SP3 （simplified P3） theory is widely used in LWR （light water reactor） analyses to partly capture the transport effect, especially for pin-by-pin core analysis with pin size homogenization. In this paper, a SP3 co...SP3 （simplified P3） theory is widely used in LWR （light water reactor） analyses to partly capture the transport effect, especially for pin-by-pin core analysis with pin size homogenization. In this paper, a SP3 code named STELLA is developed and verified at SNERDI （Shanghai Nuclear Engineering Research and Design Institute）. For SP3 method, neutron transport equation can be transformed into two coupled equations in the same mathematical form as diffusion equation. In this work, SANM （semi-analytic nodal method） is used to solve diffusion-like equation, due to its easy to handle multi-group problem. Whole core nodal boundary net current coupling is used to improve convergence stability in SANM, instead of solving two-node problem. CMFD （coarse-mesh finite difference） acceleration method is employed for 0-th SP3 equation, which represents the neutron balance relationship. Three benchmarks are used to verify the SP3 code, STELLA. The first one is a self-defined one dimensional problem, which demonstrates SP3 method is extremely accurate, due to no academic approximation in one dimensional for SP3. The second one is a two dimensional one-group problem cited from Larsen＇s paper, which is usually used to verify and prove the SP3 code correct and accurate. And the third one is modified from 2D C5G7-MOX benchmark, whose numerical results indicate that STELLA is accurate and efficient in pin size level, compared to diffusion model.展开更多
[Objectives]To explore the expression of interleukin 34(IL-34)in gastric adenocarcinoma tissues and its relationship with apoptosis of gastric adenocarcinoma cells.[Methods]60 cases of surgically resected human gastri...[Objectives]To explore the expression of interleukin 34(IL-34)in gastric adenocarcinoma tissues and its relationship with apoptosis of gastric adenocarcinoma cells.[Methods]60 cases of surgically resected human gastric adenocarcinoma tissue specimen and 50 cases of adjacent normal gastric mucosa tissue specimen were collected,and the expression of IL-34 protein was determined by immunohistochemical streptavidin-perosidase(SP)method.Cell apoptosis in tissue specimen was detected by TUNEL staining method,and the relationship between IL-34 protein expression and apoptosis of gastric adenocarcinoma cells was analyzed.[Results]Immunohistochemical SP experiment indicated that the expression of IL-34 protein in gastric adenocarcinoma was higher than that in adjacent normal gastric mucosa(P<0.05);its positive expression was related to histological differentiation,TNM stage,invasion depth,and lymph node metastasis of gastric adenocarcinoma(P<0.05),but not to gender and age(P>0.05).TUNEL experiment showed that compared with the adjacent normal gastric mucosa group,the apoptosis index(AI)of gastric adenocarcinoma group was significantly lower(P<0.05);the AI was related to histological differentiation,TNM stage,tumor invasion depth and lymph node metastasis of gastric adenocarcinoma(P<0.05),but not to gender and age(P>0.05).In gastric adenocarcinoma,the AI of IL-34 positive expression group was lower than that of IL-34 negative expression group,and the results were statistically significant(P<0.05).[Conclusions]IL-34 has high expression in gastric adenocarcinoma tissues and is negatively correlated with cancer cell apoptosis.Abnormal expression of IL-34 is involved in the occurrence and development of gastric adenocarcinoma.This provides a new idea for the pathogenesis research and clinical treatment of gastric adenocarcinoma.展开更多
文摘SP3 （simplified P3） theory is widely used in LWR （light water reactor） analyses to partly capture the transport effect, especially for pin-by-pin core analysis with pin size homogenization. In this paper, a SP3 code named STELLA is developed and verified at SNERDI （Shanghai Nuclear Engineering Research and Design Institute）. For SP3 method, neutron transport equation can be transformed into two coupled equations in the same mathematical form as diffusion equation. In this work, SANM （semi-analytic nodal method） is used to solve diffusion-like equation, due to its easy to handle multi-group problem. Whole core nodal boundary net current coupling is used to improve convergence stability in SANM, instead of solving two-node problem. CMFD （coarse-mesh finite difference） acceleration method is employed for 0-th SP3 equation, which represents the neutron balance relationship. Three benchmarks are used to verify the SP3 code, STELLA. The first one is a self-defined one dimensional problem, which demonstrates SP3 method is extremely accurate, due to no academic approximation in one dimensional for SP3. The second one is a two dimensional one-group problem cited from Larsen＇s paper, which is usually used to verify and prove the SP3 code correct and accurate. And the third one is modified from 2D C5G7-MOX benchmark, whose numerical results indicate that STELLA is accurate and efficient in pin size level, compared to diffusion model.
基金Supported by Cultivation Fund of National Natural Science Foundation of China Project(202114)Major Program at School Level(201711).
文摘[Objectives]To explore the expression of interleukin 34(IL-34)in gastric adenocarcinoma tissues and its relationship with apoptosis of gastric adenocarcinoma cells.[Methods]60 cases of surgically resected human gastric adenocarcinoma tissue specimen and 50 cases of adjacent normal gastric mucosa tissue specimen were collected,and the expression of IL-34 protein was determined by immunohistochemical streptavidin-perosidase(SP)method.Cell apoptosis in tissue specimen was detected by TUNEL staining method,and the relationship between IL-34 protein expression and apoptosis of gastric adenocarcinoma cells was analyzed.[Results]Immunohistochemical SP experiment indicated that the expression of IL-34 protein in gastric adenocarcinoma was higher than that in adjacent normal gastric mucosa(P<0.05);its positive expression was related to histological differentiation,TNM stage,invasion depth,and lymph node metastasis of gastric adenocarcinoma(P<0.05),but not to gender and age(P>0.05).TUNEL experiment showed that compared with the adjacent normal gastric mucosa group,the apoptosis index(AI)of gastric adenocarcinoma group was significantly lower(P<0.05);the AI was related to histological differentiation,TNM stage,tumor invasion depth and lymph node metastasis of gastric adenocarcinoma(P<0.05),but not to gender and age(P>0.05).In gastric adenocarcinoma,the AI of IL-34 positive expression group was lower than that of IL-34 negative expression group,and the results were statistically significant(P<0.05).[Conclusions]IL-34 has high expression in gastric adenocarcinoma tissues and is negatively correlated with cancer cell apoptosis.Abnormal expression of IL-34 is involved in the occurrence and development of gastric adenocarcinoma.This provides a new idea for the pathogenesis research and clinical treatment of gastric adenocarcinoma.
