The effects of Saponins of Panax Quinquefolium Leaf and Stem(SPQLS)were evaluatedin the rabbit sinus node and in the guinea pig papillary muscles both showing slow responses in high[k+].and being exposed to 0.3 μmol/...The effects of Saponins of Panax Quinquefolium Leaf and Stem(SPQLS)were evaluatedin the rabbit sinus node and in the guinea pig papillary muscles both showing slow responses in high[k+].and being exposed to 0.3 μmol/L verapamil using conventional microelcctrode technique.Inthe sinus node, SPQLS 100 mg/L decreased the APA and Vmax.At the concentration of 200 mg/L,in addition to further depressing the upotroke,SPQIS decreased the SP4,shortened the APD and prolonged the SCL.In the guinea Pig papillary muscle,SPQLS shortened the APD and decreased theAPA as well as Vmax in high[k+3].When verapamil was exposed to the normal Tyrode's solution,SPQLS depressed the upstroke without-affecting the APD in the guinea pig papillary muscle.Thesefindings suggest that SPQLS exerted a blockade effect on the transmembrane Ca2+ influx and Na+ influx in myocardium.展开更多
文摘The effects of Saponins of Panax Quinquefolium Leaf and Stem(SPQLS)were evaluatedin the rabbit sinus node and in the guinea pig papillary muscles both showing slow responses in high[k+].and being exposed to 0.3 μmol/L verapamil using conventional microelcctrode technique.Inthe sinus node, SPQLS 100 mg/L decreased the APA and Vmax.At the concentration of 200 mg/L,in addition to further depressing the upotroke,SPQIS decreased the SP4,shortened the APD and prolonged the SCL.In the guinea Pig papillary muscle,SPQLS shortened the APD and decreased theAPA as well as Vmax in high[k+3].When verapamil was exposed to the normal Tyrode's solution,SPQLS depressed the upstroke without-affecting the APD in the guinea pig papillary muscle.Thesefindings suggest that SPQLS exerted a blockade effect on the transmembrane Ca2+ influx and Na+ influx in myocardium.
