Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardiz...Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.展开更多
文摘Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.
文摘目的:考察SPG复方对小鼠急性酒精性肝损伤的保护作用及其急性毒性。方法:ICR小鼠随机分为空白对照组、模型组和低、中、高三个复方剂量组(质量分数分别为0.975、1.95、3.9 g/kg)。各治疗组分别灌胃给予相应治疗药物,10天后除空白对照组外,其余小鼠一次经口给予14 m L/kg 50%乙醇致急性肝损伤,观察小鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性及对肝组织匀浆中丙二醛(MDA)、甘油三酯(TG)、谷胱甘肽(GSH)水平的影响,并观察肝组织病理形态变化。再以最大给药量法灌胃观察该复方的口服急性毒性。结果:SPG复方中、高剂量组可显著抑制肝损伤小鼠血清中ALT与AST活性的升高(P<0.01,P<0.05),对肝组织GSH水平有显著升高作用(P<0.05),并能显著降低MDA水平(P<0.05)。高剂量组对TG的降低具有显著意义(P<0.05)。肝组织病理显示,中、高剂量组小鼠肝细胞未见明显异常。SPG复方灌胃每日最大剂量是人用量的456倍,无死亡及小鼠脏器异常情况。结论:SPG复方对小鼠急性酒精性肝损伤有一定的保护作用,机制可能与其抗氧化作用相关,口服给药低毒安全。
