这一研究揭示了长江三角洲地区旱灾险情的时空特征,对长江三角洲地区农业生产、农业结构调整和灌溉管理防灾抗灾等方面都能提供科学依据,具有较强的科学性。该研究是利用长三角地区气象站点数据,通过地理信息系统(GIS)对近40年(1980~20...这一研究揭示了长江三角洲地区旱灾险情的时空特征,对长江三角洲地区农业生产、农业结构调整和灌溉管理防灾抗灾等方面都能提供科学依据,具有较强的科学性。该研究是利用长三角地区气象站点数据,通过地理信息系统(GIS)对近40年(1980~2020)干旱等级的时间和空间演化特征进行评价,分析时空干旱灾害的危险性。分析结果显示:以SPI分析结果为基础,在波动中逐渐增强的年际尺度上表现为干旱趋势;季节尺度上的旱灾风险在空间上的分布差异是明显的,南方低北方高的变化特征是旱灾风险的表现;时间尺度上连旱特征显著。This paper shows the temporal and spatial characteristics of drought risk in the Yangtze River Delta region, which can provide scientific basis for agricultural production, agricultural structure adjustment and irrigation management in the Yangtze River Delta region. Based on the data of meteorological stations in the Yangtze River Delta, this study evaluates the temporal and spatial evolution characteristics of drought levels in recent 40 years (1980~2020) through SPI, and analyzes the risk of temporal and spatial drought disasters through GIS. The analysis results show that: based on SPI analysis results, the drought trend on the interannual scale is gradually strengthened in fluctuations;The distribution difference of drought disaster risk on seasonal scale is obvious in space, and the risk of drought disaster is characterized by low in the south and high in the north. On the time scale, it is characterized by continuous drought.展开更多
Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elu...Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elusive.Our findings demonstrate that SPI1 plays a significant role in counteracting chondrocyte senescence and inhibiting OA progression.SPI1 binds to the PERK promoter,thereby promoting its transcriptional activity.Importantly,PERK,rather than GCN2,facilitates eIF2αphosphorylation,activating the mitochondrial unfolded protein response(UPRmt)and impeding chondrocyte senescence.Deficiency of SPI1 in mechanical overload-induced mice leads to diminished UPRmt activation and accelerated OA progression.Intra-articular injection of adenovirus vectors overexpressing SPI1 and PERK effectively mitigates cartilage degeneration.In summary,our study elucidates the crucial regulatory role of SPI1 in the pathogenesis of chondrocyte senescence by activating UPRmt signaling through PERK,which may present a novel therapeutic target for treating OA.展开更多
The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investig...The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investigates the interdependencies among SPI components and their impact on country-level sustainability performance.Using a Bayesian Belief Network(BBN)approach,the analysis explores the interdependencies among 12 SPI components(including advanced education,basic education,environmental quality,freedom and choice,health,housing,inclusive society,information and communications,nutrition and medical care,rights and voice,safety,and water and sanitation)and their collective influence on sustainability performance.Data from the Sustainable Development Report and SPI datasets,covering 162 countries(including Australia,China,United Arab Emirates,United Kingdom,United States,and so on),were used to assess the relative importance of each SPI component.The key findings indicate that advanced education,inclusive society,and freedom and choice make substantial contributions to high sustainability performance,whereas deficiencies in nutrition and medical care,water and sanitation,and freedom and choice are associated with poor sustainability performance.The results reveal that sustainability performance is shaped by a network of interlinked SPI components,with education and inclusion emerging as key levers for progress.The study emphasizes that targeted improvements in specific SPI components can significantly enhance a country’s overall sustainability performance.Rather than visualizing countries’progress through composite indicator-based heat maps,this study explores the interdependencies among SPI components and their role in sustainability performance at the global level.The study underscores the importance of a multidimensional policy approach that addresses social and environmental factors to enhance sustainability.The findings contribute to a deeper understanding of how SPI components interact and shape sustainable development.展开更多
Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related t...Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation.However,the effect of Spi1 on intracerebral hemorrhage remains unclear.In this study,we found that Spi1 may regulate recovery from the neuroinflammation and neurofunctional damage caused by intracerebral hemorrhage by modulating the microglial/macrophage transcriptome.We showed that high Spi1expression in microglia/macrophages after intracerebral hemorrhage is associated with the activation of many pathways that promote phagocytosis,glycolysis,and autophagy,as well as debris clearance and sustained remyelination.Notably,microglia with higher levels of Soil expression were chara cterized by activation of pathways associated with a variety of hemorrhage-related cellular processes,such as complement activation,angiogenesis,and coagulation.In conclusion,our results suggest that Spi1 plays a vital role in the microglial/macrophage inflammatory response following intracerebral hemorrhage.This new insight into the regulation of Spi1 and its target genes may advance our understanding of neuroinflammation in intracerebral hemorrhage and provide therapeutic targets for patients with intracerebral hemorrhage.展开更多
文摘这一研究揭示了长江三角洲地区旱灾险情的时空特征,对长江三角洲地区农业生产、农业结构调整和灌溉管理防灾抗灾等方面都能提供科学依据,具有较强的科学性。该研究是利用长三角地区气象站点数据,通过地理信息系统(GIS)对近40年(1980~2020)干旱等级的时间和空间演化特征进行评价,分析时空干旱灾害的危险性。分析结果显示:以SPI分析结果为基础,在波动中逐渐增强的年际尺度上表现为干旱趋势;季节尺度上的旱灾风险在空间上的分布差异是明显的,南方低北方高的变化特征是旱灾风险的表现;时间尺度上连旱特征显著。This paper shows the temporal and spatial characteristics of drought risk in the Yangtze River Delta region, which can provide scientific basis for agricultural production, agricultural structure adjustment and irrigation management in the Yangtze River Delta region. Based on the data of meteorological stations in the Yangtze River Delta, this study evaluates the temporal and spatial evolution characteristics of drought levels in recent 40 years (1980~2020) through SPI, and analyzes the risk of temporal and spatial drought disasters through GIS. The analysis results show that: based on SPI analysis results, the drought trend on the interannual scale is gradually strengthened in fluctuations;The distribution difference of drought disaster risk on seasonal scale is obvious in space, and the risk of drought disaster is characterized by low in the south and high in the north. On the time scale, it is characterized by continuous drought.
基金supported by the Anhui Provincial Natural Science Foundation(Grant No.2308085MH250)the Natural Science Research Project of Anhui Educational Committee(Grant No.2023AH053327)the Scientific Research Fund Project of Anhui Medical University(2020xkj039).
文摘Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elusive.Our findings demonstrate that SPI1 plays a significant role in counteracting chondrocyte senescence and inhibiting OA progression.SPI1 binds to the PERK promoter,thereby promoting its transcriptional activity.Importantly,PERK,rather than GCN2,facilitates eIF2αphosphorylation,activating the mitochondrial unfolded protein response(UPRmt)and impeding chondrocyte senescence.Deficiency of SPI1 in mechanical overload-induced mice leads to diminished UPRmt activation and accelerated OA progression.Intra-articular injection of adenovirus vectors overexpressing SPI1 and PERK effectively mitigates cartilage degeneration.In summary,our study elucidates the crucial regulatory role of SPI1 in the pathogenesis of chondrocyte senescence by activating UPRmt signaling through PERK,which may present a novel therapeutic target for treating OA.
基金the resources and support provided by the American University of Sharjah to conduct this research
文摘The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investigates the interdependencies among SPI components and their impact on country-level sustainability performance.Using a Bayesian Belief Network(BBN)approach,the analysis explores the interdependencies among 12 SPI components(including advanced education,basic education,environmental quality,freedom and choice,health,housing,inclusive society,information and communications,nutrition and medical care,rights and voice,safety,and water and sanitation)and their collective influence on sustainability performance.Data from the Sustainable Development Report and SPI datasets,covering 162 countries(including Australia,China,United Arab Emirates,United Kingdom,United States,and so on),were used to assess the relative importance of each SPI component.The key findings indicate that advanced education,inclusive society,and freedom and choice make substantial contributions to high sustainability performance,whereas deficiencies in nutrition and medical care,water and sanitation,and freedom and choice are associated with poor sustainability performance.The results reveal that sustainability performance is shaped by a network of interlinked SPI components,with education and inclusion emerging as key levers for progress.The study emphasizes that targeted improvements in specific SPI components can significantly enhance a country’s overall sustainability performance.Rather than visualizing countries’progress through composite indicator-based heat maps,this study explores the interdependencies among SPI components and their role in sustainability performance at the global level.The study underscores the importance of a multidimensional policy approach that addresses social and environmental factors to enhance sustainability.The findings contribute to a deeper understanding of how SPI components interact and shape sustainable development.
基金supported by the National Natural Science Foundation of China,No.81971097(to JY)。
文摘Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation.However,the effect of Spi1 on intracerebral hemorrhage remains unclear.In this study,we found that Spi1 may regulate recovery from the neuroinflammation and neurofunctional damage caused by intracerebral hemorrhage by modulating the microglial/macrophage transcriptome.We showed that high Spi1expression in microglia/macrophages after intracerebral hemorrhage is associated with the activation of many pathways that promote phagocytosis,glycolysis,and autophagy,as well as debris clearance and sustained remyelination.Notably,microglia with higher levels of Soil expression were chara cterized by activation of pathways associated with a variety of hemorrhage-related cellular processes,such as complement activation,angiogenesis,and coagulation.In conclusion,our results suggest that Spi1 plays a vital role in the microglial/macrophage inflammatory response following intracerebral hemorrhage.This new insight into the regulation of Spi1 and its target genes may advance our understanding of neuroinflammation in intracerebral hemorrhage and provide therapeutic targets for patients with intracerebral hemorrhage.
