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基于STK/Scheduler的空间天文卫星任务规划研究 被引量:3
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作者 刘雯 李立钢 《遥感技术与应用》 CSCD 北大核心 2014年第6期908-914,共7页
空间天文卫星任务规划是一类复杂的NP难问题,将STK/Scheduler(Satellite Tool Kit/Scheduler,卫星仿真工具包/任务规划)商业软件从对地观测任务规划领域拓展应用至空间天文卫星任务规划领域,对于获取可靠解算结果、快速构建地面运控仿... 空间天文卫星任务规划是一类复杂的NP难问题,将STK/Scheduler(Satellite Tool Kit/Scheduler,卫星仿真工具包/任务规划)商业软件从对地观测任务规划领域拓展应用至空间天文卫星任务规划领域,对于获取可靠解算结果、快速构建地面运控仿真环境、提供解算参考基准具有重要意义。根据空间天文卫星任务规划问题,建立了以最大获取科学回报为目标的多约束任务规划模型,开展了基于STK/Scheduler的空间天文卫星任务规划解算和实例验证。实验结果表明:利用STK/Scheduler开展空间天文卫星任务规划能够适应多种规划时段和解算要求,具有求解稳定等特点,可以满足空间天文卫星任务规划的基本需求。 展开更多
关键词 空间天文卫星 任务规划 stk/scheduler
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基于STK/Scheduler的航天任务调度应用研究 被引量:2
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作者 白敬培 阎慧 +1 位作者 高永明 王忠敏 《装备指挥技术学院学报》 2010年第3期71-75,共5页
STK/Scheduler是与STK(satellite tool kits)完全集成的任务调度软件,通过它可方便的定义任务、资源和各种约束关系。介绍了STK/Scheduler的主要功能,在分析航天任务调度的特点及要素的基础上,建立了调度模型,并利用STK/Scheduler实现... STK/Scheduler是与STK(satellite tool kits)完全集成的任务调度软件,通过它可方便的定义任务、资源和各种约束关系。介绍了STK/Scheduler的主要功能,在分析航天任务调度的特点及要素的基础上,建立了调度模型,并利用STK/Scheduler实现了2个典型的卫星任务调度。结果表明:STK/Scheduler能基本满足航天任务调度的需求。 展开更多
关键词 资源 任务 航天任务调度 stk/scheduler软件
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STK/Scheduler在卫星数传调度中的应用研究 被引量:5
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作者 李云峰 武小悦 《计算机仿真》 CSCD 2008年第3期70-74,共5页
卫星数传调度问题是一类复杂的组合优化问题,即如何为卫星数传任务分配地面资源的问题,它是当前航天领域需要重点研究的问题之一。STK/Scheduler模块是STK工具包中的调度模块,对外提供了二次开发功能。针对卫星数传调度问题,研究了STK/S... 卫星数传调度问题是一类复杂的组合优化问题,即如何为卫星数传任务分配地面资源的问题,它是当前航天领域需要重点研究的问题之一。STK/Scheduler模块是STK工具包中的调度模块,对外提供了二次开发功能。针对卫星数传调度问题,研究了STK/Scheduler模块在该问题中的应用。首先在分析问题的基础上建立了卫星数传任务模型和调度模型,然后对基于STK/Scheduler的卫星数传调度系统进行了设计。最后利用AFIT基准数据进行了验证,结果表明在卫星数传任务规模不太大的情况下,STK/Scheduler为卫星数传调度问题的求解提供了一条捷径。 展开更多
关键词 卫星 地面站 数传 调度
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基于STK的城市场景下无人机航路导航性能仿真分析
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作者 周超 黄韬 +2 位作者 李鑫 黄驰 李有森 《现代电子技术》 北大核心 2025年第14期103-107,共5页
为解决复杂城市场景下,应用无人机实际飞行测试航路导航性能的方法效率低、结果不具有普遍性的问题,基于卫星仿真工具包(STK),建立一种GPS卫星系统,并完成三维场景构建。利用STK的覆盖分析功能分析无人机航路的卫星可见数和几何精度因子... 为解决复杂城市场景下,应用无人机实际飞行测试航路导航性能的方法效率低、结果不具有普遍性的问题,基于卫星仿真工具包(STK),建立一种GPS卫星系统,并完成三维场景构建。利用STK的覆盖分析功能分析无人机航路的卫星可见数和几何精度因子(GDOP)值,以达到评估城市无人机航路导航性能的目的。仿真结果表明,此次实验所规划的无人机航路GPS卫星可见数较多且GDOP值所对应的定位精度均维持在“优”等级,同时,GPS卫星系统在该航线能够提供稳定的导航定位服务。针对同一三维场景,构建不同高度的建筑物,仿真分析了建筑物高度对无人机航线导航性能的影响。所设计系统为城市无人机航路规划提供了可靠的数据支撑,并能提高无人机在城市场景下运行的安全性。 展开更多
关键词 stk 无人机导航 航路规划 GPS 三维场景 卫星可见数 几何精度因子
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利用STK和MATLAB互联实现低倾角卫星轨道优化设计
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作者 赵文策 舒传华 王盛玺 《电子技术应用》 2025年第9期106-110,共5页
提出针对特定纬度区域目标的低倾角卫星轨道设计方法。首先,分析了低倾角卫星轨道的特点;然后,以卫星一个回归周期内覆盖时间最长为性能指标,构建了卫星轨道设计的优化模型;最后,在利用STK和MATLAB互联的基础上,充分利用STK的覆盖分析... 提出针对特定纬度区域目标的低倾角卫星轨道设计方法。首先,分析了低倾角卫星轨道的特点;然后,以卫星一个回归周期内覆盖时间最长为性能指标,构建了卫星轨道设计的优化模型;最后,在利用STK和MATLAB互联的基础上,充分利用STK的覆盖分析能力和MATLAB的遗传算法工具箱,优化设计出符合模型需求的最优解。所提方法实现了软件的优势组合,简单且易于实现,具有较高的求解效率,为卫星轨道设计提供了新的思路和途径。 展开更多
关键词 stk MATLAB 低倾角卫星轨道 回归 遗传算法
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KRAS(G12D+)、STK11共突变伴PD-L1高表达的晚期肺腺癌患者1例
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作者 朱琳 穆传勇 《当代医药论丛》 2025年第5期149-152,共4页
现回顾性分析1例程序性死亡配体1(PD-L1)高表达伴KRAS(G12D+)、STK11共突变的晚期肺腺癌,该患者在接受一线化疗联合免疫治疗后病情进展,随后接受二线化疗、免疫联合抗血管生成治疗,病情仍不断进展,再次检测得出患者PD-L1含量降为60%。... 现回顾性分析1例程序性死亡配体1(PD-L1)高表达伴KRAS(G12D+)、STK11共突变的晚期肺腺癌,该患者在接受一线化疗联合免疫治疗后病情进展,随后接受二线化疗、免疫联合抗血管生成治疗,病情仍不断进展,再次检测得出患者PD-L1含量降为60%。该患者的病理提示肿瘤组织中可见散在印戒样细胞。对于初始PD-L1表达高的患者而言,由于STK11突变阳性,免疫逃逸发生的可能性更大。此外,印戒细胞癌患者本身预后不佳。因此,在选择PD-L1高表达的晚期肺腺癌患者的治疗方案及评估其预后时,临床医生应密切关注其基因突变状态、病理类型。 展开更多
关键词 晚期肺腺癌 基因突变 stk11 KRAS 免疫治疗
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MCWOA Scheduler:Modified Chimp-Whale Optimization Algorithm for Task Scheduling in Cloud Computing 被引量:1
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作者 Chirag Chandrashekar Pradeep Krishnadoss +1 位作者 Vijayakumar Kedalu Poornachary Balasundaram Ananthakrishnan 《Computers, Materials & Continua》 SCIE EI 2024年第2期2593-2616,共24页
Cloud computing provides a diverse and adaptable resource pool over the internet,allowing users to tap into various resources as needed.It has been seen as a robust solution to relevant challenges.A significant delay ... Cloud computing provides a diverse and adaptable resource pool over the internet,allowing users to tap into various resources as needed.It has been seen as a robust solution to relevant challenges.A significant delay can hamper the performance of IoT-enabled cloud platforms.However,efficient task scheduling can lower the cloud infrastructure’s energy consumption,thus maximizing the service provider’s revenue by decreasing user job processing times.The proposed Modified Chimp-Whale Optimization Algorithm called Modified Chimp-Whale Optimization Algorithm(MCWOA),combines elements of the Chimp Optimization Algorithm(COA)and the Whale Optimization Algorithm(WOA).To enhance MCWOA’s identification precision,the Sobol sequence is used in the population initialization phase,ensuring an even distribution of the population across the solution space.Moreover,the traditional MCWOA’s local search capabilities are augmented by incorporating the whale optimization algorithm’s bubble-net hunting and random search mechanisms into MCWOA’s position-updating process.This study demonstrates the effectiveness of the proposed approach using a two-story rigid frame and a simply supported beam model.Simulated outcomes reveal that the new method outperforms the original MCWOA,especially in multi-damage detection scenarios.MCWOA excels in avoiding false positives and enhancing computational speed,making it an optimal choice for structural damage detection.The efficiency of the proposed MCWOA is assessed against metrics such as energy usage,computational expense,task duration,and delay.The simulated data indicates that the new MCWOA outpaces other methods across all metrics.The study also references the Whale Optimization Algorithm(WOA),Chimp Algorithm(CA),Ant Lion Optimizer(ALO),Genetic Algorithm(GA)and Grey Wolf Optimizer(GWO). 展开更多
关键词 Cloud computing schedulING chimp optimization algorithm whale optimization algorithm
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山羊FAM135A和STK3基因多态性与产羔性能的关联分析
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作者 余平 狄冉 储明星 《特产研究》 2025年第3期27-32,38,共7页
本研究旨在分析序列相似性家族135成员A(Family With Sequence Similarity 135 Member A, FAM135A)基因和丝/酪氨酸蛋白激酶3(Serine/Threonine Protein Kinase 3, STK3)基因的多态性位点与山羊产羔数的关联。基于Sequenom MassARRAY SN... 本研究旨在分析序列相似性家族135成员A(Family With Sequence Similarity 135 Member A, FAM135A)基因和丝/酪氨酸蛋白激酶3(Serine/Threonine Protein Kinase 3, STK3)基因的多态性位点与山羊产羔数的关联。基于Sequenom MassARRAY SNP技术对FAM135A和STK3基因的4个候选位点进行分型,并分析了云上黑山羊(n=544)、济宁青山羊(n=133)和辽宁绒山羊(n=91)3个群体中4个候选位点的遗传学特征,同时将这些突变位点与云上黑山羊的繁殖性能(包括产羔数、初生窝重和断奶窝重)作了关联分析。结果显示,在不同繁殖力品种(济宁青山羊和辽宁绒山羊)中,FAM135A基因的g.91260230 G>T和g.91261141 G>A位点以及STK3基因的g.16434985 C>T位点基因型的分布存在着极显著差异(P <0.01);而不同繁殖力品种中STK3基因的g.16648187 C>T位点的基因型分布却没有明显差异(P>0.05)。关联分析结果表明,g.91260230 G>T位点的各基因型在云上黑山羊的产羔数、初生窝重和断奶窝重上都没有明显差异(P>0.05);但g.91261141 G>A位点与产羔数和初生窝重显著相关,GG型产羔数和窝重均显著高于AG型(P <0.05);g.16434985 C>T位点TT型的初生窝重显著高于CT型(P <0.05),但该位点的各基因型对山羊的产羔数和断奶窝重并没有显著影响(P>0.05);g.16648187 C>T位点与山羊的产羔数和初生窝重之间都没有显著关联(P>0.05)。综上,本研究发现FAM135A基因的g.91261141 G>A位点是云上黑山羊产羔数与初生窝重选择的潜在遗传标记。STK3基因的g.16434985 C>T位点适合初生窝重的选择。 展开更多
关键词 山羊 产羔数 窝重 FAM135A基因 stk3基因
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Autonomous sortie scheduling for carrier aircraft fleet under towing mode 被引量:1
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作者 Zhilong Deng Xuanbo Liu +4 位作者 Yuqi Dou Xichao Su Haixu Li Lei Wang Xinwei Wang 《Defence Technology(防务技术)》 2025年第1期1-12,共12页
Safe and efficient sortie scheduling on the confined flight deck is crucial for maintaining high combat effectiveness of the aircraft carrier.The primary difficulty exactly lies in the spatiotemporal coordination,i.e.... Safe and efficient sortie scheduling on the confined flight deck is crucial for maintaining high combat effectiveness of the aircraft carrier.The primary difficulty exactly lies in the spatiotemporal coordination,i.e.,allocation of limited supporting resources and collision-avoidance between heterogeneous dispatch entities.In this paper,the problem is investigated in the perspective of hybrid flow-shop scheduling problem by synthesizing the precedence,space and resource constraints.Specifically,eight processing procedures are abstracted,where tractors,preparing spots,catapults,and launching are virtualized as machines.By analyzing the constraints in sortie scheduling,a mixed-integer planning model is constructed.In particular,the constraint on preparing spot occupancy is improved to further enhance the sortie efficiency.The basic trajectory library for each dispatch entity is generated and a delayed strategy is integrated to address the collision-avoidance issue.To efficiently solve the formulated HFSP,which is essentially a combinatorial problem with tightly coupled constraints,a chaos-initialized genetic algorithm is developed.The solution framework is validated by the simulation environment referring to the Fort-class carrier,exhibiting higher sortie efficiency when compared to existing strategies.And animation of the simulation results is available at www.bilibili.com/video/BV14t421A7Tt/.The study presents a promising supporting technique for autonomous flight deck operation in the foreseeable future,and can be easily extended to other supporting scenarios,e.g.,ammunition delivery and aircraft maintenance. 展开更多
关键词 Carrier aircraft Autonomous sortie scheduling Resource allocation Collision-avoidance Hybrid flow-shop scheduling problem
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Integrated Optimization Scheduling Model for Ship Outfitting Production with Endogenous Uncertainties 被引量:1
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作者 Lijun Liu Pu Cao +2 位作者 Yajing zhou Zhixin Long Zuhua Jiang 《哈尔滨工程大学学报(英文版)》 2025年第1期194-209,共16页
Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan ... Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan is one of the crucial issues in shipbuilding.In this paper,production scheduling and material ordering with endogenous uncertainty of the outfitting process are investigated.The uncertain factors in outfitting equipment production are usually decision-related,which leads to difficulties in addressing uncertainties in the outfitting production workshops before production is conducted according to plan.This uncertainty is regarded as endogenous uncertainty and can be treated as non-anticipativity constraints in the model.To address this problem,a stochastic two-stage programming model with endogenous uncertainty is established to optimize the outfitting job scheduling and raw material ordering process.A practical case of the shipyard of China Merchants Heavy Industry Co.,Ltd.is used to evaluate the performance of the proposed method.Satisfactory results are achieved at the lowest expected total cost as the complete kit rate of outfitting equipment is improved and emergency replenishment is reduced. 展开更多
关键词 Ship outfitting Production scheduling Purchase planning Endogenous uncertainty Multistage stochastic programming
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Providing Robust and Low-Cost Edge Computing in Smart Grid:An Energy Harvesting Based Task Scheduling and Resource Management Framework 被引量:1
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作者 Xie Zhigang Song Xin +1 位作者 Xu Siyang Cao Jing 《China Communications》 2025年第2期226-240,共15页
Recently,one of the main challenges facing the smart grid is insufficient computing resources and intermittent energy supply for various distributed components(such as monitoring systems for renewable energy power sta... Recently,one of the main challenges facing the smart grid is insufficient computing resources and intermittent energy supply for various distributed components(such as monitoring systems for renewable energy power stations).To solve the problem,we propose an energy harvesting based task scheduling and resource management framework to provide robust and low-cost edge computing services for smart grid.First,we formulate an energy consumption minimization problem with regard to task offloading,time switching,and resource allocation for mobile devices,which can be decoupled and transformed into a typical knapsack problem.Then,solutions are derived by two different algorithms.Furthermore,we deploy renewable energy and energy storage units at edge servers to tackle intermittency and instability problems.Finally,we design an energy management algorithm based on sampling average approximation for edge computing servers to derive the optimal charging/discharging strategies,number of energy storage units,and renewable energy utilization.The simulation results show the efficiency and superiority of our proposed framework. 展开更多
关键词 edge computing energy harvesting energy storage unit renewable energy sampling average approximation task scheduling
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A Latency-Aware and Fault-Tolerant Framework for Resource Scheduling and Data Management in Fog-Enabled Smart City Transportation Systems
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作者 Ibrar Afzal Noor ul Amin +1 位作者 Zulfiqar Ahmad Abdulmohsen Algarni 《Computers, Materials & Continua》 SCIE EI 2025年第1期1377-1399,共23页
Thedeployment of the Internet of Things(IoT)with smart sensors has facilitated the emergence of fog computing as an important technology for delivering services to smart environments such as campuses,smart cities,and ... Thedeployment of the Internet of Things(IoT)with smart sensors has facilitated the emergence of fog computing as an important technology for delivering services to smart environments such as campuses,smart cities,and smart transportation systems.Fog computing tackles a range of challenges,including processing,storage,bandwidth,latency,and reliability,by locally distributing secure information through end nodes.Consisting of endpoints,fog nodes,and back-end cloud infrastructure,it provides advanced capabilities beyond traditional cloud computing.In smart environments,particularly within smart city transportation systems,the abundance of devices and nodes poses significant challenges related to power consumption and system reliability.To address the challenges of latency,energy consumption,and fault tolerance in these environments,this paper proposes a latency-aware,faulttolerant framework for resource scheduling and data management,referred to as the FORD framework,for smart cities in fog environments.This framework is designed to meet the demands of time-sensitive applications,such as those in smart transportation systems.The FORD framework incorporates latency-aware resource scheduling to optimize task execution in smart city environments,leveraging resources from both fog and cloud environments.Through simulation-based executions,tasks are allocated to the nearest available nodes with minimum latency.In the event of execution failure,a fault-tolerantmechanism is employed to ensure the successful completion of tasks.Upon successful execution,data is efficiently stored in the cloud data center,ensuring data integrity and reliability within the smart city ecosystem. 展开更多
关键词 Fog computing smart cities smart transportation data management fault tolerance resource scheduling
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安道麦与STK达成独家合作,生物杀菌剂Timorex^(■) Gold在智利获登并上市
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《农药》 北大核心 2025年第7期540-540,共1页
安道麦智利公司近日宣布与STK生物农业技术公司(STK Bio-Ag Technologies)建立战略合作伙伴关系。自2025年7月1日起,安道麦将正式成为STK旗下Timorex^(■) Gold和Regev^(■)产品在智利市场的独家经销商。Timorex^(■) Gold是一种基于茶... 安道麦智利公司近日宣布与STK生物农业技术公司(STK Bio-Ag Technologies)建立战略合作伙伴关系。自2025年7月1日起,安道麦将正式成为STK旗下Timorex^(■) Gold和Regev^(■)产品在智利市场的独家经销商。Timorex^(■) Gold是一种基于茶树提取物(茶树精油)开发的广谱生物杀菌剂和细菌抑制剂,已获得智利官方登记,可用于防治10多种作物的病害。该产品凭借其天然配方,能够有效减少农业对合成化学药剂的依赖,同时确保防治效果不受影响,可整合至各类植物卫生管理方案中。 展开更多
关键词 茶树精油 生物杀菌剂 安道麦 stk
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An Iterated Greedy Algorithm with Memory and Learning Mechanisms for the Distributed Permutation Flow Shop Scheduling Problem
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作者 Binhui Wang Hongfeng Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期371-388,共18页
The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because o... The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because of its straightforward,single-solution evolution framework.However,a potential draw-back of IGA is the lack of utilization of historical information,which could lead to an imbalance between exploration and exploitation,especially in large-scale DPFSPs.As a consequence,this paper develops an IGA with memory and learning mechanisms(MLIGA)to efficiently solve the DPFSP targeted at the mini-malmakespan.InMLIGA,we incorporate a memory mechanism to make a more informed selection of the initial solution at each stage of the search,by extending,reconstructing,and reinforcing the information from previous solutions.In addition,we design a twolayer cooperative reinforcement learning approach to intelligently determine the key parameters of IGA and the operations of the memory mechanism.Meanwhile,to ensure that the experience generated by each perturbation operator is fully learned and to reduce the prior parameters of MLIGA,a probability curve-based acceptance criterion is proposed by combining a cube root function with custom rules.At last,a discrete adaptive learning rate is employed to enhance the stability of the memory and learningmechanisms.Complete ablation experiments are utilized to verify the effectiveness of the memory mechanism,and the results show that this mechanism is capable of improving the performance of IGA to a large extent.Furthermore,through comparative experiments involving MLIGA and five state-of-the-art algorithms on 720 benchmarks,we have discovered that MLI-GA demonstrates significant potential for solving large-scale DPFSPs.This indicates that MLIGA is well-suited for real-world distributed flow shop scheduling. 展开更多
关键词 Distributed permutation flow shop scheduling MAKESPAN iterated greedy algorithm memory mechanism cooperative reinforcement learning
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基于STK的综合作战场景可视化仿真系统
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作者 谢伟 田野 周奕雯 《计算机测量与控制》 2025年第6期153-160,共8页
在当今复杂而动态的战场环境中,对武器性能进行准确评估和优化具有至关重要的意义;研究采用STK平台成功开发了一套综合作战场景可视化仿真系统,能够在这种复杂环境中对武器系统进行全面模拟和评估;重点研究了离线场景建模技术、模型动... 在当今复杂而动态的战场环境中,对武器性能进行准确评估和优化具有至关重要的意义;研究采用STK平台成功开发了一套综合作战场景可视化仿真系统,能够在这种复杂环境中对武器系统进行全面模拟和评估;重点研究了离线场景建模技术、模型动画优化和多种数据处理传输方法等方面;经实验测试,实现了模拟系统在武器性能评估和优化、战术规划和军事演习、实时决策支持、武器系统集成验证等多个领域的关键作用;研究推动了技术创新和研究方向的拓展,着眼于确保成本效益的目标;通过对战场环境的深入理解和模拟,为提升武器系统的性能和应对复杂作战环境提供了有力支持,为未来的军事应用和决策制定奠定了坚实基础。 展开更多
关键词 stk 可视化仿真 综合作战场景 三维建模 数据传输
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Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing
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作者 Xin Zhang Mingming Yao +3 位作者 Daiwen He Jihong Zhang Peihong Yang Xiaoming Zhang 《Energy Engineering》 EI 2025年第1期349-378,共30页
In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy sys... In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load aggregator.Owing to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption power.The price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption power.Mutual benefits and win-win situations are achieved between the upper and lower multistakeholders.Finally,CPLEX is used to iteratively solve the bilevel optimization model.The optimal solution is selected according to the joint optimal discrimination mechanism.Thesimulation results indicate that the sourceload coordinate operation can reduce the upper and lower operation costs.Using the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified. 展开更多
关键词 Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism
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STK4-AS1通过MYG1/Notch信号通路对食管鳞癌恶性生物学行为的影响
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作者 冯博 曹家瑞 +2 位作者 李东东 许彦超 马纯政 《实用医学杂志》 北大核心 2025年第17期2661-2669,共9页
目的 探讨STK4-AS1通过MYG1/Notch信号通路抑制食管鳞癌细胞增殖、侵袭以及迁移能力。方法 采用实时荧光定量PCR(qRT-PCR)检测食管鳞癌细胞中STK4-AS1表达。通过MTS、划痕愈合实验、Transwell小室侵袭实验检测各组食管鳞癌细胞Eca109和K... 目的 探讨STK4-AS1通过MYG1/Notch信号通路抑制食管鳞癌细胞增殖、侵袭以及迁移能力。方法 采用实时荧光定量PCR(qRT-PCR)检测食管鳞癌细胞中STK4-AS1表达。通过MTS、划痕愈合实验、Transwell小室侵袭实验检测各组食管鳞癌细胞Eca109和Kyse150的增殖、迁移以及侵袭能力。通过mRNA测序(mRNA-seq)检测STK4-AS1下游作用靶基因。通过KEGG功能富集分析预测可能的生物学过程和信号通路。采用qRT-PCR和Western blot方法检测MYG1以及Notch信号通路下游关键转录因子HES1、HES5、HEY1的mRNA表达和NICD1蛋白质表达。共转染质粒(针对STK4-AS1和MYG1过表达)检测食管鳞癌细胞的Notch信号通路下游关键转录因子HES1、HES5、HEY1的m RNA表达和NICD1蛋白质表达以及食管鳞癌细胞增殖、迁移和侵袭能力的影响。结果 STK4-AS1在食管鳞癌细胞系中表达降低(P<0.01)。过表达STK4-AS1后抑制食管鳞癌细胞Eca109和Kyse150增殖、迁移和侵袭能力(P<0.05)。过表达STK4-AS1负向调控MYG1的表达(P<0.01),MYG1在食管鳞癌细胞系中表达升高(P<0.01)。过表达MYG1可部分逆转STK4-AS1对Eca109和Kyse150细胞恶性生物学行为的影响(P<0.05),以及Notch信号通路下游关键转录因子HES1、HES5、HEY1的mRNA表达和NICD1蛋白质表达(P<0.05)。结论 STK4-AS1通过MYG1/Notch信号通路影响食管鳞癌恶性生物学行为。 展开更多
关键词 食管鳞状细胞癌 长链非编码RNA stk4-AS1 NOTCH信号通路
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A two-stage scheduling algorithm based on pointer network with attention mechanism for micro-nano Earth observation satellite constellation
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作者 Hai LI Yuanhao LIU +5 位作者 Boyu DENG Yongjun LI Xin LI Yu LI Taijiang ZHANG Shanghong ZHAO 《Chinese Journal of Aeronautics》 2025年第8期433-448,共16页
Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growin... Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem. 展开更多
关键词 Micro-nano earth observation satellite Observation scheduling Large-scale scheduling Two-stage optimization Pointer network Attention mechanism
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Integrated Scheduling of Communication,Sensing,and Control for UAV-aided FSO Systems
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作者 LU Dingshan YU Yinchang +1 位作者 SU Daopeng WANG Jinyuan 《电讯技术》 北大核心 2025年第6期892-902,共11页
Recently,unmanned aerial vehicle(UAV)-aided free-space optical(FSO)communication has attracted widespread attentions.However,most of the existing research focuses on communication performance only.The authors investig... Recently,unmanned aerial vehicle(UAV)-aided free-space optical(FSO)communication has attracted widespread attentions.However,most of the existing research focuses on communication performance only.The authors investigate the integrated scheduling of communication,sensing,and control for UAV-aided FSO communication systems.Initially,a sensing-control model is established via the control theory.Moreover,an FSO communication channel model is established by considering the effects of atmospheric loss,atmospheric turbulence,geometrical loss,and angle-of-arrival fluctuation.Then,the relationship between the motion control of the UAV and radial displacement is obtained to link the control aspect and communication aspect.Assuming that the base station has instantaneous channel state information(CSI)or statistical CSI,the thresholds of the sensing-control pattern activation are designed,respectively.Finally,an integrated scheduling scheme for performing communication,sensing,and control is proposed.Numerical results indicate that,compared with conventional time-triggered scheme,the proposed integrated scheduling scheme obtains comparable communication and control performance,but reduces the sensing consumed power by 52.46%. 展开更多
关键词 FSO communications integrated scheduling of communication sensing and control unmanned aerial vehicle(UAV)
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Adaptive dwell scheduling based on Q-learning for multifunctional radar system
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作者 HENG Siyu CHENG Ting +2 位作者 HE Zishu WANG Yuanqing LIU Luqing 《Journal of Systems Engineering and Electronics》 2025年第4期985-993,共9页
The dwell scheduling problem for a multifunctional radar system is led to the formation of corresponding optimiza-tion problem.In order to solve the resulting optimization prob-lem,the dwell scheduling process in a sc... The dwell scheduling problem for a multifunctional radar system is led to the formation of corresponding optimiza-tion problem.In order to solve the resulting optimization prob-lem,the dwell scheduling process in a scheduling interval(SI)is formulated as a Markov decision process(MDP),where the state,action,and reward are specified for this dwell scheduling problem.Specially,the action is defined as scheduling the task on the left side,right side or in the middle of the radar idle time-line,which reduces the action space effectively and accelerates the convergence of the training.Through the above process,a model-free reinforcement learning framework is established.Then,an adaptive dwell scheduling method based on Q-learn-ing is proposed,where the converged Q value table after train-ing is utilized to instruct the scheduling process.Simulation results demonstrate that compared with existing dwell schedul-ing algorithms,the proposed one can achieve better scheduling performance considering the urgency criterion,the importance criterion and the desired execution time criterion comprehen-sively.The average running time shows the proposed algorithm has real-time performance. 展开更多
关键词 multifunctional radar dwell scheduling reinforce-ment learning Q-learning.
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