目的:观察二陈汤加减联合奥沙利铂+替吉奥(SOX)方案治疗晚期胃癌的临床疗效及其对患者炎症因子水平和生存质量的影响。方法:选取60例晚期胃癌患者,将其随机分为治疗组和对照组,每组各30例。对照组采用SOX方案治疗,治疗组在对照组基础上...目的:观察二陈汤加减联合奥沙利铂+替吉奥(SOX)方案治疗晚期胃癌的临床疗效及其对患者炎症因子水平和生存质量的影响。方法:选取60例晚期胃癌患者,将其随机分为治疗组和对照组,每组各30例。对照组采用SOX方案治疗,治疗组在对照组基础上加用二陈汤加减治疗。比较2组疾病缓解率、中医证候评分、炎症因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)]水平、生命质量测定量表(Quality of Life Measurement Scale,EORTC QLQ-C30)评分和不良反应发生情况。结果:疾病缓解率治疗组为80.00%(24/30),对照组为53.33%(16/30),2组比较,差异有统计学意义(P<0.05);2组中医证候评分、炎症因子水平、EORTC QLQ-C30评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05);不良反应发生率治疗组为13.33%(4/30),对照组为6.67%(2/30),2组比较,差异无统计学意义(P>0.05)。结论:二陈汤加减联合SOX方案治疗晚期胃癌,可协同提升疾病缓解率,降低中医证候评分,改善炎症指标与生活质量,且安全性良好,值得临床推广。展开更多
The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3...The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3727/096504017X14973124850905 URL:https://www.techscience.com/or/v26n3/56651 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Neural stem cells(NSCs)have the potential for self-renewal and multidirectional differentiation,and their transplantation has achieved good efficacy in a variety of diseases.However,only 1%-10%of transplanted NSCs sur...Neural stem cells(NSCs)have the potential for self-renewal and multidirectional differentiation,and their transplantation has achieved good efficacy in a variety of diseases.However,only 1%-10%of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus.^(Sox2)is an important factor for NSCs to maintain proliferation.Therefore,^(Sox2)-overexpressing NSCs(NSC^(Sox2))may be more successful in improving neurological dysfunction after posthemorrhagic hydrocephalus.In this study,human NSC^(Sox2)was transplanted into a posthemorrhagic hydrocephalus mouse model,and retinoic acid was administered to further promote NSC differentiation.The results showed that NSC^(Sox2)attenuated the ventricular enlargement caused by posthemorrhagic hydrocephalus and improved neurological function.NSC^(Sox2)also promoted nerve regeneration,inhibited neuroinflammation and promoted M2 polarization(anti-inflammatory phenotype),thereby reducing cerebrospinal fluid secretion in choroid plexus.These findings suggest that NSC^(Sox2)rescued ventricular enlargement and neurological dysfunction induced by posthemorrhagic hydrocephalus through neural regeneration and modulation of inflammation.展开更多
Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and th...Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and the presence of narrow interests along with stereotypical repetitive behaviors.Recent research has shown that the Sox5 transcription factor plays a significant role in the axonal projection,migration,localization,and communication of newly generated neurons[1].Defects in the Sox5 gene are known to increase the risk of autism.A clinical study on 16 patients with Sox5 gene defects found that Sox5 haploinsufficiency is closely linked to key traits like developmental delay,language delay,behavioral problems,and minor deformities such as a protruding forehead and a wide,flat nasal bridge[2].展开更多
文摘目的:观察二陈汤加减联合奥沙利铂+替吉奥(SOX)方案治疗晚期胃癌的临床疗效及其对患者炎症因子水平和生存质量的影响。方法:选取60例晚期胃癌患者,将其随机分为治疗组和对照组,每组各30例。对照组采用SOX方案治疗,治疗组在对照组基础上加用二陈汤加减治疗。比较2组疾病缓解率、中医证候评分、炎症因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)]水平、生命质量测定量表(Quality of Life Measurement Scale,EORTC QLQ-C30)评分和不良反应发生情况。结果:疾病缓解率治疗组为80.00%(24/30),对照组为53.33%(16/30),2组比较,差异有统计学意义(P<0.05);2组中医证候评分、炎症因子水平、EORTC QLQ-C30评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05);不良反应发生率治疗组为13.33%(4/30),对照组为6.67%(2/30),2组比较,差异无统计学意义(P>0.05)。结论:二陈汤加减联合SOX方案治疗晚期胃癌,可协同提升疾病缓解率,降低中医证候评分,改善炎症指标与生活质量,且安全性良好,值得临床推广。
文摘The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3727/096504017X14973124850905 URL:https://www.techscience.com/or/v26n3/56651 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
基金supported by the National Natural Science Foundation of China,Nos.82473334(to LZ),82401629(to XL)the Major Scientific and Technological Achievements Transformation Project of Ningxia Hui Autonomous Region,No.2022CJE09013(to LZ)+4 种基金Mianyang Science and Technology Bureau(Mianyang Science and Technology Program),No.2023ZYDF097(to LZ)NHC Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital),No.2023HYX001(to LZ)Spinal Cord Diseases Clinical Medical Center of Yunnan Province,No.2024JSKFKT-16(to BG)the Natural Science Foundation of Sichuan Province,No.2024NSFSC1646(to XL)the China Postdoctoral Science Foundation,Nos.GZC20231811(to XL),2024T170601(to XL)and 2024M76228(to XL).
文摘Neural stem cells(NSCs)have the potential for self-renewal and multidirectional differentiation,and their transplantation has achieved good efficacy in a variety of diseases.However,only 1%-10%of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus.^(Sox2)is an important factor for NSCs to maintain proliferation.Therefore,^(Sox2)-overexpressing NSCs(NSC^(Sox2))may be more successful in improving neurological dysfunction after posthemorrhagic hydrocephalus.In this study,human NSC^(Sox2)was transplanted into a posthemorrhagic hydrocephalus mouse model,and retinoic acid was administered to further promote NSC differentiation.The results showed that NSC^(Sox2)attenuated the ventricular enlargement caused by posthemorrhagic hydrocephalus and improved neurological function.NSC^(Sox2)also promoted nerve regeneration,inhibited neuroinflammation and promoted M2 polarization(anti-inflammatory phenotype),thereby reducing cerebrospinal fluid secretion in choroid plexus.These findings suggest that NSC^(Sox2)rescued ventricular enlargement and neurological dysfunction induced by posthemorrhagic hydrocephalus through neural regeneration and modulation of inflammation.
基金supported by the Fujian Provincial Science and Technology Youth Project(2021111)the Technology Innovation Joint Funding Project(2023Y9289)the National Natural Science Foundation of China(82401643).
文摘Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and the presence of narrow interests along with stereotypical repetitive behaviors.Recent research has shown that the Sox5 transcription factor plays a significant role in the axonal projection,migration,localization,and communication of newly generated neurons[1].Defects in the Sox5 gene are known to increase the risk of autism.A clinical study on 16 patients with Sox5 gene defects found that Sox5 haploinsufficiency is closely linked to key traits like developmental delay,language delay,behavioral problems,and minor deformities such as a protruding forehead and a wide,flat nasal bridge[2].
