Objective:To observe the changes of serum soluble ST-2(suppressive tumorigenicity-2,sST2)and serum transforming growth factor-β2(TGF-β2)levels in patients with atrial fibrillation,and analyze the two with known left...Objective:To observe the changes of serum soluble ST-2(suppressive tumorigenicity-2,sST2)and serum transforming growth factor-β2(TGF-β2)levels in patients with atrial fibrillation,and analyze the two with known left atrium The correlation of left atrial diameter(LAD),to explore its relationship with the development of atrial fibrillation.Methods:126 patients with atrial fibrillation(AF)who were treated in the Department of Cardiology of the First Affiliated Hospital of Bengbu Medical College from December 2019 to July 2020 were selected,including 69 males and 57 females,aged 62-74 years,average(64.38±5.31)years old,patients with atrial fibrillation were divided into three groups according to the relevant guidelines,namely,paroxysmal AF group(Paroxysmal AF group)45 cases,persistent atrial fibrillation AF group(Persistent AF group)42 cases,permanent 39 cases in the Permanent AF group.64 healthy sinus rhythms(SR)were selected as the healthy control group during the same period of physical examination,including 34 males and 30 females,aged 60-75 years,average(65.25±4.37)years,using enzyme-linked adsorption Immunoassay(ELISA)was used to determine the levels of ST-2 and TGF-β2 in the serum,and to analyze the correlation with the measured LAD.Results:Compared with the control group,the ST-2 level in the experimental group was significantly higher,and the serum ST-2 level:permanent atrial fibrillation group>persistent atrial fibrillation group>paroxysmal atrial fibrillation group.Compared with the control group,the TGF-β2 level in the experimental group was significantly higher,and the serum TGF-β2 level:permanent atrial fibrillation group>persistent atrial fibrillation group>paroxysmal atrial fibrillation group.The correlation analysis between ST-2,TGF-β2 and LAD was carried out.Correlation analysis showed that the concentration of ST-2 was significantly positively correlated with the size of LAD in all experimental groups(γ=0.784,P<0.001).Correlation analysis showed that there was a significant positive correlation between TGF-β2 and LAD in all experimental groups(γ=0.815,P<0.001).Correlation analysis showed that there was a significant positive correlation between ST-2 and TGF-β2 concentrations in all experimental groups(γ=0.777,P<0.001).Conclusion:ST-2 and TGF-β2 are closely related in the development of atrial fibrillation,and can be used as new indicators to predict the prognosis of atrial fibrillation and provide new ideas and references for the diagnosis and treatment of atrial fibrillation.ST-2 and TGF-β2 are correlated with the development of atrial fibrillation.High levels of ST-2 and TGF-β2 may indicate poor prognosis and treatment effects in patients with atrial fibrillation.展开更多
目的 探讨血清可溶性人基质裂解素-2(sST-2)水平在急性失代偿性心力衰竭患者预后判断中的价值。方法 连续纳入该院心内科急性失代偿性心力衰竭患者208例,采集相关临床信息,并随访1年。采用多因素COX回归分析sST-2水平和终点事件的相关性...目的 探讨血清可溶性人基质裂解素-2(sST-2)水平在急性失代偿性心力衰竭患者预后判断中的价值。方法 连续纳入该院心内科急性失代偿性心力衰竭患者208例,采集相关临床信息,并随访1年。采用多因素COX回归分析sST-2水平和终点事件的相关性,绘制不同sST-2水平的心力衰竭患者预后的生存曲线,并比较不同回归模型对终点事件的预测能力。结果 以死亡和心力衰竭再入院为终点事件,高水平sST-2可显著升高终点事件的发生率( HR :1.57,95% CI :1.37~1.78, P <0.05),且不同sST-2水平的心力衰竭患者其终点事件发生率差异有统计学意义( P <0.05)。结论 高水平sST-2与急性失代偿性心力衰竭患者的不良预后显著相关,检测sST-2水平有助于判断该类患者不良事件的发生。展开更多
目的探讨可溶性ST-2和半乳糖凝集素-3（Galectin-3）水平与肥厚型心肌病患者行室间隔心肌切除术后心房颤动（房颤）的相关性。方法纳入2011年3月至2016年2月在阜外医院成人外科58病区行室间隔心肌切除术的肥厚型心肌病患者170例，收集...目的探讨可溶性ST-2和半乳糖凝集素-3（Galectin-3）水平与肥厚型心肌病患者行室间隔心肌切除术后心房颤动（房颤）的相关性。方法纳入2011年3月至2016年2月在阜外医院成人外科58病区行室间隔心肌切除术的肥厚型心肌病患者170例，收集患者临床资料。采用酶联免疫吸附法检测可溶性ST-2与Galectin-3浓度，分析术后房颤发生的相关因素。结果共16例于住院期间发生术后房颤。与无术后房颤患者相比，发生术后房颤的患者平均年龄更大[（49.8±9.6）岁对（42.1±14.2）岁，P=0.036]，吸烟患者比例更高（62.5%对38.3%，P=0.047）。两组患者之间可溶性ST-2[9.0（7.3~22.2）对12.6（8.7~18.0）ng/ml，P=0.37]和Galectin-3[7.2（6.2~9.9）对7.1（5.4~8.7）ng/ml，P=0.45]浓度差异无统计学意义。经多因素回归分析，年龄是术后房颤发生的独立危险因素[OR=1.065（95% CI 1.007~1.126），P=0.028]。结论可溶性ST-2和Galectin-3与肥厚型心肌病患者室间隔心肌切除术后房颤发生无相关。年龄增长可能是术后房颤发生的独立危险因素。展开更多
基金National natural science foundation of China(No.81970313)Key research and development plan of Anhui province(No.180h08020246)。
文摘Objective:To observe the changes of serum soluble ST-2(suppressive tumorigenicity-2,sST2)and serum transforming growth factor-β2(TGF-β2)levels in patients with atrial fibrillation,and analyze the two with known left atrium The correlation of left atrial diameter(LAD),to explore its relationship with the development of atrial fibrillation.Methods:126 patients with atrial fibrillation(AF)who were treated in the Department of Cardiology of the First Affiliated Hospital of Bengbu Medical College from December 2019 to July 2020 were selected,including 69 males and 57 females,aged 62-74 years,average(64.38±5.31)years old,patients with atrial fibrillation were divided into three groups according to the relevant guidelines,namely,paroxysmal AF group(Paroxysmal AF group)45 cases,persistent atrial fibrillation AF group(Persistent AF group)42 cases,permanent 39 cases in the Permanent AF group.64 healthy sinus rhythms(SR)were selected as the healthy control group during the same period of physical examination,including 34 males and 30 females,aged 60-75 years,average(65.25±4.37)years,using enzyme-linked adsorption Immunoassay(ELISA)was used to determine the levels of ST-2 and TGF-β2 in the serum,and to analyze the correlation with the measured LAD.Results:Compared with the control group,the ST-2 level in the experimental group was significantly higher,and the serum ST-2 level:permanent atrial fibrillation group>persistent atrial fibrillation group>paroxysmal atrial fibrillation group.Compared with the control group,the TGF-β2 level in the experimental group was significantly higher,and the serum TGF-β2 level:permanent atrial fibrillation group>persistent atrial fibrillation group>paroxysmal atrial fibrillation group.The correlation analysis between ST-2,TGF-β2 and LAD was carried out.Correlation analysis showed that the concentration of ST-2 was significantly positively correlated with the size of LAD in all experimental groups(γ=0.784,P<0.001).Correlation analysis showed that there was a significant positive correlation between TGF-β2 and LAD in all experimental groups(γ=0.815,P<0.001).Correlation analysis showed that there was a significant positive correlation between ST-2 and TGF-β2 concentrations in all experimental groups(γ=0.777,P<0.001).Conclusion:ST-2 and TGF-β2 are closely related in the development of atrial fibrillation,and can be used as new indicators to predict the prognosis of atrial fibrillation and provide new ideas and references for the diagnosis and treatment of atrial fibrillation.ST-2 and TGF-β2 are correlated with the development of atrial fibrillation.High levels of ST-2 and TGF-β2 may indicate poor prognosis and treatment effects in patients with atrial fibrillation.
文摘目的 探讨血清可溶性人基质裂解素-2(sST-2)水平在急性失代偿性心力衰竭患者预后判断中的价值。方法 连续纳入该院心内科急性失代偿性心力衰竭患者208例,采集相关临床信息,并随访1年。采用多因素COX回归分析sST-2水平和终点事件的相关性,绘制不同sST-2水平的心力衰竭患者预后的生存曲线,并比较不同回归模型对终点事件的预测能力。结果 以死亡和心力衰竭再入院为终点事件,高水平sST-2可显著升高终点事件的发生率( HR :1.57,95% CI :1.37~1.78, P <0.05),且不同sST-2水平的心力衰竭患者其终点事件发生率差异有统计学意义( P <0.05)。结论 高水平sST-2与急性失代偿性心力衰竭患者的不良预后显著相关,检测sST-2水平有助于判断该类患者不良事件的发生。
文摘目的探讨可溶性ST-2和半乳糖凝集素-3（Galectin-3）水平与肥厚型心肌病患者行室间隔心肌切除术后心房颤动（房颤）的相关性。方法纳入2011年3月至2016年2月在阜外医院成人外科58病区行室间隔心肌切除术的肥厚型心肌病患者170例，收集患者临床资料。采用酶联免疫吸附法检测可溶性ST-2与Galectin-3浓度，分析术后房颤发生的相关因素。结果共16例于住院期间发生术后房颤。与无术后房颤患者相比，发生术后房颤的患者平均年龄更大[（49.8±9.6）岁对（42.1±14.2）岁，P=0.036]，吸烟患者比例更高（62.5%对38.3%，P=0.047）。两组患者之间可溶性ST-2[9.0（7.3~22.2）对12.6（8.7~18.0）ng/ml，P=0.37]和Galectin-3[7.2（6.2~9.9）对7.1（5.4~8.7）ng/ml，P=0.45]浓度差异无统计学意义。经多因素回归分析，年龄是术后房颤发生的独立危险因素[OR=1.065（95% CI 1.007~1.126），P=0.028]。结论可溶性ST-2和Galectin-3与肥厚型心肌病患者室间隔心肌切除术后房颤发生无相关。年龄增长可能是术后房颤发生的独立危险因素。
