OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided int...OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.展开更多
BACKGROUND Cervical spondylosis(CS)frequently co-occurs with generalized anxiety disorder(GAD),presenting a complex clinical challenge.Managing CS-related pain in patients with GAD is particularly challenging because ...BACKGROUND Cervical spondylosis(CS)frequently co-occurs with generalized anxiety disorder(GAD),presenting a complex clinical challenge.Managing CS-related pain in patients with GAD is particularly challenging because of the bidirectional relationship between pain and anxiety,necessitating integrated treatment strategies.AIM To evaluate the efficacy of electroacupuncture(EA)in treating CS-related pain and anxiety in patients with GAD.METHODS This retrospective cohort study analyzed data from 83 patients with CS-related pain and GAD who received EA treatment over 2-year period.Pain intensity was assessed using the visual analog scale,and anxiety symptoms were measured using the Hamilton Anxiety Rating Scale.Additionally,neuroinflammatory markers,including interleukin-6,tumor necrosis factor-alpha,and high-sensitivity C-reactive protein,were examined.Outcomes were evaluated at baseline,after 4 weeks,and after 8 weeks of treatment.RESULTS EA treatment significantly reduced CS-related pain(mean visual analog scale reduction:3.24±1.18;P<0.001)and improved anxiety symptoms(mean Hamilton Anxiety Rating Scale reduction:7.83±2.65;P<0.001)after 8 weeks of treatment.Neuroinflammatory markers also showed significant reductions,with interleukin-6 and tumor necrosis factor-alpha levels decreasing by 32.7%and 28.5%,respectively(P<0.01).Pain reduction was significantly correlated with improvements in anxiety symptoms(r=0.68;P<0.001)and a decrease in inflammatory markers(r=0.54;P<0.01).CONCLUSION EA demonstrates significant efficacy in reducing CS-related pain in patients with comorbid GAD,along with concurrent improvements in anxiety symptoms and neuroinflammatory profiles.These findings suggest that EA may offer a valuable integrative approach for managing this complex clinical presentation,potentially addressing both pain and anxiety through the modulation of neuroinflammatory pathways.展开更多
BACKGROUND Neck pain,a primary symptom of cervical spondylosis,affects patients'physical and mental health,reducing their quality of life.Pain and emotional state interact;however,their longitudinal interrelations...BACKGROUND Neck pain,a primary symptom of cervical spondylosis,affects patients'physical and mental health,reducing their quality of life.Pain and emotional state interact;however,their longitudinal interrelationship remains unclear.In this study,we applied a dual-trajectory model to assess how neck pain and emotional state evolve together over time and how clinical interventions,particularly acupuncture,influence these trajectories.AIM To investigate the longitudinal relationship between neck pain and emotional state in patients with cervical spondylosis.METHODS This prospective cohort study included 472 patients with cervical spondylosis from eight Chinese hospitals.Participants received acupuncture or medication and were followed up at baseline,and at 1,2,4,6,and 8 weeks.Neck pain and emotional distress were assessed using the Northwick Park Neck Pain Questionnaire(NPQ)and the affective subscale of the Short-Form McGill Pain Questionnaire(SF-MPQ),respectively.Group-based trajectory models and dual trajectory analysis were used to identify and correlate pain-emotion trajectories.Multivariate logistic regression identified predictors of group membership.RESULTS Three trajectory groups were identified for NPQ and SF-MPQ scores(low,medium,and high).Higher NPQ trajectory was associated with older age(OR=1.058,P<0.001)and was significantly reduced by acupuncture(OR=0.382,P<0.001).Similarly,acupuncture lowered the odds of high SF-MPQ trajectory membership(OR=0.336,P<0.001),while age increased it(OR=1.037,P<0.001).Dual-trajectory analysis revealed bidirectional associations:69.1%of patients with low NPQ had low SF-MPQ scores,and 42.6%of patients with high SF-MPQ also had high NPQ scores.Gender was a predictor for medium SF-MPQ trajectory(OR=1.629,P=0.094).Occupation and education levels differed significantly across the trajectory groups(P<0.05).CONCLUSION Over time,neck pain and emotional distress are closely associated in patients with cervical spondylosis.Acupuncture alleviates both outcomes significantly,while age is a risk factor.Integrated approaches to pain and emotional management are encouraged.展开更多
[Objectives]To intervene in cervical spondylosis of arterialtype(CSA)using moxibustion therapy,and analyze its clinical efficacy.[Methods]36 patients with CSA admitted to the Xingfu Yiyang Nursing Home from January to...[Objectives]To intervene in cervical spondylosis of arterialtype(CSA)using moxibustion therapy,and analyze its clinical efficacy.[Methods]36 patients with CSA admitted to the Xingfu Yiyang Nursing Home from January to July 2025 were selected as the research subjects.Moxibustion treatment was applied,and a retrospective analysis of the clinical efficacy was conducted on the patients.[Results]Among the 36 patients with CSA treated with moxibustion,28 cases showed significant improvement in symptoms,accounting for 77.78%;6 cases showed no significant improvement in symptoms,accounting for 22.22%;no ineffective cases were observed,and the total treatment effectiveness rate was 100%.Compared with those before treatment,both groups showed an increase in ESCV scores,a decrease in VAS scores,an increase in Vs and Vm,and a decrease in PI and RI after treatment(P<0.05).The changes were more significant in the observation group than in the control group(P<0.05).[Conclusions]Moxibustion therapy has significant therapeutic effects on CSA.Additionally,moxibustion therapy is easy to operate,has no side effects,and is highly safe,making it worthy of clinical promotion and application.展开更多
Objective To observe the influence of different acupoint combinations on immediate effect of surface electromyography of patients with cervical spondylosis, and to explore the interactions and laws among different acu...Objective To observe the influence of different acupoint combinations on immediate effect of surface electromyography of patients with cervical spondylosis, and to explore the interactions and laws among different acupoint combinations. Methods Acupuncture in three kinds of different acupoint combinations was conducted on 90 patients with cervical spondylosis（three groups）： group A [distal point selection group： Kūnlún（昆仑 BL 60） and Hòuxī（后溪 SI 3）]; group B [local point selection group： Fēngchí（风池 GB 20） and Tiānzhù（天柱 BL 10）]; group C（distal and local point selection group： BL 60, SI 3, GB 20 and BL 10）. Self control before and after treatment was adopted to observe the mean value of surface electromyography（SEMG） amplitude, to measure the mean values of integrated electromyography（IEMG） and electromyography root mean square（RMS）, and to calculate the variation rate of electromyography amplitude of trapezius on the affected side of patients before and after acupuncture. The differences of influences of different acupoint combinations on immediate effect of surface electromyography were compared intra-group, and the differences among the three groups after acupuncture were also compared. Results According to the intragroup comparison before and after acupuncture, the differences of mean value of electromyography amplitude, variation rate of electromyography amplitude, IEMG and RMS were both statistically significant（all P〈0.05）. According to the inter-group comparison after acupuncture, the mean value of electromyography amplitude, variation rate of electromyography amplitude, IEMG and RMS varied in different degrees, however, the differences were not significant（all P〉0.05）; there was no significant difference in the total effective rate among the three groups（P〉0.05）. Conclusion Acupuncture treatment in different acupoint combinations can increase IEMG and RMS and reduce mean value of electromyography amplitude and variation rate of electromyography amplitude, enhance cervical vertebral stability and active contractility of muscle fiber, and improve the fatigue resistance of neck flexion; while, the therapeutic effect of acupuncture on cervical spondylosis has nothing to do with the distance or the number of selected acupoint.展开更多
Objective To observe the clinical efficacy of transverse striation needling in treatment of cervical spondylosis.Method Thirty patients were diagnosed with cervical spondylosis in Guoyitang Clinic,Yanwu Branch of Zhon...Objective To observe the clinical efficacy of transverse striation needling in treatment of cervical spondylosis.Method Thirty patients were diagnosed with cervical spondylosis in Guoyitang Clinic,Yanwu Branch of Zhongshan Hospital,Xiamen University from July,2013 to March,2015,and were included into this study.Transverse striation needling,i.e.transverse insertion into the transverse striation of the cervical vertebra,was adopted for the 30 patients,and conventional acupuncture at Fēngchí（风池 GB 20,bilateral）,Jiānj？ng（肩井 GB 21,bilateral） and Jiānzhōngshù（肩中俞 SI 15,bilateral） was combined.The treatment was conducted for once a day,twice a week,and 6 times were needed in total.Follow-up visit was performed two months after the treatment.Result Among the 30 patients,the markedly effective rate was 70.0%（21/30）,effective rate was 30.0%（9/30）,and the total effective rate was 100.0%.There was no relapse during two months after the treatment.Conclusion The therapeutic effect of transverse striation needling in treatment of cervical spondylosis was good.展开更多
Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number...Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number table, 150 cases of cervical spondylosis of nerve root type were randomized into an acupuncture-moxibustion group （75 cases） and a control group （75 cases）. In the acupuncture-moxibustion group, the warm needling at EX-B 2 and tapping with plum-blossom needle were applied. EX-B 2 on the affected segments were selected and stimulated with warm needling technique for 20– 30 min. Afterward, the plum-blossom needle was used to tap the skin around the acupoints, for 3 min on each site. The treatment was given once every day. Seven treatments made one session. The interval between two sessions was 1 day. In the control group, the medication was used in combination with traction therapy. The intravenous drip with 5% glucose 250 mL and compound salvia miltiorrhiza injection 40 mL was used, once a day. In traction treatment, the patient was in a sitting position, neck anteflexion at 15°–30°, traction force at 10%–20% of the body mass, for 20–30 min in each time. The treatment was given once every day. The appointed person evaluated therapeutic effects after the three sessions of treatment in the two groups. Results The clinical curative rate was 49.3% （37/75） and the total effective rate was 94.7% （71/75） in the acupuncture-moxibustion group and those were 24.0% （18/75） and 81.3% （61/75） respectively in the control group. The total effective rate and clinical curative rate in the acupuncture-moxibustion group were superior to the control group （both P0.05）. In the comparison of the duration of treatment and effect in the cured patients between the two groups, the curative rate in the 1st session of treatment in the acupuncture-moxibustion group was higher than that in the control group （P0.05）. In the comparison of the 6-month follow-up visit in the cured patients between the two groups, the effect in the acupuncture-moxibustion group was much more stable （P0.05）. Conclusion The warm needling therapy at EX-B 2 and tapping therapy with plum-blossom needle achieve the significant effect on cervical spondylosis of nerve root type.展开更多
Objective To compare the differences in the efficacy on cervical spondylosis of the vertebral artery type （CSA） treated with the warm needling therapy combined with the rehabilitation physiotherapy, the simple warm ...Objective To compare the differences in the efficacy on cervical spondylosis of the vertebral artery type （CSA） treated with the warm needling therapy combined with the rehabilitation physiotherapy, the simple warm needling therapy and the simple rehabilitation physiotherapy separately and observe the impacts of them on the vertebral basilar artery （VBA） in hemodynamics. Methods Ninety cases of CSA patients were randomized divided into an acupuncture plus rehabilitation group, a warm needling group and a rehabilitation group, 30 cases in each. In the acupuncture ＋ rehabilitation group, the warm needling therapy was used at Jiájǐ （夹脊 EX-B 2） from C3 to C7 in combination with the rehabilitation physiotherapy such as traction and magnetic therapy. In the warm needling group, the simple warm needling therapy was applied. In the rehabilitation group, the simple rehabilitation physiotherapy was adopted. The VBA hemodynamic parameters, Vp, Vd, Vm and PI values were detected under the transcranial Doppler and taken as the indexes for the efficacy assessment of the groups. The efficacy of each group was assessed in association with the clinical curative rate. Results After treatment, the VBA hemodynamic parameters, Vp, Vd, Vm and PI values were all remarkably improved as compared with those before treatment in the three groups （P〈0.01, P〈0.05）. The improvement of the indexes in the acupuncture plus rehabilitation group were more significant as compared with either of the other two groups （all P〈0.01）. The clinical curative rate was 70.0% （21/30） in the acupuncture plus rehabilitation group, which was superior to 53.3% （16/30） in the warm needling group and 53.3% （16/30） in the rehabilitation group （all P〈0.01）. Conclusion The warm needling in combination with the rehabilitation physiotherapy significantly improves in VBA hemodynamic parameters for CSA and its clinical efficacy is superior to either the simple warm needling or the rehabilitation physiotherapy. Hence, this combined therapy was highly deserved to be promoted in clinical practice.展开更多
A case of amyotrophic cervical spondylosis was healed by using acupuncture in combination with electroacupuncture, needling was carried out on fengchi（风池 GB 20）, Tianzhu （天柱 BE 10）, Dazhui （大椎 GV 14）, Jian...A case of amyotrophic cervical spondylosis was healed by using acupuncture in combination with electroacupuncture, needling was carried out on fengchi（风池 GB 20）, Tianzhu （天柱 BE 10）, Dazhui （大椎 GV 14）, Jianjing （肩井GB 21）, Zhiyang （至阳 GV 9）, Jianzhen （肩贞SI 9）, Jianyu （肩髃 El 15）, Shousanli （手三里LI 10）, Houxi （后溪SI 3）, Kunlun （昆仑 BE 60） and Shugu （束骨 BL 65）. BL 10 on the left side and LI 10 on the right side, GB 20 on the right side and GV 9 were connected for electroacupuncture, once a day, 12 treatments as one treatment course, a interval of 5 days was set between two treatment courses, and totally 6 treatment courses were carried out. The patient was clinically healed after the treatment and the disease did not recur during the follow-up for six months.展开更多
Objective To observe the clinical effects of cervical spondylosis treated with electroacupuncture （EA）, cupping and TDP irradiation. Methods Ninety cases of mixed cervical spondylosis were randomized into 3 groups. ...Objective To observe the clinical effects of cervical spondylosis treated with electroacupuncture （EA）, cupping and TDP irradiation. Methods Ninety cases of mixed cervical spondylosis were randomized into 3 groups. Of which, in the treatment of observation group （30 cases）, the acupoints included Fengchi （风池 GB 20）, Jianjing （肩井GB 21）, Tianzong （天宗SI 11）, etc. EA, cupping and TDP irradiation were provided in combination. Two control groups were divided. In control group 1 （30 cases）, cervical traction was adopted in treatment. In control group 2 （30 cases）, stimulation with medium frequency was provided. In all of 3 groups, 5 treatments were given each week. 10 treatments made one course. The therapeutic effects of 3 groups were compared one course of treatment later. Resuits The total effective rate was 93.3% in observation group, 70.0% in control group 1 and 66.7% in control group 2. Significant differences were presented statistically in comparison between observation group and 2 control groups （both P〈0.05）. Conclusion The treatment with EA, cupping and TDP irradiation achieves quite satisfactory therapeutic effect on cervical spondylosis in clinical application.展开更多
Cervical spondylosis of vertebral artery type is one of the chief patterns of cervical spondylosis.It is often described as neck pain accompanied with radiating pain and neurologic symptoms,such as sudden dizziness,bl...Cervical spondylosis of vertebral artery type is one of the chief patterns of cervical spondylosis.It is often described as neck pain accompanied with radiating pain and neurologic symptoms,such as sudden dizziness,blurred vision,tinnitus,nausea,vomiting,memory loss,and sudden fainting.The incidence of cervical spondylosis increases and patients with cervical spondylosis become progressively younger.Acupuncture in the cervical spondylosis of vertebral artery type treatment has a local positive reaction“Liuhe point”,in order to dredge the local Qi and blood.More and more evidences into the effectiveness and safety of cervical spine acupuncture for cervical spondylosis,specific neck pain,cervical radiculopathy,etc.This article summarizes the recent literature on acupuncture and acupuncture combined with other therapies for cervical spondylosis of vertebral artery type treatment and provides a comprehensive review from the perspectives of acupuncture therapy,warm needle moxibustion therapy,electroacupuncture,and acupuncture combined with other therapies,in order to provide reference and reference for clinical treatment.展开更多
Objective To observe the clinical effect of blood-letting puncture and cupping at Chōngxiāo（冲霄 Extra） point of Dong＇s unique Extra-ordinary points in the treatment of neck type of cervical spondylosis.Methods S...Objective To observe the clinical effect of blood-letting puncture and cupping at Chōngxiāo（冲霄 Extra） point of Dong＇s unique Extra-ordinary points in the treatment of neck type of cervical spondylosis.Methods Sixty-five patients of neck type of cervical spondylosis were selected and treated with blood-letting puncture and cupping at Chōngxiāo（冲霄 Extra） point once every two or three days,three times constituted one course and two successive courses were given,then the clinical effect was evaluated.Results The curative rate was 69.2%（45/65）,and the total effective rate was 92.3%（60/65）.Conclusion Blood-letting puncture and cupping at Dong＇s Chōngxiāo（冲霄 Extra） point can be used to treat neck type of cervical spondylosis with simple manipulation and obvious efficacy.展开更多
OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP...OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP changes and therapeutic effectiveness, and provide evidence for outcome prediction and objective evaluation of CS treatment before and after acupuncture treatment. METHODS： Patients with CS were treated with acupuncture and measured with a pulse acquisition device based on image （PADBI） before the first and after the tenth acupuncture sessions. Changes in PDP from before until after the acupuncture sessions and patient impressions were analyzed to judge the effect of acupuncture treatment for. RESULTS： The PDP values in effective patients were closer to normal values. This indicated that Qi stagnation and blood stasis of the patients was improved. The PDP changes from before to after the first acupuncture treatment were more obvious than those from before to after the tenth acupunc- ture treatment. This result indicates that the speed of symptom improvement decreased significantly after several acupuncture courses. Analysis of correlation between efficacy and PDP showed that the changes in PDP in five patients was abnormal, which mainly manifested as values of hl, u, p, Pp, and tl, and no significant changes or differences were increased with standard values. This indicated that the symptoms of CS were not improved in these patients. CONCLUSION; PADBI can provide evidence for outcome prediction of acupuncture treatment in patients with CS. PADBI can provide evidence for objective evaluation of acupuncture treatment of CS.展开更多
OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twent...OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twenty six cervical spondylosis patients(vertebral artery type) were randomly divided into test and control groups.Patients in the test group were treated with innovative Tuina manipulations,while those in the control group were treated with the routine Tuina manipulations according to the textbook of Chinese Massage for Acupuncture and Moxibustion majors.The clinical effects,treatment times,clinical symptoms,and cerebral blood flow were measured.RESULTS:The response to the treatment was 100% in the test group and 88.71% in the control group.Patients in the test group required(7 ± 4) treatments before recovery,while those in the control group required(15 ± 7) treatments before recovery(P<0.05).The clinical symptoms exhibited greater improvement in the test group compared to the control group(P<0.05).There were no differences in cerebral blood flow between the two groups.CONCLUSION:Both innovative Tuina manipulations and routine Tuina manipulations produced satisfactory therapeutic results in vertebral artery type cervical spondylosis patients.However,the innovative manipulation was more effective in improving the functional symptoms,although there were no changes in the cerebral blood flow.展开更多
OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:T...OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis.展开更多
AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by d...AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and the cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls. c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10 most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P＜0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P＜0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by further studies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.展开更多
Objective To investigate the correlation between subaxial cervical spine instability and cervical spondylotic sympathetic symptoms as well as the difference of cervical spondylotic subaxial instability between male an...Objective To investigate the correlation between subaxial cervical spine instability and cervical spondylotic sympathetic symptoms as well as the difference of cervical spondylotic subaxial instability between male and female patients. Methods We analyzed retrospectively 318 surgical cases of cervical spondylosis treated at Department of Orthopedic Surgery of Peking Union Medical College Hospital between July 2003 and December 2007. All cases were divided into group A without sympathetic symptoms (n=284) and group B with sympathetic symptoms (n=34). Angular and horizontal translation values between two adjacent vertebral bodies from C2 to C7 were measured separately on hyperflexion and hyperextension lateral cervical spine radiographs. Fisher's exact test was used to evaluate the correlation between subaxial cervical instability and sympathetic symptoms. Intragroup correlation between patient gender and subaxial cervical instability was also evaluated. Results Subaxial instability incidences in groups A and B were 21.8% (62/284) and 55.9% (19/34), respectively. Statistical analysis indicated a definite correlation between subaxial cervical instability and sympathetic symptoms (P=0.000). Among patients without sympathetic symptoms, subaxial instability incidences were 21.4% (37/173) in males and 22.5% (25/111) in females, respectively (P=0.883). While among patients with sympathetic symptoms, subaxial instability incidences were 27.3% (3/11) in males and 69.6% (16/23) in females, respectively, indicating significant difference (P=0.030). Subaxial instability was most commonly seen at C4-C5 intervertebral space in sympathetic cervical spondylosis patients. Conclusions High correlation exists between subaxial cervical spine instability and cervical spondylotic sympathetic symptoms, especially in female patients. Hyperextension and hyperflexion radiographs of cervical spine are important to assess sympathetic cervical spondylotic subaxial instability.展开更多
Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division an...Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared "bounded" from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these "complications" of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI.展开更多
Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movem...Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movement therapy on 57 cases of cervical spondylosis(Group Acup.+M) was observed and compared with that of conventional acupuncture(Group Acup.) on 65 cases of cervical spondylosis with the same types of the disease during the same observation period as those treated by the former therapy.Results:The cured rate,effective rate and total effective rate were 52.63%,45.61% and 98.24%,respectively in Group Acup.+M;46.15%,50.77% and 96.92%,respectively in Group Acup.There were no significant differences in therapeutic effects between the two groups,shown by Ridit test(P>0.05).Conclusion:Both acupuncture plus movement therapy and conventional acupuncture were similarly effective in treating cervical spondylosis,but the former was superior to the latter in shorter treatment course and fewer points used.展开更多
Objective To observe the clinical efficacy of acupuncture at the superficial fascia for cervical type of cervical spondylosis. Methods Acupuncture at the superficial fascia was carried out for 48 patients with cervica...Objective To observe the clinical efficacy of acupuncture at the superficial fascia for cervical type of cervical spondylosis. Methods Acupuncture at the superficial fascia was carried out for 48 patients with cervical type of cervical spondylosis by selecting the tender points on both sides of the cervical vertebral body and on the neck and shoulders. The treatment was conducted for once a day and treatment for 5 times was considered as 1 course of treatment. Two days were free from treatment between courses, and 3 courses were needed in total. The scores of McGill pain questionnaire [MPQ, including three indexes： Pain rating index （PRI）, Visual analogue scale （VAS） and Present pain intensity （PPI） ] of patients before and after treatment were compared, therapeutic effct of cervical type of cervical spondylosis was evaluated. Results According to the comparison before and after treatment, the scores of PRI （29.44±9.26 vs13.15±7.04）, VAS （5.63±2.73 vs 1.23±1.15）, and PPI （3.00±1.24 vs 0.38±0.49） of patients with cervical type of cervical spondylosis reduced significantly （all P〈0.05）, indicating that the differences were statistically significant. Among 48 cases, cured 40 cases （83.33%）, markedly effective 4 cases （8.34%）, effective 3 cases （6.25%）, ineffective i case （2.08%）. The total effective rate was 97.92% （47/48）. Conclusion The curative effect of acupuncture at the superficial fascia for cervical type of cervical spondylosis was satisfactory.展开更多
基金Suppoorted by Sichuan Provincial Administration of Traditional Chinese Medicine Key Project of Scientific Research in Traditional Chinese Medicine:Deep Learning-based Three-dimensional Finite Element Analysis of Pestle Needle Therapy for the Treatment of Cervical Spine Physiologic Curvature Abnormalities(2023zd025)Scientific Research Project of Sichuan Provincial Science and Technology Department:Improvement of cartilage Degeneration in Knee Osteoarthritis by Regulating Zn^(2+)Homeostasis via Autophagy in Duhuo Jisheng Decoction(23NFSC2298)。
文摘OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.
文摘BACKGROUND Cervical spondylosis(CS)frequently co-occurs with generalized anxiety disorder(GAD),presenting a complex clinical challenge.Managing CS-related pain in patients with GAD is particularly challenging because of the bidirectional relationship between pain and anxiety,necessitating integrated treatment strategies.AIM To evaluate the efficacy of electroacupuncture(EA)in treating CS-related pain and anxiety in patients with GAD.METHODS This retrospective cohort study analyzed data from 83 patients with CS-related pain and GAD who received EA treatment over 2-year period.Pain intensity was assessed using the visual analog scale,and anxiety symptoms were measured using the Hamilton Anxiety Rating Scale.Additionally,neuroinflammatory markers,including interleukin-6,tumor necrosis factor-alpha,and high-sensitivity C-reactive protein,were examined.Outcomes were evaluated at baseline,after 4 weeks,and after 8 weeks of treatment.RESULTS EA treatment significantly reduced CS-related pain(mean visual analog scale reduction:3.24±1.18;P<0.001)and improved anxiety symptoms(mean Hamilton Anxiety Rating Scale reduction:7.83±2.65;P<0.001)after 8 weeks of treatment.Neuroinflammatory markers also showed significant reductions,with interleukin-6 and tumor necrosis factor-alpha levels decreasing by 32.7%and 28.5%,respectively(P<0.01).Pain reduction was significantly correlated with improvements in anxiety symptoms(r=0.68;P<0.001)and a decrease in inflammatory markers(r=0.54;P<0.01).CONCLUSION EA demonstrates significant efficacy in reducing CS-related pain in patients with comorbid GAD,along with concurrent improvements in anxiety symptoms and neuroinflammatory profiles.These findings suggest that EA may offer a valuable integrative approach for managing this complex clinical presentation,potentially addressing both pain and anxiety through the modulation of neuroinflammatory pathways.
基金Supported by 2022 Chinese Medicine Scientific Research Project of Hebei Administration of Traditional Chinese Medicine,No.20221572025 Annual Scientific Research Project of Higher Education Institutions in Hebei Province,No.QN2025654.
文摘BACKGROUND Neck pain,a primary symptom of cervical spondylosis,affects patients'physical and mental health,reducing their quality of life.Pain and emotional state interact;however,their longitudinal interrelationship remains unclear.In this study,we applied a dual-trajectory model to assess how neck pain and emotional state evolve together over time and how clinical interventions,particularly acupuncture,influence these trajectories.AIM To investigate the longitudinal relationship between neck pain and emotional state in patients with cervical spondylosis.METHODS This prospective cohort study included 472 patients with cervical spondylosis from eight Chinese hospitals.Participants received acupuncture or medication and were followed up at baseline,and at 1,2,4,6,and 8 weeks.Neck pain and emotional distress were assessed using the Northwick Park Neck Pain Questionnaire(NPQ)and the affective subscale of the Short-Form McGill Pain Questionnaire(SF-MPQ),respectively.Group-based trajectory models and dual trajectory analysis were used to identify and correlate pain-emotion trajectories.Multivariate logistic regression identified predictors of group membership.RESULTS Three trajectory groups were identified for NPQ and SF-MPQ scores(low,medium,and high).Higher NPQ trajectory was associated with older age(OR=1.058,P<0.001)and was significantly reduced by acupuncture(OR=0.382,P<0.001).Similarly,acupuncture lowered the odds of high SF-MPQ trajectory membership(OR=0.336,P<0.001),while age increased it(OR=1.037,P<0.001).Dual-trajectory analysis revealed bidirectional associations:69.1%of patients with low NPQ had low SF-MPQ scores,and 42.6%of patients with high SF-MPQ also had high NPQ scores.Gender was a predictor for medium SF-MPQ trajectory(OR=1.629,P=0.094).Occupation and education levels differed significantly across the trajectory groups(P<0.05).CONCLUSION Over time,neck pain and emotional distress are closely associated in patients with cervical spondylosis.Acupuncture alleviates both outcomes significantly,while age is a risk factor.Integrated approaches to pain and emotional management are encouraged.
文摘[Objectives]To intervene in cervical spondylosis of arterialtype(CSA)using moxibustion therapy,and analyze its clinical efficacy.[Methods]36 patients with CSA admitted to the Xingfu Yiyang Nursing Home from January to July 2025 were selected as the research subjects.Moxibustion treatment was applied,and a retrospective analysis of the clinical efficacy was conducted on the patients.[Results]Among the 36 patients with CSA treated with moxibustion,28 cases showed significant improvement in symptoms,accounting for 77.78%;6 cases showed no significant improvement in symptoms,accounting for 22.22%;no ineffective cases were observed,and the total treatment effectiveness rate was 100%.Compared with those before treatment,both groups showed an increase in ESCV scores,a decrease in VAS scores,an increase in Vs and Vm,and a decrease in PI and RI after treatment(P<0.05).The changes were more significant in the observation group than in the control group(P<0.05).[Conclusions]Moxibustion therapy has significant therapeutic effects on CSA.Additionally,moxibustion therapy is easy to operate,has no side effects,and is highly safe,making it worthy of clinical promotion and application.
基金Supported by “The 12th five-year plan” programmed project of educational science in Hubei Province:2014B095
文摘Objective To observe the influence of different acupoint combinations on immediate effect of surface electromyography of patients with cervical spondylosis, and to explore the interactions and laws among different acupoint combinations. Methods Acupuncture in three kinds of different acupoint combinations was conducted on 90 patients with cervical spondylosis（three groups）： group A [distal point selection group： Kūnlún（昆仑 BL 60） and Hòuxī（后溪 SI 3）]; group B [local point selection group： Fēngchí（风池 GB 20） and Tiānzhù（天柱 BL 10）]; group C（distal and local point selection group： BL 60, SI 3, GB 20 and BL 10）. Self control before and after treatment was adopted to observe the mean value of surface electromyography（SEMG） amplitude, to measure the mean values of integrated electromyography（IEMG） and electromyography root mean square（RMS）, and to calculate the variation rate of electromyography amplitude of trapezius on the affected side of patients before and after acupuncture. The differences of influences of different acupoint combinations on immediate effect of surface electromyography were compared intra-group, and the differences among the three groups after acupuncture were also compared. Results According to the intragroup comparison before and after acupuncture, the differences of mean value of electromyography amplitude, variation rate of electromyography amplitude, IEMG and RMS were both statistically significant（all P〈0.05）. According to the inter-group comparison after acupuncture, the mean value of electromyography amplitude, variation rate of electromyography amplitude, IEMG and RMS varied in different degrees, however, the differences were not significant（all P〉0.05）; there was no significant difference in the total effective rate among the three groups（P〉0.05）. Conclusion Acupuncture treatment in different acupoint combinations can increase IEMG and RMS and reduce mean value of electromyography amplitude and variation rate of electromyography amplitude, enhance cervical vertebral stability and active contractility of muscle fiber, and improve the fatigue resistance of neck flexion; while, the therapeutic effect of acupuncture on cervical spondylosis has nothing to do with the distance or the number of selected acupoint.
文摘Objective To observe the clinical efficacy of transverse striation needling in treatment of cervical spondylosis.Method Thirty patients were diagnosed with cervical spondylosis in Guoyitang Clinic,Yanwu Branch of Zhongshan Hospital,Xiamen University from July,2013 to March,2015,and were included into this study.Transverse striation needling,i.e.transverse insertion into the transverse striation of the cervical vertebra,was adopted for the 30 patients,and conventional acupuncture at Fēngchí（风池 GB 20,bilateral）,Jiānj？ng（肩井 GB 21,bilateral） and Jiānzhōngshù（肩中俞 SI 15,bilateral） was combined.The treatment was conducted for once a day,twice a week,and 6 times were needed in total.Follow-up visit was performed two months after the treatment.Result Among the 30 patients,the markedly effective rate was 70.0%（21/30）,effective rate was 30.0%（9/30）,and the total effective rate was 100.0%.There was no relapse during two months after the treatment.Conclusion The therapeutic effect of transverse striation needling in treatment of cervical spondylosis was good.
文摘Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number table, 150 cases of cervical spondylosis of nerve root type were randomized into an acupuncture-moxibustion group （75 cases） and a control group （75 cases）. In the acupuncture-moxibustion group, the warm needling at EX-B 2 and tapping with plum-blossom needle were applied. EX-B 2 on the affected segments were selected and stimulated with warm needling technique for 20– 30 min. Afterward, the plum-blossom needle was used to tap the skin around the acupoints, for 3 min on each site. The treatment was given once every day. Seven treatments made one session. The interval between two sessions was 1 day. In the control group, the medication was used in combination with traction therapy. The intravenous drip with 5% glucose 250 mL and compound salvia miltiorrhiza injection 40 mL was used, once a day. In traction treatment, the patient was in a sitting position, neck anteflexion at 15°–30°, traction force at 10%–20% of the body mass, for 20–30 min in each time. The treatment was given once every day. The appointed person evaluated therapeutic effects after the three sessions of treatment in the two groups. Results The clinical curative rate was 49.3% （37/75） and the total effective rate was 94.7% （71/75） in the acupuncture-moxibustion group and those were 24.0% （18/75） and 81.3% （61/75） respectively in the control group. The total effective rate and clinical curative rate in the acupuncture-moxibustion group were superior to the control group （both P0.05）. In the comparison of the duration of treatment and effect in the cured patients between the two groups, the curative rate in the 1st session of treatment in the acupuncture-moxibustion group was higher than that in the control group （P0.05）. In the comparison of the 6-month follow-up visit in the cured patients between the two groups, the effect in the acupuncture-moxibustion group was much more stable （P0.05）. Conclusion The warm needling therapy at EX-B 2 and tapping therapy with plum-blossom needle achieve the significant effect on cervical spondylosis of nerve root type.
文摘Objective To compare the differences in the efficacy on cervical spondylosis of the vertebral artery type （CSA） treated with the warm needling therapy combined with the rehabilitation physiotherapy, the simple warm needling therapy and the simple rehabilitation physiotherapy separately and observe the impacts of them on the vertebral basilar artery （VBA） in hemodynamics. Methods Ninety cases of CSA patients were randomized divided into an acupuncture plus rehabilitation group, a warm needling group and a rehabilitation group, 30 cases in each. In the acupuncture ＋ rehabilitation group, the warm needling therapy was used at Jiájǐ （夹脊 EX-B 2） from C3 to C7 in combination with the rehabilitation physiotherapy such as traction and magnetic therapy. In the warm needling group, the simple warm needling therapy was applied. In the rehabilitation group, the simple rehabilitation physiotherapy was adopted. The VBA hemodynamic parameters, Vp, Vd, Vm and PI values were detected under the transcranial Doppler and taken as the indexes for the efficacy assessment of the groups. The efficacy of each group was assessed in association with the clinical curative rate. Results After treatment, the VBA hemodynamic parameters, Vp, Vd, Vm and PI values were all remarkably improved as compared with those before treatment in the three groups （P〈0.01, P〈0.05）. The improvement of the indexes in the acupuncture plus rehabilitation group were more significant as compared with either of the other two groups （all P〈0.01）. The clinical curative rate was 70.0% （21/30） in the acupuncture plus rehabilitation group, which was superior to 53.3% （16/30） in the warm needling group and 53.3% （16/30） in the rehabilitation group （all P〈0.01）. Conclusion The warm needling in combination with the rehabilitation physiotherapy significantly improves in VBA hemodynamic parameters for CSA and its clinical efficacy is superior to either the simple warm needling or the rehabilitation physiotherapy. Hence, this combined therapy was highly deserved to be promoted in clinical practice.
文摘A case of amyotrophic cervical spondylosis was healed by using acupuncture in combination with electroacupuncture, needling was carried out on fengchi（风池 GB 20）, Tianzhu （天柱 BE 10）, Dazhui （大椎 GV 14）, Jianjing （肩井GB 21）, Zhiyang （至阳 GV 9）, Jianzhen （肩贞SI 9）, Jianyu （肩髃 El 15）, Shousanli （手三里LI 10）, Houxi （后溪SI 3）, Kunlun （昆仑 BE 60） and Shugu （束骨 BL 65）. BL 10 on the left side and LI 10 on the right side, GB 20 on the right side and GV 9 were connected for electroacupuncture, once a day, 12 treatments as one treatment course, a interval of 5 days was set between two treatment courses, and totally 6 treatment courses were carried out. The patient was clinically healed after the treatment and the disease did not recur during the follow-up for six months.
文摘Objective To observe the clinical effects of cervical spondylosis treated with electroacupuncture （EA）, cupping and TDP irradiation. Methods Ninety cases of mixed cervical spondylosis were randomized into 3 groups. Of which, in the treatment of observation group （30 cases）, the acupoints included Fengchi （风池 GB 20）, Jianjing （肩井GB 21）, Tianzong （天宗SI 11）, etc. EA, cupping and TDP irradiation were provided in combination. Two control groups were divided. In control group 1 （30 cases）, cervical traction was adopted in treatment. In control group 2 （30 cases）, stimulation with medium frequency was provided. In all of 3 groups, 5 treatments were given each week. 10 treatments made one course. The therapeutic effects of 3 groups were compared one course of treatment later. Resuits The total effective rate was 93.3% in observation group, 70.0% in control group 1 and 66.7% in control group 2. Significant differences were presented statistically in comparison between observation group and 2 control groups （both P〈0.05）. Conclusion The treatment with EA, cupping and TDP irradiation achieves quite satisfactory therapeutic effect on cervical spondylosis in clinical application.
文摘Cervical spondylosis of vertebral artery type is one of the chief patterns of cervical spondylosis.It is often described as neck pain accompanied with radiating pain and neurologic symptoms,such as sudden dizziness,blurred vision,tinnitus,nausea,vomiting,memory loss,and sudden fainting.The incidence of cervical spondylosis increases and patients with cervical spondylosis become progressively younger.Acupuncture in the cervical spondylosis of vertebral artery type treatment has a local positive reaction“Liuhe point”,in order to dredge the local Qi and blood.More and more evidences into the effectiveness and safety of cervical spine acupuncture for cervical spondylosis,specific neck pain,cervical radiculopathy,etc.This article summarizes the recent literature on acupuncture and acupuncture combined with other therapies for cervical spondylosis of vertebral artery type treatment and provides a comprehensive review from the perspectives of acupuncture therapy,warm needle moxibustion therapy,electroacupuncture,and acupuncture combined with other therapies,in order to provide reference and reference for clinical treatment.
文摘Objective To observe the clinical effect of blood-letting puncture and cupping at Chōngxiāo（冲霄 Extra） point of Dong＇s unique Extra-ordinary points in the treatment of neck type of cervical spondylosis.Methods Sixty-five patients of neck type of cervical spondylosis were selected and treated with blood-letting puncture and cupping at Chōngxiāo（冲霄 Extra） point once every two or three days,three times constituted one course and two successive courses were given,then the clinical effect was evaluated.Results The curative rate was 69.2%（45/65）,and the total effective rate was 92.3%（60/65）.Conclusion Blood-letting puncture and cupping at Dong＇s Chōngxiāo（冲霄 Extra） point can be used to treat neck type of cervical spondylosis with simple manipulation and obvious efficacy.
基金Supported by the National Natural Science Foundation of China(Study on the Formation and Influencing Factors of the Pulse in Traditional Chinese Medicine,No.81173202)National Basic Research Program of China(973 program,Study on the Original Thoughts of Traditional Chinese Medicine and the System of Recognition Methods of Health State,No.2011CB505406)Natural Science Foundation of Tianjin(the Theory and Methods of Objective Evaluation of Chinese Medicine Efficacy on Major Diseases,No.10JCZDJC20000)
文摘OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP changes and therapeutic effectiveness, and provide evidence for outcome prediction and objective evaluation of CS treatment before and after acupuncture treatment. METHODS： Patients with CS were treated with acupuncture and measured with a pulse acquisition device based on image （PADBI） before the first and after the tenth acupuncture sessions. Changes in PDP from before until after the acupuncture sessions and patient impressions were analyzed to judge the effect of acupuncture treatment for. RESULTS： The PDP values in effective patients were closer to normal values. This indicated that Qi stagnation and blood stasis of the patients was improved. The PDP changes from before to after the first acupuncture treatment were more obvious than those from before to after the tenth acupunc- ture treatment. This result indicates that the speed of symptom improvement decreased significantly after several acupuncture courses. Analysis of correlation between efficacy and PDP showed that the changes in PDP in five patients was abnormal, which mainly manifested as values of hl, u, p, Pp, and tl, and no significant changes or differences were increased with standard values. This indicated that the symptoms of CS were not improved in these patients. CONCLUSION; PADBI can provide evidence for outcome prediction of acupuncture treatment in patients with CS. PADBI can provide evidence for objective evaluation of acupuncture treatment of CS.
基金Supported by the Fund of Capital Medical Development and Research(No.Ⅲ-11)the Subject Growth Fund of Guang'anmen Hospital,China Academy of Chinese Medical Sciences(No.81392)
文摘OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twenty six cervical spondylosis patients(vertebral artery type) were randomly divided into test and control groups.Patients in the test group were treated with innovative Tuina manipulations,while those in the control group were treated with the routine Tuina manipulations according to the textbook of Chinese Massage for Acupuncture and Moxibustion majors.The clinical effects,treatment times,clinical symptoms,and cerebral blood flow were measured.RESULTS:The response to the treatment was 100% in the test group and 88.71% in the control group.Patients in the test group required(7 ± 4) treatments before recovery,while those in the control group required(15 ± 7) treatments before recovery(P<0.05).The clinical symptoms exhibited greater improvement in the test group compared to the control group(P<0.05).There were no differences in cerebral blood flow between the two groups.CONCLUSION:Both innovative Tuina manipulations and routine Tuina manipulations produced satisfactory therapeutic results in vertebral artery type cervical spondylosis patients.However,the innovative manipulation was more effective in improving the functional symptoms,although there were no changes in the cerebral blood flow.
文摘OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis.
基金Supported by the Medical Research Fund of Guangdong Province, No. A2004434
文摘AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and the cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls. c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10 most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P＜0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P＜0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by further studies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.
文摘Objective To investigate the correlation between subaxial cervical spine instability and cervical spondylotic sympathetic symptoms as well as the difference of cervical spondylotic subaxial instability between male and female patients. Methods We analyzed retrospectively 318 surgical cases of cervical spondylosis treated at Department of Orthopedic Surgery of Peking Union Medical College Hospital between July 2003 and December 2007. All cases were divided into group A without sympathetic symptoms (n=284) and group B with sympathetic symptoms (n=34). Angular and horizontal translation values between two adjacent vertebral bodies from C2 to C7 were measured separately on hyperflexion and hyperextension lateral cervical spine radiographs. Fisher's exact test was used to evaluate the correlation between subaxial cervical instability and sympathetic symptoms. Intragroup correlation between patient gender and subaxial cervical instability was also evaluated. Results Subaxial instability incidences in groups A and B were 21.8% (62/284) and 55.9% (19/34), respectively. Statistical analysis indicated a definite correlation between subaxial cervical instability and sympathetic symptoms (P=0.000). Among patients without sympathetic symptoms, subaxial instability incidences were 21.4% (37/173) in males and 22.5% (25/111) in females, respectively (P=0.883). While among patients with sympathetic symptoms, subaxial instability incidences were 27.3% (3/11) in males and 69.6% (16/23) in females, respectively, indicating significant difference (P=0.030). Subaxial instability was most commonly seen at C4-C5 intervertebral space in sympathetic cervical spondylosis patients. Conclusions High correlation exists between subaxial cervical spine instability and cervical spondylotic sympathetic symptoms, especially in female patients. Hyperextension and hyperflexion radiographs of cervical spine are important to assess sympathetic cervical spondylotic subaxial instability.
文摘Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared "bounded" from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these "complications" of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI.
基金supported by a grant from National Natural Science Foundation of China (No 30772839, No30873302)
文摘Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movement therapy on 57 cases of cervical spondylosis(Group Acup.+M) was observed and compared with that of conventional acupuncture(Group Acup.) on 65 cases of cervical spondylosis with the same types of the disease during the same observation period as those treated by the former therapy.Results:The cured rate,effective rate and total effective rate were 52.63%,45.61% and 98.24%,respectively in Group Acup.+M;46.15%,50.77% and 96.92%,respectively in Group Acup.There were no significant differences in therapeutic effects between the two groups,shown by Ridit test(P>0.05).Conclusion:Both acupuncture plus movement therapy and conventional acupuncture were similarly effective in treating cervical spondylosis,but the former was superior to the latter in shorter treatment course and fewer points used.
基金Supported by Project of Academic School Studio of Zheng’s Acupuncture Manipulation in GansuState Administration of Traditional Chinese Medicine of the People’s Republic of China:2305135901
文摘Objective To observe the clinical efficacy of acupuncture at the superficial fascia for cervical type of cervical spondylosis. Methods Acupuncture at the superficial fascia was carried out for 48 patients with cervical type of cervical spondylosis by selecting the tender points on both sides of the cervical vertebral body and on the neck and shoulders. The treatment was conducted for once a day and treatment for 5 times was considered as 1 course of treatment. Two days were free from treatment between courses, and 3 courses were needed in total. The scores of McGill pain questionnaire [MPQ, including three indexes： Pain rating index （PRI）, Visual analogue scale （VAS） and Present pain intensity （PPI） ] of patients before and after treatment were compared, therapeutic effct of cervical type of cervical spondylosis was evaluated. Results According to the comparison before and after treatment, the scores of PRI （29.44±9.26 vs13.15±7.04）, VAS （5.63±2.73 vs 1.23±1.15）, and PPI （3.00±1.24 vs 0.38±0.49） of patients with cervical type of cervical spondylosis reduced significantly （all P〈0.05）, indicating that the differences were statistically significant. Among 48 cases, cured 40 cases （83.33%）, markedly effective 4 cases （8.34%）, effective 3 cases （6.25%）, ineffective i case （2.08%）. The total effective rate was 97.92% （47/48）. Conclusion The curative effect of acupuncture at the superficial fascia for cervical type of cervical spondylosis was satisfactory.
