SPIN1(spindlin 1)是一种组蛋白修饰阅读器蛋白,通过识别组蛋白H3第4位赖氨酸三甲基化(trimethylation of lysine 4 on histone H3 protein subunit,H3K4me3)促进核糖体RNA的表达,从而影响表观遗传的调控,以此发挥其生物学作用。SPIN1...SPIN1(spindlin 1)是一种组蛋白修饰阅读器蛋白,通过识别组蛋白H3第4位赖氨酸三甲基化(trimethylation of lysine 4 on histone H3 protein subunit,H3K4me3)促进核糖体RNA的表达,从而影响表观遗传的调控,以此发挥其生物学作用。SPIN1在多种恶性肿瘤中过表达,可受多种长链非编码RNA(long non-coding RNA,lncRNA)、微RNA(microRNA,miRNA)及环状RNA(circularRNA,circRNA)的负向调控,并可由转录因子腺病毒E2因子1(adenovirus E2 factor 1,E2F1)转录激活,通过Wnt、磷脂酰肌醇3激酶/蛋白激酶B(phosphatidylinositol 3-kinase/protein kinase B,PI3K/Akt)、转染过程重排(rearrangement during transfection,RET)因子、鼠双微体基因-p53(murine double minute 2-p53,MDM2-p53)等与肿瘤发生相关的信号通路,促进肿瘤的发生、发展,并与不良预后密切相关。随着对SPIN1的研究越来越深入,发现SPIN1可作为多种恶性肿瘤治疗的潜在靶点。目前已开发出针对SPIN1和H3K4me3间相互作用的抑制剂,以此阻断SPIN1的致癌能力。展开更多
Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of S...Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of SPIN1 remains unclear.Here,we demonstrated that SPIN1 can form phase-separated and liquid-like condensates both in vitro and in vivo through its N-terminal intrinsically disordered region(IDR).The phase separation of SPIN1 recruits the histone methyltransferase MLL1 to the same condensates and enriches the H3K4 methylation marks.This process also facilitates the binding of SPIN1 to H3K4me3 and activates tumorigenesis-related genes.Moreover,SPIN1-IDR enhances the genome-wide chromatin binding of SPIN1 and facilitates its localization to genes associated with the MAPK signaling pathway.These findings provide new insights into the biological function of the IDR in regulating SPIN1 activity and reveal a previously unrecognized role of SPIN1-IDR in histone methylation readout.Our study uncovers the crucial role of appropriate biophysical properties of SPIN1 in facilitating gene expression and links phase separation to tumorigenesis,which provides a new perspective for understanding the function of SPIN1.展开更多
Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were...Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were included in this study. These patients were with documented primary tumors. Four MR pulse sequences, T1-weighted spin echo (T1WI SE), T2-weighted fast spin echo (T2WI FSE), short time inversion recovery (STIR), and gradient echo 2-D multi echo data imaging combination (GE Me-2D) were used to detect spinal metastasis. Results Fifteen vertebral bodies were entire involvement, 38 vertebral bodies were section involvement, and totally 53 vertebral bodies were involved. There were 19 focal infections in pedicle of vertebral arch, 15 metastases in spinous process and transverse process. Fifty-three vertebral bodies were abnormal in T1WI SE and GE Me-2D, 35 vertebral bodies were found abnormal in T2WI FSE, and 50 vertebral bodies were found abnormal in STIR. The verges of focal signal of involved vertebral bodies were comparatively clear in T1WI SE, comparatively clear or vague in T2WI FSE, vague in STIR, and clear in GE Me-2D.Conclusions GE Me-2D may be the most sensitive technique to detect metastases. So three sequences (T1WI SE, T2WI FSE, GE Me-2D) can demonstrate the early changes of spinal metastasis roundly.展开更多
In this paper, an algorithm to produce a transition matrix between all states in ideal anti-paramagetic system under the simulated annealing condition that only moves to lower energy states are accepted. The check the...In this paper, an algorithm to produce a transition matrix between all states in ideal anti-paramagetic system under the simulated annealing condition that only moves to lower energy states are accepted. The check the accuracy of the transition matrix is confirmed by computer simulation, showing close agreement between model and simulation results.展开更多
Experiments including C-13 spin-lattice relaxation, C-13 heteronuclear dipolar dephasing and H-1 spin diffusion are performed on poly (2,6-dimethyl-1,4-phenylene oxide) (PPO). The results show that the rotation of the...Experiments including C-13 spin-lattice relaxation, C-13 heteronuclear dipolar dephasing and H-1 spin diffusion are performed on poly (2,6-dimethyl-1,4-phenylene oxide) (PPO). The results show that the rotation of the methyl groups in solid PPO is partially restricted, which results in a surprisingly efficient spin diffusion between the aromatic proton and methyl proton characterized by a diffusion time of 150 mu s. The results also show that the aromatic ring in solid PPO is rigid and twisted, which causes all aromatic carbons to be chemically unequivalent.展开更多
C NMR spin-lattice relaxation times (T1), line widths, nuclear Overhauser effects (NOE) at room temperature have been measured for radiated ets 1,4-polybutadiene.With the increase of radiation dose T1 is almost invari...C NMR spin-lattice relaxation times (T1), line widths, nuclear Overhauser effects (NOE) at room temperature have been measured for radiated ets 1,4-polybutadiene.With the increase of radiation dose T1 is almost invariant, but line width of the methylene (-CH2-) carbon increases remarkably, and its NOE factor decreases sharply. This implies that the long-range segmental motion is hindered, and saturated tertiary carbon (-C H- ) is formed during crosslinking of ets 1,4-polybutadiene.展开更多
The recent discovery of hidden spin polarization emerging in layered materials of specific nonmagnetic crystal is a fascinating phenomenon, though hardly explored yet. Here, we have studied hidden spin tex- tures in l...The recent discovery of hidden spin polarization emerging in layered materials of specific nonmagnetic crystal is a fascinating phenomenon, though hardly explored yet. Here, we have studied hidden spin tex- tures in layered nonmagnetic 1 T-phase transition-metal dichalcogenides MX2 （M = Zr, Hf; X = S, Se, Te） by using first-principles calculations. Spin-layer locking effect, namely, energy-degenerate opposite spins spatially separated in the top and bottom layer respectively, has been identified. In particular, the hidden spin polarization of 13-band can be easily probed, which is strongly affected by the strength of spin-orbit coupling. The hidden spin polarization of k-band locating at high symmetry M point （conduction band minimum） has a strong anisotropy. In the bilayer, the hidden spin polarization is preserved at the upmost Se layer, while being suppressed if the ZrSe2 layer is taken as the symmetry partner. Our results on hidden spin polarization in 1 T-phase dichalcogenides, verifiable by spin-resolved and angle-resolved photoemis- sion spectroscopy （ARPES）, enrich our understanding of spin physics and provide important clues to search for specific spin polarization in two dimensional materials for spintronic and quantum informa- tion applications.展开更多
In this paper,we investigate the controllability of spin 1 systems and the realization of ternary gates.Using dipole and quadrupole operators as the orthogonal basis of su(3) algebra,we discuss the controllability of ...In this paper,we investigate the controllability of spin 1 systems and the realization of ternary gates.Using dipole and quadrupole operators as the orthogonal basis of su(3) algebra,we discuss the controllability of one spin 1 systems and offer the concept of a complete set of control operators first.Then we present the controllability of two spin 1 systems coupled with Ising interaction and the transforming relations of the drift process of the system.Finally the specific realization of the ternary SWAP gate in these systems is discussed.It takes 9 drift processes and 25 basic control processes.展开更多
Manufacturing and sales According to data collected from 11,934 statistics-worthy Chinese cotton spinning enterprises surveyed by National Bureau of Statistics of China, total industrial production value of the indust...Manufacturing and sales According to data collected from 11,934 statistics-worthy Chinese cotton spinning enterprises surveyed by National Bureau of Statistics of China, total industrial production value of the industry increased 27.39展开更多
基金National Natural Science Foundation of China(32071277)Science and Technology Program of Hebei Province(216Z2602G)+1 种基金Natural Science Foundation of Hebei Province(C2021201012)Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006).
文摘Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of SPIN1 remains unclear.Here,we demonstrated that SPIN1 can form phase-separated and liquid-like condensates both in vitro and in vivo through its N-terminal intrinsically disordered region(IDR).The phase separation of SPIN1 recruits the histone methyltransferase MLL1 to the same condensates and enriches the H3K4 methylation marks.This process also facilitates the binding of SPIN1 to H3K4me3 and activates tumorigenesis-related genes.Moreover,SPIN1-IDR enhances the genome-wide chromatin binding of SPIN1 and facilitates its localization to genes associated with the MAPK signaling pathway.These findings provide new insights into the biological function of the IDR in regulating SPIN1 activity and reveal a previously unrecognized role of SPIN1-IDR in histone methylation readout.Our study uncovers the crucial role of appropriate biophysical properties of SPIN1 in facilitating gene expression and links phase separation to tumorigenesis,which provides a new perspective for understanding the function of SPIN1.
文摘Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were included in this study. These patients were with documented primary tumors. Four MR pulse sequences, T1-weighted spin echo (T1WI SE), T2-weighted fast spin echo (T2WI FSE), short time inversion recovery (STIR), and gradient echo 2-D multi echo data imaging combination (GE Me-2D) were used to detect spinal metastasis. Results Fifteen vertebral bodies were entire involvement, 38 vertebral bodies were section involvement, and totally 53 vertebral bodies were involved. There were 19 focal infections in pedicle of vertebral arch, 15 metastases in spinous process and transverse process. Fifty-three vertebral bodies were abnormal in T1WI SE and GE Me-2D, 35 vertebral bodies were found abnormal in T2WI FSE, and 50 vertebral bodies were found abnormal in STIR. The verges of focal signal of involved vertebral bodies were comparatively clear in T1WI SE, comparatively clear or vague in T2WI FSE, vague in STIR, and clear in GE Me-2D.Conclusions GE Me-2D may be the most sensitive technique to detect metastases. So three sequences (T1WI SE, T2WI FSE, GE Me-2D) can demonstrate the early changes of spinal metastasis roundly.
文摘In this paper, an algorithm to produce a transition matrix between all states in ideal anti-paramagetic system under the simulated annealing condition that only moves to lower energy states are accepted. The check the accuracy of the transition matrix is confirmed by computer simulation, showing close agreement between model and simulation results.
文摘Experiments including C-13 spin-lattice relaxation, C-13 heteronuclear dipolar dephasing and H-1 spin diffusion are performed on poly (2,6-dimethyl-1,4-phenylene oxide) (PPO). The results show that the rotation of the methyl groups in solid PPO is partially restricted, which results in a surprisingly efficient spin diffusion between the aromatic proton and methyl proton characterized by a diffusion time of 150 mu s. The results also show that the aromatic ring in solid PPO is rigid and twisted, which causes all aromatic carbons to be chemically unequivalent.
文摘C NMR spin-lattice relaxation times (T1), line widths, nuclear Overhauser effects (NOE) at room temperature have been measured for radiated ets 1,4-polybutadiene.With the increase of radiation dose T1 is almost invariant, but line width of the methylene (-CH2-) carbon increases remarkably, and its NOE factor decreases sharply. This implies that the long-range segmental motion is hindered, and saturated tertiary carbon (-C H- ) is formed during crosslinking of ets 1,4-polybutadiene.
基金financially supported by the National Basic Research Program of China (2015CB921001, 2013CBA01600, and 2016YFA0300902)the National Natural Science Foundation of China (61306114)+2 种基金‘‘Strategic Priority Research Program (B)" of Chinese Academy of Sciences (XDB07030100)the National Natural Science Foundation of China Academy of Engineering Physics (U1430117)the Science Challenge Project (TZ2016001)
文摘The recent discovery of hidden spin polarization emerging in layered materials of specific nonmagnetic crystal is a fascinating phenomenon, though hardly explored yet. Here, we have studied hidden spin tex- tures in layered nonmagnetic 1 T-phase transition-metal dichalcogenides MX2 （M = Zr, Hf; X = S, Se, Te） by using first-principles calculations. Spin-layer locking effect, namely, energy-degenerate opposite spins spatially separated in the top and bottom layer respectively, has been identified. In particular, the hidden spin polarization of 13-band can be easily probed, which is strongly affected by the strength of spin-orbit coupling. The hidden spin polarization of k-band locating at high symmetry M point （conduction band minimum） has a strong anisotropy. In the bilayer, the hidden spin polarization is preserved at the upmost Se layer, while being suppressed if the ZrSe2 layer is taken as the symmetry partner. Our results on hidden spin polarization in 1 T-phase dichalcogenides, verifiable by spin-resolved and angle-resolved photoemis- sion spectroscopy （ARPES）, enrich our understanding of spin physics and provide important clues to search for specific spin polarization in two dimensional materials for spintronic and quantum informa- tion applications.
基金supported by the Project of Natural Science Foundation of Jiangsu Education Bureau,China (Grant No. 09KJB140010)the Project Prepared for National Natural Science Foundation of Xuzhou Normal University (Grant No. 08XLY03)the Innovation Project of Postgraduate Students of Xuzhou Normal University (Key Project, Grant No. 08YLA005)
文摘In this paper,we investigate the controllability of spin 1 systems and the realization of ternary gates.Using dipole and quadrupole operators as the orthogonal basis of su(3) algebra,we discuss the controllability of one spin 1 systems and offer the concept of a complete set of control operators first.Then we present the controllability of two spin 1 systems coupled with Ising interaction and the transforming relations of the drift process of the system.Finally the specific realization of the ternary SWAP gate in these systems is discussed.It takes 9 drift processes and 25 basic control processes.
文摘Manufacturing and sales According to data collected from 11,934 statistics-worthy Chinese cotton spinning enterprises surveyed by National Bureau of Statistics of China, total industrial production value of the industry increased 27.39
