Objectives This study aimed to develop and preliminarily assess the quality of a Mindfulness Breast Care(MBC)App to reduce body image distress and stigma among breast cancer survivors(BCSs).Methods The development pro...Objectives This study aimed to develop and preliminarily assess the quality of a Mindfulness Breast Care(MBC)App to reduce body image distress and stigma among breast cancer survivors(BCSs).Methods The development process of the MBC App involved:1)establishing a research group;2)determining of the content of the MBC App based on Mindfulness-Based Cognitive Therapy and 3)technical exploitation and maintenance.A mixed-methods study was conducted.We selected ten BCSs by a convenience sampling method.After using the APP for three months,five assessed the quality using the Mobile App Rating Scale:User Version(uMARS)and another five were interviewed for process evaluation.Results The MBC App was developed with three modules:1)Library to provide health education information on body image,stigma,mindfulness,recovery and etc;2)Mindfulness Yoga to offer 12 Hatha yoga videos for daily practice;and 3)Mindfulness Practices to have 12 sessions of mindfulness videoconferences.Based on the uMARS data,the MBC App received high ratings for functionality(4.10±0.34),aesthetics(3.93±0.55),information quality(4.10±0.72),and perceived impact(4.03±0.96),as well as moderate ratings for engagement(3.72±0.94)and subjective quality(3.87±0.77).Participants indicated that the MBC App provided reliable knowledge,information,and emotional support.Recommendations from participants included categorizing knowledge in the Library Module,recording videoconferences of mindfulness practice,and adding discussion sessions in the videoconference.Afterward,we optimized the MBC App to enhance the user experience accordingly.Conclusions The MBC App offers online mindfulness interventions specifically for BCSs in China.The preliminary quality assessment indicates that the MBC App may be a promising tool for delivering mindfulness interventions to BCSs.展开更多
Bioethics is the argumentative discipline of decisions and actions that reduce conflicts of interest,dilemmas,or asymmetries between the parties involved in biomedical research.The objective of this work was to review...Bioethics is the argumentative discipline of decisions and actions that reduce conflicts of interest,dilemmas,or asymmetries between the parties involved in biomedical research.The objective of this work was to review and compare the dimensions used by bioethics in the communicative management of the pandemic,namely:risk,vulnerability,resilience,and stigma.A documentary,exploratory,transversal,and retrospective work was carried out with a sample of sources indexed in international repositories,considering the search by keywords and the publication period from 2020 to 2024.The results demonstrate the prevalence of supply,contagion,symptoms,and help against COVID-19.展开更多
Objective:To understand the intertwined stigma experiences of the families of depression patients,providing a basis for implementing targeted interventions for depression patients and their families.To provide a basis...Objective:To understand the intertwined stigma experiences of the families of depression patients,providing a basis for implementing targeted interventions for depression patients and their families.To provide a basis for targeted interventions for patients with depression and their families.Methods:Based on the principle of data saturation,the family members of depressed patients in the mental health department and psychological outpatient clinic of a tertiary hospital in Hangzhou from March to May 2025 were selected by the purpose sampling method,and the semi-structured interview method was used to conduct in-depth interviews with the research subjects,and the Colaizzi 7-step analysis method was used for data analysis.Results:A total of 4 themes,and 8 sub-themes were extracted,namely cognitive responses(cognitive biases),emotional responses(internalized stigma and self-blame,feelings of shame,worries and concerns),behavioral responses(concealing the illness,social avoidance),and the potential impact of associated illness stigma(impact on the profession of relatives,emergence of internal family conflicts).Conclusion:Healthcare workers should gain an in-depth understanding of the associated stigma faced by the families of patients with depression and provide targeted psychological support.At the same time,there should be a call for society to pay positive and appropriate attention to patients with depression and their families,improving the families’understanding of the illness so that they can cope with the associated stigma in a positive manner.展开更多
Objectives:Schizophrenia is a profoundly stigmatized mental health condition,characterized by misconceptions that affect societal attitudes,policy development,and the lived experiences of individuals with the conditio...Objectives:Schizophrenia is a profoundly stigmatized mental health condition,characterized by misconceptions that affect societal attitudes,policy development,and the lived experiences of individuals with the condition.This study aimed to develop and validate a multidimensional scale for assessing societal stigma towards schizophrenia,while exploring how demographic factors influence such attitudes.Methods:Drawing on an extensive literature review and consultations,the study identified five domains of stigma:Workplace Capability,Intimate Relationships,Autonomy,Risk Perception,and Recovery.Using a two-phase methodology,a preliminary 38-itemscale was administered to 729 participants from the general Spanish population,refining the measure through descriptive and exploratory factor analysis.Subsequently,a revised 34-item scale was validated through confirmatory factor analysis with an independent sample of 417 participants.Results:The final model showed good fit(RMSEA=0.056,CFI=0.938,TLI=0.933)and strong internal consistency(α=0.73–0.86).Findings revealed that stigma was most pronounced in the domain of Autonomy(Mean=2.83,SD=0.91),reflecting pervasive doubts about individuals’ability to live independently and achieve meaningful integration into society.Stigma varied significantly across demographic variables,with higher levels reported among men,older individuals,married participants,and those outside health professions(p<0.01).Conversely,healthcare professionals,younger individuals,and those familiar with someone with schizophrenia generally reported less stigma(p<0.01).Conclusion:This study developed and validated a robust multidimensional scale for assessing societal stigma toward schizophrenia.The five-factor model—Workplace Capability,Intimate Relationships,Autonomy,Risk Perception,and Recovery—was empirically supported.Autonomy and Recovery emerged as themost stigmatized domains across the Spanish general population.The scale demonstrated strong psychometric properties and effectively captured stigma patterns linked to key sociodemographic variables.展开更多
Objective:This study has the objective to offer a thorough overview of the current state and future research possibilities regarding the social stigma of tuberculosis(TB).Given the growing volume and variety of resear...Objective:This study has the objective to offer a thorough overview of the current state and future research possibilities regarding the social stigma of tuberculosis(TB).Given the growing volume and variety of research in this field,a quantitative approach is essential for mapping existing themes and pinpointing potential areas for further investigation.To accomplish this,a bibliometric and content analysis was performed to explore the current literature and emphasize key themes and future directions.Methods:The study examines 770 bibliographic records from Scopus and visualizes the results of the bibliometric analysis using co-occurrence and thematic map analyses with VOSviewer and Tableau Public software.Additionally,a content analysis was conducted based on the findings from the co-occurrence analysis.Results:The findings indicate a notable rise in publications and citations related to the social stigma of TB,with prominent research topics including healthcare workers,social support,mobile health technology(mHealth),nursing,and attitudes.Emerging areas of research encompass epidemiology,public health,patient delays,multidrug-resistant TB(MDR-TB),corona virus disease 2019,and mHealth.Future studies might concentrate on the factors leading to patient delays,as well as the development of diagnostic tools and effective treatment regimens for MDR-TB cases.Conclusion:This study offers important insights into the current state of social stigma in TB research and identifies promising areas for future investigation.By addressing these research gaps and refining methodological approaches,researchers can strengthen initiatives to combat TB stigma,ultimately resulting in more effective treatments and improved adherence among TB patients.展开更多
Background:Limited mental health literacy(MHL)among university service providers is a significant obstacle to effective psychological support.Developing and systematically assessing evidence-based interventions is an ...Background:Limited mental health literacy(MHL)among university service providers is a significant obstacle to effective psychological support.Developing and systematically assessing evidence-based interventions is an urgent priority,particularly in low-and middle-income countries(LMICs).This study aimed to evaluate the effectiveness of the Acceptance&Commitment to Empowerment:Linking Youths AND‘Xin’(Hearts)(ACE-LYNX)intervention in reducing stigma,improving psychological well-being,and enhancing the MHL and empowerment practices of university mental health providers in China.Methods:A total of 124 trained providers participated in this longitudinal study.Quantitative data were collected at baseline,immediately post-intervention,and three-month follow-up using the validated scale(CAMI,DASS-21)and weekly activity logs recording empowerment practices.Generalized estimating equations(GEEs)and qualitative content analysis were used for data analysis.Results:Quantitative analysis showed a significant reduction in stigma immediately postintervention,particularly in the Social Restriction subscale(β=1.35,p<0.001),though this effect diminished by the 3-month follow-up(β=1.80,p=0.001).Notably,a lasting reduction in the providers’stress levels was maintained.Activity logs showed the highest level of engagement at the individual level(51.4%),followed by group level(32.0%),organizational level(10.5%),and community level(6.1%).Qualitative analysis revealed three themes:Skill-based empowerment enhances professional efficacy,embedded interventions expand service boundaries,and organizational empowerment fosters sustainability.Conclusions:This dual-focus ACE-LYNX intervention effectively improved MHL and both attitudinal and functional competencies among providers.It provides a scalable framework for fostering sustainable and inclusive campus mental health ecosystems,with significant implication for enhance psychological services in resource-constrained educational settings.展开更多
[Objective] This study aimed to investigate the correlation between stigma characteristics and outcrossing rate of photo-thermo sensitive genic male sterile（PTGMS） rice lines. [Method] The stigma exsertion rate, sti...[Objective] This study aimed to investigate the correlation between stigma characteristics and outcrossing rate of photo-thermo sensitive genic male sterile（PTGMS） rice lines. [Method] The stigma exsertion rate, stigma size and stigma vitality of Chuang 5S, Yun 9S, Peiai 64 S, P88 S and Y58 S were analyzed. Using R608 as a male parent, outcrossing rate of these five PTGMS lines was determined. [Result]There were differences in stigma exsertion rate, stigma size and stigma vitality among five PTGMS lines. P88 S exhibited the best stigma characteristics and relatively strong stigma vitality, with the stigma exsertion rate of 95.94%, stigma vitality coefficient of 2.71, outcrossing rate of 84.02% in the field. Peiai 64 s had the minimum stigma length（2.41 mm） and stigma width（1.10 mm） and the weakest stigma vitality, with the stigma exsertion rate of 93.04%, outcrossing rate of 65.47%. Yun 9S,Y58 S and Chuang 5S displayed medium stigma characteristics, among which Yun9 S exhibited higher outcrossing rate than other two PTGMS lines. Correlation analysis showed that stigma exsertion rate, stigma length, stigma width, stigma area and stigma volume were significantly correlated to outcrossing rate（P〈0.05）, with correlation coefficients of 0.897, 0.934, 0.934, 0.939 and 0.937, respectively. However,there was no significant correlation between stigma vitality coefficient and outcrossing rate. [Conclusion] Based on stigma characteristics of five PTGMS lines, auxiliary pollination measures should be adopted reasonably to save production costs and improve hybrid rice seed yield.展开更多
Objective] This study aimed to investigate the relationship between pistil-late flower developmental morphology and stigma receptivity in Euphorbia pulcherri-ma. [Method] One-year-old adult plants of E. pulcherrima cu...Objective] This study aimed to investigate the relationship between pistil-late flower developmental morphology and stigma receptivity in Euphorbia pulcherri-ma. [Method] One-year-old adult plants of E. pulcherrima cultivar ‘Mil enium’ were used as experimental materials to analyze pistil ate flower development process by macroscopic and scanning electron microscope （SEM） observation. Stigma receptivity was detected with benzidine-hydrogen peroxide method and in vivo pol en germina-tion method. [Result] The pistil ate flower development process of E. pulcherrima was consisted of columnar stigma phase, stigma lobe slightly opening phase, Y-shape stigma lobe phase, inverse V-shaped stigma lobe phase and stigma curling phase. Pistil ate flower development and stigma receptivity of E. pulcherrima exhibit-ed certain correlation. The stigma receptive period lasted from stigma lobe slightly opening phase to inverse V-shaped stigma lobe phase; inverse V-shaped stigma lobe phase was appropriate for pol ination, lasting for 3-5 d, with V-shaped stigma lobe and a large amount of exudates on stigma surface according to SEM obser-vation. Stigma receptivity of E. pulcherrima detected with benzidine-hydrogen perox-ide method was consistent with that detected in vivo pol en germination method. [Conclusion] ln breeding practice, the optimal pol ination period of E. pulcherrima can be determined based on the developmental morphology of pistil ate flower.展开更多
The stigmas of five species, Populus euphratica Oliv., P. alba L., P. simonii Carr., P. lasiocarpa Oliv. and P. nigra L. have been studied. Scanning electron microscopy re veals that exudates are present in the ...The stigmas of five species, Populus euphratica Oliv., P. alba L., P. simonii Carr., P. lasiocarpa Oliv. and P. nigra L. have been studied. Scanning electron microscopy re veals that exudates are present in the intercellular spaces, in the clefts between the multicel lular papillae and on the receptive surface. Release and movement of exudates can be visual ized when the fresh stigmas are stained with sudan Ⅲ and auramine O. Paraffin and semi thin resin sections of stigmas after glutaraldehyde osmium fixation evidence the lipidic nature of the exudates. Transmission electron microscopy reveals the glandular features of the stigmatic papillae cells, such as abundance of rough and smooth endoplasmic reticulum, polyribosomes, and well developed dictyosomes with secretory vesicles. Pellicle and epicuticular lamellate layers which have been considered as typical features of the dry type stigmas are also present in the species where stigmas appear extremely wet. It is concluded that stigmas in all of the five species are secretory at the receptive stage. Well developed generative and sperm cells were observed in the pollen tubes penetrating through the deep layers of the stigmatic tissue in the reciprocal crosses between P. euphratica and P. simonii, which indicated that there is no significant barrier in the stigma.展开更多
The precise factors afecting stigma behavior in Campsis radicans(L)Seem.ex Bureau.remain unclear up to now.In this study mechanical touch。self-and cross-pollination,and pollination with variable amounts of pollen gra...The precise factors afecting stigma behavior in Campsis radicans(L)Seem.ex Bureau.remain unclear up to now.In this study mechanical touch。self-and cross-pollination,and pollination with variable amounts of pollen grains separately contacting with stigmas have been conducted to determine the exact factor afecting the stigma behavior.Results show that mechanical touch alone cannot make the stigmas close permanently.It is the adequate pollen(>350)deposition that causes the stigma permanent closure which is in accordance with previous reports that s cient pollen grains are necessary f0r fruit development.In addition。the stigma behavior does not display differences when pollinated with cross..or self-pollen separately;both self and cross pollen grains can germinate and grow successfully.Our results cannot demonstrate that the stigma behavior in radicans is an outcrossing mechanism。but strongly indicate it acts as a mechanism to facilitate pollination。and then enhance the reproductive success.展开更多
Rong 18A is an Indica three-line sterile line bred with M5B×D Xing B, and has the characteristics of stable sterility, high outcrossing rate, good combining ability and good quality. With Rong 18A as an experimen...Rong 18A is an Indica three-line sterile line bred with M5B×D Xing B, and has the characteristics of stable sterility, high outcrossing rate, good combining ability and good quality. With Rong 18A as an experimental material and Ⅱ-32A, Jin 23A and Gang46 A as the CK materials, a seed setting rate estimation method by daily pollination was used for measuring its stigma vigor, to comparatively analyze the decreasing rates and lasting time of stigma vigor of various materials under natural condition. According to experimental results and combining with field breeding practice, the application of stigma vigor of sterile lines on hybrid rice seed production was discussed.展开更多
Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigat...Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigate the inheritance of stigma exertion. K239 S and K92 S are TPSGMS lines with higher and lower stigma exertion rates（SER）, respectively. The SERs of parents, reciprocal crosses and the DH population were evaluated for two consecutive years. The results showed that no significant difference was observed in SER between F1 s of K239S/K92 S and K92S/K239 S,implying that stigma exertion was a trait controlled by nuclear gene（s）. In the DH population, the segregation of low and high SERs fitted to a ratio of 3 ∶1 by Chisquare test, suggesting that the stigma exertion of K239 S was controlled by one pair of recessive genes. In addition, the effects of temperature and humidity on the expression of stigma exertion were also discussed.展开更多
<strong>Purpose:</strong> Disease-related Stigma is negative emotions, attitudes, stereotypes, and beliefs about diseases. Cancer is one of the diseases that can be exposed to stigma. Regarding the effects...<strong>Purpose:</strong> Disease-related Stigma is negative emotions, attitudes, stereotypes, and beliefs about diseases. Cancer is one of the diseases that can be exposed to stigma. Regarding the effects of stigma on the quality of life;admission and adherence to treatment, and considering stigma as a barrier to health promotion and cancer screening, the aim of this study was to provide a care plan for reducing stigma in cancer. <strong>Methods:</strong> This research was carried out during three phases of qualitative, quantitative studies and a review of the literature. The qualitative phase was conducted by conventional content analysis to find effective factors on the reduction of stigma through face to face semi-structured interviews. The quantitative phase was a cross-sectional descriptive study to measure the level of stigma. By using both quantitative and qualitative findings, and a review of the literature, a comprehensive care plan to reduce stigma in families with cancer patients was developed. <strong>Results:</strong> The results showed two categories of data;1) reducing stigma at the individual or family level which needs increasing awareness, teaching coping skills, and support, as well as counseling;and 2) stigma reduction at the community level and policy rules which involve public education and cultural changes. <strong>Conclusion:</strong> Implementation of a care plan for reducing stigma can increase the physical and psychological health outcomes of people influenced by cancer, and at the community level, improves the attitude toward cancer and the success of screening programs, and ultimately reduces disability and mortality of the disease.展开更多
[Objective] The primary aims of this study were to understand the characteristic of floralorgan development in ‘Dongxing＇, and analyze its differences with other apricot varieties. [Method] Floral organ morphology, ...[Objective] The primary aims of this study were to understand the characteristic of floralorgan development in ‘Dongxing＇, and analyze its differences with other apricot varieties. [Method] Floral organ morphology, pollen quantity, pollen viability and stigma receptivityof ‘Dongxing＇ and other apricot varieties were observed and measured. [Result] The ratio between the medium style and long style of‘Dongxing＇ was 82.4%, and the ratio of pistillode was lower than that in the other apricot varieties. Its pollen quantity was 32 183.2 grains per flower, and was fewer than the others. The pollen germination of ‘Dongxing＇ in optimum medium（1% agar ＋15% sucrose ＋ 0.01% boric acid） was 53.0%, i.e. its pollen viability was low. The pollen viability increased at first and then decreased following the period of the bud stage to flowering stage, and pollen viability reached maximum value at the 1st d after flowering. Meanwhile the stored pollen viability continuously decreased with the extension of storage time, and pollen viability of the both vivo or vitro stored was decreased to the half of the maximum value at the 3rdd after flowering or storage.The stigma receptivity of ‘ongxing＇ enhanced at first then weakened, maximum stigma receptivity was found at the period of 2 h to 4 h after flowering. The optimum time for artificial pollination was 1 h to 8 h after flowering and it was shorter than the other apricot varieties was. [Conclusion] The ratio between the medium style and long style of ‘Dongxing＇ was higher than the other apricot varieties, while the pollen viability of ‘Dongxing＇ on the contrary. Its pollen viability reached maximum value at the 1st d after flowering and the optimum time for artificial pollination was1 h to 8h after flowering.展开更多
Psychiatrists require frequent contact with and treatment of patients with mental illnesses.Due to the influence of associative stigma,psychiatrists may also be targets of stigma.Occupational stigma warrants special c...Psychiatrists require frequent contact with and treatment of patients with mental illnesses.Due to the influence of associative stigma,psychiatrists may also be targets of stigma.Occupational stigma warrants special consideration because it significantly affects psychiatrists'career advancement,well-being,and their patients’health.Given that there is no complete summary of this issue,this study reviewed the existing literature on psychiatrists'occupational stigma to clearly synthesize its concepts,measurement tools,and intervention strategies.Herein,we emphasize that psychiatrists’occupational stigma is a multifaceted concept that simultaneously encompasses physically,socially,and morally tainted aspects.Currently,standardized methods to specifically measure psychiatrists’occupational stigma are lacking.Interventions for psychiatrists’occupational stigma may consider the use of protest,contact,education,comprehensive and systematic methods,as well as the use of psychotherapeutic approaches.This review provides a theoretical basis for the development of relevant measurement tools and intervention practices.Overall,this review seeks to raise public awareness of psychiatrists'occupational stigma,thereby promoting psychiatric professionalism and reducing its stigma.展开更多
People with mental illness have not only struggled with the psychological and physical symptoms of the disease but also suffered from social discrimination and prejudice.[1]This article expresses the negative impact o...People with mental illness have not only struggled with the psychological and physical symptoms of the disease but also suffered from social discrimination and prejudice.[1]This article expresses the negative impact of mental illness stigma on the stigmatized group through the study of previous literature.The purpose of this article is to improve the public’s stereotypes and prejudices of people with mental illness,so as to provide a basis for researchers to identify effective de-stigmatization strategies.展开更多
With global warming, rice plants may be subjected to heat stress more regularly during the heatsensitive flowering stage, causing spikelet sterility and grain yield loss.Stigma exsertion is considered to increase poll...With global warming, rice plants may be subjected to heat stress more regularly during the heatsensitive flowering stage, causing spikelet sterility and grain yield loss.Stigma exsertion is considered to increase pollen reception and promote female reproductive success.The aim of this study was to investigate the role of stigma exsertion on spikelet fertility at high temperatures.Five rice cultivars(Liangyoupeijiu, Shanyou 63, Huanghuazhan, Nagina 22, and IR64) with differing degrees of stigma exsertion were cultivated and exposed to high temperature at anthesis.Heat-tolerant cultivars did not always show a high percentage of spikelets with exserted stigmas, and vice versa.Irrespective of the presence of more pollen grains on exserted stigmas, spikelets with exserted stigmas did not show greater spikelet fertility than spikelets with fewer exserted stigmas or hidden stigmas under heat stress.GA3 application augmented the percentage of spikelets with exserted stigmas;however, it did not increase spikelet fertility under heat stress.Spikelet fertility of whole panicles was negatively correlated with the percentage of spikelets with exserted stigmas, but positively with that with hidden stigmas.Viability of the hidden stigmas was less reduced than that of exserted stigmas under heat stress, suggesting that hidden stigmas have an advantage in maintaining viability.Heat stress delayed anther dehiscence and reduced the viabilities of both exserted stigmas and pollens, thereby causing low spikelet fertility.Together, these results suggest that high spikelet fertility does not depend on stigma exsertion and that enclosed stigma generally contributes to higher spikelet fertility and heat tolerance under high-temperature conditions during flowering in rice.展开更多
Stigma exsertion in male sterile lines of hybrid rice is important for seed yield.In the present study, ZS616 [Oryza sativa subsp.Xian(indica)], a male sterile line with a stigma exsertion rate(SER) as high as 94.5%, ...Stigma exsertion in male sterile lines of hybrid rice is important for seed yield.In the present study, ZS616 [Oryza sativa subsp.Xian(indica)], a male sterile line with a stigma exsertion rate(SER) as high as 94.5%, was crossed to DS552, a japonica line with almost no exserted stigmas.F3 plants with extremely low and high SER were sequenced to identify SER-associated quantitative trait loci(QTL).A major QTL for SER, qSER-3.1, was identified along with other QTL on chromosome 3 in a 3.9 Mb region.A total of 307 nonsynonymous single-nucleotide polymorphisms(SNPs) and 27 frame-shift insertion/deletions(InDels)differentiating ZS616 and DS552 were identified in the region containing qSER-3.1.Most SNPs(294) and InDels(25) were excluded after further analysis because they were shared by ZS616 and low(<2.0%) SER accessions in the Huazhong Agricultural University(HAU) core rice collection.Association analysis using the full HAU collection identified a 17-bp InDel in OS03 G0689400 as the most likely causal genetic variant underlying qSER-3.1.ZS616-type accessions(n = 54, with the 17-bp insertion) in the HAU collection had minimum(16.5%)and mean(39.6%) SERs significantly greater than those(n = 424) without the insertion(with minimum and mean SERs of 0.2% and 20.6%, respectively).Thus, this study identified a major QTL for stigma exsertion and revealed the mutation in a candidate gene for the QTL.展开更多
The infection with hepatitis C virus(HCV)is one of the most important global chronic viral infections worldwide.It is estimated to affect around 3%of the world population,about 170-200 million people.Great part of the...The infection with hepatitis C virus(HCV)is one of the most important global chronic viral infections worldwide.It is estimated to affect around 3%of the world population,about 170-200 million people.Great part of the infections are asymptomatic,the patient can be a chronic carrier for decades without knowing it.The most severe consequences of the chronic infection are liver cirrhosis and hepatocellular carcinoma,which appears in 20%-40%of the patients,leading to hepatic failure and death.The HCV was discovered 25 years ago in 1989,is a RNA virus and classified by the World Health Organization as an oncogenic one.Hepatocellular carcinoma is one of the most important cancers,the fifth worldwide in terms of mortality.It has been increasing in the Ocidental world,mainly due to chronic hepatitis C.Hepatitis C is not only a liver disease and a cause of cirrhosis,but also a mental,psychological,familiar,and social disease.The stigma that the infected person sometimes carries is tremendous having multiple consequences.The main cause is lack of adequate information,even in the health professionals setting.But,besides the"drama"of being infected,health professionals,family,society and the infected patients,must be aware of the chance of real cure and total and definitive elimination of the virus.The treatment for hepatitis C has begun in the last 80′s with a percentage of cure of 6%.Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications,the so called Direct Antiviral Agents-DAAs of new generation,is around 80%-90%.展开更多
基金supported by the National Natural Science Foundation of China(No.71974162 and No.7231101009).
文摘Objectives This study aimed to develop and preliminarily assess the quality of a Mindfulness Breast Care(MBC)App to reduce body image distress and stigma among breast cancer survivors(BCSs).Methods The development process of the MBC App involved:1)establishing a research group;2)determining of the content of the MBC App based on Mindfulness-Based Cognitive Therapy and 3)technical exploitation and maintenance.A mixed-methods study was conducted.We selected ten BCSs by a convenience sampling method.After using the APP for three months,five assessed the quality using the Mobile App Rating Scale:User Version(uMARS)and another five were interviewed for process evaluation.Results The MBC App was developed with three modules:1)Library to provide health education information on body image,stigma,mindfulness,recovery and etc;2)Mindfulness Yoga to offer 12 Hatha yoga videos for daily practice;and 3)Mindfulness Practices to have 12 sessions of mindfulness videoconferences.Based on the uMARS data,the MBC App received high ratings for functionality(4.10±0.34),aesthetics(3.93±0.55),information quality(4.10±0.72),and perceived impact(4.03±0.96),as well as moderate ratings for engagement(3.72±0.94)and subjective quality(3.87±0.77).Participants indicated that the MBC App provided reliable knowledge,information,and emotional support.Recommendations from participants included categorizing knowledge in the Library Module,recording videoconferences of mindfulness practice,and adding discussion sessions in the videoconference.Afterward,we optimized the MBC App to enhance the user experience accordingly.Conclusions The MBC App offers online mindfulness interventions specifically for BCSs in China.The preliminary quality assessment indicates that the MBC App may be a promising tool for delivering mindfulness interventions to BCSs.
文摘Bioethics is the argumentative discipline of decisions and actions that reduce conflicts of interest,dilemmas,or asymmetries between the parties involved in biomedical research.The objective of this work was to review and compare the dimensions used by bioethics in the communicative management of the pandemic,namely:risk,vulnerability,resilience,and stigma.A documentary,exploratory,transversal,and retrospective work was carried out with a sample of sources indexed in international repositories,considering the search by keywords and the publication period from 2020 to 2024.The results demonstrate the prevalence of supply,contagion,symptoms,and help against COVID-19.
基金The 2025 Diligent Research and Innovation and Entrepreneurship Project of Hangzhou Normal University。
文摘Objective:To understand the intertwined stigma experiences of the families of depression patients,providing a basis for implementing targeted interventions for depression patients and their families.To provide a basis for targeted interventions for patients with depression and their families.Methods:Based on the principle of data saturation,the family members of depressed patients in the mental health department and psychological outpatient clinic of a tertiary hospital in Hangzhou from March to May 2025 were selected by the purpose sampling method,and the semi-structured interview method was used to conduct in-depth interviews with the research subjects,and the Colaizzi 7-step analysis method was used for data analysis.Results:A total of 4 themes,and 8 sub-themes were extracted,namely cognitive responses(cognitive biases),emotional responses(internalized stigma and self-blame,feelings of shame,worries and concerns),behavioral responses(concealing the illness,social avoidance),and the potential impact of associated illness stigma(impact on the profession of relatives,emergence of internal family conflicts).Conclusion:Healthcare workers should gain an in-depth understanding of the associated stigma faced by the families of patients with depression and provide targeted psychological support.At the same time,there should be a call for society to pay positive and appropriate attention to patients with depression and their families,improving the families’understanding of the illness so that they can cope with the associated stigma in a positive manner.
文摘Objectives:Schizophrenia is a profoundly stigmatized mental health condition,characterized by misconceptions that affect societal attitudes,policy development,and the lived experiences of individuals with the condition.This study aimed to develop and validate a multidimensional scale for assessing societal stigma towards schizophrenia,while exploring how demographic factors influence such attitudes.Methods:Drawing on an extensive literature review and consultations,the study identified five domains of stigma:Workplace Capability,Intimate Relationships,Autonomy,Risk Perception,and Recovery.Using a two-phase methodology,a preliminary 38-itemscale was administered to 729 participants from the general Spanish population,refining the measure through descriptive and exploratory factor analysis.Subsequently,a revised 34-item scale was validated through confirmatory factor analysis with an independent sample of 417 participants.Results:The final model showed good fit(RMSEA=0.056,CFI=0.938,TLI=0.933)and strong internal consistency(α=0.73–0.86).Findings revealed that stigma was most pronounced in the domain of Autonomy(Mean=2.83,SD=0.91),reflecting pervasive doubts about individuals’ability to live independently and achieve meaningful integration into society.Stigma varied significantly across demographic variables,with higher levels reported among men,older individuals,married participants,and those outside health professions(p<0.01).Conversely,healthcare professionals,younger individuals,and those familiar with someone with schizophrenia generally reported less stigma(p<0.01).Conclusion:This study developed and validated a robust multidimensional scale for assessing societal stigma toward schizophrenia.The five-factor model—Workplace Capability,Intimate Relationships,Autonomy,Risk Perception,and Recovery—was empirically supported.Autonomy and Recovery emerged as themost stigmatized domains across the Spanish general population.The scale demonstrated strong psychometric properties and effectively captured stigma patterns linked to key sociodemographic variables.
文摘Objective:This study has the objective to offer a thorough overview of the current state and future research possibilities regarding the social stigma of tuberculosis(TB).Given the growing volume and variety of research in this field,a quantitative approach is essential for mapping existing themes and pinpointing potential areas for further investigation.To accomplish this,a bibliometric and content analysis was performed to explore the current literature and emphasize key themes and future directions.Methods:The study examines 770 bibliographic records from Scopus and visualizes the results of the bibliometric analysis using co-occurrence and thematic map analyses with VOSviewer and Tableau Public software.Additionally,a content analysis was conducted based on the findings from the co-occurrence analysis.Results:The findings indicate a notable rise in publications and citations related to the social stigma of TB,with prominent research topics including healthcare workers,social support,mobile health technology(mHealth),nursing,and attitudes.Emerging areas of research encompass epidemiology,public health,patient delays,multidrug-resistant TB(MDR-TB),corona virus disease 2019,and mHealth.Future studies might concentrate on the factors leading to patient delays,as well as the development of diagnostic tools and effective treatment regimens for MDR-TB cases.Conclusion:This study offers important insights into the current state of social stigma in TB research and identifies promising areas for future investigation.By addressing these research gaps and refining methodological approaches,researchers can strengthen initiatives to combat TB stigma,ultimately resulting in more effective treatments and improved adherence among TB patients.
基金funded by the National Natural Science Foundation of China(NSFC,grant 81761128033)the Canadian Institutes of Health Research(CIHR,FRN 154986)through the Collaborative Health Program of the Global Alliance for Chronic Disease(GACD).
文摘Background:Limited mental health literacy(MHL)among university service providers is a significant obstacle to effective psychological support.Developing and systematically assessing evidence-based interventions is an urgent priority,particularly in low-and middle-income countries(LMICs).This study aimed to evaluate the effectiveness of the Acceptance&Commitment to Empowerment:Linking Youths AND‘Xin’(Hearts)(ACE-LYNX)intervention in reducing stigma,improving psychological well-being,and enhancing the MHL and empowerment practices of university mental health providers in China.Methods:A total of 124 trained providers participated in this longitudinal study.Quantitative data were collected at baseline,immediately post-intervention,and three-month follow-up using the validated scale(CAMI,DASS-21)and weekly activity logs recording empowerment practices.Generalized estimating equations(GEEs)and qualitative content analysis were used for data analysis.Results:Quantitative analysis showed a significant reduction in stigma immediately postintervention,particularly in the Social Restriction subscale(β=1.35,p<0.001),though this effect diminished by the 3-month follow-up(β=1.80,p=0.001).Notably,a lasting reduction in the providers’stress levels was maintained.Activity logs showed the highest level of engagement at the individual level(51.4%),followed by group level(32.0%),organizational level(10.5%),and community level(6.1%).Qualitative analysis revealed three themes:Skill-based empowerment enhances professional efficacy,embedded interventions expand service boundaries,and organizational empowerment fosters sustainability.Conclusions:This dual-focus ACE-LYNX intervention effectively improved MHL and both attitudinal and functional competencies among providers.It provides a scalable framework for fostering sustainable and inclusive campus mental health ecosystems,with significant implication for enhance psychological services in resource-constrained educational settings.
基金Supported by National Science and Technology Support Program of China(2014BAD06B07)~~
文摘[Objective] This study aimed to investigate the correlation between stigma characteristics and outcrossing rate of photo-thermo sensitive genic male sterile（PTGMS） rice lines. [Method] The stigma exsertion rate, stigma size and stigma vitality of Chuang 5S, Yun 9S, Peiai 64 S, P88 S and Y58 S were analyzed. Using R608 as a male parent, outcrossing rate of these five PTGMS lines was determined. [Result]There were differences in stigma exsertion rate, stigma size and stigma vitality among five PTGMS lines. P88 S exhibited the best stigma characteristics and relatively strong stigma vitality, with the stigma exsertion rate of 95.94%, stigma vitality coefficient of 2.71, outcrossing rate of 84.02% in the field. Peiai 64 s had the minimum stigma length（2.41 mm） and stigma width（1.10 mm） and the weakest stigma vitality, with the stigma exsertion rate of 93.04%, outcrossing rate of 65.47%. Yun 9S,Y58 S and Chuang 5S displayed medium stigma characteristics, among which Yun9 S exhibited higher outcrossing rate than other two PTGMS lines. Correlation analysis showed that stigma exsertion rate, stigma length, stigma width, stigma area and stigma volume were significantly correlated to outcrossing rate（P〈0.05）, with correlation coefficients of 0.897, 0.934, 0.934, 0.939 and 0.937, respectively. However,there was no significant correlation between stigma vitality coefficient and outcrossing rate. [Conclusion] Based on stigma characteristics of five PTGMS lines, auxiliary pollination measures should be adopted reasonably to save production costs and improve hybrid rice seed yield.
基金Supported by Fund for Independent Innovation of Agricultural Science and Technologyin Jiangsu Province[CX(10)411]~~
文摘Objective] This study aimed to investigate the relationship between pistil-late flower developmental morphology and stigma receptivity in Euphorbia pulcherri-ma. [Method] One-year-old adult plants of E. pulcherrima cultivar ‘Mil enium’ were used as experimental materials to analyze pistil ate flower development process by macroscopic and scanning electron microscope （SEM） observation. Stigma receptivity was detected with benzidine-hydrogen peroxide method and in vivo pol en germina-tion method. [Result] The pistil ate flower development process of E. pulcherrima was consisted of columnar stigma phase, stigma lobe slightly opening phase, Y-shape stigma lobe phase, inverse V-shaped stigma lobe phase and stigma curling phase. Pistil ate flower development and stigma receptivity of E. pulcherrima exhibit-ed certain correlation. The stigma receptive period lasted from stigma lobe slightly opening phase to inverse V-shaped stigma lobe phase; inverse V-shaped stigma lobe phase was appropriate for pol ination, lasting for 3-5 d, with V-shaped stigma lobe and a large amount of exudates on stigma surface according to SEM obser-vation. Stigma receptivity of E. pulcherrima detected with benzidine-hydrogen perox-ide method was consistent with that detected in vivo pol en germination method. [Conclusion] ln breeding practice, the optimal pol ination period of E. pulcherrima can be determined based on the developmental morphology of pistil ate flower.
基金the NationalNaturalScience Foundation ofChina (NNSFC)
文摘The stigmas of five species, Populus euphratica Oliv., P. alba L., P. simonii Carr., P. lasiocarpa Oliv. and P. nigra L. have been studied. Scanning electron microscopy re veals that exudates are present in the intercellular spaces, in the clefts between the multicel lular papillae and on the receptive surface. Release and movement of exudates can be visual ized when the fresh stigmas are stained with sudan Ⅲ and auramine O. Paraffin and semi thin resin sections of stigmas after glutaraldehyde osmium fixation evidence the lipidic nature of the exudates. Transmission electron microscopy reveals the glandular features of the stigmatic papillae cells, such as abundance of rough and smooth endoplasmic reticulum, polyribosomes, and well developed dictyosomes with secretory vesicles. Pellicle and epicuticular lamellate layers which have been considered as typical features of the dry type stigmas are also present in the species where stigmas appear extremely wet. It is concluded that stigmas in all of the five species are secretory at the receptive stage. Well developed generative and sperm cells were observed in the pollen tubes penetrating through the deep layers of the stigmatic tissue in the reciprocal crosses between P. euphratica and P. simonii, which indicated that there is no significant barrier in the stigma.
文摘The precise factors afecting stigma behavior in Campsis radicans(L)Seem.ex Bureau.remain unclear up to now.In this study mechanical touch。self-and cross-pollination,and pollination with variable amounts of pollen grains separately contacting with stigmas have been conducted to determine the exact factor afecting the stigma behavior.Results show that mechanical touch alone cannot make the stigmas close permanently.It is the adequate pollen(>350)deposition that causes the stigma permanent closure which is in accordance with previous reports that s cient pollen grains are necessary f0r fruit development.In addition。the stigma behavior does not display differences when pollinated with cross..or self-pollen separately;both self and cross pollen grains can germinate and grow successfully.Our results cannot demonstrate that the stigma behavior in radicans is an outcrossing mechanism。but strongly indicate it acts as a mechanism to facilitate pollination。and then enhance the reproductive success.
文摘Rong 18A is an Indica three-line sterile line bred with M5B×D Xing B, and has the characteristics of stable sterility, high outcrossing rate, good combining ability and good quality. With Rong 18A as an experimental material and Ⅱ-32A, Jin 23A and Gang46 A as the CK materials, a seed setting rate estimation method by daily pollination was used for measuring its stigma vigor, to comparatively analyze the decreasing rates and lasting time of stigma vigor of various materials under natural condition. According to experimental results and combining with field breeding practice, the application of stigma vigor of sterile lines on hybrid rice seed production was discussed.
基金Supported by Applied Basic Research Program of Yunnan Province(2010CD096)National High-tech Research and Development Program of China(863 Program)(2011AA10A106)Key New Products Development Program of Department of Science and Technology,Yunnan Province(2012BB015)~~
文摘Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigate the inheritance of stigma exertion. K239 S and K92 S are TPSGMS lines with higher and lower stigma exertion rates（SER）, respectively. The SERs of parents, reciprocal crosses and the DH population were evaluated for two consecutive years. The results showed that no significant difference was observed in SER between F1 s of K239S/K92 S and K92S/K239 S,implying that stigma exertion was a trait controlled by nuclear gene（s）. In the DH population, the segregation of low and high SERs fitted to a ratio of 3 ∶1 by Chisquare test, suggesting that the stigma exertion of K239 S was controlled by one pair of recessive genes. In addition, the effects of temperature and humidity on the expression of stigma exertion were also discussed.
文摘<strong>Purpose:</strong> Disease-related Stigma is negative emotions, attitudes, stereotypes, and beliefs about diseases. Cancer is one of the diseases that can be exposed to stigma. Regarding the effects of stigma on the quality of life;admission and adherence to treatment, and considering stigma as a barrier to health promotion and cancer screening, the aim of this study was to provide a care plan for reducing stigma in cancer. <strong>Methods:</strong> This research was carried out during three phases of qualitative, quantitative studies and a review of the literature. The qualitative phase was conducted by conventional content analysis to find effective factors on the reduction of stigma through face to face semi-structured interviews. The quantitative phase was a cross-sectional descriptive study to measure the level of stigma. By using both quantitative and qualitative findings, and a review of the literature, a comprehensive care plan to reduce stigma in families with cancer patients was developed. <strong>Results:</strong> The results showed two categories of data;1) reducing stigma at the individual or family level which needs increasing awareness, teaching coping skills, and support, as well as counseling;and 2) stigma reduction at the community level and policy rules which involve public education and cultural changes. <strong>Conclusion:</strong> Implementation of a care plan for reducing stigma can increase the physical and psychological health outcomes of people influenced by cancer, and at the community level, improves the attitude toward cancer and the success of screening programs, and ultimately reduces disability and mortality of the disease.
基金Supported by Xinjiang Uygur Nationality Autonomous Region Science and Technology Project(201130102-1)Xinjiang Uygur Nationality Autonomous Region Key Subjects of Pomology~~
文摘[Objective] The primary aims of this study were to understand the characteristic of floralorgan development in ‘Dongxing＇, and analyze its differences with other apricot varieties. [Method] Floral organ morphology, pollen quantity, pollen viability and stigma receptivityof ‘Dongxing＇ and other apricot varieties were observed and measured. [Result] The ratio between the medium style and long style of‘Dongxing＇ was 82.4%, and the ratio of pistillode was lower than that in the other apricot varieties. Its pollen quantity was 32 183.2 grains per flower, and was fewer than the others. The pollen germination of ‘Dongxing＇ in optimum medium（1% agar ＋15% sucrose ＋ 0.01% boric acid） was 53.0%, i.e. its pollen viability was low. The pollen viability increased at first and then decreased following the period of the bud stage to flowering stage, and pollen viability reached maximum value at the 1st d after flowering. Meanwhile the stored pollen viability continuously decreased with the extension of storage time, and pollen viability of the both vivo or vitro stored was decreased to the half of the maximum value at the 3rdd after flowering or storage.The stigma receptivity of ‘ongxing＇ enhanced at first then weakened, maximum stigma receptivity was found at the period of 2 h to 4 h after flowering. The optimum time for artificial pollination was 1 h to 8 h after flowering and it was shorter than the other apricot varieties was. [Conclusion] The ratio between the medium style and long style of ‘Dongxing＇ was higher than the other apricot varieties, while the pollen viability of ‘Dongxing＇ on the contrary. Its pollen viability reached maximum value at the 1st d after flowering and the optimum time for artificial pollination was1 h to 8h after flowering.
文摘Psychiatrists require frequent contact with and treatment of patients with mental illnesses.Due to the influence of associative stigma,psychiatrists may also be targets of stigma.Occupational stigma warrants special consideration because it significantly affects psychiatrists'career advancement,well-being,and their patients’health.Given that there is no complete summary of this issue,this study reviewed the existing literature on psychiatrists'occupational stigma to clearly synthesize its concepts,measurement tools,and intervention strategies.Herein,we emphasize that psychiatrists’occupational stigma is a multifaceted concept that simultaneously encompasses physically,socially,and morally tainted aspects.Currently,standardized methods to specifically measure psychiatrists’occupational stigma are lacking.Interventions for psychiatrists’occupational stigma may consider the use of protest,contact,education,comprehensive and systematic methods,as well as the use of psychotherapeutic approaches.This review provides a theoretical basis for the development of relevant measurement tools and intervention practices.Overall,this review seeks to raise public awareness of psychiatrists'occupational stigma,thereby promoting psychiatric professionalism and reducing its stigma.
文摘People with mental illness have not only struggled with the psychological and physical symptoms of the disease but also suffered from social discrimination and prejudice.[1]This article expresses the negative impact of mental illness stigma on the stigmatized group through the study of previous literature.The purpose of this article is to improve the public’s stereotypes and prejudices of people with mental illness,so as to provide a basis for researchers to identify effective de-stigmatization strategies.
基金supported by the National Natural Science Foundation of China (30971707, 31361140368)the National Key Research and Development Program of China (2017YFD0300100)+2 种基金the Natural Science Foundation of Jiangsu Province (BK20180537)the China Postdoctoral Science Foundation (2017M621757)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘With global warming, rice plants may be subjected to heat stress more regularly during the heatsensitive flowering stage, causing spikelet sterility and grain yield loss.Stigma exsertion is considered to increase pollen reception and promote female reproductive success.The aim of this study was to investigate the role of stigma exsertion on spikelet fertility at high temperatures.Five rice cultivars(Liangyoupeijiu, Shanyou 63, Huanghuazhan, Nagina 22, and IR64) with differing degrees of stigma exsertion were cultivated and exposed to high temperature at anthesis.Heat-tolerant cultivars did not always show a high percentage of spikelets with exserted stigmas, and vice versa.Irrespective of the presence of more pollen grains on exserted stigmas, spikelets with exserted stigmas did not show greater spikelet fertility than spikelets with fewer exserted stigmas or hidden stigmas under heat stress.GA3 application augmented the percentage of spikelets with exserted stigmas;however, it did not increase spikelet fertility under heat stress.Spikelet fertility of whole panicles was negatively correlated with the percentage of spikelets with exserted stigmas, but positively with that with hidden stigmas.Viability of the hidden stigmas was less reduced than that of exserted stigmas under heat stress, suggesting that hidden stigmas have an advantage in maintaining viability.Heat stress delayed anther dehiscence and reduced the viabilities of both exserted stigmas and pollens, thereby causing low spikelet fertility.Together, these results suggest that high spikelet fertility does not depend on stigma exsertion and that enclosed stigma generally contributes to higher spikelet fertility and heat tolerance under high-temperature conditions during flowering in rice.
基金supported by the Zhejiang Provincial S&T Project on Breeding of Agricultural (Food) Crops (2016C020502)the Major Science and Technology Innovation Program of Hangzhou, China (2015012A09)
文摘Stigma exsertion in male sterile lines of hybrid rice is important for seed yield.In the present study, ZS616 [Oryza sativa subsp.Xian(indica)], a male sterile line with a stigma exsertion rate(SER) as high as 94.5%, was crossed to DS552, a japonica line with almost no exserted stigmas.F3 plants with extremely low and high SER were sequenced to identify SER-associated quantitative trait loci(QTL).A major QTL for SER, qSER-3.1, was identified along with other QTL on chromosome 3 in a 3.9 Mb region.A total of 307 nonsynonymous single-nucleotide polymorphisms(SNPs) and 27 frame-shift insertion/deletions(InDels)differentiating ZS616 and DS552 were identified in the region containing qSER-3.1.Most SNPs(294) and InDels(25) were excluded after further analysis because they were shared by ZS616 and low(<2.0%) SER accessions in the Huazhong Agricultural University(HAU) core rice collection.Association analysis using the full HAU collection identified a 17-bp InDel in OS03 G0689400 as the most likely causal genetic variant underlying qSER-3.1.ZS616-type accessions(n = 54, with the 17-bp insertion) in the HAU collection had minimum(16.5%)and mean(39.6%) SERs significantly greater than those(n = 424) without the insertion(with minimum and mean SERs of 0.2% and 20.6%, respectively).Thus, this study identified a major QTL for stigma exsertion and revealed the mutation in a candidate gene for the QTL.
文摘The infection with hepatitis C virus(HCV)is one of the most important global chronic viral infections worldwide.It is estimated to affect around 3%of the world population,about 170-200 million people.Great part of the infections are asymptomatic,the patient can be a chronic carrier for decades without knowing it.The most severe consequences of the chronic infection are liver cirrhosis and hepatocellular carcinoma,which appears in 20%-40%of the patients,leading to hepatic failure and death.The HCV was discovered 25 years ago in 1989,is a RNA virus and classified by the World Health Organization as an oncogenic one.Hepatocellular carcinoma is one of the most important cancers,the fifth worldwide in terms of mortality.It has been increasing in the Ocidental world,mainly due to chronic hepatitis C.Hepatitis C is not only a liver disease and a cause of cirrhosis,but also a mental,psychological,familiar,and social disease.The stigma that the infected person sometimes carries is tremendous having multiple consequences.The main cause is lack of adequate information,even in the health professionals setting.But,besides the"drama"of being infected,health professionals,family,society and the infected patients,must be aware of the chance of real cure and total and definitive elimination of the virus.The treatment for hepatitis C has begun in the last 80′s with a percentage of cure of 6%.Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications,the so called Direct Antiviral Agents-DAAs of new generation,is around 80%-90%.
