important indicator of subjective well-being(SWB),decent work is a key guarantee for the sustainable development of teachers and their psychological health and work quality.Faced with the rapid development of artificial intelligence and the global labor market,vocational college teachers are facing challenges such as workload pressure and limited career development,which may harm their well-being.This study aims to localize the measurement method of decent work in Chinese vocational education based on the theory of the Psychology of Working Theory,and explore the relationship mechanism between organizational support,career adaptability,decent work,and job satisfaction among vocational college teachers.Methods:A cross-sectional survey was conducted with 422 HVCU teachers in China(202 male,220 female)using the localized Perceived Organizational Support Scale,Career Adaptability Scale,Decent Work Scale,and Job Satisfaction Scale.Results:The overall level of HVCU teachers’decent work was above the median(Mean=4.09,SD=0.69),laying a foundation for their SWB.Decent work significantly and positively predicted job satisfaction(β=0.620,p<0.001).Organizational support(r=0.58,p<0.001)and career adaptability(r=0.82,p<0.001)can positively affect decent work,and further improve job satisfaction(collective R2 rising from 38.3%to 41.1%).Bootstrap analysis confirmed these mediating effects were robust.Conclusions:This study confirms that the combined effects of organizational support and career adaptability can enhance decent work,further improving teachers’job satisfaction and subsequent subjective well-being.Besides,this study provides an empirical basis for improving the well-being of higher vocational teachers and the sustainable development of vocational education,and has practical significance for improving the teacher incentive policy. 展开更多
关键词 Higher vocational teachers organizational support career adaptability decent work job satisfaction subjective well-being
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Advancing osteoarthritis research:the role of AI in clinical,imaging and omics fields 被引量:2
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作者 Jingfeng Ou Jin Zhang +4 位作者 Momen Alswadeh Zhenglin Zhu Jijun Tang Hongxun Sang Ke Lu 《Bone Research》 2025年第2期307-319,共13页
Osteoarthritis(OA)is a degenerative joint disease with significant clinical and societal impact.Traditional diagnostic methods,including subjective clinical assessments and imaging techniques such as X-rays and MRIs,a... Osteoarthritis(OA)is a degenerative joint disease with significant clinical and societal impact.Traditional diagnostic methods,including subjective clinical assessments and imaging techniques such as X-rays and MRIs,are often limited in their ability to detect early-stage OA or capture subtle joint changes.These limitations result in delayed diagnoses and inconsistent outcomes.Additionally,the analysis of omics data is challenged by the complexity and high dimensionality of biological datasets,making it difficult to identify key molecular mechanisms and biomarkers.Recent advancements in artificial intelligence(AI)offer transformative potential to address these challenges.This review systematically explores the integration of AI into OA research,focusing on applications such as AI-driven early screening and risk prediction from electronic health records(EHR),automated grading and morphological analysis of imaging data,and biomarker discovery through multi-omics integration.By consolidating progress across clinical,imaging,and omics domains,this review provides a comprehensive perspective on how AI is reshaping OA research.The findings have the potential to drive innovations in personalized medicine and targeted interventions,addressing longstanding challenges in OA diagnosis and management. 展开更多
关键词 subjective clinical assessments analysis omics data degenerative joint disease OSTEOARTHRITIS imaging techniques clinical assessment biological datasetsmaking diagnostic methodsincluding
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Subject Editors-in-Chief
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《中国科学技术大学学报》 北大核心 2025年第2期I0005-I0005,共1页
Quanming Lu,Prosessor,Changjiang Distinguished Professor,National Science Fund for Distinguished Young Scholars.Rongbin Zhou,Prosessor,Changjiang Distinguished Professor,National Science Fund for Distinguished Young S... Quanming Lu,Prosessor,Changjiang Distinguished Professor,National Science Fund for Distinguished Young Scholars.Rongbin Zhou,Prosessor,Changjiang Distinguished Professor,National Science Fund for Distinguished Young Scholars,Deputy Director,Life Sciences and Medicine,USTC. 展开更多
关键词 PROFESSOR subject editors chief National Science Fund Distinguished Young Scholars Changjiang Distinguished Professor Rongbin Zhou Quanming Lu
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My Best Friend,Jiang Shaohong
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作者 温沐杭 张超(指导) 《中学生英语》 2025年第23期7-7,共1页
Jiang Shaohong is my best friend.He is 14years old and he is in Class 1,Grade 8.He is clever and can learn things quickly.He works hard at all his subjects.He has many hobbies,such as reading,singing,dancing,and playi... Jiang Shaohong is my best friend.He is 14years old and he is in Class 1,Grade 8.He is clever and can learn things quickly.He works hard at all his subjects.He has many hobbies,such as reading,singing,dancing,and playing sports.He loves animals,so he keeps a small dog as a pet and takes good care of it at home.He is kind and helpful.He often helps his classmates with their studies. 展开更多
关键词 best friend age Class Grade SUBJECTS Jiang Shaohong hobbies hardworking CLEVER
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Interplay among bedtime procrastination,sleep patterns,and subjective wellbeing in the Indian population:An observational study
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作者 Gunjan Parasher Shikhar Gupta Sujita Kumar Kar 《World Journal of Psychiatry》 2025年第8期270-280,共11页
BACKGROUND Sleep deprivation is a common problem in society,and bedtime procrastination(BtP)has become a significant cause of poor sleep among healthy individuals across various countries.AIM To study BtP,sleep behavi... BACKGROUND Sleep deprivation is a common problem in society,and bedtime procrastination(BtP)has become a significant cause of poor sleep among healthy individuals across various countries.AIM To study BtP,sleep behavior,and subjective well-being in the Indian population.METHODS This was a cross-sectional study.The recruited participants were evaluated using the BtP Scale,World Health Organzation-5 Well-Being index,Patient Health Ques-tionnaire-2,Generalized Anxiety Disorder 2-item,Munich Chronotype Questionnaire and Single-Item Sleep Quality Scale.RESULTS A total of 401 participants were recruited for the study.Symptoms of anxiety were higher in the female participants compared to males.Among females,there was a significant positive correlation between BtP score with symptoms of anxiety(r=0.23)and depression(r=0.15)and a negative correlation with subjective wellbeing(r=-0.23).A significant negative correlation was found between the ages of women and BtP score(r=-0.15).Among the male participants,there was a significant negative correlation of age with BtP score(r=-0.3)and anxiety(r=-0.19).Here,too,the BtP score was positively correlated with depression(r=0.18)and anxiety(r=0.35).CONCLUSION BtP worsens anxiety,depression,sleep quality,and subjective well-being.It needs to be targeted for the promotion and prevention of mental health. 展开更多
关键词 Bedtime procrastination Sleep quality Subjective well-being ANXIETY DEPRESSION SLEEP
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Relocation for improved ecosystem service and human wellbeing?Evidence from Fuping,Hebei,China
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作者 WU Pengxin LIU Mingyao +7 位作者 ZHENG Mingze LIAO Chuan HUA Xiaobo FEI Ding BAI Yansong ZHOU Yuchen ZHOU Yihan HUANG Qingxu 《Journal of Geographical Sciences》 2025年第7期1556-1574,共19页
Migration is a potential strategy to reduce poverty in the Global South.In China,the Poverty-alleviation Relocation(PAR)is a government-led,large-scale migration initiative aimed at eliminating poverty and promoting e... Migration is a potential strategy to reduce poverty in the Global South.In China,the Poverty-alleviation Relocation(PAR)is a government-led,large-scale migration initiative aimed at eliminating poverty and promoting environmental sustainability.To examine the ecological and socio-economic effects of the PAR,we quantified the changes in five types of ecosystem services(ES)as well as the subjective well-being of rural residents in Fuping county,Hebei province of China,by using ES mapping,household survey,and semi-structured interviews.We found that the PAR improves people's quality of life,with the well-being scores associated with transportation,communication,education,and healthcare increasing by 0.45–0.81.Additionally,the PAR enhances the supply of ES,evidenced by the increases in four types of ES in both in-migration and out-migration areas.The ES growth rates in in-migration areas ranged from 0.7%to 3.9%,while in out-migration areas,the rates ranged from 0.4%to 2.5%.However,the changes in income and food well-being are minimal,with scores at 0 and 0.32,respectively.More importantly,the elderly and low-educated residents experience minimal improvements in well-being after relocation.Our findings suggest that for other developing countries seeking to adopt PAR,it is crucial to provide targeted support for livelihood transitions,particularly for marginalized social groups,restore out-migration areas,and strengthen cross-regional cooperation to better address ecological constraints on livelihoods. 展开更多
关键词 ecosystem services land use rural sustainability subjective wellbeing social-ecological system URBANIZATION
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Exploring Subjective Well-Being in Adolescents:The Role of Mental Health and Addictive Behaviors through Machine Learning
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作者 Yajing Xu Luze Xie +3 位作者 Menghan Bao Xingyi Yang Sitong Chen Zhuoning Gao 《International Journal of Mental Health Promotion》 2025年第5期667-682,共16页
Background Adolescents’subjective well-being(SWB)is strongly linked to mental health,academic achievement,social relationships,and quality of life,and is a key predictor of life outcomes in adulthood.Mental health an... Background Adolescents’subjective well-being(SWB)is strongly linked to mental health,academic achievement,social relationships,and quality of life,and is a key predictor of life outcomes in adulthood.Mental health and addictive behaviors are the two main factors influencing SWB.This study aimed to identify key mental health and addictive behavior factors associated with adolescent SWB through machine learning models.Methods The data for this study comes from the Health Behaviour in School-aged Children(HBSC)survey 2017/18.The study data contains health data from 60,450 adolescents aged 10–16 years.The study used the XGBoost machine learning model to analyze the impact of mental health and addictive behaviors on adolescent SWB.Gain was used to analyze the significance of the variables.The direction of action of the variables and the interaction between the variables were analyzed using the SHapley Additive exPlanations(SHAP)method.Results The model in this study has an accuracy of 86.7%and an AUC value of 0.85,showing its good predictive performance.Six key variables were filtered through Gain analysis.Feeling low and health as the two most important factors affecting SWB,with these two variables contributing 51.38%and 19.65%,respectively.Friends and thinking body as major factors influencing SWB in mental health.Smoking lifetime and sweets as major factors influencing SWB in addictive behaviors.The interactions and characteristic dependencies between these variables were further analyzed.The results showed that feeling low,friends,and sweets had a positive effect on SWB,while health and smoking lifetime showed a negative effect.In addition,a moderate thinking body contributes to SWB,whereas being too fat and too thin are both associated with decreased levels of SWB.Conclusion Mental health and addictive behavioral factors such as feeling low,friends,sweets,and smoking lifetime were significant factors influencing SWB.This provides a scientific basis for the development of public health policies and interventions aimed at enhancing adolescent well-being. 展开更多
关键词 Machine learning subjective well-being ADOLESCENT mental health addictive behavior
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Giulia Lama’s Saturn Devouring His Child:Mysterious Fatherly Love
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作者 Liana De Girolami Cheney 《Cultural and Religious Studies》 2025年第7期382-387,共6页
Set against the cultural and historical backdrop of 18th-century Venice,Giulia Elisabetta Lama’s(1681-1747)remarkable paintings reveal intriguing connections to mythology and science.Lama’s notable depiction of Satu... Set against the cultural and historical backdrop of 18th-century Venice,Giulia Elisabetta Lama’s(1681-1747)remarkable paintings reveal intriguing connections to mythology and science.Lama’s notable depiction of Saturn Devouring His Child,painted in oils in 1729 and now in a private collection,draws significant attention. 展开更多
关键词 Giulia Lama SATURN MYTHOLOGY 18th-century art VENICE heartless subjects fatherly love
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Digital literacy and subjective well-being among older adults:The chain mediating effect of physical exercise and consumption
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作者 Jiahan Li You Zhou +1 位作者 Jie Yang Lei Yuan 《Journal of Psychology in Africa》 2025年第2期249-256,共8页
Subjective well-being is a key indicator of quality of life and a crucial factor for successful aging among older adults.However,few studies have explored the subjective well-being among older adults from the perspect... Subjective well-being is a key indicator of quality of life and a crucial factor for successful aging among older adults.However,few studies have explored the subjective well-being among older adults from the perspective of digital literacy.Therefore,this study explores the relationship between digital literacy and subjective well-being using data on 4270 older adults from the 2020 China Family Panel Studies(CFPS)dataset.PROCESS mediation analysis results indicated digital literacy is associated with higher subjective well-being among the older adults.Digital literacy was associated with the frequency of physical exercise and consumption.Moreover,Digital literacy can also enhance the subjective well-being among older adults by increasing the frequency of physical exercise,and consumption,and a chain mediator subjective well-being.These findings align with the theoretical framework of digital health literacy.Theory which posits that health information obtained through digital literacy can help older adults better engage in healthy lifestyles,thereby enhancing their quality of life.These findings hold significant practical implications for enhancing the subjective well-being among older adults and advancing the development of successful aging. 展开更多
关键词 digital literacy subjective well-being physical exercise CONSUMPTION older adults
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A Study of the English Article System from the Perspective of Cognitive Grammar
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作者 LIU Han 《Journal of Literature and Art Studies》 2025年第8期642-646,共5页
Although the English article system is ostensibly composed of two basic forms,“a/an”and“the”actual usage demonstrates a high degree of semantic complexity and cognitive diversity.Traditional grammatical frameworks... Although the English article system is ostensibly composed of two basic forms,“a/an”and“the”actual usage demonstrates a high degree of semantic complexity and cognitive diversity.Traditional grammatical frameworks often treat article usage through a dichotomy of“specific vs.non-specific reference”,yet struggle to effectively explain numerous marginal and unconventional linguistic phenomena,such as expressions like“go to the hospital”and“a Mr.Brown”.With the development of cognitive linguistics,language is viewed as an externalization of mental activity,and the intrinsic connection between linguistic structure and cognitive mechanisms has gained increasing attention.This paper,grounded in Ronald Langacker’s Cognitive Grammar theory,systematically analyzes the semantic construction process and cognitive motivations of English articles by integrating cognitive mechanisms such as figure-ground alignment,subjectivity,and mental spaces.By combining typical sentence examples,the paper reveals the deep cognitive structures underlying article usage from the dual perspectives of semantic representation and communicative function,aiming to provide a more explanatory theoretical framework for the grammatical teaching and cognitive research of English articles. 展开更多
关键词 Cognitive Grammar English articles FIGURE-GROUND SUBJECTIVITY mental space semantic construction language cognition
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International Journal of Plant Engineering and Management Call for Papers
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《International Journal of Plant Engineering and Management》 2025年第4期F0003-F0003,共1页
Journal Introduction″International Journal of Plant Engineering and Management″is in the charge of Ministry of Industry and Information Technology of the People′s Republic of China,and organized by Northwestern Pol... Journal Introduction″International Journal of Plant Engineering and Management″is in the charge of Ministry of Industry and Information Technology of the People′s Republic of China,and organized by Northwestern Polytechnical University.It is a kind of English academic quarterly publication publicly issued at home and abroad.Plant engineering and management is a comprehensive interdisciplinary sub-ject mainly reporting academic research on the application technology of e-quipment and industry management. 展开更多
关键词 interdisciplinary subject equipment application technology plant engineering international journal MANAGEMENT
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Affirming Animal Subjectivity through Equine Individualistic Behaviors in Jane Smiley’s The Horses of Oak Valley Ranch Series
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作者 WU Li-min 《Journal of Literature and Art Studies》 2025年第7期521-525,共5页
Unlike traditional literature where animals are often portrayed allegorically as mere symbols,in Pulitzer Prize winner Jane Smiley’s The Horses of Oak Valley Ranch series,the portrayal of horses underscores their dis... Unlike traditional literature where animals are often portrayed allegorically as mere symbols,in Pulitzer Prize winner Jane Smiley’s The Horses of Oak Valley Ranch series,the portrayal of horses underscores their distinct individuality and autonomy.Focusing on three novels in the series-A Good Horse,True Blue,and Pie in the Sky,this paper analyzes how Smiley crafts a narrative that resists anthropocentrism and validates the subjectivity of nonhuman animals.By examining the unique reactions of horses in various situations,such as their differing facial expressions before a jump,their various responses to feeding and grooming,and their individualistic moving behaviors,this study reveals how Smiley highlights the psychological and physical diversity within a single species.The horses’individual traits are portrayed not as mere animal instinct but as conscious,intentional responses that signify their agency.Drawing on Marc Bekoff’s defense of animal individuality,Val Plumwood’s condemnation of anthropocentrism,and Cynthia Willett’s critique of speciesism,the paper argues that Smiley’s representation of equine individualistic behaviors is an affirmation of the inherent subjectivity of animals.Through these detailed descriptions,Smiley challenges the Cartesian notion of animals as mere automatons and encourages readers to recognize animals as complex individuals.Ultimately,this study emphasizes the significance of acknowledging animal subjectivity in fostering a more ethical and harmonious human-animal relationship. 展开更多
关键词 animal subjectivity individualistic behavior ANTHROPOCENTRISM nonhuman agency
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Home-based acupressure for managing constipation and subjective well-being in spinal cord injury survivors:A randomized controlled trial
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作者 Meng-qi Li Yan Li +7 位作者 Winsome Lam Wing Fai Yeung Yuen Shan Ho Jia-ying Li Tsz Ching Sun Sam Yuen Yu-le Hu Jannelle Yorke 《Journal of Integrative Medicine》 2025年第6期660-669,共10页
Background:Spinal cord injury(SCI)survivors often experience constipation,which contributes to a reduced sense of well-being and a lower quality of life.Acupressure offers a non-pharmacological and non-invasive altern... Background:Spinal cord injury(SCI)survivors often experience constipation,which contributes to a reduced sense of well-being and a lower quality of life.Acupressure offers a non-pharmacological and non-invasive alternative therapy for treating constipation.Objective:This study examined the effects of home-based acupressure on constipation and subjective well-being among SCI survivors.Design,setting,participants and interventions:This randomized controlled trial randomly assigned 80adults from Hong Kong with SCI to two study groups.Using a video demonstration filmed by a registered traditional Chinese medicine practitioner,the intervention group performed home-based acupressure(self-administered or caregiver-assisted)twice daily,15 min/session,for 10 consecutive days.The control group performed manual light touching of the abdomen with the same frequency and duration as the intervention group.Both groups received defecation education through a structured booklet.Main outcomes measures:The primary outcome was constipation severity.Secondary outcomes included bowel habits,psychological well-being,and quality of life.Focus group interviews were conducted after the intervention to collect subjective feedback from participants.Results:Significant group-by-time interaction effects on constipation severity(P=0.005)and quality of life(P=0.001)revealed that home-based acupressure produced better results than the control.These treatment effects persisted at the one-month follow-up and continued to have a large effect size(Cohen's d>0.8).Compared to the control group,the acupressure group also had improvements in anxiety(Cohen's d=0.69)and depression(Cohen's d=0.72)at the end of the intervention period.Three qualitative categories were identified from the focus group interviews:improvements in bowel function and management;reduced psychological distress following relief from constipation;and acceptability of home-based acupressure.Conclusion:Acupressure effectively relieves constipation,enhances psychological well-being,and improves quality of life in people with SCI.These data provide novel evidence supporting the use of home-based acupressure as an acceptable and effective therapy for treating constipation after SCI. 展开更多
关键词 Spinal cord injury ACUPRESSURE CONSTIPATION Subjective well-being Psychological health Quality of life
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Analysis on the Correlation Between Perceived Stress,Job Burnout,and Subjective Well-being Among Undergraduate Nursing Interns
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作者 Xiaoping Yu Xinyin Li Chunhong Li 《Journal of Clinical and Nursing Research》 2025年第12期344-350,共7页
Objective:To analyze the correlation between perceived stress,job burnout,and subjective well-being among undergraduate nursing interns.Methods:A total of 260 clinical nursing interns who interned in tertiary hospital... Objective:To analyze the correlation between perceived stress,job burnout,and subjective well-being among undergraduate nursing interns.Methods:A total of 260 clinical nursing interns who interned in tertiary hospitals from July 2024 to April 2025 were selected as the survey subjects.They were administered the Chinese version of the Perceived Stress Scale(CPSS),the Maslach Burnout Inventory-Human Services Survey(MBI-HSS),and the General Well-being Schedule(GWB)to evaluate the correlation between perceived stress,job burnout,and subjective well-being.Results:The subjective well-being scores of those with higher perceived stress were lower than those with moderate stress;individuals with severe job burnout had lower subjective well-being compared to those without job burnout or with mild to moderate job burnout levels(p<0.05).Correlation analysis revealed that the subjective well-being of undergraduate nursing interns was negatively correlated with perceived stress and job burnout(p<0.05).Conclusion:Undergraduate nursing interns experience significant perceived stress and a strong sense of job burnout.Their subjective well-being is correlated with their perceived stress and job burnout.It is necessary to optimize the clinical teaching model and provide psychological skills training to alleviate the interns’perceived stress and job burnout,thereby significantly enhancing their subjective well-being. 展开更多
关键词 Undergraduate nursing interns Perceived stress Job burnout Subjective well-being CORRELATION
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Influence of Height of Bionic Hexagonal Texture on Tactile Perception
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作者 WANG Lei ZHU Yuqin +2 位作者 FANG Xingxing WANG Shuai TANG Wei 《Journal of Shanghai Jiaotong university(Science)》 2025年第3期461-468,共8页
It is significant to process textures with special functions similar to animal surfaces based on bionics and improve the friction stability and contact comfort of contact surfaces for the surface texture design of tac... It is significant to process textures with special functions similar to animal surfaces based on bionics and improve the friction stability and contact comfort of contact surfaces for the surface texture design of tactile products.In this paper,a bionic hexagonal micro-convex texture was prepared on an acrylic surface by laser processing.The friction mechanism of a finger touching the bionic hexagonal micro-convex texture under different touch speeds and pressures,and the effect of the height of the texture on tactile perception were investigated by finite element,subjective evaluation,friction,and EEG tests.The results showed that the deformation friction was the main friction component when the finger touched the bionic hexagonal texture,and the slipperiness and friction factor showed a significant negative correlation.As the touch speed decreased or the touch force increased,the hysteresis friction of the fingers as well as the interlocking friction increased,and the slipperiness perception decreased.The bionic hexagonal texture with higher convexity caused a higher friction factor,lower slipperiness perception,and lower P300 peak.Hexagonal textures with lower convexity,lower friction factor,and higher slipperiness perception required greater brain attentional resources and intensity of tactile information processing during tactile perception. 展开更多
关键词 bionic hexagonal texture tactile perception FRICTION event-related potentials subjective evaluation
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Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations
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作者 Hui Liu Ting Li +2 位作者 Xin-Lei Chen Hong-Ling Yu Ye-Rong Yu 《World Journal of Diabetes》 2025年第2期47-54,共8页
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques... BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin. 展开更多
关键词 Euglycemic clamp Target glucose setting Healthy subject C-PEPTIDE PHARMACODYNAMICS Endogenous insulin secretion
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Autorefraction versus subjective refraction in high astigmatism
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作者 Haleh Kangari Hassan Hashemi +3 位作者 Saeed Rahmani Elnaz Ahmadian Abbasali Yekta Mehdi Khabazkhoob 《International Journal of Ophthalmology(English edition)》 2025年第3期504-509,共6页
AIM:To compare the subjective refraction data with autorefraction findings in high astigmatisms.METHODS:In a cross-sectional study,sampling was done from in different geographic regions in Iran using a multistage rand... AIM:To compare the subjective refraction data with autorefraction findings in high astigmatisms.METHODS:In a cross-sectional study,sampling was done from in different geographic regions in Iran using a multistage random cluster sampling method.All study participants underwent cycloplegic auto-refraction and subjective refraction using the red-green test.RESULTS:In this study,277 eyes of 158 students aged 8 to 15y were analyzed.According to the results,the mean difference between subjective refraction and autorefraction in measuring sphere,cylinder,spherical equivalent,J0,and J45 was-0.18±0.76,-0.36±0.40,-0.36±0.79,0.15±0.20,and 0.05±0.21 respectively.The correlation of these two refraction methods in measuring the aforementioned indices was 0.963,0.898,0.960,0.931,and 0.948 respectively.The 95%limits of agreement of the two methods in measuring the above indices were-1.66 to 1.31,-1.14 to 0.42,-1.91 to 1.19,-0.24 to 0.54,and-0.36 to 0.47 respectively.The agreement between the two methods decreased with increasing cylinder power,and the best agreement was found in myopic individuals.CONCLUSION:The measurements obtained by autorefractometer have a significantly higher cylinder average compared to subjective refraction.However,in the cylinder range of 4–5 diopters,the values of J0 and J45 do not have a high correlation. 展开更多
关键词 subjective refraction autorefraction ASTIGMATISM
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Subjective visual vertical in first time seafarers experiencing sea sickness
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作者 Bhaumik Patel Deepika Tanwar Sunil Goyal 《Journal of Otology》 2025年第4期268-273,共6页
Objectives:Sea sickness, a form of motion sickness, is a common condition among sailors on various sailing vessels, primarily due to their roll and pitch movements. While the exact neurobiological mechanisms remain un... Objectives:Sea sickness, a form of motion sickness, is a common condition among sailors on various sailing vessels, primarily due to their roll and pitch movements. While the exact neurobiological mechanisms remain unclear, the most widely accepted explanation is the sensory conflict theory,which identifies two main sources of conflict: discrepancies between visual and vestibular inputs and conflicts within the vestibular system itself.This study aims to evaluate otolith-mediated verticality perception in first-time seafarers on board a naval frigate ship using the Subjective Visual Vertical(SVV) test.Methods:This observational study was conducted on board a naval frigate and involved two groups. The case group consisted of50 newly recruited sailors experiencing their first sea voyage. The SVV test was conducted at three time points: prior to embarkation, during an active episode of sea sickness, and after disembarkation. A control group of 50 healthy, experienced sailors-regular seafarers with no history of vestibular symptoms underwent the same SVV testing at corresponding intervals. The results from both groups were collected and analyzed to assess changes in verticality perception related to sea exposure and sea sickness.Results:Analysis of the SVV test data from the 50 newly recruited sailors(case group) demonstrated a statistically significant difference compared to the control group of experienced sailors. During an active episode of sea sickness, the case group exhibited a notable tilt and deviation in SVV angles, indicating altered verticality perception. These deviations reduced significantly 24 hours post-disembarkation, suggesting an improvement in verticality perception once the motion stimulus was removed.Conclusion:This distinctive study assessed otolith-mediated verticality perception using the SVV test in first-time seafarers experiencing sea sickness aboard a naval frigate. Our findings emphasize the functional importance of the otolith organs in maintaining spatial orientation during maritime motion exposure. The observed SVV deviations support the subjective vertical conflict theory, highlighting the role of vestibular-visual mismatch in the development of sea sickness. However, our findings more likely reflect transient functional disturbance or overstimulation rather than a pre-existing utricular asymmetry alone. Based on the pattern of SVV deviation and recovery, we propose that the utricle may play a more significant role than the saccule in inducing sea sickness. 展开更多
关键词 Sea sickness motion sickness subjective visual vertical vestibular system
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